Revista Espanola De Medicina Nuclear E Imagen Molecular最新文献

{"title":"Desarrollo y validación de un procedimiento alternativo para realizar los controles de pureza radioquímica de radiofármacos de 99mTc con un contador Geiger Müller","authors":"M.M. Gonzalez ,&nbsp;A.L. Poma ,&nbsp;N. Cuello ,&nbsp;A.L. Soldati","doi":"10.1016/j.remn.2024.500006","DOIUrl":"https://doi.org/10.1016/j.remn.2024.500006","url":null,"abstract":"<div><h3>Background and objectives</h3><p>In a hospital radiopharmacy with 2a operational level, including the preparation of radiopharmaceuticals from prepared and approved reagent kits, it is common to have a single activimeter or dose calibrator for labeling and fractionation, and to perform the quality controls of the ^99mTc-radiopharmaceuticals. In certain cases, the accumulation of radioactive material or accidental contamination of the work area causes the background to exceed the limits to carry out the radiochemical purity analyses and it is necessary to look for viable alternatives. In this work, a Geiger Müller detector (equipped with a probe for measuring surface contamination) frequently used for radioprotection purposes, was validated as an alternative and its performance was compared against the activimeter for ^99mTc-radiopharmaceuticals.</p></div><div><h3>Materials and methods</h3><p>Using [^99mTc]pertechnetate, systematic studies of error analyses and detector response to activity concentration, activity and measurement time were carried out in liquid matrices and in paper. The results were compared against an activimeter calibrated for [^99mTc]Tc.</p></div><div><h3>Results</h3><p>The developed method was used to determine the radiochemical purity of the compounds [^99mTc]Tc-MDP and [^99mTc]Tc-MIBI by ascending paper chromatography tests, obtaining comparable values to those measured with an activimeter in the same system (within 1% uncertainty) and using the method of vial partitioning in a dedicated equipment.</p></div><div><h3>Conclusions</h3><p>This work demonstrates that a Geiger Müller detector with a probe for measuring surface contamination can be adequately used to replace other equipment in the control of radiochemical purity in the hospital radiopharmacy.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"43 3","pages":"Article 500006"},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141073173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osificación de la hoz del cerebro en cáncer de mama metastásico","authors":"S. de la Torre Fernández,&nbsp;M.J. Tello Galán,&nbsp;B. Aradas Cabado,&nbsp;A.E. Seva Delgado,&nbsp;C.M. Hernández Heredia,&nbsp;A.J. Fernández Sánchez","doi":"10.1016/j.remn.2024.500001","DOIUrl":"10.1016/j.remn.2024.500001","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"43 3","pages":"Article 500001"},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140794680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valor añadido de la PET/TC con [18F]fluorocolina en la valoración del hiperparatiroidismo secundario o terciario","authors":"S. Abouzian ,&nbsp;D.A. López-Mora ,&nbsp;A. Fernández-León ,&nbsp;C. Facundo ,&nbsp;P. Stefaneli ,&nbsp;A. Flotats","doi":"10.1016/j.remn.2024.500005","DOIUrl":"https://doi.org/10.1016/j.remn.2024.500005","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"43 3","pages":"Article 500005"},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Una arquitectura de análisis de imágenes seriadas con la tomografía por emisión de positrones mediante la aplicación de machine learning combinado para la detección del cáncer de pulmón","authors":"S. Guzmán Ortiz ,&nbsp;R. Hurtado Ortiz ,&nbsp;A. Jara Gavilanes ,&nbsp;R. Ávila Faican ,&nbsp;B. Parra Zambrano","doi":"10.1016/j.remn.2024.500003","DOIUrl":"10.1016/j.remn.2024.500003","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>Lung cancer is the second type of cancer with the second highest incidence rate and the first with the highest mortality rate in the world. Machine learning through the analysis of imaging tests such as positron emission tomography/computed tomography (PET/CT) has become a fundamental tool for the early and accurate detection of cancer. The objective of this study was to propose an image analysis architecture (PET/CT) ordered in phases through the application of ensemble or combined machine learning methods for the early detection of lung cancer by analyzing PET/CT images.</p></div><div><h3>Material and methods</h3><p>A retrospective observational study was conducted utilizing a public dataset titled «A large-scale CT and PET/CT dataset for lung cancer diagnosis.» Various imaging modalities, including CT, PET, and fused PET/CT images, were employed. The architecture or framework of this study comprised the following phases: 1.