Theoretical and Natural Science最新文献_第8页

Inhibitory effects of methylglyoxal (MGO) on the formation of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) in model system 甲基乙二醛（MGO）对模型系统中 2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶（PhIP）形成的抑制作用

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240756

Di Yu, Youyou Li, Fanlei Kong, Wenpei Xie

{"title":"Inhibitory effects of methylglyoxal (MGO) on the formation of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) in model system","authors":"Di Yu, Youyou Li, Fanlei Kong, Wenpei Xie","doi":"10.54254/2753-8818/29/20240756","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240756","url":null,"abstract":"Methylglyoxal was produced by the degradation of glucose, and its role in producing 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) was studied attempting to clarify the reaction pathways. The study showed that the PhIP yield was decreased when glucose was added to a mixture of phenylacetaldehyde and creatinine or when methylglyoxal was incorporated into a blend of phenylalanine (phenylacetaldehyde), creatinine and glucose in proportions of 1:1:0.5. PhIP yield was firstly increased and then decreased when glucose was incorporated into a blend of phenylalanine and creatinine. When methylglyoxal was added to the creatinine/phenylacetaldehyde/glucose mixture, methylglyoxal achieved around 83.2% inhibition of PhIP. However methylglyoxal achieved around 39% inhibition of PhIP in the creatinine/phenylalanine/glucose mixture. All of these results indicate that the addition of methylglyoxal to the phenylacetaldehyde/creatinine mixture inhibited the formation of PhIP. A pathway which the inhibitory effect of methylglyoxal on PhIP composition is proposed. Meanwhile, this study explained the ways in which glucose are involved in the composition of PhIP, and helped us better study the formation mechanism of PhIP.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"68 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequence and structure statistics of the nanobody database and molecular dynamics simulation analysis of the nanobody VHH 纳米抗体数据库的序列和结构统计以及纳米抗体 VHH 的分子动力学模拟分析

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240615

Xusheng Zhang

引用次数: 0

Insight into breast cancer mechanism, drug resistance and treatment methods 洞察乳腺癌的发病机制、耐药性和治疗方法

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240791

Jingyu Chen

引用次数: 0

Research on the effects of extreme heat exposure on human health 研究极端高温对人体健康的影响

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240777

Menghan Li

{"title":"Research on the effects of extreme heat exposure on human health","authors":"Menghan Li","doi":"10.54254/2753-8818/29/20240777","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240777","url":null,"abstract":"Nowadays, more and more studies indicate that heat exposure negatively affects human health. As climate change and global warming increased, extreme heat exposure became more rigorous and killed mountains of people every year. Extreme heat is not only a threat to physical health but also to mental health. Epidemiological studies have shown that heat waves can increase peoples morbidity and mortality. This literature review will discuss in detail the impact of extreme heat on human health, and what measures governments and individuals can take to respond to or prevent the damage of extreme heat. We used extreme heat and human health as keywords to collect the papers in the Embase database and review all the results. After sorting out all the results, the research focuses on the effect of extreme heat exposure on human physical and mental health. It can be found that extreme heat exposure causes heat-related illnesses (HRI) and aggravates chronic diseases, especially cardiovascular and respiratory diseases. And extreme heat can also lead to Preterm birth (PTB) which threatens the lives of pregnant women and infants. Mental health and related deaths are also affected by extreme heat exposure.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"78 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vagus nerve stimulation on epilepsy and depression 迷走神经刺激对癫痫和抑郁症的影响

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240760

Yuxiao Lin

引用次数: 0

Recent treatments to Hepatocellular Carcinoma Cancer(HCC): update and outlook 肝细胞癌（HCC）的最新治疗方法：更新与展望

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240643

Letao Lu, Sishuo Ye

{"title":"Recent treatments to Hepatocellular Carcinoma Cancer(HCC): update and outlook","authors":"Letao Lu, Sishuo Ye","doi":"10.54254/2753-8818/29/20240643","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240643","url":null,"abstract":"In the US, hepatocellular carcinoma (HCC), which accounts for 75%85% of instances of liver cancer, is a substantial cause of cancer-related fatalities. This review focuses on the recent developments in managing HCC, specifically through Trans-arterial Chemoembolization (TACE), which is currently first-line recommended and boasts a high survival rate. We have also discussed gene therapy, which aims to correct or replace faulty genes contributing to HCC development. Although it is still on trial, early results show promise. There are also various treatments such as OLT, molecularly targeted therapy, radiation therapy, locoregional therapies, gene therapy and immunotherapy. We have also come up with an innovative idea of creating a therapeutic vaccine using circRNA instead of mRNA, along with LNP, to treat HCC. This approach combines the benefits and functions of both circRNA and LNP. Different components of LNP aid in diverse benefits, to name but a few, stability, encapsulation and delivery efficiency, and higher targeting specificity. The use of circRNA offers adjuvant to immune response and better stability. Recent studies suggest that this hypothesis is theoretically possible. A better understanding of the hazardous disease could lead to the development of more effective treatments, which are urgently needed.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"59 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism analysis of toxic and side effects of chemicals on human body 化学品对人体毒副作用的机理分析

