Revista Espanola De Medicina Nuclear E Imagen Molecular最新文献

{"title":"Un caso infrecuente de paragangliomas multicéntricos sincrónicos detectado mediante PET/TC con [68Ga]Ga-DOTATATE","authors":"N. Aydinbelge Dizdar, A. Dursun, M. Samsum, O. Ozmen","doi":"10.1016/j.remn.2025.500233","DOIUrl":"10.1016/j.remn.2025.500233","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 5","pages":"Article 500233"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148859083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfil de toxicidad renal y hematológica de la terapia con radioligandos dirigida al PSMA marcada con 177Lu (177Lu-PSMA-RLT): estudio de cohorte retrospectivo","authors":"M. Yalçınkaya,&nbsp;F. Demir,&nbsp;S. Karaçavuş,&nbsp;M. Demir","doi":"10.1016/j.remn.2026.500306","DOIUrl":"10.1016/j.remn.2026.500306","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to retrospectively evaluate the renal and hematologic toxicity profile of 177Lu-PSMA-RLT in patients with metastatic castration-resistant prostate cancer.</div></div><div><h3>Methods</h3><div>Renal function (GFR, BUN, and creatinine) and hematological parameters (hemoglobin, leukocyte, platelet) before and after treatment were examined in 41 patients who received 177Lu-PSMA-RLT at our clinic, and changes along with toxicity grades were determined. Additionally, pre-treatment PSMA PET/CT findings and other demographic and clinical data were assessed.</div></div><div><h3>Results</h3><div>In terms of renal toxicity, G0-G1 level toxicity was observed in 97.6% of cases, while G2 toxicity was observed in only one patient. This patient already had a low GFR before treatment and experienced only a 3-unit decrease. Regarding hematological toxicity, the rates of G3-4 toxicity were as follows: leukocytes 7.3%, hemoglobin 9.8%, platelets 7.3%.</div></div><div><h3>Conclusion</h3><div>No clinically significant nephrotoxicity was observed with 177Lu-PSMA-RLT.</div><div>Hematologic toxicity is significant but manageable, and severe side effects are rare and within predictable limits.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 5","pages":"Article 500306"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148859679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hipometabolismo cortical reversible en migraña con aura prolongada: hallazgos en PET/TC con 18[F]FDG","authors":"D.A. López-Mora,&nbsp;L. Lozano Murgas,&nbsp;A. Mestre-Fusco,&nbsp;M.I. Santisteban Gutierrez,&nbsp;A.A. Rodriguez Revuelto","doi":"10.1016/j.remn.2025.500279","DOIUrl":"10.1016/j.remn.2025.500279","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 5","pages":"Article 500279"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148859222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posicionamiento de la Sociedad Española de Medicina Nuclear e Imagen Molecular para la preparación del sistema sanitario ante la llegada de los nuevos tratamientos contra la enfermedad de Alzheimer","authors":"Junta Directiva de la Sociedad Española de Medicina Nuclear e Imagen Molecular","doi":"10.1016/j.remn.2025.500267","DOIUrl":"10.1016/j.remn.2025.500267","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 5","pages":"Article 500267"},"PeriodicalIF":1.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148859675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluación de la eficacia diagnóstica del análisis radiómico de la PET con [18F]FDG para la diferenciación tumoral en los pacientes con cáncer no microcítico de pulmón","authors":"X. Boulvard Chollet,&nbsp;M.P. Garrastachu Zumarán,&nbsp;L.G. Romero Robles,&nbsp;A. Santapau Traveria,&nbsp;M.C. Albornoz Almada,&nbsp;R. Ramírez Lasanta,&nbsp;J.G. Pichel,&nbsp;R.C. Delgado Bolton","doi":"10.1016/j.remn.2025.500250","DOIUrl":"10.1016/j.remn.2025.500250","url":null,"abstract":"<div><h3>Purpose</h3><div>The aim of this study was to evaluate the utility of radiomics based on [¹⁸F]FDG PET/CT imaging for the prediction of histological differentiation grade in patients with non-small cell lung cancer (NSCLC) of either adenocarcinoma or squamous cell carcinoma subtype.</div></div><div><h3>Materials and methods</h3><div>A single-center retrospective observational study was conducted, including 150 patients with histologically confirmed NSCLC who underwent [¹⁸F]FDG PET/CT imaging prior to complete surgical resection of the tumor. Patients were excluded if they showed no significant FDG uptake, lacked differentiation data, or had insufficient tumor volume. Image segmentation and feature extraction were performed using LIFEx® software, obtaining both textural and morphological features. Predictive variables were selected using classical statistical techniques and LASSO regression, and model performance was evaluated using ROC curve analysis.