<!--> <!-->image loading or collection; 2.<!--> <!-->image selection; 3.<!--> <!-->image transformation, and 4.<!--> <!-->balancing the frequency distribution of image classes. Predictive models for lung cancer detection using PET/CT images included: a)<!--> <!-->the Stacking model, which used Random Forest and Support Vector Machine (SVM) as base models and complemented them with a Logistic Regression model, and b)<!--> <!-->the Boosting model, which employed the Adaptive Boosting (AdaBoost) model for comparison with the Stacking model. Quality metrics used for evaluation included accuracy, precision, recall, and F1-score.</p></div><div><h3>Results</h3><p>This study showed a general performance of 94% with the Stacking method and a general performance of 77% with the Boosting method.</p></div><div><h3>Conclusions</h3><p>The Stacking method proved to be a model with high performance and quality for lung cancer detection when analyzing PET/CT images.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"43 3","pages":"Article 500003"},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140788992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controversia en la estadificación inicial ganglionar del cáncer de recto (¿RM o PET/TC?)","authors":"E. López Llobet ,&nbsp;M. Coronado Poggio ,&nbsp;C. Lancha Hernández ,&nbsp;C. Martín Hervás ,&nbsp;D. Travaglio Morales ,&nbsp;D. Monachello Araujo ,&nbsp;S. Rodado Marina ,&nbsp;L. Domínguez Gadea","doi":"10.1016/j.remn.2024.500004","DOIUrl":"10.1016/j.remn.2024.500004","url":null,"abstract":"<div><h3>Objective</h3><p>To compare the usefulness of MRI and PET/CT in nodal staging (N) of patients with locally advanced rectal cancer (LARC).</p></div><div><h3>Material and methods</h3><p>Retrospective study of patients with LARC, who completed their initial staging with PET/CT, between January 2020 and March 2023. Regional nodes were assessed, and N was determined using both techniques according to TNM criteria. Concordance between MRI and PET/CT was analyzed. The accuracy of both techniques was calculated for those patients who underwent direct surgery. Non-regional pelvic lymph nodes were evaluated by both modalities.</p></div><div><h3>Results</h3><p>Among the 73 patients, 48 were ultimately diagnosed with a locally advanced stage. Of these, 39 underwent neoadjuvant treatment (chemoradiotherapy) followed by surgery, and 9 direct surgery. In 25, the PET/CT extension study revealed distant disease, leading to systemic treatment. Weak concordance was observed between MRI and PET/CT in determining N (k<!--> <!-->=<!--> <!-->0.286; <em>P</em> <!-->&lt;<!--> <!-->.005). Out of 73 patients, 31 (42%) exhibited concordance, and 42 (58%) showed discordance. In 83% of the discordant cases, MRI overstaged compared to PET/CT, with 17 cases indicating nodal involvement (N+) by MRI and N0 by PET/CT. Diagnostic accuracy was 78% for both techniques. Sensitivity, specificity, positive predictive value, and negative predictive value were 80%, 75%, 80%, and 75% for MRI, and 60%, 100%, 100%, and 67%, for PET/CT. PET/CT identified pelvic metastatic adenopathies in 8 patients that were not visible/doubtful by MRI.</p></div><div><h3>Conclusions</h3><p>In the initial nodal staging of rectal cancer MRI overstages relative to PET/CT. Both modalities are complementary, PET/CT offers higher specificity and MRI higher sensitivity.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"43 3","pages":"Article 500004"},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141049627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PET/TC con FAPI: procedimiento y revisión de la evidencia en oncología","authors":"A.P. Caresia Aróztegui ,&nbsp;J. Jo Rosales ,&nbsp;M. Rodríguez Fraile ,&nbsp;A. Arçay Öztürk ,&nbsp;Carlos Artigas ,&nbsp;en nombre del Grupo Oncología de la SEMNIM","doi":"10.1016/j.remn.2023.11.006","DOIUrl":"10.1016/j.remn.2023.11.006","url":null,"abstract":"<div><p>Neoplasms are composed of malignant tumour cells, which are surrounded by other non-tumour cellular elements, what has been defined as the microenvironment or tumour stroma. Evidence on the importance of the tumour microenvironment has not stopped growing in recent years. It plays a central role for cell proliferation, tissue invasion, angiogenesis and cell migration.</p><p>The paradigm is the family of new FAPI radiopharmaceuticals that show us the density of the fibroblast activation protein (FAP) that is overexpressed in the cell membrane of activated cancer-associated fibroblasts (CAF), and its presence is related to poor prognosis.