Revista Portuguesa De Cardiologia最新文献

{"title":"Cardioprotective effect of chelidonic acid against doxorubicin-induced cardiac toxicity in rats","authors":"Shraddha I. Khairnar,&nbsp;Yogesh A. Kulkarni,&nbsp;Kavita Singh","doi":"10.1016/j.repc.2024.06.003","DOIUrl":"10.1016/j.repc.2024.06.003","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>The current study evaluates the effect of chelidonic acid on doxorubicin-induced cardiac toxicity. Chelidonic acid (CA) is a natural pyran-skeleton heterocyclic compound found in rhizomes of the perennial plant, celandine (<em>Chelidonium majus</em>).</div></div><div><h3>Methods</h3><div>Wistar rats were given an intraperitoneal injection of doxorubicin (1.25 mg/kg, cumulative dose of 20 mg/kg) four times per week for a duration of four weeks to induce cardiotoxicity. CA treatment (10, 20, and 40 mg/kg orally for four weeks) was started together with doxorubicin.</div></div><div><h3>Results</h3><div>CA treatment reduced myocardial damage and improved cardiac dysfunction in doxorubicin-treated rats. It improved blood pressure, restored ST wave height and normalized the QTc interval compared to the rats treated only with doxorubicin. Administration of CA for four weeks reduced left ventricular end-diastolic pressure. Moreover, CA treatment decreased the level of cardiac markers such as creatine kinase-myocardial band (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and cardiac troponin-T. Masson's trichrome, hematoxylin, and eosin staining of heart tissue revealed that CA attenuated the deleterious effects of doxorubicin and prevented further damage and fibrosis in rats.</div></div><div><h3>Conclusion</h3><div>The study findings confirm that CA treatment can protect the myocardium against doxorubicin-induced cardiotoxicity.</div></div>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"44 3","pages":"Pages 141-153"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the challenges of ST-segment elevation myocardial infarction in women: A closer look","authors":"Marisa Trabulo ,&nbsp;Ana Teresa Timóteo","doi":"10.1016/j.repc.2025.01.002","DOIUrl":"10.1016/j.repc.2025.01.002","url":null,"abstract":"","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"44 3","pages":"Pages 177-178"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commissural malalignment on echocardiography as a predictor of coronary artery abnormalities in newborns with transposition of great arteries","authors":"Erkut Öztürk ,&nbsp;Selman Gokalp ,&nbsp;İbrahim Cansaran Tanıdır","doi":"10.1016/j.repc.2024.09.002","DOIUrl":"10.1016/j.repc.2024.09.002","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>This study evaluated commissural malalignment on echocardiography as a predictor of coronary anomalies.</div></div><div><h3>Methods</h3><div>All newborns diagnosed with transposition of great arteries in the pediatric cardiac intensive care unit between 1 August 2020 and 1 February 2022 were included in this study. The ratio of distances (C-ratio) from the anterior commissure to the right-sided commissure of the pulmonary valve and the distance from the anterior commissure to the left sided commissure of the pulmonary valve were calculated. According to the median effective level (EL50), it was classified as minor alignment or malalignment (C-ratio ≤EL50) or major malalignment (C-ratio &gt;EL50). Preoperative classification results were compared with the intraoperative coronary anomalies defined by the surgeon.</div></div><div><h3>Results</h3><div>A total of 60 cases were included in the study. Echocardiography revealed 16/38 (42%) commissural malalignment in the patient group with the usual coronary artery pattern and 15/22 (68%) in the patients with abnormal coronary artery patterns. The median commissural rotation angle was 28° (IQR 20–42). Although it was associated with the commissural malalignment (cut-off 30°, sensitivity 80% and specificity 85%, p=0.001), the commissural rotation angle was unrelated to the presence of a coronary artery anomaly. The C-ratio was 42% (0.42) according to the median effective level. Abnormal coronary artery pattern was more common in patients with major malalignment (C-ratio &gt;0.42) (sensitivity 82% and specificity 88%, p=0.003).</div></div><div><h3>Conclusion</h3><div>The incidence of coronary artery anomalies in patients with transposition of great arteries increases with major commissural malalignment. A high C-ratio might be a predictor of coronary artery anomaly.