P. Zaragoza-Ballester , P. Sarandeses Fernández , I. González Martín , C. Martin-Arriscado Arroba , M.I. Cabanillas Pérez , X. Guarnizo Poma , I. Castel de Lucas , A. Galiana Morón , D. Vega Pérez , A.I. Romero Reina , M.J. Tabuenca Mateo , S. Ruiz Solís
{"title":"Una comida sólida hipoalergénica para la gammagrafía de vaciado gástrico basada en la dieta mediterránea. «Una dieta para vaciarlos a todos»","authors":"P. Zaragoza-Ballester , P. Sarandeses Fernández , I. González Martín , C. Martin-Arriscado Arroba , M.I. Cabanillas Pérez , X. Guarnizo Poma , I. Castel de Lucas , A. Galiana Morón , D. Vega Pérez , A.I. Romero Reina , M.J. Tabuenca Mateo , S. Ruiz Solís","doi":"10.1016/j.remn.2024.500093","DOIUrl":"10.1016/j.remn.2024.500093","url":null,"abstract":"<div><h3>Aim</h3><div>We aim to establish normal values and standardize a hypoallergenic and Mediterranean diet for gastric emptying scintigraphy (GES).</div></div><div><h3>Material and methods</h3><div>In a prospective cohort of healthy volunteers, we performed GES of a [<sup>99</sup>Tc]TcDTPA<sup>2</sup><sup>−</sup> labelled hypoallergenic meal (egg, potato, rice and olive oil). Anterior and posterior images were simultaneously acquired at 0, 30, 60, 110, 120, 130, 180, 230, 240 and 250<!--> <!-->minutes. Cross-sectional analysis was performed between demographic data and gastric retention values. A score covariance analysis model was used to observer changes between measurements over time.</div></div><div><h3>Results</h3><div>50 participants (29 women) were included. Mean values and standard deviation (5-95th) for gastric retention percentages at 60, 120, 180, 240<!--> <!-->minutes were 51.40<!--> <!-->±<!--> <!-->8.63 (36.5-66.1), 21.66<!--> <!-->±<!--> <!-->9.40 (6.5-38.2), 7.58<!--> <!-->±<!--> <!-->5.77 (1.5-19.1) and 2.94<!--> <!-->±<!--> <!-->2.08 (1-7.3), respectively. Male participants had a significative faster gastric emptying compared to women in practically all the acquisitions. Male participants and smoker participants generated a significative decrease of gastric retention values in generalized linear model (male coefficient −4.818, 95%<!--> <!-->CI: −7.24 to −2.39, <em>P</em> <!--><<!--> <!-->.001; and smoker coefficient of −3.484, 95%<!--> <!-->CI: −6.29 to −0.67, <em>P</em> <!--><<!--> <!-->.05).</div></div><div><h3>Conclusion</h3><div>This study standardizes and establishes normal values for GES with the first hypoallergenic solid meal based on consensus recommendations and a Mediterranean diet; suitable for most patients with allergic or sensitive-conditions to other meal components.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500093"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Canales Rodríguez , M. Mitjavila Casanovas , S. Ruiz Solís
{"title":"Justificación e impacto del uso de la SPECT 123I-FP-CIT en el diagnóstico diferencial y manejo de los trastornos del movimiento (TM) en un hospital de referencia nacional","authors":"L. Canales Rodríguez , M. Mitjavila Casanovas , S. Ruiz Solís","doi":"10.1016/j.remn.2024.500092","DOIUrl":"10.1016/j.remn.2024.500092","url":null,"abstract":"<div><h3>Introduction</h3><div>Cerebral single photon emission computed tomography (SPECT) using <sup>123</sup>I-FP-CIT is a key tool in the differential diagnosis of movement disorders (MD), but its appropriate indication is essential to optimize resources and avoid unnecessary tests.</div></div><div><h3>Objective</h3><div>To evaluate the adequacy and impact of SPECT <sup>123</sup>I-FP-CIT in the diagnosis and management of MD according to clinical guidelines.</div></div><div><h3>Methodology</h3><div>Retrospective study involving 249 patients with suspected parkinsonism (PK) of uncertain origin. All underwent SPECT <sup>123</sup>I-FP-CIT and had a clinical follow-up of exceeding 12 months. Requests were classified based on their adherence to clinical guidelines. Variables analyzed included sex, age, justification for the request, management after SPECT, and final diagnosis.</div></div><div><h3>Results</h3><div>91.57% of the requests were appropriate, while 8.43% did not adhere to the guidelines. Diagnosis changed in 48.6% of cases and management in 70.68% after the scan, especially in inconclusive cases and initiation of therapy. General neurologists evaluated more cases and made more appropriate requests (96,3% vs 76,67%;p<!--> <!--><<!--> <!-->0,001). However, MD specialists, despite less appropriate use of the text, achieved a higher number of conclusive diagnoses in complex cases.</div></div><div><h3>Conclusion</h3><div>SPECT <sup>123</sup>I-FP-CIT has significant clinical impact when used in accordance with clinical guidelines, improving the diagnosis and management of MD. Unjustified scans reduce its utility. Collaboration between general neurologists and MD specialists is fundamental; the latter, although showing less adherence to guidelines in requesting the test, achieve a higher number of conclusive diagnoses in complex cases.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500092"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M.N. Acar Tayyar , M.Ö. Tamam , G.B. Babacan , M.C. Şahin , H. Özçevik , S. Şengiz Erhan , A.E. Öztürk
