Brazilian Oral Research最新文献_第4页

Impact of COVID-19 pandemic on completed treatments and referrals during urgent dental visits. COVID-19大流行对完成治疗和紧急牙科就诊期间转诊的影响。

IF 2.5 4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0087

Luciéli Andréia Zajkowski, Roberta Kochenborger Scarparo, Heloisa Grehs E Silva, Roger Keller Celeste, Patrícia Maria Poli Kopper

{"title":"Impact of COVID-19 pandemic on completed treatments and referrals during urgent dental visits.","authors":"Luciéli Andréia Zajkowski, Roberta Kochenborger Scarparo, Heloisa Grehs E Silva, Roger Keller Celeste, Patrícia Maria Poli Kopper","doi":"10.1590/1807-3107bor-2023.vol37.0087","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0087","url":null,"abstract":"This ecological study assessed the impact of the COVID-19 pandemic on completed treatments (CTs) and referrals during urgent dental visits to primary health care units in Brazil, and their associations with socioeconomic, geodemographic, and pandemic index factors in Brazilian municipalities. The difference in rates of procedures 12 months before and during the pandemic was calculated. Data were extracted at baseline from health information systems of all municipalities that provided urgent dental care (n = 5,229 out of 5,570). Multiple logistic regression predicted the factors associated with referrals and CTs. The number of dental urgencies increased from 3,987.9 to 4,272.4 per 100,000 inhabitants. The rates of referrals decreased in 44.1% of the municipalities, while 53.9% had lower rates of CTs. Municipalities with a greater number of oral health teams in the primary health care system (OR = 1.52, 95%CI:1.21-1.91) and with specialized services (OR = 1.80, 95%CI:1.50-2.16) were more likely to decrease referrals during the pandemic. Higher HDI and GDP per capita were associated with a larger decrease in referrals and smaller decrease in CTs. The calamity generated by the long pandemic period resulted in a greater demand for urgent visits. Less developed and larger cities seem to have been more likely to not complete treatments during urgent visits in primary dental care units in times of calamity. Primary dental care offices in smaller and less developed municipalities should be better equipped to provide appropriate assistance and to improve the problem-solving capacity of dental services during emergencies.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10180823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of a modified implant macrogeometry on biomechanical parameters and bone-related markers in rats. 改良种植体宏观几何形状对大鼠生物力学参数和骨相关标志物的影响。

IF 2.5 4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0044

Mounir Colares Mussi, Fernanda Vieira Ribeiro, Monica Grazieli Corrêa, Cristiane Ribeiro Salmon, Suzana Peres Pimentel, Fabiano Ribeiro Cirano, Marcio Zaffalon Casati

{"title":"Impact of a modified implant macrogeometry on biomechanical parameters and bone-related markers in rats.","authors":"Mounir Colares Mussi, Fernanda Vieira Ribeiro, Monica Grazieli Corrêa, Cristiane Ribeiro Salmon, Suzana Peres Pimentel, Fabiano Ribeiro Cirano, Marcio Zaffalon Casati","doi":"10.1590/1807-3107bor-2023.vol37.0044","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0044","url":null,"abstract":"This study investigated the impact of a modified implant macrogeometry on peri-implant healing and its effect on bone-related molecules in rats. Eighteen rats received one implant in each tibia: the control group received implants with conventional macrogeometry and the test group received implants with modified macrogeometry. After 30 days, the implants were removed for biomechanical analysis and the bone tissue around them was collected for quantifying gene expression of OPN, Runx2, β-catenin, BMP-2, Dkk1, and RANKL/OPG. Calcein and tetracycline fluorescent markers were used for analyzing newly formed bone at undecalcified sections of the tibial implants. These fluorescent markers showed continuous bone formation at cortical bone width and sparse new bone formed along the medullary implant surface in both groups. However, higher counter-torque values and upregulation of OPN expression were achieved by test implants when compared to controls. The modified macrogeometry of implants optimized peri-implant healing, favoring the modulation of OPN expression in the osseous tissue around the implants.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9757176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of access cavities on root canal preparation, restorative protocol quality, and fracture resistance of teeth 通道腔对根管预备、修复方案质量和牙齿抗折性的影响

