{"title":"MYH7-HCM – A bad disease… or a disease that can be bad?","authors":"Nuno Cardim","doi":"10.1016/j.repc.2026.08.005","DOIUrl":"10.1016/j.repc.2026.08.005","url":null,"abstract":"","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"45 10","pages":"Pages 579-580"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francisco Mourão, Dan Miloslavschi, Joana Santos Gonçalves, Leonor Quelhas Pinto, João Pereira
{"title":"Socioeconomic inequality in cardiovascular disease and related illnesses in Portugal","authors":"Francisco Mourão, Dan Miloslavschi, Joana Santos Gonçalves, Leonor Quelhas Pinto, João Pereira","doi":"10.1016/j.repc.2026.06.007","DOIUrl":"10.1016/j.repc.2026.06.007","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Cardiovascular disease (CVD) and related illnesses remain a leading cause of morbidity in Portugal. Socioeconomic status (SES) is known to influence cardiovascular outcomes, but there is limited evidence of this relationship in the Portuguese context. The objective of this article is to analyse inequalities in the prevalence of CVD and related illnesses according to SES in Portugal, focusing on the association with income and education.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted using data from the 2019 Portuguese National Health Survey. Socioeconomic inequalities in CVD and related illnesses were assessed using relative concentration curves and indices (RCI), among adults aged 35–79. Inequality measures of health outcomes were adjusted for age and sex.</div></div><div><h3>Results</h3><div>Lower income is significantly associated with a higher prevalence of myocardial infarction, hypertension, coronary disease or angina, stroke, diabetes, elevated blood cholesterol and kidney disease with RCI of −0.104, −0.094, −0.185, −0.114, −0.112, −0.069, −0.170, respectively. Individuals with a lower education level also show a significantly higher concentration of CVD and related illnesses, with a RCI of −0.295 for myocardial infarction, −0.201 for hypertension, −0.305 for coronary disease, −0.325 for stroke, −0.268 for diabetes, −0.168 for elevated blood cholesterol, and −0.239 for kidney disease. In general, lower educational attainment showed a greater association with disease concentration disparities.</div></div><div><h3>Conclusion</h3><div>Inequalities in CVD and related illnesses in Portugal underline the need for comprehensive health promotion, disease prevention and management strategies that consider individuals’ SES. Further research is essential to develop targeted interventions aimed at reducing these health inequalities effectively and to understand the interaction between SES and health outcomes.</div></div>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"45 10","pages":"Pages 553-560"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Paroxysmal elevation of blood pressure in older adults: A frequent but misinterpreted clinical presentation","authors":"João Gorjão Clara","doi":"10.1016/j.repc.2026.08.004","DOIUrl":"10.1016/j.repc.2026.08.004","url":null,"abstract":"","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"45 10","pages":"Pages 601-602"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148833763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jéni Quintal, Catarina Lagoas Pohle, Rui Antunes Coelho, Patrícia Bernardes, David Campos, Marco Tomaz, Sara Gonçalves, Tatiana Duarte, Quitéria Rato, Filipe Seixo
{"title":"Underinformed and overlooked: Cardiovascular health literacy in Portuguese women","authors":"Jéni Quintal, Catarina Lagoas Pohle, Rui Antunes Coelho, Patrícia Bernardes, David Campos, Marco Tomaz, Sara Gonçalves, Tatiana Duarte, Quitéria Rato, Filipe Seixo","doi":"10.1016/j.repc.2026.05.005","DOIUrl":"10.1016/j.repc.2026.05.005","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Cardiovascular disease is the leading cause of death in women, yet remains underrecognized. Cardiovascular health literacy – the ability to access, understand, and apply health information – is crucial for effective risk management. This study aimed to assess cardiovascular health literacy awareness in a sample of Portuguese women and to identify predictors of low self-reported awareness.