{"title":"Relación entre el estado de HER2 adquirido a partir de los datos patológicos y los parámetros metabólicos obtenidos mediante [18F]FDG PET/TC pretratamiento en adenocarcinomas gástricos","authors":"M.N. Acar Tayyar , M.Ö. Tamam , G.B. Babacan , M.C. Şahin , H. Özçevik , S. Şengiz Erhan , A.E. Öztürk","doi":"10.1016/j.remn.2024.500080","DOIUrl":"10.1016/j.remn.2024.500080","url":null,"abstract":"<div><h3>Objective</h3><div>Overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) is thought to be more aggressive in gastric cancer. This study aimed to evaluate the predictability of HER2 status and other prognostic pathologic parameters using [<sup>18</sup>F]FDG PET/CT and to investigate its impact on survival.</div></div><div><h3>Methods</h3><div>Pretreatment metabolic parameters measured by [<sup>18</sup>F]FDG PET/CT as a prognostic factor were retrospectively evaluated in 117 HER2-analysed patients. The relationship between pathological data, tumor metabolic characteristics, and distant metastases was examined, and the effect on survival was investigated.</div></div><div><h3>Results</h3><div>Among the 117 patients, 17.1% were HER2-positive (HER2<sup>+</sup>), and 82.9% were HER2-negative (HER2<sup>−</sup>). There was no significant association between PET/CT parameters in the HER2<sup>+</sup> and HER2<sup>−</sup> patient groups. HER2<sup>+</sup> patients had higher 1- and 3-year survival expectations than HER2<sup>−</sup> patients (80-37.9%; 47.5-20%; respectively). There was no statistically significant difference in overall survival. In Cox-regression analysis, while the presence of vascular invasion, local invasion, and distant metastasis were poor prognostic factors, HER2 was not a prognostic factor. Vascular invasion and local invasion (T3/T4) were also associated with higher SUVmax values. Patients with distant metastases had significantly higher SUVmax, SUVmean, and TLG.</div></div><div><h3>Conclusion</h3><div>This study showed no association between HER2 expression and [<sup>18</sup>F]FDG PET/CT metabolic parameters. However, regardless of HER2 status, the results indicated distant metastasis, local invasion, and vascular invasion could be associated with primary tumor metabolism. PET/CT parameters predict tumor aggressiveness and disease prognosis better than HER2 status.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500080"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Torres , R. Ramos , M.L. Domínguez , J.J. Rosales , A. Roteta , E. Prieto , L. Sancho , M. de Arcocha , G. Quincoces , en nombre del Grupo de Oncología de la SEMNIM
{"title":"Estado del arte y perspectivas futuras de nuevos radionúclidos en Medicina Nuclear: Parte III","authors":"I. Torres , R. Ramos , M.L. Domínguez , J.J. Rosales , A. Roteta , E. Prieto , L. Sancho , M. de Arcocha , G. Quincoces , en nombre del Grupo de Oncología de la SEMNIM","doi":"10.1016/j.remn.2025.500161","DOIUrl":"10.1016/j.remn.2025.500161","url":null,"abstract":"<div><div>In this third installment of the continuing education series, the clinical and therapeutic applications of zirconium, astatine and thorium are analyzed in depth. Although they are not described as theragnostic pairs, each of these radionuclides plays a fundamental role in precision medicine, which is rapidly advancing within Nuclear Medicine.</div><div>We begin by analyzing zirconium-89, a positron emitter whose long half-life makes it particularly suitable for labeling large molecules with slow kinetics, such as antibodies, playing a crucial role in immunotherapy. The use of astatine-211, an alpha-emitting radionuclide with a simple decay scheme and chemical behavior similar to iodine, is also discussed. Its main challenge lies in its production, as it requires cyclotrons capable of generating highly energetic alpha particle beams. Furthermore, thorium-227, a 100% alpha emitter, is reviewed. This radionuclide exhibits excellent chelation properties, enabling its conjugation with tumor-targeting molecules to produce thorium-labeled conjugates. While this technique is yielding promising preclinical results, the use of thorium faces challenges, including the potential separation of radium-223 from the molecule and the dependence of activity measurements on the time of production. Since it takes 100 days to reach equilibrium, activity assessment is based on photons emitted by its daughter radionuclides.