4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0096

Heitor Silva PRADO, Igor Bassi Ferreira PETEAN, Natália Junqueira Saud FRANCO, Rafael Verardino CAMARGO, Kleber Kildare Teodoro de CARVALHO, Jardel Francisco MAZZI-CHAVES, Fabiane Carneiro LOPES-OLHÊ, Yara Teresinha Corrêa SILVA-SOUSA, Aline Evangelista SOUZA-GABRIEL, Manoel Damião SOUSA-NETO

{"title":"Impact of access cavities on root canal preparation, restorative protocol quality, and fracture resistance of teeth","authors":"Heitor Silva PRADO, Igor Bassi Ferreira PETEAN, Natália Junqueira Saud FRANCO, Rafael Verardino CAMARGO, Kleber Kildare Teodoro de CARVALHO, Jardel Francisco MAZZI-CHAVES, Fabiane Carneiro LOPES-OLHÊ, Yara Teresinha Corrêa SILVA-SOUSA, Aline Evangelista SOUZA-GABRIEL, Manoel Damião SOUSA-NETO","doi":"10.1590/1807-3107bor-2023.vol37.0096","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0096","url":null,"abstract":"The survival of endodontically treated teeth depends on the remaining tooth structure. The aim of this study was to evaluate the impact of different access cavities on root canal preparation, restorative protocol, and fracture resistance of endodontically treated teeth. Fifty-six mandibular molars were divided into control (n=8) and experimental (n=16) groups according to access cavity: Traditional, Conservative, and Truss; and redistributed (n=8) according to instrumentation protocols: Reciproc Blue and R-motion. After, teeth were scanned in micro-CT and then filled and redistributed according to composite resin restoration (n=8): Filtek One BulkFill and Filtek Z350. A new micro-CT scan was performed to analyze the restorative material. Then, samples were submitted to fracture resistance testing and the failure pattern was determined. Data were analyzed using paired T-test, ANOVA, Tukey, and chi-square tests (α=0.05). In Truss, R-Motion promoted less transportation in different thirds of root canals. Higher percentages of voids (5.05%) and filling material (11.7%) were observed in Truss. Fracture resistance values were higher for the control group, followed by Truss, Conservative, and Traditional. The predominant failure pattern was type-II. In Truss, reciprocating instruments with smaller taper showed less canal transportation. Also, Truss provided higher values of fracture resistance, although it presented a higher percentage of voids and remaining filling material. Thus, in Truss, reciprocating files with smaller taper showed less canal transportation, and these cavities provided higher values of fracture resistance, although it presented a higher percentage of voids and remaining filling material.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135213371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 and changes in dental practices in the Brazilian Public Health System: perception of the oral health team COVID-19与巴西公共卫生系统牙科实践的变化:对口腔卫生团队的看法

4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0117

Suzely Adas Saliba MOIMAZ, Carolina Carvalho Menez Pinto NASCIMENTO, Tânia Adas SALIBA, Cléa Adas Saliba GARBIN, Nemre Adas SALIBA

