Theoretical and Natural Science最新文献_第10页

Stem cell: Therapeutic approach and potential future 干细胞：治疗方法和潜在的未来

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240817

Yuming Lu

{"title":"Stem cell: Therapeutic approach and potential future","authors":"Yuming Lu","doi":"10.54254/2753-8818/29/20240817","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240817","url":null,"abstract":"The numerous medical breakthroughs stem cell therapy can provide have led to stem cell research experiencing a surge in popularity. Thus, as modern technology develops, stem cell research may become a turning point for the medical field. Stem cell therapy provides several advantages over traditional treatments like surgical procedures, including lower risks, the absence of surgical wounds, and a non-invasive approach. Besides, undifferentiated organism treatment holds more potential to treat a more extensive assortment of illnesses compared with conventional medicines. This writing survey talks about late discoveries on numerous kinds of immature microorganisms, examining their sources, current clinical relevance, and expected potential outcomes. In particular, this audit looks at the accompanying areas of undeveloped cell research: undifferentiated cell treatment in regenerative medication; instigated pluripotent undifferentiated cells (iPSCs) and sickness demonstration; undeveloped cells and neurodegenerative infection; undeveloped cells and immunotherapy; undeveloped cells in regenerative medication; and, whats more, immature microorganisms and maturing. Through our examination, the paper has found that immature microorganisms have extraordinary potential for relieving infections that are impervious to conventional medicines. In any case, moral contemplations remain a worry, and there are as yet many difficulties to beat in the field. This audit means to sum up and look at the momentum of immature microorganism research while likewise featuring the far-reaching capability of undifferentiated cell movement in medication.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"76 s323","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139629337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal embryonic leucine zipper kinase in cancer progress and therapeutic potentials 癌症进展和治疗潜力中的母体胚胎亮氨酸拉链激酶

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240631

Qianyao Cheng

{"title":"Maternal embryonic leucine zipper kinase in cancer progress and therapeutic potentials","authors":"Qianyao Cheng","doi":"10.54254/2753-8818/29/20240631","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240631","url":null,"abstract":"This review delves into the investigation of Maternal Embryonic Leucine Zipper Kinase (MELK) and its significance in different cancer types. The primary emphasis is placed on understanding its role in cancer cell proliferation, migration, invasion, and resistance to therapeutic interventions. The intricate mechanisms of action exhibited by MELK are of significant importance in the context of cancer progression. These mechanisms encompass a wide range of biological processes, including gene regulation, cellular activities, and interactions at the tissue level. This highlights the multifaceted nature of MELKs involvement in cancer development and underscores its significance in this context. This essay explores the potential of MELK as a diagnostic and prognostic biomarker, with a focus on its altered expression patterns in various cancer types. Furthermore, this study delves into the investigation of MELK as a highly promising target for cancer therapy. It provides an in-depth analysis of the progress made in the development of MELK inhibitors and explores their potential clinical applications. The research endeavours in this study focus on addressing challenges related to therapeutic resistance and biomarker validation. Additionally, the investigation explores potential opportunities for combination therapies and personalised medicine approaches. The future directions of research on maternal embryonic leucine zipper kinase (MELK) encompass an in-depth investigation into its underlying molecular mechanisms, the validation of clinical biomarkers associated with MELK, and the exploration of effective combination strategies involving MELK. The role of MELK in cancer and the possibility to utilize it as a target for therapy have garnered significant attention due to their potential to advance precision cancer care and improve patient outcomes.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"40 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Golf's physical training and psychological training 高尔夫的体能训练和心理训练

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240814

Mingho Song

引用次数: 0

Music therapy in insomnia 失眠症的音乐疗法

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240783

Zhen He

引用次数: 0

A review of the effect of phone use on sleep and methods to sleep better 回顾使用手机对睡眠的影响以及改善睡眠的方法

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240805

Shijie Chen

引用次数: 0

Cyclin D1 in various cancers: Mechanisms and clinical implications 各种癌症中的细胞周期蛋白 D1：机制和临床意义

