{"title":"Response to Letter to the Editor, regarding \"Use of direct oral anticoagulants in patients with stroke transferred for thrombectomy\".","authors":"Gustavo C Santo, Ana Isabel Rodrigues","doi":"10.1016/j.repc.2025.10.001","DOIUrl":"https://doi.org/10.1016/j.repc.2025.10.001","url":null,"abstract":"","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diogo Mendes , Daniel Figueiredo , Carlos Alves , Ricardo Amaral , Beatriz Costa , Ana Penedones , Francisco Batel-Marques
{"title":"The impact of the COVID-19 pandemic on arterial hypertension monitoring in Portugal","authors":"Diogo Mendes , Daniel Figueiredo , Carlos Alves , Ricardo Amaral , Beatriz Costa , Ana Penedones , Francisco Batel-Marques","doi":"10.1016/j.repc.2025.06.005","DOIUrl":"10.1016/j.repc.2025.06.005","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>This study aimed to evaluate the impact of the COVID-19 pandemic on healthcare provided to patients with arterial hypertension in Portugal.</div></div><div><h3>Methods</h3><div>The pre-pandemic and pandemic periods were compared using publicly available data on performance and health outcome indicators from the Portuguese National Health Service (NHS). Pre-pandemic data were modeled to project hypothetical scenarios without a pandemic using an exponential smoothing algorithm, and then compared with data collected during the COVID-19 pandemic. A cohort model was developed to estimate the number of all-cause deaths and years of life lost (YLL) due to the reduction in blood pressure (BP) monitoring and in BP records <150/90 mmHg during the first two years of the pandemic. Microsoft Excel® was used for statistical analyses.</div></div><div><h3>Results</h3><div>There was a 26.4% relative reduction in the number of patients with hypertension under 65 years of age with at least one BP measurement, and a 21.8% relative reduction in the proportion of patients with BP <150/90 mmHg during the first two years of the pandemic. The model projections were 176 additional deaths and 3287 YLL among the Portuguese population of patients with hypertension.</div></div><div><h3>Conclusions</h3><div>The disruption in BP testing in Portugal during the pandemic increased hypertension-associated morbidity and mortality, with significant YLL. The long-term implications of impaired monitoring of patients with hypertension should be assessed, and proactive strategies implemented to mitigate the increase in hypertension morbidity and mortality associated with the COVID-19 pandemic.</div></div>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"44 10","pages":"Pages 621-628"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quality of life score association with other patient-reported outcomes: Validating Minnesota Living with Heart Failure Questionnaire to Portuguese","authors":"Irene Marques , Sofia Viamonte , Milton Severo , António Gomes Pinto , Cândida Fonseca , Henrique Cyrne Carvalho","doi":"10.1016/j.repc.2025.03.005","DOIUrl":"10.1016/j.repc.2025.03.005","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Pragmatic validated instruments are needed to assess quality of life (QoL) in the real-world care of heart failure (HF) patients. This study aimed to validate the Minnesota Living with Heart Failure Questionnaire (MLHFQ) in European Portuguese and to search for associations with other patient-reported outcomes (PROs).</div></div><div><h3>Methods</h3><div>This is a single-center prospective study with two samples of HF patients, used for MLHFQ translation, cultural adaptation and validation. Validation sample included patients managed in a multidisciplinary HF clinic between February 29, 2016, and February 29, 2020.</div></div><div><h3>Results</h3><div>The validation sample included 294 HF patients, with a median age of 78 years, 53.1% female sex, 45.2% with reduced left ventricle ejection fraction (LVEF) and 43.9% with preserved LVEF. The principal component analysis identified three components, representing three groups of questions from the MLHFQ, each related to one domain and subscore: physical, emotional and social. The validated version showed a reliable general factor and good internal consistency. MLHFQ total score was associated with all the other variables studied. All the scores were strongly associated with NYHA functional class. Associations were found between the physical score and both the Borg fatigue score and the six-minute walking distance. Emotional score was associated with both anxiety and depression scores from Hospital Anxiety and Depression Scale.</div></div><div><h3>Conclusions</h3><div>This study validated the MLHFQ in Portuguese and revealed the existence of three subscores. It enables the pragmatic assessment of the QoL of Portuguese HF patients, particularly of those with preserved LVEF, and future research concerning PROs.</div></div>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"44 10","pages":"Pages 607-618"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inês Machado Martins , Carla Oliveira Ferreira , Cátia Costa Oliveira , Carlos Galvão Braga , Jorge Marques