</div></div><div><h3>Results</h3><div>Among the 150 patients included, 25 had well-differentiated tumors, 88 moderately differentiated, and 37 had poorly differentiated. Comparison between well-differentiated tumors and those with moderate or poor differentiation revealed statistically significant differences in several radiomic features. The LASSO model identified seven variables with high discriminative power. The model achieved a sensitivity of 76%, specificity of 99.2%, positive predictive value of 95%, negative predictive value of 95.4%, and an overall accuracy of 95.3%.</div></div><div><h3>Conclusions</h3><div>Radiomic features extracted from [¹⁸F]FDG PET/CT images can predict tumor differentiation grade in NSCLC with high specificity. This non-invasive approach may serve as a valuable adjunct to histopathological evaluation, potentially aiding clinical decision-making.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 4","pages":"Article 500250"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148545623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlación entre los parámetros metabólicos derivados de la PET/TC con [18F]FDG y la expresión de PD-L1 en pacientes con cáncer de pulmón no microcítico","authors":"Selin Kesim,&nbsp;Filiz Ozulker,&nbsp;Gonca Gul Gecmen,&nbsp;Nedim Turan","doi":"10.1016/j.remn.2025.500258","DOIUrl":"10.1016/j.remn.2025.500258","url":null,"abstract":"<div><h3>Objectives</h3><div>Programmed death-ligand<!--> <!-->1 (PD-L1) expression serves as a critical biomarker for selecting patients eligible for treatment with immune checkpoint inhibitors. Herein, we investigated the association between PD-L1 expression and various FDG PET/CT-derived metabolic parameters in patients with non-small cell lung cancer (NSCLC).</div></div><div><h3>Materials and methods</h3><div>This retrospective study included 81 NSCLC patients who underwent pre-treatment [¹⁸F]FDG PET/CT imaging and histopathological evaluation of PD-L1 expression. PD-L1 tumour proportion score (TPS) was determined using the SP263 immunohistochemical assay. PD-L1 positivity was defined as TPS ≥<!--> <!-->1%. Quantitative PET/CT parameters—SUVmax, SUVmean, SULpeak, SULmax, metabolic tumor volume (MTV), total lesion glycolysis (TLG), and heterogeneity indices (coefficient of variation [COV] and SUV-based heterogeneity index [HI])—were analyzed in relation to PD-L1 TPS.</div></div><div><h3>Results</h3><div>PD-L1 positivity was identified in 30 patients (37%). Although SUVmax, SUVmean, SULpeak, and SULmax values tended to be higher in PD-L1-positive patients, these differences were not statistically significant. Conversely, MTV and TLG were higher in the PD-L1-negative group. Among all parameters, HI was significantly elevated in the PD-L1-positive group (<em>P</em> <!-->=<!--> <!-->.031), and remained significant across PD-L1 expression strata (<em>P</em> <!-->=<!--> <!-->.037). In metastatic patients, HI and COV showed significant positive correlation with PD-L1 expression (r<!--> <!-->=<!--> <!-->0.34 and 0.33, respectively). ROC analysis identified a HI cut-off of 1.59 to predict PD-L1 positivity with 90% sensitivity and 50% specificity (AUC<!--> <!-->=<!--> <!-->0.674).</div></div><div><h3>Conclusions</h3><div>Tumor heterogeneity indices, particularly HI and COV derived from FDG PET/CT, demonstrated stronger predictive value for PD-L1 expression than conventional metabolic parameters. These findings suggest that metabolic heterogeneity may serve as a useful noninvasive imaging biomarker for guiding immunotherapy in NSCLC.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 4","pages":"Article 500258"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148545622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediastinitis aguda necrosante descendente como complicación de un absceso retrofaríngeo: diagnóstico mediante 18F-FDG PET/TC","authors":"P. Dauden-Onate,&nbsp;L.F. León-Ramírez,&nbsp;G. Cuesta-Domingo,&nbsp;M. Vaillant-Lopez,&nbsp;C. González-Roiz,&nbsp;M.N. Cabrera-Martín","doi":"10.1016/j.remn.2025.500234","DOIUrl":"10.1016/j.remn.2025.500234","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 4","pages":"Article 500234"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148545616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluación de la función renal diferencial en niños con infección del tracto urinario complicada por hidronefrosis mediante técnicas de imagen renal dinámica y estática","authors":"X. Ruan,&nbsp;H. Wu,&nbsp;Z. Chen","doi":"10.1016/j.remn.2025.500260","DOIUrl":"10.1016/j.remn.2025.500260","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;This study aims to compare differential renal function (DRF) results obtained from Tc- 99m DTPA and Tc-99m DMSA scintigraphy in children with urinary tract infection (UTI) combined with varying degrees of hydronephrosis. We evaluate the diagnostic performance of both methods and provide recommendations for selecting individualized imaging strategies based on specific case characteristics.