Theoretical and Natural Science最新文献_第7页

Current available treatments for NSCLC 现有的 NSCLC 治疗方法

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240638

Xia Philip Q H

引用次数: 0

Exploration of adolescent criminal psychology and psychological intervention 探讨青少年犯罪心理和心理干预

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240776

Sicheng Xiang

{"title":"Exploration of adolescent criminal psychology and psychological intervention","authors":"Sicheng Xiang","doi":"10.54254/2753-8818/29/20240776","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240776","url":null,"abstract":"This literature review delves into adolescent criminal psychology and investigates the potential effectiveness of psychological interventions in reducing youth crime. The issue of teenage delinquency is a pressing societal concern with far-reaching consequences. This paper thoroughly examines this complex subject by synthesizing existing literature. The review assesses key findings in adolescent criminal psychology, including the impact of family dynamics and social factors on crime rates. This review sheds light on the multifaceted nature of juvenile delinquency by illuminating the complex interplay of factors that contribute to it. It emphasizes the importance of addressing individual psychological determinants in addition to broader socio-environmental contexts. This literature review explores adolescent criminal psychology and evaluates the effectiveness of psychological interventions in reducing youth crime. The paper provides insights into the psychological underpinnings of childish criminal behavior and the potential strategies for intervention. It delves into the complexity of juvenile delinquency, highlighting the interplay of factors that contribute to it, such as family dynamics, mental health, and social influences. The findings emphasize the importance of addressing these factors to develop more effective approaches to mitigating youth crime.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Older residents experience of loneliness in nursing homes: A qualitative study 老年居民在养老院中的孤独体验：定性研究

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240780

Mengyao Zhuansun, Lamei Liu, Tong-yao Xu, Yu-meng Qian

{"title":"Older residents experience of loneliness in nursing homes: A qualitative study","authors":"Mengyao Zhuansun, Lamei Liu, Tong-yao Xu, Yu-meng Qian","doi":"10.54254/2753-8818/29/20240780","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240780","url":null,"abstract":"Aims: This qualitative study investigates the multifaceted experiences of loneliness among elderly residents in long-term care facilities, delving into the intricacies of this pervasive issue. Loneliness is a detrimental issue among this vulnerable group, and understanding its impact on the well-being of older individuals is crucial in that it shows requirements of both humanitarian spirit and traditional moral code. Methods: In this research, a qualitative approach is employed among a diverse group of residents in a certain care home, including in-depth interviews, observational data, and content analysis of personal narratives. Results: Thematic analysis revealed accordingly several common themes related to loneliness, including the common feelings of loneliness, its contributing factors, and individual coping strategies. Conclusion: The findings underscore the complexity of the loneliness experience among the elderly living in care facilities and highlight the need for targeted interventions and policies in long-term care settings to address this significant issue. The insights gained from this research provide valuable information for future policymakers, healthcare providers, and care facility administrators in improving the well-being of elderly residents.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"126 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139629066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effect and potential application of scorpion venom peptide 蝎毒肽的治疗效果和潜在应用

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240771

Yuhao Du

引用次数: 0

Machine learning drug discovery based on graph neural network and large language model 基于图神经网络和大型语言模型的机器学习药物发现

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240825

Tianqi Huang

{"title":"Machine learning drug discovery based on graph neural network and large language model","authors":"Tianqi Huang","doi":"10.54254/2753-8818/29/20240825","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240825","url":null,"abstract":"The COVID-19 pandemic has presented an urgent need to understand the long-term health implications faced by survivors. Post-COVID-19 complications, such as acute kidney injury, arrhythmia, and stroke, pose significant challenges to public health. Despite extensive research on COVID-19 complications, a comprehensive understanding of the risk factors remains elusive due to the potential confounding variables present in the data. Traditional statistical models, while insightful, may not fully capture the causal relationships between these risk factors and post-COVID-19 complications. Motivated by this gap in the literature, we propose a novel approach using causal inference models to predict the likelihood of post-COVID-19 complications based on patient demographics and pre-existing conditions. Our model, trained on a dataset of COVID-19 inpatients in Wuhan Province, China, estimates the causal effect of these factors on the likelihood of patients experiencing post-COVID-19 complications. This approach allows us to isolate the causal impact of each factor while accounting for potential confounders, providing a more accurate understanding of the underlying mechanisms driving these relationships. Unlike traditional models that predict the probability of certain outcomes, our model provides insights into the causal relationships between risk factors and complications, offering a more reliable and comprehensive understanding of the underlying mechanisms. This approach can help identify at-risk patients, inform targeted interventions, and contribute to the development of effective prevention and treatment strategies. Our work aims to contribute to the current understanding of the virus and inform public health policies and interventions.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"81 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139629504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of sickle cell anemia using CRISPR and prime editing 利用 CRISPR 和基因编辑技术治疗镰状细胞性贫血