{"title":"Wait time impact on prognosis for patients awaiting an aortic valve replacement","authors":"Inês Machado Martins , Carla Oliveira Ferreira , Cátia Costa Oliveira , Carlos Galvão Braga , Jorge Marques","doi":"10.1016/j.repc.2024.11.020","DOIUrl":"10.1016/j.repc.2024.11.020","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>The only effective treatment for severe aortic stenosis (AS) is aortic valve replacement (AVR). The intervention should happen as soon as possible to lower the risk of heart failure and death. We aimed to assess the time between referral to the surgery center and performing the AVR for a sample of patients with severe AS diagnosis, as well as the impact it may have on hospitalization and mortality.</div></div><div><h3>Methods</h3><div>This was a retrospective study including 241 patients with severe AS submitted to AVR at the surgery center between January 2018 and December 2021, or patients that died during that period.</div></div><div><h3>Results</h3><div>In a total of 174 ambulatory patients who underwent AVR, 82.2% had surgical aortic valve replacement (SAVR) and 17.8% transcatheter aortic valve implantation (TAVI). The median wait time for SAVR and TAVI was 226 and 426 days, respectively. From a total of 56 hospitalized patients who underwent AVR, 89.3% had SAVR and 10.7% TAVI. The mean wait time for SAVR and TAVI was 9 and 15 days, respectively. While waiting for intervention, 13% of patients were hospitalized and 6% died.</div></div><div><h3>Conclusions</h3><div>The wait times for AVR found in our study are substantially longer than recommended for outpatient regimen. Extended wait times are linked to an increasing incidence of adverse events.</div></div>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"44 10","pages":"Pages 595-602"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nur Nabihah Ahmad Rafie , Putri Yubbu , Shankar Aissvarya , Rajendran Pujita , Nurul Huda Musa , Noor Haliza Mohamed Ibrahim , Karuppiah Thilakavathy
{"title":"Genetic aspects of congenital heart disease in heterotaxy syndrome","authors":"Nur Nabihah Ahmad Rafie , Putri Yubbu , Shankar Aissvarya , Rajendran Pujita , Nurul Huda Musa , Noor Haliza Mohamed Ibrahim , Karuppiah Thilakavathy","doi":"10.1016/j.repc.2025.05.007","DOIUrl":"10.1016/j.repc.2025.05.007","url":null,"abstract":"<div><div>Abnormal arrangement of thoracoabdominal organs, situs ambiguous, is also known as heterotaxy syndrome (HTX). It has been frequently linked with congenital heart diseases (CHD), which are commonly reported as atrioventricular septal defects (AVSD), atrial septal defects (ASD), ventricle septal defects (VSD), transposition of the great artery, and pulmonary stenosis or atresia. Two HTX categories are right atrial isomerism (RAI) and left atrial isomerism (LAI), which are distinguished by the organ's sidedness as well as their complexity. The etiology of the syndrome is being studied widely, where recent studies are more focused on the effect of gene variants present in affected individuals. <em>DNAH11</em>, <em>DNAH5</em>, <em>ZIC3</em>, <em>NODAL</em>, and <em>LEFTY</em> are among the genes studied and associated with HTX. <em>DNAH11</em> and <em>DNAH5</em> are associated with ciliary function while <em>ZIC3</em>, <em>NODAL</em> and <em>LEFTY</em> are associated with signaling pathways. As multiple genes are involved, HTX has been reported to have an autosomal dominant, autosomal recessive or X-linked inheritance patterns, depending on the causative genes in the individual. This review aims to summarize several previously reported HTX gene variants, inheritance patterns, as well as the cardiac and extracardiac clinical manifestations.</div></div>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"44 10","pages":"Pages 633-648"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Caldeira , Beatriz Garcia , Fausto J. Pinto
{"title":"HowBP study: A cross-sectional study evaluating how blood pressure is usually measured","authors":"Daniel Caldeira , Beatriz Garcia , Fausto J. Pinto","doi":"10.1016/j.repc.2025.05.006","DOIUrl":"10.1016/j.repc.2025.05.006","url":null,"abstract":"","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"44 10","pages":"Pages 653-655"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francisco Dias Claudio , Nuria Vallejo , Lourdes Mateu , Antoni Bayes-Genis , Victoria Delgado , Albert Teis
{"title":"Chest pain in long COVID disease. Insights from stress cardiovascular magnetic resonance","authors":"Francisco Dias Claudio , Nuria Vallejo , Lourdes Mateu , Antoni Bayes-Genis , Victoria Delgado , Albert Teis","doi":"10.1016/j.repc.2025.03.008","DOIUrl":"10.1016/j.repc.2025.03.008","url":null,"abstract":"","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"44 10","pages":"Pages 649-651"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The critical challenge of aortic valve replacement waiting times is just the tip of the iceberg: A call for systematic healthcare reform","authors":"Gonçalo F. Coutinho","doi":"10.1016/j.repc.2025.08.003","DOIUrl":"10.1016/j.repc.2025.08.003","url":null,"abstract":"","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"44 10","pages":"Pages 603-605"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}