Brazilian Oral Research最新文献_第6页

Craniofacial morphology of patients with unilateral cleft lip and palate at two stages of skeletal maturation. 单侧唇腭裂患者骨骼成熟两个阶段的颅面形态。

IF 2.5 4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0009

Eduardo Murad Villoria, Bernardo Quiroga Souki, Flávio Lucena Antunes, Marina Araújo Leite Assis, Ildeu Andrade Júnior, Dauro Douglas Oliveira, Rodrigo Villamarim Soares

{"title":"Craniofacial morphology of patients with unilateral cleft lip and palate at two stages of skeletal maturation.","authors":"Eduardo Murad Villoria, Bernardo Quiroga Souki, Flávio Lucena Antunes, Marina Araújo Leite Assis, Ildeu Andrade Júnior, Dauro Douglas Oliveira, Rodrigo Villamarim Soares","doi":"10.1590/1807-3107bor-2023.vol37.0009","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0009","url":null,"abstract":"The aim of this retrospective cross-sectional investigation was to perform a 3D analysis of craniofacial morphology of patients with unilateral cleft lip and palate (UCLP) at two stages of skeletal maturation. Cone-beam computed tomography (CBCT) scans of 52 UCLP patients (34 prepubertal; 18 pubertal) were collected from an outpatient referral center for the treatment of craniofacial deformities. In total 15 multiplanar craniofacial landmarks were identified, 3D virtual surface models were created, and 13 variables were measured to assess the 3D Euclidean distances between landmarks and spatial position of the landmarks in the projected X, Y and Z components. Maxillary and mandibular pitch (clockwise, counterclockwise) rotation relative to the cranial base was also evaluated. The significance level was set at 5%. Maxillary retrusion value relative to the cranial base was higher and statistically significant greater (p = 0.028) in pubertal (SNA, 77.4° ± 6.2; N-ANS Y, 3.3 mm ± 3.1) than in prepubertal patients (SNA 81.0° ± 5.2; N-ANS Y, 5.8 mm ± 2.7). The posterior cranial base length (S-Ba Y) was significantly longer (p = 0.013) in pubertal (20.7 mm ± 3.4) than in prepubertal patients (18.4 mm ± 2.7). The upper facial height (N-ANS Z) was significantly greater (p = 0.01) in pubertal (46.9 mm ± 4.5) than in prepubertal patients (43.4 mm ± 3.0). Prepubertal and pubertal UCLP patients presented distinct patterns of craniofacial morphology, mainly in the sagittal component of the maxilla and in the posterior cranial base length. Pubertal patients had greater maxillary retrusion and posterior cranial base length.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9072168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of the contextual effects on the prevalence of periodontitis: a systematic review. 评估对牙周炎流行的环境影响:一项系统综述。

IF 2.5 4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2022.vol36.0125

Leonardo Vilar Filgueiras, Willian Konflanz, Alex Nogueira Haas, Roger Keller Celeste

{"title":"Assessment of the contextual effects on the prevalence of periodontitis: a systematic review.","authors":"Leonardo Vilar Filgueiras, Willian Konflanz, Alex Nogueira Haas, Roger Keller Celeste","doi":"10.1590/1807-3107bor-2022.vol36.0125","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2022.vol36.0125","url":null,"abstract":"This study reviews the influence of contextual factors on periodontitis based on a systematic search of studies recorded in the PubMed, Scopus, Web of Science, and EMBASE databases. Periodontitis was assessed by clinical attachment loss and probing depth for studies with data on the socioeconomic status (SES) of a specific area (area-level SES) or dental care service (service-level) in a catchment area among individuals aged 18 and over. Two independent reviewers performed study selection, data extraction, and assessment of methodological quality. Of the 646 articles identified, 13 were included in the systematic review, representing 101,362 individuals from five countries (USA, UK, Brazil, China, and Uruguay). A higher prevalence of periodontitis was described in lower SES neighborhoods, more deprived postcodes, and poorer provinces. Gini Index results were mixed and inconclusive. Three studies showed that higher coverage of primary dental care at the municipal level was associated with a lower prevalence of periodontitis. Contextual factors at the area-level SES and dental care service might influence periodontitis, but the existing evidence is unclear. The contextual effect is important for periodontal health and may contribute to the prevalence of periodontitis, independent of well-known risk factors and individual levels.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9108965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparative study of sex estimates in adult skulls using direct measurement and tomographic image reconstruction. 成人颅骨性别直接测量与断层图像重建之比较研究。