</div><div>Despite these challenges, these radionuclides are driving the evolution of precision medicine, expanding therapeutic and diagnostic possibilities within Nuclear Medicine.</div><div>Nuclear Medicine.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500161"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Casanueva-Eliceiry , M. Manyalich-Blasi , A. Farré-Melero , A. Niñerola-Baizán , D. Saavedra , M. Mora-Porta , F.A. Hanzu , A. Orois , M. Squarcia , M. Rodrigo-Calvo , M. Tormo-Ratera , K. Quintero-Martinez , D. Fuster-Pelfort , O. Vidal-Pérez , S. Vidal-Sicart
{"title":"Redefiniendo la localización preoperatoria basada en imágenes de los adenomas en pacientes con hiperparatiroidismo primario candidatos a cirugía mínimamente invasiva","authors":"S. Casanueva-Eliceiry , M. Manyalich-Blasi , A. Farré-Melero , A. Niñerola-Baizán , D. Saavedra , M. Mora-Porta , F.A. Hanzu , A. Orois , M. Squarcia , M. Rodrigo-Calvo , M. Tormo-Ratera , K. Quintero-Martinez , D. Fuster-Pelfort , O. Vidal-Pérez , S. Vidal-Sicart","doi":"10.1016/j.remn.2024.500091","DOIUrl":"10.1016/j.remn.2024.500091","url":null,"abstract":"<div><h3>Background and objectives</h3><div>To compare the diagnostic accuracy of [<sup>18</sup>F]-Fluorocholine (FCH) PET/CT with conventional [<sup>99m</sup>Tc]Tc-MIBI scintigraphy and cervical ultrasound (USG) for the preoperative localization of hyperfunctioning parathyroid tissue (HFPT) in patients with primary hyperparathyroidism (PHPT).</div></div><div><h3>Materials and methods</h3><div>This prospective study included 90 patients diagnosed with PHPT who underwent [<sup>18</sup>F]F-CH PET/CT, [<sup>99m</sup>Tc]Tc-MIBI SPECT/CT and Neck USG. The diagnostic accuracy of each imaging modality was assessed using intraoperative findings and histopathological confirmation as the gold standard. The localization accuracy was evaluated based on specific quadrant detection, laterality, and ectopic gland identification. The study also explored the correlation between imaging findings and biochemical parameters, including preoperative and postoperative PTH and calcium levels.</div></div><div><h3>Results</h3><div>[<sup>18</sup>F]F-CH PET/CT demonstrated superior accuracy in detecting pathological parathyroid glandscompared to [<sup>99m</sup>Tc]Tc-MIBI SPECT/CT and USG. [<sup>18</sup>F]F-CH PET/CT correctly identified 98.9% of patientswith pathological glands, with a specific location accuracy of 93.2%, 65.9% and 38.8% for [<sup>18</sup>F]F-CH PET/CT,[<sup>99m</sup>Tc]Tc-MIBI SPECT/CT and USG, respectively.</div><div>For ectopic adenomas, FCH PET/CT achieved an accuracy of 100% (4/4), while MIBI and neck ultrasound identified these in 50% (2/4) and 0% (0/4) of cases, respectively.</div><div>There were two cases of multiglandular disease, [<sup>18</sup>F]F-CH PET/CT and [99mTc]Tc-MIBI each detected one gland in one case (50%) while USG detected none; in the other case, [<sup>18</sup>F]F-CH PET/CT and USG identified both glands (100%), and [99mTc]Tc-MIBI detected none.</div><div>Significant correlations were observed between SUVmax values from [<sup>18</sup>F]F-CH PET/CT and gland size, weight, and preoperative PTH levels.</div></div><div><h3>Conclusions</h3><div>[<sup>18</sup>F]F-CH PET/CT outperformed conventional imaging modalities in the preoperative localization of HFPT, particularly in challenging cases such ectopic or multiglandular disease. These findings support its potential as an effective and reliable imaging tool for the management of primary hyperparathyroidism.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 4","pages":"Article 500091"},"PeriodicalIF":1.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G.B. Babacan , M.Ö. Tamam , S. Saraçoğlu , M.N. Acar Tayyar , M.C. Şahin , H. Özçevik , G. Kulduk , Ö.B. Ekinci , E. Çelik