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240772

Yinzhi Shen

{"title":"Mechanism analysis of toxic and side effects of chemicals on human body","authors":"Yinzhi Shen","doi":"10.54254/2753-8818/29/20240772","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240772","url":null,"abstract":"The exposure of the human body to different chemical substances poses a critical hazard to public well-being. Chemical toxicity is fundamentally ascribed to the disturbance of typical biological processes and can result in unfavorable health results. Understanding the components by which chemical substances apply their harmful impacts is vital for surveying and moderating these dangers. In this research, it will discuss the different routes of exposure, such as inhalation ingestion and dermal contact through which chemicals can enter the body. This research investigates the complex instruments at the atomic and cellular levels, counting oxidative stretch DNA harm and disturbance of enzymatic pathways by which harmful impacts are actuated. The evaluation of chemical toxicity includes a range of toxicological considerations, including acute and chronic toxicity tests, genotoxicity measures, and carcinogenicity evaluations. The development of reliable toxicity evaluation strategies, such as in vitro and in silico models, plays an urgent part in predicting the adverse impacts of chemical substances. Administrative systems and hazard evaluation techniques are discussed to guarantee peoples and the environments security. A comprehensive understanding of the components and assessment of poisonous side impacts is essential for defending open health and minimizing the hindering effects of chemical exposure.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"59 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of the circadian clock on cardiovascular physiology and pathophysiology 昼夜节律对心血管生理和病理生理学的影响

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240770

Anqi Lin

{"title":"Impact of the circadian clock on cardiovascular physiology and pathophysiology","authors":"Anqi Lin","doi":"10.54254/2753-8818/29/20240770","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240770","url":null,"abstract":"Circadian rhythms are the innate approximately 24-hour oscillations that orchestrate a multitude of physiological processes encompassing sleep-wake cycles, hormone secretion, thermoregulation, metabolism, and behavioral patterns. Also, those rhythms are intrinsically governed by the suprachiasmatic nucleus (SCN) ensconced in the anterior hypothalamic region. The SCN, synchronized during daylight hours receives and transmits diverse bodily signals to calibrate physiological dynamics, and imbue disturbances with potential repercussions reverberating across a plethora of physiological and behavioral domains. Previous studies have proven that the diurnal changes in the circadian rhythm multiple myocardial processes and have a critical impact on the physiology and pathophysiology of the cardiovascular system. This comprehensive review emphasizes the profound influence of circadian rhythms, orchestrated by the suprachiasmatic nucleus, on cardiovascular health. It reveals that disruptions in circadian rhythms impact blood pressure, myocardial function, platelet responsiveness, and the autonomic nervous system, all of which are critical for cardiovascular well-being. The significance of this research lies in its potential to guide interventions for cardiovascular disease prevention and management, particularly in the context of modern challenges like shift work. Understanding this intricate relationship is crucial for safeguarding cardiovascular health in our fast-paced world.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"169 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut-to-brain axis provides novel therapeutic targets for depression 肠脑轴为抑郁症提供了新的治疗靶点

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240754

Yixin Xu

{"title":"Gut-to-brain axis provides novel therapeutic targets for depression","authors":"Yixin Xu","doi":"10.54254/2753-8818/29/20240754","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240754","url":null,"abstract":"As an essential counterpart of the human internal environment, the gut microbiome has been investigated extensively in light of multiple diseases. This study aims to find out potential treatments for depression by altering gut microbiome composition in order to alleviate side effects caused by traditional medications. According to previous findings, the human gut correlates with the brain through pathways known as the gut-brain axis. Two genera of microbiome, Lactobacillus and Bifidobacterium, have been mentioned by researchers to be crucial to depression-related neurotransmitter secretion in GBA. Besides, they have already been used in clinical as effective probiotics for gut-related diseases. The paper hypothesized particular interactions between the two genera and the human nerve that enable them to be therapeutic cures in adequate amounts. In this study, a range of available single-cell data about depression and lactobacillus and bifidobacterium were analyzed and adjusted into proper figures. I discuss the efficacy of different species, concentrations, and other elements of those probiotics, eventually proposing a novel way of treating and classifying depressive disorders. The study puts forth a perspective of maintaining a depression-free state with an internal factor, the gut microbiome, instead of targeting the efferent neurons directly with external drugs which could cause resistance and severe side effects.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"189 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on prosthesis customization with 3D modeling and printing technology 利用三维建模和打印技术进行假肢定制研究

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240768

Yunlin Chen

引用次数: 0