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240752

Wuwei Zhao

{"title":"Cyclin D1 in various cancers: Mechanisms and clinical implications","authors":"Wuwei Zhao","doi":"10.54254/2753-8818/29/20240752","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240752","url":null,"abstract":"Gastrointestinal cancers, including esophageal, gastric, hepatic, pancreatic, and colorectal malignancies, present a significant global health challenge. Their distinct characteristics characterized by abnormal cell proliferation, invasive behavior, and tumor formation make them highly aggressive and detrimental to human health. These diseases often lead to malnutrition, organ failure, and obstruction. Cyclin D1 protein is a critical regulator of cell cycle progression and an essential marker for comprehending the complex landscape of cancer biology. This research provides an in-depth exploration of gastrointestinal cancers by shedding light on their adverse effects on the human body while emphasizing the critical role played by cyclin D1 within this challenging disease context. Extensively studied in colorectal cancer as well as esophageal squamous cell carcinoma (ESCC), gastric cancer, and pancreatic cancer contexts. Cyclin D1 emerges as a key player. Specifically, in cases of colorectal cancer, overexpression of cyclin D1 is frequently linked to aggressive tumor behavior brought on by APC gene mutations and abnormal Wnt signalling pathway activation. Esophageal cancer patients especially those with ESCC frequently exhibit elevated levels of Cyclin D1 indicating poor prognosis. A similar trend is observed in gastric cancer where increased expression of cyclin D1 is linked to disease severity.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"3 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139628658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Pathogenesis and Differences in molecule of Autism 自闭症的发病机制和分子差异

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240705

Jingwen Xie

引用次数: 0

Childhood trauma and major depression in Chinese college students: mediating role of Internet addiction and victimization of domestic violence 中国大学生的童年创伤与重度抑郁症：网络成瘾和家庭暴力受害的中介作用

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240764

ZeZheng Wang

{"title":"Childhood trauma and major depression in Chinese college students: mediating role of Internet addiction and victimization of domestic violence","authors":"ZeZheng Wang","doi":"10.54254/2753-8818/29/20240764","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240764","url":null,"abstract":"Aim: Major depression disorder in adolescents has received much attention around the world. While the factors correlated with major depression in adolescents have been extensively described, the mechanisms underlying the complexity of the relationship between childhood traumatic experiences and major depression have been less studied. This study investigated both the direct influence of childhood trauma on major depression and whether the mediation of domestic violence victimization and Internet addiction played a role in connecting childhood trauma to major depression. Method: The school-based mental health survey was conducted in April 2023 in northeast Chinas Heilongjiang Province. We collected sociodemographic information and targeted mental health outcomes with standardized questionnaires. Hierarchical multiple logistic regression and structural equation modeling were used to analyze the data. Results: The study included 596 college students. The prevalence of major depression and Internet addiction was 31.2% and 21.6%, respectively. 16.4% of participants reported experiences of childhood trauma and 12.8% reported being victims of domestic violence. Childhood trauma, domestic violence victimization and Internet addiction have direct effects on major depression. The total effect of childhood trauma on suicidal ideation was 0.201 (p < 0.001). Domestic violence victimization and Internet addiction play mediating roles between childhood trauma and depression. Internet addiction plays a mediating role between domestic violence and major depression. Childhood trauma has direct and indirect effects on major depression of college students. Domestic violence victimization and Internet addiction play mediating roles in major depression of college students. Understanding these relationships will help develop and implement more targeted interventions and strategies to improve the mental health of Chinese college students.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"146 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139629125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress in the hemostasis of traumatic liver rupture during interventional embolization 介入栓塞术中外伤性肝破裂的止血进展

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240831

Yi Luo, Juntao Liu, Yuting Chen, Jiaman Li

{"title":"Progress in the hemostasis of traumatic liver rupture during interventional embolization","authors":"Yi Luo, Juntao Liu, Yuting Chen, Jiaman Li","doi":"10.54254/2753-8818/29/20240831","DOIUrl":"https://doi.org/10.54254/2753-8818/29/20240831","url":null,"abstract":"This paper mainly discusses the progress of hemostasis of traumatic liver rupture in interventional embolization. Traumatic liver rupture is a common intraabdominal traumatic disease in the clinic, and the incidence of right liver injury is generally high. The liver was located under the right diaphragm of the abdominal cavity, deep to both ribs. When subjected to external trauma or acute puncture, it can cause liver rupture and bleeding. If the liver is swollen due to lesions, the chance of liver rupture is relatively large. Severe hemorrhagic shock usually occurs after liver injury, causing bile peritonitis due to bile leakage into the abdominal cavity, and then infection occurs. How to improve the success rate of rescue has always been a difficult problem. This review described the pathological classification, classification and grading of liver rupture and combined with comprehensive studies of hemostatic materials at home and abroad to make a thorough analysis of vascular interventional embolization technique. The purpose of these analyses is to propose that embolization technology has good results for patients with liver rupture and bleeding, which can effectively reduce the disability rate and reduce complications, which is worth advocating clinically. Therefore, with the development of hemostatic materials science, the technology of hemostatic materials and related products has developed greatly, and the vascular interventional embolization technology has been widely improved in the clinical practice of surgery.","PeriodicalId":489336,"journal":{"name":"Theoretical and Natural Science","volume":"8 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in early diagnosis and treatments of kidney cancer 肾癌早期诊断和治疗的进展

Theoretical and Natural Science Pub Date : 2024-01-08 DOI: 10.54254/2753-8818/29/20240699

Haowei Zhang

引用次数: 0