IF 2.5 4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0064

Ezequiel Ortiz Rosa, Edgard Michel Crosato, Claudio Campi Castro, Rodrigo Elias Oliveira, Maria Gabriela Haye Biazevic

{"title":"Comparative study of sex estimates in adult skulls using direct measurement and tomographic image reconstruction.","authors":"Ezequiel Ortiz Rosa, Edgard Michel Crosato, Claudio Campi Castro, Rodrigo Elias Oliveira, Maria Gabriela Haye Biazevic","doi":"10.1590/1807-3107bor-2023.vol37.0064","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0064","url":null,"abstract":"Sex estimation is an important procedure in forensic anthropology for human identification. The development of new technologies, such as three-dimensional computed tomography (CT), has provided excellent alternatives for this purpose. This study examined and compared a morphological method for sex estimation using two different approaches - direct measurement of physical structures and tomographic analysis using 3D images. A total of 111 skulls from the Museum of Human Anatomy at the University of São Paulo (MAH-USP) were used, (60 males and 51 females). All specimens were scanned by Philips Brilliance 64 CT scanner equipment and their corresponding images were reconstructed in three-dimensional (3D) models. The morphological characteristics of the skulls were analyzed by an observer who was blinded to the sex of the specimens. Five cranial structures were analyzed: external occipital crest, mastoid process, supraorbital margin, glabella, and mental eminence. The structures were scored 1 to 5 according to Buikstra and Ubelaker and validated by Walker. The success rates of the sex estimates obtained through direct measurement of the dry skulls ranged from 67.4% to 70.4% as compared to 60.2% to 68.1% for CT reconstruction. When analyzed separately, the maximum accuracy of the method was 68.33% in males and 88.24% in females in the physical analysis of structures. The glabella and mastoid process were the most effective structures to estimate sex through both techniques, respectively. Our results show that 3D CT images can be accurately used in the morphological analysis for sex estimation, representing a viable alternative in forensic anthropology.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9665096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Associations between physical activity domains and oral health: an analysis of a Brazilian population-based study. 体育活动领域与口腔健康之间的关系:一项基于巴西人群的研究分析

IF 2.5 4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0071

Stefany Duarte Dos Anjos, Rafael Milani Ferro, Bernardo Novak Laskawski, Alex Nogueira Haas, Rodolfo Coelho Prates, Joao Paulo Steffens

{"title":"Associations between physical activity domains and oral health: an analysis of a Brazilian population-based study.","authors":"Stefany Duarte Dos Anjos, Rafael Milani Ferro, Bernardo Novak Laskawski, Alex Nogueira Haas, Rodolfo Coelho Prates, Joao Paulo Steffens","doi":"10.1590/1807-3107bor-2023.vol37.0071","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0071","url":null,"abstract":"Physical activity comprises four domains (leisure, transportation, domestic, and work activities) that may be differently associated with oral health. The aim of this study was to assess the association between each physical activity domain and oral health conditions in Brazilian adults. A total of 38,539 participants in the 2019 Brazilian Health Survey aged 30 years or older were analyzed. The outcomes were self-perceived oral health (dichotomous) and self-reported number of missing teeth (counts). The presence, frequency, and time of activity in each domain and their combination were analyzed as main exposures. Odds ratios (OR) and mean ratios (MR) were estimated by fitting multivariable models. Higher leisure time physical activity was the only domain associated with better self-perception of oral health (OR = 1.32; 95%CI 1.26-1.38) and lower tooth loss (MR=0.88; 95%CI 0.86-0.90). Higher levels of work, transportation, and household activities were significantly associated with worse self-perception of oral health, while higher levels of work- and transportation-related physical activities were also associated with greater tooth loss. When the total recommended weekly physical activity time was analyzed, no significant associations were found. Sensitivity analysis suggested that this pattern persists in potential periodontitis-related cases, such as when selecting older age or excluding individuals with no tooth loss. In conclusion, leisure physical activity was the only domain with the potential of reflecting the benefits of physical activity on oral health. The inclusion of other domains can confound this association.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9812952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do patients with molar incisor hypomineralization have more dental anxiety and behavior management problems? A systematic review with meta-analysis. 臼齿低矿化患者是否有更多的牙齿焦虑和行为管理问题?荟萃分析的系统综述。

IF 2.5 4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0069

Patrícia Papoula Gorni Reis, Roberta Costa Jorge, Daniele Masterson Tavares Pereira Ferreira, Guido Artemio Marañón-Vásquez, Lucianne Cople Maia, Vera Mendes Soviero

