Theoretical and Natural Science最新文献_第9页

A review of research advances in the clinical management of adolescent depression 青少年抑郁症临床治疗研究进展综述

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240815

Siyuan Liu

引用次数: 0

Analysis of the current status and development prospects of artificial hearts 人工心脏的现状和发展前景分析

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240755

Yuan Yuan

{"title":"Analysis of the current status and development prospects of artificial hearts","authors":"Yuan Yuan","doi":"10.54254/2753-8818/29/20240755","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240755","url":null,"abstract":"Confronted with the rapid need for transplantable hearts, patients who need a heart transplant cannot receive the suitable configuration. Thus contributes to the development of artificial hearts, which can be created to substitute the old, the ill heart without waiting for transplantable hearts. Nowadays, this paper shows the public the artificial hearts. Through the extensive literature, it is clear that the development of artificial hearts. Dating back to the fifties of the last century, scientists began studying artificial hearts. Till now, China has created four generations of artificial hearts. They became more and more strong. The importance of the heart goes without saying, however, every year there are more and more heart failure patients. Paying more attention to the artificial hearts helps reduce the death rate of heart failures. Actually, although the patients can get the heart donors, they may not tolerate rejection. So research into artificial hearts more suitable for patients is imminent. This paper mainly introduces the fourth-generation artificial hearts (in fact, it is an improved version of the third generation), the magnetic levitation artificial heart attracts much more attention, and its composition and function have been greatly improved, reducing the difficulty of surgery. It is hoped that people can know much more about artificial hearts, and prospects for better methods to make better artificial hearts, and promote heart transplantations.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"80 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139629505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on the relationship between sleep and aging 睡眠与衰老之间关系的研究

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240847

Yihan Chang

{"title":"Research on the relationship between sleep and aging","authors":"Yihan Chang","doi":"10.54254/2753-8818/29/20240847","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240847","url":null,"abstract":"With the in-depth development of population aging, the level of health reduction of the elderly groups sharply increased, the rapid aging of the population brought health problems became a major challenge of 21st-century Chinese society, how to healthy aging, continuously improve the health level of older people, improve the quality of life in old age, there is no doubt more holistic, targeted and innovative thinking. Several studies have proved that a healthy lifestyle can effectively improve the health of the elderly. However, a series of factors, such as poor sleep quality, continue to harm the health of the elderly, resulting in reduced quality of life. With the large scale and rapid aging, the proportion of the elderly in the population is also increasing. In an aging society, the biggest problems plaguing the elderly are the loss of sleep quality and the loss of memory and concentration. People may have sleep disorders as they get older, and sleep problems will affect memory. This study used literature research to summarize the relationship between population aging and sleep. Compared with previous studies, this paper is more targeted and comprehensive in explaining the relationship between the three from micro and macro perspectives: aging leads to changes in sleep structure and duration, which further affects memory ability.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"44 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

L-theanine mechanism and application in the treatment of breast cancer 左旋茶氨酸治疗乳腺癌的机制和应用

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240762

Cong Li, Renyue Cai, Linjiusheng Chen, Shizhen Xu, Xiaoyu Yang, Yixin Huang

引用次数: 0

Immune checkpoint inhibitor combination therapy 免疫检查点抑制剂联合疗法

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240664

Xiaoying Liu

引用次数: 0

Obesity rates and its various impact to adults over the age of 18 in the United States 肥胖率及其对美国 18 岁以上成年人的各种影响

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240822

Yanbo Han

{"title":"Obesity rates and its various impact to adults over the age of 18 in the United States","authors":"Yanbo Han","doi":"10.54254/2753-8818/29/20240822","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240822","url":null,"abstract":"Obesity has become a global public health problem, which will negatively affect individual health along with the social economy, but there are fewer effective ways to control obesity and useful methods to prevent obesity from occurring. A data set about obesity rate was used as the basic data set, and the average obesity rate and BMI for each group were calculated using formulas of descriptive statistics. Then the results were shown through figures using the method of correlation analysis. Also, in addition, for a more comprehensive understanding of the differences between different regions, the study of Ward et al was also referred. Through analysis, obesity rates of adults in different age group in the U.S has a tendency of rising in recent years. There are also differences in obesity rates by various circumstances. In addition, there is a correlation between genetic factors, family environment, social impact, and obesity rates. And a high obesity rate will have bad effects on both adults in the society and the society itself. Obesity causes various impacts on adults over the age of 18 in America. And more usable and effective ways of dealing with obesity should be created.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"114 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early diagnosis and treatment strategies for pediatric growth hormone deficiency 小儿生长激素缺乏症的早期诊断和治疗策略

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240827

Zhaoqi Wang

引用次数: 0

Mitochondria in aging: A review of structure, function, and interorganelle relationships 衰老中的线粒体：结构、功能和细胞器间关系综述

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240749

Mingyuan Chen

引用次数: 0

Analysis on type 2 diabetes genetic polymorphism of different races/ethnicity 不同种族/族裔的 2 型糖尿病基因多态性分析

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240763

Rui Cai

引用次数: 0

Improving brain penetration using elacridara P-glycoprotein and BCRP inhibitor 使用艾拉克拉P-糖蛋白和BCRP抑制剂提高脑渗透率

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240729

Xinyue Yao

{"title":"Improving brain penetration using elacridara P-glycoprotein and BCRP inhibitor","authors":"Xinyue Yao","doi":"10.54254/2753-8818/29/20240729","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240729","url":null,"abstract":"The central nervous system (CNS) is a site for a myriad of disorders and diseases, such as schizophrenia, Alzheimers disease, and Parkinsons disease. Many medications targeting these illnesses remain challenged due to efflux transporters forming a blood-brain barrier (BBB). To combat such challenges, elacridar shown promise at inhibiting such transporters, such as P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), therefore improving brain penetration. However, as an early clinical candidate, many remain unknown about elacridars pharmacokinetic (PK) properties in the human body. This paper aims to obtain a better understanding of elacridars pharmacokinetic profile and predict the optimal dose and dose interval for its application in the clinic. To begin with, a series of basic PK models were created using fundamental PK equations and the models were fit to elacridar clinical data to obtain elacridar-specific PK parameters. Next, elacridar preclinical PK as well as in vitro inhibition assay were used to determine the therapeutic window. Our final, multiple-dose extravascular PK model reveals that the most convenient and effective dose regimen is 900 mg BID (bis in die; twice per day). With this elacridar PK model, researchers can leverage elacridar human PK to improve clinical outcomes.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"3 s4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0