{"title":"COVID-19 and changes in dental practices in the Brazilian Public Health System: perception of the oral health team","authors":"Suzely Adas Saliba MOIMAZ, Carolina Carvalho Menez Pinto NASCIMENTO, Tânia Adas SALIBA, Cléa Adas Saliba GARBIN, Nemre Adas SALIBA","doi":"10.1590/1807-3107bor-2023.vol37.0117","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0117","url":null,"abstract":"The aim of this study was to verify the perception of the oral health team regarding work safety and aspects related to changes in dental practices during the COVID-19 pandemic. A descriptive, exploratory, quantitative, and qualitative cross-sectional study was conducted using an electronic questionnaire sent via email to health professionals (n = 197) affiliated with the Brazilian Public Health System (SUS), from December 2020 to September 2021, in a municipality located in the northeast of the state of São Paulo, Brazil. The variables of interest were sociodemographic characteristics and those related to the professionals’ perception of oral health care during the pandemic and its impact on these workers’ occupational safety. Descriptive statistics were performed, and the absolute and relative frequencies of quantitative variables were calculated, whereas lexical analysis was performed for textual content using the descending hierarchical classification (CHD). Out of the total sample, elective and urgent/emergency care was provided by 58.95% (n = 56); physical barriers were absent between the teams in 54.74% (n = 52); minimally invasive techniques were applied in 71.58% (n = 68); personal protective equipment (PPE) was replaced in 81.05% (n = 77) between appointments; and occupational safety was reported by 49.47% (n = 47). Textual analysis showed a decrease in appointments and consultations, with a longer interval between appointments. The professionals noticed changes in dental practices during the pandemic, mainly regarding the use of PPE, the type of treatment performed, the number of treated patients, and the greater time interval between consultations. The physical infrastructure of health units and the availability of PPE to patients needed some adjustments. A significant number of workers felt safe in providing dental care during the pandemic.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135611925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clarity of publications on HPV in Instagram profiles of official health agencies in Brazil 巴西官方卫生机构Instagram资料中关于HPV的出版物的清晰度

4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0103

Wanúbia Barbosa NUNES, Ramon Targino FIRMINO, Angélica Maria Cupertino Lopes MARINHO, Lílian de Sá BARRETO, Myrelle Leal Campos SOUSA, Samara Ellen da SILVA, Edja Maria Melo de Brito COSTA, Matheus França PERAZZO, Ana Flávia GRANVILLE-GARCIA

{"title":"Clarity of publications on HPV in Instagram profiles of official health agencies in Brazil","authors":"Wanúbia Barbosa NUNES, Ramon Targino FIRMINO, Angélica Maria Cupertino Lopes MARINHO, Lílian de Sá BARRETO, Myrelle Leal Campos SOUSA, Samara Ellen da SILVA, Edja Maria Melo de Brito COSTA, Matheus França PERAZZO, Ana Flávia GRANVILLE-GARCIA","doi":"10.1590/1807-3107bor-2023.vol37.0103","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0103","url":null,"abstract":"The study analyzed the clarity of publications on human papillomavirus (HPV) in the Instagram profiles of official Brazilian health agencies. An infodemiological study analyzed publications on HPV in the 81 Instagram profiles selected from the Health Ministry, States' Health Departments, and dental councils and associations. The following data were collected: classification of content, type of profiles, type of media, how the content was addressed, number of posts, frequency, likes, comments, viewings, and hashtags, and how the HPV vaccine was addressed. The clarity of the educational publications was assessed using the Brazilian version of the Clear Communication Index (BR-CDC-CCI). Data analysis was performed with Spearman's correlation and the Mann-Whitney test (p < 0.05). A total of 504 publications on HPV were found. The average number of likes was 528.3 (SD = 2388.2) and the average BR-CDC-CCI score was 67.1 (SD = 14.1). The quality and clarity of the information was considered adequate (BR-CDC-CCI score ≥ 90) in 6.9% of the publications. A weak positive correlation was found between the number of likes and both the BR-CDC-CCI score (r = 0.195) and number of posts (r = 0.124). Publications from the Health Ministry had a significantly higher BR-CDC-CCI score (72.9) compared to the other profiles analyzed (p = 0.01). Most publications concerned government actions, had low engagement, and written educational information was of low clarity and quality. However, the effort to reach the population was evident, with an increase in publications over the years.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134883848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protease-activated receptor type 2 activation downregulates osteogenesis in periodontal ligament stem cells. 蛋白酶激活受体2型激活下调牙周韧带干细胞成骨。