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A retrospective analysis was conducted on 57 children with UTI combined with ipsilateral hydronephrosis. Clinical data collected included gender, age, urinary ultrasound findings, and results from renal dynamic and static scintigraphy. Hydronephrosis was classified by ultrasound into mild (&lt;15&lt;!--&gt; &lt;!--&gt;mm), moderate (15–30&lt;!--&gt; &lt;!--&gt;mm), and severe (&gt;30&lt;!--&gt; &lt;!--&gt;mm). The kidney volume ratio between the affected and unaffected sides was calculated. DRF percentages for each kidney were separately obtained from both scintigraphy methods, and the deviation in DRF of the affected kidney was calculated. Based on the degree of deviation, results were categorized as normal (&lt;5%), differing (5%–10%), or significantly different (&gt;10%). The non-parametric Mann-Whitney U test was used to compare DRF values between Tc-99m DMSA and Tc-99m DTPA. Spearman correlation analysis assessed the relationship between hydronephrosis and DRF deviation. Receiver operating characteristic (ROC) curves were used to determine diagnostic thresholds and assess the predictive value of renal pelvic and calyceal dilation for DRF deviations.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Among the 57 children, the median DRF of the affected kidney was 50.84% (IQR: 43.24,55.00) by Tc-99m DMSA and45% (IQR: 35.35, 47.95) by Tc-99m DTPA, with the difference being statistically significant (Z = -4.074, p ˂ 0.000). Of these, 34 children had a DRF deviation &gt;&lt;!--&gt; &lt;!--&gt;5%, and 16 had a deviation&lt;!--&gt; &lt;!--&gt;&gt; 10%. Positive correlations were observed between DRF deviation and renal pelvic dilation (r&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.299, p&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.024), calyceal dilation (r&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.235, p&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.078), and kidney volume ratio (r&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;4.416, p&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.001). A renal pelvic dilation&lt;!--&gt; &lt;!--&gt;&gt; 13.5&lt;!--&gt; &lt;!--&gt;mm or calyceal dilation&lt;!--&gt; &lt;!--&gt;&gt; 8.8&lt;!--&gt; &lt;!--&gt;mm predicted DRF deviations&lt;!--&gt; &lt;!--&gt;&gt; 5% with a sensitivity of 73.5% and 79.4%, respctively. For deviations&lt;!--&gt; &lt;!--&gt;&gt; 10%, a calyceal dilation long axis&lt;!--&gt; &lt;!--&gt;&gt;23.2&lt;!--&gt; &lt;!--&gt;mm yielded a diagnostic specificity of 100%.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Tc-99m DMSA-derived DRF may be affected by the degree of hydronephrosis. In children with UTI combined with hydronephrosis, significant differences in DRF assessment exist between Tc-99m DMSA and Tc-99m DTPA. When renal pelvic dilation exceeds 13.5&lt;!--&gt; &lt;!--&gt;mm or calyceal diameter reaches 23.2&lt;!--&gt; &lt;!--&gt;mm, Tc-99m DMSA may overestimat","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 4","pages":"Article 500260"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148545620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valoración de la reperfusión pulmonar post-TEP mediante segmentación automática y análisis cuantitativo del SPECT/TC de perfusión pulmonar","authors":"N. Álvarez Mena,&nbsp;F. Sebastián Palacid,&nbsp;B. Pérez López,&nbsp;S. Pena Vaquero,&nbsp;A.E. Hurtado Romero,&nbsp;R.C. Zambrano Infantino,&nbsp;R. Ruano Pérez","doi":"10.1016/j.remn.2025.500262","DOIUrl":"10.1016/j.remn.2025.500262","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the diagnostic impact of using automatic segmentation and quantitative analysis of lung perfusion SPECT/CT in the evaluation of pulmonary reperfusion in patients undergoing follow-up for pulmonary thromboembolism (PTE).</div></div><div><h3>Materials and methods</h3><div>A prospective study was conducted from October 2021 to October 2024. We included 132 patients with PTE diagnosed by lung perfusion scintigraphy with SPECT/CT, who underwent a follow-up scan at 6 months.