{"title":"Do patients with molar incisor hypomineralization have more dental anxiety and behavior management problems? A systematic review with meta-analysis.","authors":"Patrícia Papoula Gorni Reis, Roberta Costa Jorge, Daniele Masterson Tavares Pereira Ferreira, Guido Artemio Marañón-Vásquez, Lucianne Cople Maia, Vera Mendes Soviero","doi":"10.1590/1807-3107bor-2023.vol37.0069","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0069","url":null,"abstract":"This systematic review evaluated the available evidence on whether children with molar incisor hypomineralization (MIH) have more dental fear and anxiety (DFA) and dental behavior management problems (DBMPs) than those without MIH (Prospero CDR42020203851). Unrestricted searches were performed in PubMed, Scopus, Web of Science, Lilacs, BBO, Embase, Cochrane Library, APA PsycINFO, Open Grey, and Google Scholar. Observational studies evaluating DFA and/or DBMPs in patients with and without MIH were eligible. Reviews, case reports, interventional studies, and those based on questionnaires to dentists were excluded. The methodological quality assessment was based on the Newcastle-Ottawa Scale. Random-effects meta-analyses were conducted to synthesize data on DFA. The certainty of evidence was performed according to GRADE. Seven studies that evaluated a total of 3,805 patients were included. All of them presented methodological issues, mainly in the comparability domain. Most studies observed no significant difference in DFA between children with and without MIH. The meta-analysis did not show a significant effect of MIH on the standardized units for the DFA scores (SMD = 0.03; 95%CI: -0.06-0.12; p = 0.53; I2 = 0%). Synthesis including only the results for severe cases of MIH also did not show a significant effect of the condition on DFA scores (MD = 8.68; 95%CI: -8.64-26.00; p = 0.33; I2 = 93%). Two articles found DBMPs were significantly more frequent in patients with MIH. The overall certainty of evidence was very low for both outcomes assessed. The current evidence suggests no difference in DFA between children with and without MIH; DBMPs are more common in patients with MIH. This information should be viewed with caution because of the very low quality evidence obtained.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9805811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parental oral health literacy influences preschool children's utilization of dental services. 父母口腔健康素养影响学龄前儿童对牙科服务的利用。

IF 2.5 4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107BOR-2023.vol37.0090

Bruna Leticia Vessoni Menoncin, Aline Fabris de Araujo Crema, Fernanda de Morais Ferreira, Andrea Ferreira Zandoná, Jose Vitor Nogara Borges de Menezes, Fabian Calixto Fraiz

{"title":"Parental oral health literacy influences preschool children's utilization of dental services.","authors":"Bruna Leticia Vessoni Menoncin, Aline Fabris de Araujo Crema, Fernanda de Morais Ferreira, Andrea Ferreira Zandoná, Jose Vitor Nogara Borges de Menezes, Fabian Calixto Fraiz","doi":"10.1590/1807-3107BOR-2023.vol37.0090","DOIUrl":"https://doi.org/10.1590/1807-3107BOR-2023.vol37.0090","url":null,"abstract":"Parental behavior towards their children's oral health is strongly influenced by parent's Oral Health Literacy (OHL) level. This study evaluated the impact of parental OHL on preschool children's utilization of dental services. A cross-sectional study was conducted with parents of 419 children aged 3 to 5 years who answered a self-administered questionnaire about their perception of their children's oral health and whether their children had already been to a dental visit. Parental OHL level was assessed by the validated version of the Oral Health Literacy Adult Questionnaire (OHL-AQ) translated into Brazilian Portuguese. Univariate and multivariate Poisson regression analyses with robust variance were used for the data analysis (α = 0.05). Most children had already been to a dental visit (73%). Overall, 31.7% of the parents or guardians reported that their children had experienced dental pain or dental caries. Parental OHL level was classified by tercile as low, medium, and high. The final model showed independent associations between children who had already been to a dental visit and higher parental OHL level (PR = 1.16; 95%CI = 1.00-1.35) when compared to the lowest OHL level, higher parental educational level (PR = 1.39; 95%CI = 1.03-1.87) when compared to lower educational level, the report of children's pain and dental caries (PR = 1.22; 95%CI = 1.09-1.36) and married parents or parents in a common-law marriage (PR = 1.17; 95%CI = 1.03-1.93). The prevalence of children who had already been to a dental visit was higher among those parents with a higher OHL level when compared to those with a lower OHL level.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10180832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sense of coherence and oral health-related quality of life among southern Brazilian male adolescents 巴西南部男性青少年的连贯感和口腔健康相关生活质量