{"title":"Nuevo método de heterogeneidad para predecir la supervivencia en el cáncer de mama triple negativo no metastásico","authors":"G.B. Babacan , M.Ö. Tamam , S. Saraçoğlu , M.N. Acar Tayyar , M.C. Şahin , H. Özçevik , G. Kulduk , Ö.B. Ekinci , E. Çelik","doi":"10.1016/j.remn.2025.500112","DOIUrl":"10.1016/j.remn.2025.500112","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the relationship between semiquantitative positron emission tomography (PET) parameters and intratumoral heterogeneity (ITH) on <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) imaging and survival data of non-metastatic triple-negative breast cancer (TNBC) patients.</div></div><div><h3>Methods</h3><div>Sixty-two consecutive female patients who underwent pretreatment <sup>18</sup>F-FDG PET/CT with non-metastatic TNBC were enrolled. Heterogeneity index (HI) variables derived from the metabolic tumor volume (MTV) and standardized uptake value (SUV) parameters of primary lesions were evaluated. A novel modified method introducing a percentage-based (30-40-50%) MTV slope comparison was proposed. The association between conventional <sup>18</sup>F-FDG PET/CT parameters, HI values, and survival results was analyzed retrospectively.</div></div><div><h3>Results</h3><div>Tumors with higher HI values were associated with shorter survival times. For overall survival (OS), HI2 and HI3 were statistically significant (<em>P</em>=.009, <em>P</em>=.016). Regarding radiological progression-free survival (rPFS), HI1 and HI3 were statistically significant (<em>P</em>=.01, <em>P</em>=.025). A significant weak correlation between HI1 (<em>P</em>=.005, rho=.34) and a strong correlation was found for HI2 (<em>P</em><.0001, rho=.89), HI3 and tumor size were not statistically significantly correlated (<em>P</em>=.063, rho=.23). T stage was statistically significantly associated with rPFS and OS (<em>P</em>=.038, <em>P</em>=.003). In contrast, no statistically significant difference was found for the N stage, anatomical, and clinical staging (<em>P</em>>.05).</div></div><div><h3>Conclusion</h3><div>This study concluded that ITH predicts survival for non-metastatic TNBC patients. This conclusion was reached with the heterogeneity index variables obtained by different methods. However, our results revealed that HI2 depends on tumor size. Our modified method (HI3) predicts survival independently of tumor size.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 5","pages":"Article 500112"},"PeriodicalIF":1.6,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. López Puche , J.G. Villanueva Curto , P. García-Talavera San Miguel , J.A. Badell Martínez , S. Rama Alonso , M.P. Tamayo Alonso
{"title":"Enfermedad de Erdheim Chester: diagnóstico y valoración de respuesta con PET/TC [18F]FDG","authors":"S. López Puche , J.G. Villanueva Curto , P. García-Talavera San Miguel , J.A. Badell Martínez , S. Rama Alonso , M.P. Tamayo Alonso","doi":"10.1016/j.remn.2025.500179","DOIUrl":"10.1016/j.remn.2025.500179","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 5","pages":"Article 500179"},"PeriodicalIF":1.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G.U. Erdem , O. Vural Topuz , E. Acar , T. Kapagan , E. Yetim , A. Ozmen , S. Gurocak , G. Usul , S. Yuksel , A.H. Yardimci , N. Bulut
{"title":"Predicción de la respuesta completa a la quimiorradioterapia neoadyuvante en el cáncer de recto localmente avanzado: papel de los parámetros volumétricos basales de la PET/TC con [18F]FDG y los marcadores inflamatorios","authors":"G.U. Erdem , O. Vural Topuz , E. Acar , T. Kapagan , E. Yetim , A. Ozmen , S. Gurocak , G. Usul , S. Yuksel , A.H. Yardimci , N. Bulut","doi":"10.1016/j.remn.2025.500113","DOIUrl":"10.1016/j.remn.2025.500113","url":null,"abstract":"<div><h3>Objectives</h3><div>We evaluated the influence of baseline volumetric 18F-fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) parameters and inflammatory prognostic markers on complete response (CR) in patients with locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiotherapy (nCRT).</div></div><div><h3>Materials and methods</h3><div>In total, 90 patients with LARC, including those with and without CR, were evaluated based on baseline volumetric PET/CT parameters, such as maximum standard uptake value, metabolic tumor volume (MTV), tumor lesion glycolysis, and inflammatory prognostic markers, including the lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio.</div></div><div><h3>Results</h3><div>Of the 90 patients, 62 (68.9%) were male and 28 (31.1%) were female. The median age was 61 (31-81) years. A complete response was observed in 20 (22%) patients following nCRT. Of these, 5 demonstrated a clinical complete response, whereas 15 exhibited a complete response after surgery. A low pretreatment PLR, low MTV levels, and stage 2 disease were identified as significant predictors of complete response. The optimal cutoff values were 16.5 for MTV (sensitivity 80%, specificity 62%) and 121 for PLR (sensitivity 73%, specificity 65%).</div></div><div><h3>Conclusion</h3><div>Our findings suggest that stage 2 disease, low pretreatment MTV, and low PLR levels may be predictive of a CR to nCRT in patients with LARC.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"44 5","pages":"Article 500113"},"PeriodicalIF":1.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}