</div><div>Reperfusion was assessed visually and quantitatively. Three grades were visually established: no reperfusion, partial reperfusion, and complete reperfusion. For quantitative analysis, automatic segmentation was performed, obtaining volumes and total counts in the baseline and follow-up SPECT/CT scans. Two parameters were established for comparison: the relative decrease in defect volume (RDV) and the relative increase in total perfused volume counts (RIC). Reperfusion was classified as: no reperfusion, partial reperfusion (minor and major), and complete reperfusion.</div><div>The scintigraphic results were correlated with demographic variables, extension and size of the PTE and other complementary diagnostic tools (pulmonary function tests and echocardiogram).</div></div><div><h3>Results</h3><div>82 patients were women (mean age 70<!--> <!-->±<!--> <!-->16 years) and 50 were men (64<!--> <!-->±<!--> <!-->15 years).</div><div>Comparing the agreement between visual and quantitative analysis (weighted Cohen's Kappa index), a slight, but non-statistically significant, agreement was demonstrated between evaluators (κ<!--> <!-->=<!--> <!-->0.04; <em>P</em> <!-->=<!--> <!-->0.464).</div><div>Pearson's assessment revealed a very high and positive assessment between RDV and RIC (r<!--> <!-->=<!--> <!-->0.77; <em>P</em> &lt;<!--> <!-->0.001).</div><div>Patients with abnormal complementary diagnostics tools at follow-up were not more likely to have residual thrombosis <em>(P</em> <!-->&gt; 0.05 in the visual and quantitative analyses). The remaining variables also did not show statistical significance in the persistence of PTE.</div></div><div><h3>Conclusions</h3><div>In the assessment of post-PTE pulmonary reperfusion, quantitative analysis of lung perfusion SPECT/CT is superior to visual analysis. Furthermore, it suggests that it is a particularly useful tool in patients in whom visual analysis does not show improvement, as it could prevent unnecessary and prolonged treatment if reperfusion is observed through quantification.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 4","pages":"Article 500262"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148545617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluación de un nuevo parámetro de la PET/TC con [18F]FDG para diferenciar entre lesiones suprarrenales benignas y malignas: el «índice densitometabólico suprarrenal (IDMS)»","authors":"E. Ciftci,&nbsp;T.Y. Erdil,&nbsp;B.K. Erkek,&nbsp;B. Akovali","doi":"10.1016/j.remn.2025.500185","DOIUrl":"10.1016/j.remn.2025.500185","url":null,"abstract":"<div><h3>Objective</h3><div>This study evaluates the diagnostic importance of a new parameter consisting of the densitometric and metabolic properties of the lesion measured by ¹⁸F-FDG PET/CT in differentiating between benign and malignant adrenal lesions in cancer patients.</div></div><div><h3>Material and methods</h3><div>We evaluated PET/CT parameters of adrenal lesions of patients between 2017 and 2019. A new parameter, “Adrenal Dansitometabolic index (ADMI)”, was investigated. Additionally, SUVmax, tumor-to-liver ratio (T/LR), Hounsfield Units (HU), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of adrenal lesions were analyzed. Logistic regression analyses were conducted to identify the most predictive parameter for malignant lesions.</div></div><div><h3>Results</h3><div>Two hundred four adrenal lesions underwent PET/CT for tumor evaluation. Based on ROC analysis, ADMI<!--> <!-->&gt;<!--> <!-->9.5, a SUVmax<!--> <!-->&gt;<!--> <!-->4.15, a T/L SUVmax ratio &gt;<!--> <!-->1.7, an attenuation value &gt;<!--> <!-->21.75<!--> <!-->HU, a TLG<!--> <!-->&gt;<!--> <!-->14.61 and a MTV<!--> <!-->&gt;<!--> <!-->4.5 were chosen as the optimal cut-off values for differentiating malignant from benign lesions. ADMI, SUVmax, and T/L ratio demonstrated similarly high diagnostic performance (AUC values: .993, .992 and 0.988 (<em>P</em>=.000), respectively). ADMI exhibited the highest sensitivity and negative predictive value. A multivariate logistic regression analysis revealed that both ADMI and T/L ratio serve as independent prognostic factors for malignancy (<em>P</em>=.001 and <em>P</em>=.003, respectively).</div></div><div><h3>Conclusion</h3><div>ADMI, effectively distinguishes benign from malignant. This technique may facilitate investigations of the adrenal lesions to clinical outcomes but needs further large series studies.</div></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"45 4","pages":"Article 500185"},"PeriodicalIF":1.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148545603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}