</div></div>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"44 3","pages":"Pages 157-163"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of commissural malalignment on echocardiography as a predictor of coronary anomalies in transposition of the great arteries","authors":"Graça Nogueira","doi":"10.1016/j.repc.2025.02.002","DOIUrl":"10.1016/j.repc.2025.02.002","url":null,"abstract":"","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"44 3","pages":"Pages 165-166"},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Portuguese National Registry of Interventional Cardiology: Official report of percutaneous coronary angiography and intervention from 2014 to 2023.","authors":"Rita Calé, Hélder Pereira, André Luz, Rui Campante Teles, Marco Costa, João Carlos Silva, Pedro Braga, Pedro Pinto Cardoso, Rui Cruz Ferreira, Filipe Seixo, João Costa, Hélder Ribeiro, João Brum da Silveira, Pedro Costa Ferreira, Jorge Guardado, Pedro Farto E Abreu, Renato Fernandes, Hugo Vinhas, Dinis Martins, Graça Caires, Tiago Adrega, Rui Caria, Luís Bernardes, José Baptista, Pedro de Araújo Gonçalves, Eduardo Infante Oliveira, Paulino Sousa, Carlos Braga, Pedro Jerónimo Sousa, Manuel Almeida","doi":"10.1016/j.repc.2024.12.003","DOIUrl":"10.1016/j.repc.2024.12.003","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>To present the report on the trends in percutaneous coronary activity data in Portugal from the last decade (from 2014 to 2023).</p><p><strong>Methods: </strong>Data were extracted from the Portuguese National Registry of Interventional Cardiology (RNCI) and the numbers in recent years were compared and complemented by information from the 2023 European Society of Cardiology Atlas in Interventional Cardiology (IC) survey, which was administered to the director of every IC department. Linear regression analysis was used to assess trends in activity over time.</p><p><strong>Results: </strong>From 2014 to 2023, there were 160101 percutaneous coronary interventions reported in the RNCI. The number of annual PCI in the last decade remained constant (1360/million inhabitants in 2014 to 1322/million in 2023; R²=0.039, p=0.276). Importantly, there was a 22% increase in primary PCI (306/million inhabitants in 2014 to 374/million inhabitants in 2023; R²=0.759, p<0.001) and there was a decrease in the geographical disparities in primary PCI across Portugal. The following PCI trends were noted: a 43% increase in PCI performed by radial access (57.4% in 2014 to 82.1% in 2023; R²=0.908, p<0.001), a 27% increase in drug-eluting stents (78.4% in 2014 to 99.2% of all PCI with stents in 2023; R²=0.638, p=0.003), and a 47% decrease of thrombectomy in primary PCI (35.0% in 2014 to 18.6% in 2023; R²=0.649, p=0.003). There was a slight increase in the use of intracoronary diagnostic devices during PCI, with intravascular imaging and physiological assessments reaching 7.6% and 4.2%, respectively, in 2023.</p><p><strong>Conclusion: </strong>The RNCI was able to depict changes in our practice along the study period. The annual PCI volume per million inhabitants remained stable, driven by an increase in primary PCI offset by a decrease in chronic coronary syndrome indications. The geographical asymmetries were markedly reduced due to the expansion on PCI capable centers, enabling a progress towards a more universal access to percutaneous coronary techniques.</p>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing atrial fibrillation treatment: Early results and future prospects for pulsed field ablation.","authors":"Nuno Cortez-Dias","doi":"10.1016/j.repc.2025.02.003","DOIUrl":"10.1016/j.repc.2025.02.003","url":null,"abstract":"","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When acute respiratory distress syndrome further complicates the prognosis of type A aortic dissection.","authors":"Rui Cerejo","doi":"10.1016/j.repc.2025.02.001","DOIUrl":"10.1016/j.repc.2025.02.001","url":null,"abstract":"","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and perception among adults of their congenital heart disease: A single center cross-sectional study","authors":"Francisco Barbas de Albuquerque ,&nbsp;Inês Neves ,&nbsp;Rita Teixeira ,&nbsp;Tânia Mano ,&nbsp;Tiago Rito ,&nbsp;Pedro O. Costa ,&nbsp;Rui Ferreira ,&nbsp;Lídia de Sousa ,&nbsp;Fátima Pinto","doi":"10.1016/j.repc.2024.06.006","DOIUrl":"10.1016/j.repc.2024.06.006","url":null,"abstract":"<div><h3>Introduction and objective</h3><div>Congenital heart disease (CHD) is a complex condition requiring a multidisciplinary approach. It is crucial that adults with CHD (CHD) have adequate knowledge of their condition, enabling them to engage in their healthcare decisions and self-management. We aimed to investigate knowledge and perception among adults of their CHD.</div></div><div><h3>Methods</h3><div>Single-center, observational, cross-sectional study. A 25-item adapted survey of Leuven Questionnaire for CHD was used to assess four main domains: (1) disease and treatment, (2) endocarditis and preventive measures, (3) physical activity and (4) reproductive issues.</div></div><div><h3>Results</h3><div>One hundred forty-eight patients participated in the study. Patients had a significant lack of knowledge localizing their heart defect, recognizing drug side effects, acting in case of experiencing drug side effects, recognizing at least two symptoms of clinical deterioration, to adequately define endocarditis and most typical signs and risk factors, to acknowledge the hereditary nature of their CHD and risk of clinical deterioration during pregnancies. Patients with an education level ≥12th grade have higher knowledge in various items and, overall, the complexity of CHD was not associated with a better performance.