IF 2.5 4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0002

Bruno Nunes de França, Letícia Miquelitto Gasparoni, Emanuel Silva Rovai, Lucas Macedo Batitucci Ambrósio, Nathalia Felix de Mendonça, Marcos Hideki Hagy, Aldrin Huamán Mendoza, Carla Renata Sipert, Marinella Holzhausen

{"title":"Protease-activated receptor type 2 activation downregulates osteogenesis in periodontal ligament stem cells.","authors":"Bruno Nunes de França, Letícia Miquelitto Gasparoni, Emanuel Silva Rovai, Lucas Macedo Batitucci Ambrósio, Nathalia Felix de Mendonça, Marcos Hideki Hagy, Aldrin Huamán Mendoza, Carla Renata Sipert, Marinella Holzhausen","doi":"10.1590/1807-3107bor-2023.vol37.0002","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0002","url":null,"abstract":"Protease-activated receptor-2 (PAR2) is associated with the pathogenesis of many chronic diseases with inflammatory characteristics, including periodontitis. This study aimed to evaluate how the activation of PAR2 can affect the osteogenic activity of human periodontal ligament stem cells (PDLSCs) in vitro. PDLSCs collected from three subjects were treated in osteogenic medium for 2, 7, 14, and 21 days with trypsin (0.1 U/mL), PAR2 specific agonist peptide (SLIGRL-NH2) (100 nM), and PAR2 antagonist peptide (FSLLRY-NH2) (100 nM). Gene (RT-qPCR) expression and protein expression (ELISA) of osteogenic factors, bone metabolism, and inflammatory cytokines, cell proliferation, alkaline phosphatase (ALP) activity, alizarin red S staining, and supernatant concentration were assessed. Statistical analysis of the results with a significance level of 5% was performed. Activation of PAR2 led to decreases in cell proliferation and calcium deposition (p < 0.05), calcium concentration (p < 0.05), and ALP activity (p < 0.05). Additionally, PAR2 activation increased gene and protein expression of receptor activator of nuclear factor kappa-Β ligand (RANKL) (p < 0.05) and significantly decreased the gene and protein expression of osteoprotegerin (p <0. 05). Considering the findings, the present study demonstrated PAR2 activation was able to decrease cell proliferation, decreased osteogenic activity of PDLSCs, and upregulated conditions for bone resorption. PAR2 may be considered a promising target in periodontal regenerative procedures.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9072163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translation and cultural adaptation of the Illness Perception Questionnaire-Revised for Dental to Brazil. 疾病感知问卷的翻译和文化适应-为巴西牙科修订。

IF 2.5 4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0004

Marjorie Izabella Batista Aguiar, Bruna Letícia Basso, Marília Leão Goettems, Marina Sousa Azevedo, Vanessa Polina Pereira da Costa, Renata Andréa Salvitti de Sá Rocha, Maria Beatriz Duarte Gavião, Taís de Souza Barbosa

{"title":"Translation and cultural adaptation of the Illness Perception Questionnaire-Revised for Dental to Brazil.","authors":"Marjorie Izabella Batista Aguiar, Bruna Letícia Basso, Marília Leão Goettems, Marina Sousa Azevedo, Vanessa Polina Pereira da Costa, Renata Andréa Salvitti de Sá Rocha, Maria Beatriz Duarte Gavião, Taís de Souza Barbosa","doi":"10.1590/1807-3107bor-2023.vol37.0004","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0004","url":null,"abstract":"This study aimed to translate and to perform the cultural adaptation of the instrument Illness Perception Questionnaire-Revised for Dental (IPQ-RD) into Brazilian Portuguese. The IPQ-RD consists of 34 items that assess the cognitive and emotional representation/perception of parents/caregivers of children with dental caries, with response options on a 5-point Likert scale, ranging from \"Strongly agree\" (score 1) to \"Strongly disagree\" (score 5). The higher the score, the lower the perception of the disease. The protocol consists of translation into Brazilian Portuguese, back-translation into English, revision by an Expert Review Committee, and pre-test (application in parents/caregivers of children in dental care). For some questions, the translated versions were identical (T1 = T2); for others, one version was preferred (T1 or T2); for still others, it was decided to modify terms to obtain greater clarity on the item (T3). In the first pre-test, three questions were misunderstood by more than 15% of the sample, after which the items were reviewed by the Expert Review Committee. In the second pre-test, the adapted version was applied to a new sample of parents/caregivers (n = 15) and the questions were understood by more than 85% of the participants. The Brazilian Portuguese version of the IPQ-RD was well understood by the evaluated population.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10608824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does resveratrol favor peri-implant bone repair in rats with ovariectomy-induced osteoporosis? Gene expression, counter-torque and micro-CT analysis. 白藜芦醇是否有利于卵巢切除术所致骨质疏松大鼠种植体周围骨修复?基因表达，反扭矩和微ct分析。