4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0113

Nicássia Cioquetta LOCK, Maria Laura Castro Alves Ribeiro GAZOLA, Patrícia Kolling MARQUEZAN, Julio Eduardo do Amaral ZENKNER, Luana Severo ALVES

{"title":"Sense of coherence and oral health-related quality of life among southern Brazilian male adolescents","authors":"Nicássia Cioquetta LOCK, Maria Laura Castro Alves Ribeiro GAZOLA, Patrícia Kolling MARQUEZAN, Julio Eduardo do Amaral ZENKNER, Luana Severo ALVES","doi":"10.1590/1807-3107bor-2023.vol37.0113","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0113","url":null,"abstract":"This study evaluated the association between sense of coherence (SoC) and oral health-related quality of life (OHRQoL) among conscripts of the Brazilian Army, in two cities of southern Brazil. A cross-sectional study included all 18-19-year-old adolescents who joined the Brazilian Army as draftees for mandatory military service in the cities of Itaqui, RS, and Santiago, RS (n = 505). Data collection was conducted from 2019 to 2021, and included the application of questionnaires and a clinical oral examination to record gingivitis, malocclusion, and dental caries. OHRQoL was collected through the Brazilian short version of the Oral Health Impact Profile (OHIP), composed of 14 questions. The adolescents’ SoC was assessed using the validated Brazilian version of the SOC-13 scale. The primary outcome of this study was OHRQoL, modeled as a discrete variable (OHIP-14 scores). The main predictor variable was SoC, categorized as low, moderate, or high. The association between predictor variables and OHRQoL was assessed by Poisson regression models using a hierarchical approach. Unadjusted and adjusted rate ratios (RR), and 95% confidence intervals (CI) were estimated. All the analyses were performed using STATA software version 14.2. Adolescents with a moderate and high SoC had 27% (RR = 0.73, 95%CI = 0.64–0.84) and 51% (RR = 0.49, 95%CI = 0.41–0.58) lower mean OHIP-14 scores, respectively, than those with a low SoC score, after the inclusion of behavioral and clinical variables. This study showed a significant association between SoC and OHRQoL among 18–19-year-old southern Brazilian adolescents. Strengthening the SoC as a psychosocial resource may improve the well-being and OHRQoL of adolescents.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135609050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of thickness and shade of CAD/CAM composite on the light transmission from different light-curing units CAD/CAM复合材料厚度和色度对不同光固化单元透光性的影响

4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0114

Julia Dantas MAZÃO, Maria Tereza Hordones RIBEIRO, Stella Sueli Lourenço BRAGA, Karla ZANCOPÉ, Richard Bengt PRICE, Carlos José SOARES

{"title":"Effect of thickness and shade of CAD/CAM composite on the light transmission from different light-curing units","authors":"Julia Dantas MAZÃO, Maria Tereza Hordones RIBEIRO, Stella Sueli Lourenço BRAGA, Karla ZANCOPÉ, Richard Bengt PRICE, Carlos José SOARES","doi":"10.1590/1807-3107bor-2023.vol37.0114","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0114","url":null,"abstract":"The thickness and shade of a restoration will affect the transmission of light from the light-curing unit (LCU). This study determined the power (mW), spectral radiant power (mW/nm), and beam profile of different LCUs through various thicknesses and shades of a CAD-CAM resin composite (BRAVA Block, FGM). Five thicknesses: 0.5; 0.75; 1.0; 1.5, and 2.0 mm, in three shades: Bleach; A2 and A3.5 of a CAD-CAM resin (n = 5). Two single-peak LCUs: EL, Elipar DeepCure-S (3M Oral Care); and OP, Optilight Max (Gnatus), and one multiple-peak LCU: VL, VALO Grand (Ultradent), were used. The LCUs were positioned touching the surface of the BRAVA Block. The power and emission spectrum were measured using a fiberoptic spectrometer attached to an integrating sphere, and the beam profiles using a laser beam profiler. The effect of the material thickness on the light attenuation coefficients was determined. VL and EL delivered more homogeneous beam profiles than OP. The type of the BRAVA Block had a significant effect on the transmitted power, and wavelengths of transmitted light (p < 0.001). There was an exponential reduction in the power and emission spectrum as the thickness of the BRAVA Block increased (p < 0.001). The light transmission through the A2 shade was least affected by the thickness (p < 0.001). The attenuation coefficient was higher for the violet light and higher for A3.5 than the A2 or Bleach shades. No violet light from the VL could be detected at the bottom of 2.0 mm of the BRAVA Block.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135609059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glycogen synthase kinase 3 inhibition enhances mineral nodule formation by cementoblasts in vitro 糖原合成酶激酶3抑制促进骨水泥母细胞形成矿物结节