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study during a cardiovascular screening event in Portugal. Women aged ≥18 years completed a validated questionnaire assessing knowledge of cardiovascular risk factors, symptoms, prevention, and appropriate response. The primary outcome was self-reported lack of awareness. Secondary outcomes summarized cardiovascular health literacy domains and barriers to healthy lifestyles. Predictors of lack of awareness were examined using multivariate logistic regression.</div></div><div><h3>Results</h3><div>We included 204 women (mean age 55±16 years); 89.2% lived in urban areas and 24% had higher education. Only 5.6% felt well-informed, while 15.4% reported no knowledge. Only 27.7% recognized cardiovascular disease as the leading cause of death in women. Symptom recognition was suboptimal. The main barriers to healthy lifestyles were financial constraints (50%) and lack of time (36.7%). In multivariate analysis, older age (≥62 years: OR 4.20, 95% CI 1.57–11.22) and primary education (OR 3.60, 95% CI 1.43–9.09) independently predicted low awareness.</div></div><div><h3>Conclusions</h3><div>Portuguese women demonstrate limited awareness and uneven cardiovascular health literacy. Older age and lower educational attainment were key predictors, highlighting the need for targeted, accessible education and mitigation of socioeconomic barriers to improve risk perception and health outcomes in this group.</div></div>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"45 10","pages":"Pages 581-589"},"PeriodicalIF":2.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical readiness and methodological rigor of AI models for ventricular arrhythmia and sudden cardiac death prediction: A systematic review with PROBAST+AI appraisal.","authors":"Mislav Puljevic, Marina Petrovic, Hana Ivandic, Nora Knez, Ana-Marija Brekalo, Lucija Kantolic, Branimir Pervan","doi":"10.1016/j.repc.2026.05.007","DOIUrl":"https://doi.org/10.1016/j.repc.2026.05.007","url":null,"abstract":"<p><p>Sudden cardiac death (SCD) remains a major cause of mortality, and risk stratification based on left ventricular ejection fraction (LVEF) has significant limitations. Artificial intelligence (AI) has emerged as a potential approach for modeling complex arrhythmic risk. We conducted a systematic review with prespecified anchor subgroup reporting (without pooling) to evaluate the performance of AI models in predicting SCD and malignant ventricular arrhythmias. We searched MEDLINE/PubMed, Embase, and Scopus from inception to 3 October 2025. Anchor subgroup reporting was restricted to studies reporting area under the receiver-operating characteristic curve (AUROC) with 95% confidence intervals (CIs) within predefined modality/horizon subgroups. Studies without CIs or relying on cross-validation variance were summarized narratively as supplementary evidence. Thirteen studies met the inclusion criteria; five reported AUROC with 95% CIs within prespecified modality/horizon subgroups and were included as anchor subgroup estimates (k=1 per subgroup). Methodological quality and reporting were limited: 54% of studies (7/13) were classified as high risk of bias according to PROBAST+AI, driven by cross-validation-only designs, unit-of-analysis issues, limited external validation, and sparse calibration reporting. Among anchor estimates, deep learning on single-lead ambulatory ECG showed high discrimination for near-term ventricular tachyarrhythmias (AUROC 0.948, 95% CI 0.926-0.967), while 12-lead ECG models achieved good performance for long-term SCD (AUROC 0.820, 95% CI 0.794-0.847). The multimodal anchor estimate (AUROC 0.84) was numerically higher than the CMR radiomics anchor (AUROC 0.70), but this represents an indirect between-study contrast. AI-ECG models show high reported discrimination in near-term risk windows, but cross-study comparisons are indirect, and methodological heterogeneity remains a barrier to translation into clinical practice.</p>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Iñigo Anduaga, Teresa Espinosa, Alejandro Alcaraz, Laura Sanchis, Carlos Igor Morr-Verenzuela, Blanca Domenech-Ximenos, Pedro Cepas-Guillén, Marta Sitges, Xavier Freixa, Eduardo Flores-Umanzor