</p><p>The paradigm is the family of new FAPI radiopharmaceuticals, which represents the density of activated fibroblasts associated with cancer. This educational document includes the procedure for performing PET/CT FAPI, biodistribution and the main potentially clinical applications in oncology to date.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"43 2","pages":"Pages 130-140"},"PeriodicalIF":1.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemangioendotelioma seudomiogénico óseo primario en la PET/RM con [18F]FDG","authors":"N. Hou,&nbsp;C. Fan","doi":"10.1016/j.remn.2023.10.003","DOIUrl":"https://doi.org/10.1016/j.remn.2023.10.003","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"43 2","pages":"Pages 117-118"},"PeriodicalIF":1.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140164069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imágenes PET con [68Ga]Ga-FAPI y [18F]FDG en un paciente con tuberculosis que imita un tumor maligno en la TC","authors":"Z. Zheng,&nbsp;P. Hu,&nbsp;Y. Lin,&nbsp;H. Shi","doi":"10.1016/j.remn.2023.11.007","DOIUrl":"10.1016/j.remn.2023.11.007","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"43 2","pages":"Pages 124-127"},"PeriodicalIF":1.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139539412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concordancia entre SPECT portátil y la gammagrafía convencional para detección de ganglio centinela en cáncer de mama","authors":"Á. Esteban Hurtado ,&nbsp;J. Orozco Cortés ,&nbsp;P. Cárcamo Ibarra ,&nbsp;U. López González ,&nbsp;Á. Badenes Romero ,&nbsp;M.Á. Navas de la Cruz ,&nbsp;C. Siscar Gelo ,&nbsp;L. Casas Calabuig ,&nbsp;P. Abreu Sánchez ,&nbsp;T. Mut Dólera ,&nbsp;D. Balaguer Muñoz ,&nbsp;M.D. Reyes Ojeda ,&nbsp;C. Plancha Mansanet ,&nbsp;E. Caballero Calabuig","doi":"10.1016/j.remn.2023.11.001","DOIUrl":"10.1016/j.remn.2023.11.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Freehand SPECT can be a useful imaging technique for preoperative planning of sentinel lymph node biopsy (SLNB) as it allows localization of the sentinel node by 3D and real-time tomographic imaging and determines its depth after a few minutes of scanning.</p><p>The aim of the study was to evaluate the correlation between the number of detected SNs between freehand SPECT images and lymphoscintigraphy (LS).</p></div><div><h3>Materials and methods</h3><p>One hundred patients with a diagnosis of invasive breast cancer and no clinical evidence of lymph node involvement prospectively underwent SLNB. The preoperative study included freehand SPECT imaging at 15<!--> <!-->min after injection and LS imaging at 25 and 60–90<!--> <!-->min after injection (early and late). The observed agreement was analyzed and a concordance study was performed between the number of SNs detected with freehand SPECT and LS.</p></div><div><h3>Results</h3><p>The observed agreement in the detection of SNs between freehand SPECT and early LS was 72%; between freehand SPECT and late LS was 85%; and between early and late LS was 87%. In the concordance study, there was moderate concordance between freehand SPECT and early LS (kappa coefficient: 0.42); moderate-high concordance between freehand SPECT and late LS (kappa coefficient: 0.60); and moderate-high concordance between early and late LS (kappa coefficient: 0.70), with no significant differences between them (<em>p</em>-value<!--> <!-->=<!--> <!-->0.16).</p></div><div><h3>Conclusion</h3><p>Freehand SPECT showed a moderate-high concordance with conventional imaging studies and could be a valid alternative for the presurgical study of SLNB in breast cancer.</p></div>","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"43 2","pages":"Pages 79-83"},"PeriodicalIF":1.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139539741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papel de la PET/TC [18F]F-FDG en la detección y diagnóstico diferencial de la tuberculosis peritoneal","authors":"S. Bondia-Bescós ,&nbsp;I.E. Sanchez-Rodríguez ,&nbsp;V. Carrero-Vasquez ,&nbsp;A. Palomar-Muñoz ,&nbsp;M. Maristany-Bosch ,&nbsp;M. Cortés-Romera","doi":"10.1016/j.remn.2024.01.003","DOIUrl":"10.1016/j.remn.2024.01.003","url":null,"abstract":"","PeriodicalId":48986,"journal":{"name":"Revista Espanola De Medicina Nuclear E Imagen Molecular","volume":"43 2","pages":"Pages 128-129"},"PeriodicalIF":1.2,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139813661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}