4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0112

Henrique ABDALLA, Rafael STORINO, Amanda BANDEIRA, Lucas TEIXEIRA, Ana MILLÁS, Paulo LISBOA-FILHO, Kamila KANTOVITZ, Francisco NOCITI JUNIOR

{"title":"Glycogen synthase kinase 3 inhibition enhances mineral nodule formation by cementoblasts in vitro","authors":"Henrique ABDALLA, Rafael STORINO, Amanda BANDEIRA, Lucas TEIXEIRA, Ana MILLÁS, Paulo LISBOA-FILHO, Kamila KANTOVITZ, Francisco NOCITI JUNIOR","doi":"10.1590/1807-3107bor-2023.vol37.0112","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0112","url":null,"abstract":"This study aimed to investigate whether GSK-3 inhibition (CHIR99021) effectively promoted mineralization by cementoblasts (OCCM-30). OCCM-30 cells were used and treated with different concentrations of CHIR99021 (2.5, 5, and 10 mM). Experiments included proliferation and viability, cellular metabolic activity, gene expression, and mineral nodule formation by Xylene Orange at the experimental time points. In general, CHIR99021 did not significantly affect OCCM-30 viability and cell metabolism (MTT assay) (p > 0.05), but increased OCCM-30 proliferation at 2.5 mM on days 2 and 4 (p < 0.05). Data analysis further showed that inhibition of GSK-3 resulted in increased transcript levels of Axin2 in OCCM-30 cells starting as early as 4 h, and regulated the expression of key bone markers including alkaline phosphatase (Alp), runt-related transcription factor 2 (Runx-2), osteocalcin (Ocn), and osterix (Osx). In addition, CHIR99021 led to an enhanced mineral nodule formation in vitro under both osteogenic and non-osteogenic conditions as early as 5 days after treatment. Altogether, the results of the current study suggest that inhibition of GSK-3 has the potential to promote cementoblast differentiation leading to increased mineral deposition in vitro.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135610635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of modeling liquids on resin composite roughness and color parameters after staining and toothbrushing. 造型液对染色和刷牙后树脂复合材料粗糙度和颜色参数的影响。

IF 2.5 4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0024

Thaís Souza Maia, Thamires Diogo Lima, Vanessa Miranda Ramos, André Luís Faria-E-Silva, Murilo de Sousa Menezes

{"title":"Effect of modeling liquids on resin composite roughness and color parameters after staining and toothbrushing.","authors":"Thaís Souza Maia, Thamires Diogo Lima, Vanessa Miranda Ramos, André Luís Faria-E-Silva, Murilo de Sousa Menezes","doi":"10.1590/1807-3107bor-2023.vol37.0024","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0024","url":null,"abstract":"This study evaluated surface roughness, color stability, whitening index, and opacity of different types of modeling liquids for resin composite coating after exposure to staining and toothbrushing. Disc-shaped resin composite (Vittra APS, FGM) specimens were fabricated and divided into four groups (n = 10 each): control group, Composite Wetting resin (Ultradent Products), Adper Scotchbond Multipurpose adhesive (3M ESPE), and Adper Universal adhesive (3M ESPE). Surface roughness (Ra) was measured using a rugosimeter, while color stability (∆E00), whitening index (WI), and opacity (%) were measured using a spectrophotometer. Assessments were made at four time points: after polishing (baseline, T1), after immersion in red wine for 24 h (T2), and after 5,000 (T3) and 10,000 (T4) cycles of toothbrushing. Scanning electron microscopy images were captured to analyze the scratches created. The data were statistically analyzed by two-way repeated-measures analysis of variance and Tukey's honestly significant difference tests (α = .05). Modeling with the Wetting resin resulted in higher surface roughness (p < 0.05) and low color stability, which were attributable to porosities. Higher color change values were observed in the control group after staining. Both adhesives showed the lowest mean ΔE00 values (p < 0.005). WI decreased after staining, except with the use of the Universal adhesive (p < 0.005). The lowest opacity values were observed at baseline for all groups (p < 0.005). The Universal and Scotchbond adhesives had lower surface roughness, better color stability, higher WI, and the lowest opacity values after staining with red wine and toothbrushing.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9257116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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