{"title":"Percutaneous management of paradoxical embolism due to coexisting patent foramen ovale and pulmonary arteriovenous malformation: A Case Report.","authors":"Iñigo Anduaga, Teresa Espinosa, Alejandro Alcaraz, Laura Sanchis, Carlos Igor Morr-Verenzuela, Blanca Domenech-Ximenos, Pedro Cepas-Guillén, Marta Sitges, Xavier Freixa, Eduardo Flores-Umanzor","doi":"10.1016/j.repc.2026.04.008","DOIUrl":"https://doi.org/10.1016/j.repc.2026.04.008","url":null,"abstract":"","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos Domínguez-Massa, Eduardo Tébar-Botí, Juan Bautista Martínez-León
{"title":"Response to \"Comment on predictive factors of mortality with short-term ventricular assist devices for heart transplantation\".","authors":"Carlos Domínguez-Massa, Eduardo Tébar-Botí, Juan Bautista Martínez-León","doi":"10.1016/j.repc.2026.08.007","DOIUrl":"https://doi.org/10.1016/j.repc.2026.08.007","url":null,"abstract":"","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on \"Predictive factors of mortality with short term ventricular assist devices for heart transplantation\".","authors":"Roshna Charro, Tabeer Arshad, Noor Ul Eman","doi":"10.1016/j.repc.2026.08.006","DOIUrl":"https://doi.org/10.1016/j.repc.2026.08.006","url":null,"abstract":"","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sofia Andraz, Joana Massa Pereira, Tânia Silva, Lucas Hamann, Joana Guerreiro Pereira, Jorge Mimoso, Pedro de Azevedo, Hugo Costa
{"title":"Intensive lipid lowering therapy strategies in acute coronary syndrome patients in contemporary clinical practice – The benefit of the “strike early, strike strong” approach","authors":"Sofia Andraz, Joana Massa Pereira, Tânia Silva, Lucas Hamann, Joana Guerreiro Pereira, Jorge Mimoso, Pedro de Azevedo, Hugo Costa","doi":"10.1016/j.repc.2026.04.005","DOIUrl":"10.1016/j.repc.2026.04.005","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Current guidelines recommend a stepwise, low-density lipoprotein cholesterol (LDL-C) guided lipid-lowering therapy (LLT) approach for patients after acute coronary syndrome (ACS). This study aimed to assess whether an early intensive “strike early, strike strong” strategy with upfront combination LLT improves LDL-C goal attainment.</div></div><div><h3>Methods</h3><div>This single-center retrospective study included 211 consecutive ACS patients admitted between January and October 2020, with a median follow-up of six months. Metabolic profiles were assessed during hospitalization and at follow-up. Patients were grouped by follow-up LDL-C levels (<55 mg/dL and ≥55 mg/dL). Discharge medication, adherence, and LDL-C reduction were compared.</div></div><div><h3>Results</h3><div>A total of 211 patients were included in the analysis, with a mean age of 65±12 years; 74% were male. LDL-C on target (<55 mg/dL) was achieved in 36% of patients during a median follow-up of six months. This group was more commonly medicated with combination therapy [high-intensity statin (HI-statin) plus ezetimibe] at discharge (46% vs. 31%, p=0.040), had higher adherence rates (94% vs. 81%, p<0.001) and had significantly greater LDL-C reduction (80±48 mg/dL vs. 49±53 mg/dL, p<0.001). The combination therapy was the only independent predictor for LDL-C on target during follow-up (OR=2.054, 95% CI: 1.063–3.969, p=0.032).</div></div><div><h3>Conclusion(s)</h3><div>Low-density lipoprotein target attainment was suboptimal at median follow-up of six months. The LDL-C target group was associated with combination therapy with HI-statins plus ezetimibe upfront, better adherence and greater LDL-C reduction. These findings support the “strike early, strike strong” approach in very high-risk patients.</div></div>","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"45 9","pages":"Pages 479-485"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandra S. Machado, Cátia Henriques, Rafael Ramos, Nadine Almeida, Rui Baptista, Heloísa Ribeiro
{"title":"Trends in infective endocarditis microbiology and valve replacement at a hospital center","authors":"Alexandra S. Machado, Cátia Henriques, Rafael Ramos, Nadine Almeida, Rui Baptista, Heloísa Ribeiro","doi":"10.1016/j.repc.2026.03.018","DOIUrl":"10.1016/j.repc.2026.03.018","url":null,"abstract":"","PeriodicalId":48985,"journal":{"name":"Revista Portuguesa De Cardiologia","volume":"45 9","pages":"Pages 525-527"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148537588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}