IF 2.5 4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0003

Rodrigo Soler Zamai, Monica Grazieli Corrêa, Fernanda Vieira Ribeiro, Fabiano Ribeiro Cirano, Marcio Zaffalon Casati, Michel Reis Messora, Suzana Peres Pimentel

{"title":"Does resveratrol favor peri-implant bone repair in rats with ovariectomy-induced osteoporosis? Gene expression, counter-torque and micro-CT analysis.","authors":"Rodrigo Soler Zamai, Monica Grazieli Corrêa, Fernanda Vieira Ribeiro, Fabiano Ribeiro Cirano, Marcio Zaffalon Casati, Michel Reis Messora, Suzana Peres Pimentel","doi":"10.1590/1807-3107bor-2023.vol37.0003","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0003","url":null,"abstract":"This study investigated the influence of resveratrol on peri-implant repair and its effects on bone-related markers in ovariectomy-induced osteoporosis in rats. Animals were divided into: OVX+PLAC (n = 10): ovariectomized animals treated with placebo; OVX+RESV (n = 10): OVX treated with resveratrol; OVX+PLAC+ZOL (n = 10): OVX treated with PLAC and zoledronate; OVX+RESV+ZOL (n = 10): OVX treated with RESV and ZOL; and SHOVX+PLAC (n = 10): sham ovariectomy treated with PLAC. RESV and PLAC were administrated after ovariectomy and ZOL after six weeks after OVX, until the end of experiment. One implant was inserted in each tibiae of animals 18 weeks after ovariectomy. After 4 weeks, one implant was removed for counter-torque, and peri-implant tissue was collected for mRNA quantification of several osteogenic markers by PCR. The other tibia was submitted to micro-computed tomography analysis. Reduced counter-torque values, bone-implant contact (BIC) and bone volume fraction (BV/TV), and higher bone porosity (BP) were detected in OVX+PLAC group when compared to SHOVX+PLAC (p < 0.05). OVX+RESV rats presented lower BIC, BV/TV, and trabecular number (Tb.N), and augmented BP and trabecular spacing (Tb.Sp) when compared to SHOVX+PLAC (p < 0.05). Higher Tb.N and connectivity density (Conn.Dn) and reduced Tb.Sp were observed in OVX rats treated with ZOL, independently of RESV, when compared to OVX+PLAC and OVX+RESV groups (p < 0.05), whereas the combination ZOL+RESV promoted lower BP when compared to OVT+PLAC and OVX+RESV (p < 0.05). Gene expression was not influenced by RESV (p > 0.05), whereas ZOL promoted up-regulation of BMP-2 (p<0.05). RESV did not improve peri-implant bone repair in rats with ovariectomy-induced osteoporosis.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9149230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Evaluation of the mechanical properties of different materials for manufacturing occlusal splints. 不同材料制造咬合夹板的力学性能评价。

IF 2.5 4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0034

Danielly Mendonça Guimaraes, Marcio Campaner, Rodrigo Wendel Dos Santos, Aldieris Alves Pesqueira, Rodrigo Antonio de Medeiros