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240766

Hongwei Yang

{"title":"Treatment of sickle cell anemia using CRISPR and prime editing","authors":"Hongwei Yang","doi":"10.54254/2753-8818/29/20240766","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240766","url":null,"abstract":"Sickle cell disease is a hereditary blood disease caused by an invisible genetic mutation on the autosome, caused by a transversion mutation in which the 6th amino acid of the -peptide chain, glutamate, is replaced by valine, resulting in the formation of sickle hemoglobin, instead of normal hemoglobin. Due to genetic mutations leading to structural abnormalities in hemoglobin and morphological changes in red blood cells, red blood cells lose their deformability in hypoxic environments, leading to vascular blockage, causing severe pain and partial tissue ischemia in patients. Oxygen needs to be transported to various parts of the body through red blood cells, thereby affecting the transportation of oxygen in the body. In general, red blood cells are circular and elastic, making them easy to move in blood vessels. However, in sickle cells, these red blood cells are compressed and deformed, causing the transportation of oxygen in the blood to become stiff and viscous, potentially slowing or blocking blood flow. The most common complication of SCA is blockage of blood vessels, which leads to pain. Although this is a complex phenomenon, HbS aggregation is a fundamental pathological physiological phenomenon in SCA. HbS aggregation can lead to malignant changes in the shape and physical properties of red blood cells, leading to hemolytic anemia and preventing blood flow, especially in small blood vessels, which may damage some organs. Clinical manifestations include anemia, immunodeficiency, multiple organ damage, severe acute and chronic pain, and premature death. The quality of life of the patients was seriously affected.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"68 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The comorbidity of anxiety-related disorders and insomnia: An analysis of mechanisms 焦虑相关障碍与失眠的并发症：机制分析

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240769

Vincent Qijun Chen

{"title":"The comorbidity of anxiety-related disorders and insomnia: An analysis of mechanisms","authors":"Vincent Qijun Chen","doi":"10.54254/2753-8818/29/20240769","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240769","url":null,"abstract":"Anxiety is a common epidemiological mental disorder that includes Generalized Anxiety Disorder (GAD), panic disorders (PD), and phobias; its causes include anxiogenic genes and the living environment; insufficient or low sleep quality can trigger and intensify anxiety disorders. Neurotransmitters play an essential role in operating our bodys crucial functions, such as emotional regulation and sleep, so much neuroimaging evidence suggests they are critical to forming anxiety and insomnia. Previous longitudinal studies suggest that insomnia is a significant index and predictor of mental health and, therefore, can also be generated from mental disorders due to their comorbidity. This short review will posit the formation of insomnia caused by the presence of anxiety disorders in patients with both insomnia and anxiety symptoms. This review further discusses some therapies that enhance and improve sleep quality among insomnia problems. It mostly debates the thesis that anxiety is the driving factor and precedes insomnia and its related neuropathological developments that can be highlighted from neurotransmitter systems and sleeping models such as the hyperarousal model. Overall, it is significant that individuals with anxiety-related disorders have lower sleeping qualities that cause functional impairment and lower subjective living qualities.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"215 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on the gold criteria of imaging to diagnose left ventricular non-compaction 研究诊断左心室不充盈的成像黄金标准

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240758

Yixuan Gu

引用次数: 0

Research on causes, treatment, prevention of dental caries 关于龋齿原因、治疗和预防的研究

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240797

Xinyi He

引用次数: 0

Analysis of the application of bioinformatics in the medicine 生物信息学在医学中的应用分析

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240751

Yinxi Zhang

{"title":"Analysis of the application of bioinformatics in the medicine","authors":"Yinxi Zhang","doi":"10.54254/2753-8818/29/20240751","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240751","url":null,"abstract":"As humans develop, science is also rapidly evolving, and biological science and medical support are vital for humans need. The development of biology has been particularly important. It stretches from the initial understanding of plants and animals to human biology and micro molecular biology, from macro understanding of life to micro molecular biology. Although it has accumulated a lot of knowledge about biology, it still has many unknowns about this giant and precise system. However, in recent years, a new interdisciplinary and emerging discipline has greatly opened up peoples understanding about biological information-bioinformatics. The most fundamental research target of bioinformatics is different sequences. The most important is the amino acid sequence of proteins and the base sequence of DNA. To study sequences and their constituent components, bioinformatics has another major research target - the biological database. This involves analysing the structure, connotation, and function of biological information through basic protein and nucleic acid sequences. Therefore, bioinformatics has made tremendous applications in the medical field. This research mainly analyzes and discusses the advantages and disadvantages of the application of bioinformatics in the medical field.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"78 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139629194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0