</div></div><div><h3>Conclusion</h3><div>This study highlights the existing knowledge gaps among adults with CHD. It underscores the need for tailored information and structured educational programs to improve management. By addressing these challenges, healthcare providers can enhance patient outcomes, improve quality of life, and promote long-term well-being for individuals with CHD.</div></div>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"44 2","pages":"Pages 95-103"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic thromboembolic pulmonary hypertension: A comprehensive review of pathogenesis, diagnosis, and treatment strategies","authors":"Daniel Inácio Cazeiro ,&nbsp;Miguel Azaredo Raposo ,&nbsp;Tatiana Guimarães ,&nbsp;Nuno Lousada ,&nbsp;David Jenkins ,&nbsp;João R. Inácio ,&nbsp;Susana Moreira ,&nbsp;Ana Mineiro ,&nbsp;Céline Freitas ,&nbsp;Susana Martins ,&nbsp;Ricardo Ferreira ,&nbsp;Rita Luís ,&nbsp;Nuno Cardim ,&nbsp;Fausto J. Pinto ,&nbsp;Rui Plácido","doi":"10.1016/j.repc.2024.04.006","DOIUrl":"10.1016/j.repc.2024.04.006","url":null,"abstract":"<div><div>Chronic thromboembolic pulmonary hypertension (CTEPH) is part of group 4 of the pulmonary hypertension (PH) classification and generally affects more than a third of patients referred to PH centers. It is a three-compartment disease involving proximal (lobar-to-segmental) and distal (subsegmental) pulmonary arteries that are obstructed by persistent fibrothrombotic material, and precapillary pulmonary arteries that can be affected as in pulmonary arterial hypertension. It is a rare complication of pulmonary embolism (PE), with an incidence of around 3% in PE survivors. The observed incidence of CTEPH in the general population is around six cases per million but could be three times higher than this, as estimated from PE incidence. However, a previous venous thromboembolic episode is not always documented. With advances in multimodality imaging and therapeutic management, survival for CTEPH has improved for both operable and inoperable patients. Advanced imaging with pulmonary angiography helps distinguish proximal from distal obstructive disease. However, right heart catheterization is of utmost importance to establish the diagnosis and hemodynamic severity of PH. The therapeutic strategy relies on a stepwise approach, starting with an operability assessment. Pulmonary endarterectomy (PEA), also known as pulmonary thromboendarterectomy, is the first-line treatment for operable patients. Growing experience and advances in surgical technique have enabled expansion of the distal limits of PEA and significant improvements in perioperative and mid- to long-term mortality. In patients who are inoperable or who have persistent/recurrent PH after PEA, medical therapy and/or balloon pulmonary angioplasty (BPA) are effective treatment options with favorable outcomes that are increasingly used. All treatment decisions should be made with a multidisciplinary team that includes a PEA surgeon, a BPA expert, and a chest radiologist.</div></div>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"44 2","pages":"Pages 121-137"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suspicion and referral of patients with transthyretin amyloid cardiomyopathy: Recommendations by a Portuguese multidisciplinary expert panel","authors":"Dulce Brito ,&nbsp;João Agostinho ,&nbsp;Carlos Aguiar ,&nbsp;Sílvia Aguiar Rosa ,&nbsp;Nuno Cardim ,&nbsp;Cândida Fonseca ,&nbsp;Nuno Marques ,&nbsp;Pedro Moraes Sarmento ,&nbsp;Patrícia Rodrigues ,&nbsp;Jonathan Santos ,&nbsp;Maria João Vidigal Ferreira ,&nbsp;Olga Azevedo","doi":"10.1016/j.repc.2024.12.002","DOIUrl":"10.1016/j.repc.2024.12.002","url":null,"abstract":"<div><div>Early diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM) is crucial for better disease management and outcome. To ensure timely diagnosis, a multidisciplinary panel of Portuguese experts, including cardiologists, internal medicine specialists, and general practitioners, have developed a national consensus to aid physicians in enhancing the referral of patients with suspicion of ATTR-CM in Portugal.</div><div>A structured approach was used to develop the consensus: (1) an online survey aimed at identifying clinical red flags, patient journeys, and diagnostic tools related to ATTR-CM; (2) a face-to-face roundtable meeting where the survey findings were discussed and a consensus was reached on referral and diagnostic algorithms for ATTR-CM in Portugal; and (3) critical review of the proposed algorithms.</div><div>The referral and diagnostic algorithms for ATTR-CM in Portugal were developed considering current recommendations, but also the existence of a nationwide network of specialized cardiomyopathy clinics and national reference centers for familial amyloid polyneuropathy due to the endemic p.V50M variant.</div><div>This collaborative effort aims to enhance awareness, facilitate timely referrals and improve early diagnosis, ultimately ensuring better management of ATTR-CM patients in Portugal.</div></div>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"44 ","pages":"Pages 59-68"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}