{"title":"Evaluation of the mechanical properties of different materials for manufacturing occlusal splints.","authors":"Danielly Mendonça Guimaraes, Marcio Campaner, Rodrigo Wendel Dos Santos, Aldieris Alves Pesqueira, Rodrigo Antonio de Medeiros","doi":"10.1590/1807-3107bor-2023.vol37.0034","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0034","url":null,"abstract":"This study aimed to compare the mechanical properties of various occlusal plate materials by analyzing surface roughness, Knoop microhardness, flexural strength, and modulus of elasticity. Fifty samples were prepared and classified as SC (self-curing acrylic resin), WB (heat-cured acrylic resin), ME (acrylic resin polymerized by microwave energy), P (resin print), and M (polymethylmethacrylate polymer block for computer-aided design/computer-aided manufacturing). The data were analyzed using a one-way analysis of variance and Tukey's honestly significant difference test. Surface roughness was the same in all groups. The surface hardness of group M was statistically superior. The samples from groups P and M had higher flexural strength than other samples. The modulus of elasticity of group SC was statistically lower than that of other groups. The mechanical properties of the materials used to make the occlusal plates differed, and group M achieved the best results in all analyses. Therefore, clinicians must consider the material used to manufacture long-lasting and efficient occlusal splints.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9460830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genome sequencing reveals molecular subgroups in oral epithelial dysplasia. 基因组测序揭示了口腔上皮发育不良的分子亚群。

IF 2.5 4区医学

Brazilian Oral Research Pub Date : 2023-01-01 DOI: 10.1590/1807-3107bor-2023.vol37.0063

Agustín Márquez, Isidora Mujica, Natalia Jordan, Pablo Baez, Sandra Tarquinio, Jean Nunes, Daniela Adorno, Benjamín Martínez, Sebastian Morales-Pison, Ricardo Fernandez-Ramires

{"title":"Genome sequencing reveals molecular subgroups in oral epithelial dysplasia.","authors":"Agustín Márquez, Isidora Mujica, Natalia Jordan, Pablo Baez, Sandra Tarquinio, Jean Nunes, Daniela Adorno, Benjamín Martínez, Sebastian Morales-Pison, Ricardo Fernandez-Ramires","doi":"10.1590/1807-3107bor-2023.vol37.0063","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2023.vol37.0063","url":null,"abstract":"This study aimed to analyze the molecular characteristics of oral epithelial dysplasia (OED), highlighting the pathways and variants of genes that are frequently mutated in oral squamous cell carcinoma (OSCC) and other cancers. Ten archival OED cases were retrieved for retrospective clinicopathological analysis and exome sequencing. Comparative genomic analysis was performed between high-grade dysplasia (HGD) and low-grade dysplasia (LGD), focusing on 57 well-known cancer genes, of which 10 were previously described as the most mutated in OSCC. HGD cases had significantly more variants; however, a similar mutational landscape to OSCC was observed in both groups. CASP8+FAT1/HRAS, TP53, and miscellaneous molecular signatures were also present. FAT1 is the gene that is most affected by pathogenic variants. Hierarchical divisive clustering showed division between the two groups: \"HGD-like cluster\" with 4HGD and 2LGD and \"LGD-like cluster\" with 4 LGD. MLL4 pathogenic variants were exclusively in the \"LGD-like cluster\". TP53 was affected in one case of HGD; however, its pathway was usually altered. We describe new insights into the genetic basis of epithelial malignant transformation by genomic analysis, highlighting those associated with FAT1 and TP53. Some LGDs presented a similar mutational landscape to HGD after cluster analysis. Perhaps molecular alterations have not yet been reflected in histomorphology. The relative risk of malignant transformation in this molecular subgroup should be addressed in future studies.","PeriodicalId":48942,"journal":{"name":"Brazilian Oral Research","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9672748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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