Allergology International最新文献

{"title":"Epidemiology and risk factors of non-esophageal eosinophilic gastrointestinal diseases in Japan: A population-based study","authors":"Akinari Sawada ,&nbsp;Takumi Imai ,&nbsp;Yasutaka Ihara ,&nbsp;Fumio Tanaka ,&nbsp;Yasuhiro Fujiwara","doi":"10.1016/j.alit.2024.10.007","DOIUrl":"10.1016/j.alit.2024.10.007","url":null,"abstract":"<div><h3>Background</h3><div>Non-esophageal eosinophilic gastrointestinal diseases (non-EoE EGIDs) are allergic conditions where Th-2-predominant inflammation causes symptoms related to gastrointestinal tract dysfunction. No studies have reported the incidence of non-EoE EGIDs. In addition, little is known about the influence of lifestyle factors on the condition.</div></div><div><h3>Methods</h3><div>We used a large health claim database from January 2005 to September 2022. Non-EoE EGIDs cases were identified on the basis of the International Classification of Diseases-tenth Revision code, K52.8. The incidence and prevalence of non-EoE EGIDs were estimated by Poisson and binomial distribution, respectively. For each case, 10 controls were randomly selected for a nested case–control study to identify potential risk factors of non-EoE EGIDs.</div></div><div><h3>Results</h3><div>Of 15,200,895 individuals, 1,368 new cases of non-EoE EGIDs were identified. The incidence and prevalence of non-EoE EGIDs in 2022 were 3.07 (95% CI 2.67–3.52) per 100,000 person-years and 17.23 (95% CI 16.38–18.11) per 100,000 individuals, respectively, which were approximately 6 and 9 times higher than those in 2010. Allergic rhinitis (OR 1.63 (95% CI 1.16–2.29), <em>p</em> = 0.005), chronic sinusitis (OR 2.41 (95% CI 1.58–3.66), <em>p</em> &lt; 0.001), and urticaria (OR 2.32 (95% CI 1.45–3.70), <em>p</em> &lt; 0.001) were related to an increased risk of adult non-EoE EGIDs. Whilst atopic dermatitis (OR 2.28 (95% CI 1.35–3.86), <em>p</em> = 0.006) and the perinatal factors (OR 3.68 (95% CI 1.13–12.02), <em>p</em> = 0.031) were associated with an increased risk of pediatric non-EoE EGIDs. No association was seen with lifestyle factors such as obesity, smoking and alcohol consumption.</div></div><div><h3>Conclusions</h3><div>The incidence and prevalence of non-EoE EGIDs have increased over the past two decades.</div></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 2","pages":"Pages 292-300"},"PeriodicalIF":6.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of benralizumab in the Tokyo Asthma Study (TOAST): A real-world prospective interventional trial","authors":"Katsunori Masaki ,&nbsp;Maho Suzukawa ,&nbsp;Hitoshi Sasano ,&nbsp;Norihiro Harada ,&nbsp;Yasunari Miyazaki ,&nbsp;Hideki Katsura ,&nbsp;Etsuko Tagaya ,&nbsp;Junko Terada ,&nbsp;Masayuki Hojo ,&nbsp;Naoya Sugimoto ,&nbsp;Hiroyuki Nagase ,&nbsp;Yuta Kono ,&nbsp;Hisato Hiranuma ,&nbsp;Yasuhiro Gon ,&nbsp;Ryo Takemura ,&nbsp;Misato Irie ,&nbsp;Reina Nakamura ,&nbsp;Hiroki Kabata ,&nbsp;Jun Miyata ,&nbsp;Koichi Fukunaga","doi":"10.1016/j.alit.2024.10.009","DOIUrl":"10.1016/j.alit.2024.10.009","url":null,"abstract":"<div><h3>Background</h3><div>Biologics are integral in the management of severe asthma. As the effectiveness of the anti-IL-5 receptor antibody benralizumab in Japan remains elusive, this study aimed to assess its real-world effectiveness in Japanese patients with severe asthma.</div></div><div><h3>Methods</h3><div>This prospective, interventional, single-arm clinical trial was conducted across ten facilities in Japan between September 2020 and July 2022. Adult patients with severe eosinophilic asthma (peripheral blood eosinophil count ≥150 cells/μl) were enrolled and treated with benralizumab. The primary endpoint was the change in ACQ-5 score from baseline to week 24.</div></div><div><h3>Results</h3><div>Of 103 patients, 98 (mean age: 62.1 years, women: 55.1 %, regular oral corticosteroids [OCS] treatment: 20.4 %) were included in the analysis. From baseline to week 24, benralizumab significantly improved ACQ-5 (−0.67, 95 % CI: −0.94 to −0.39) and AQLQ (0.71, 95 % CI: 0.46 to 0.96) scores with an increase in FEV1 (87 ml, 95 % CI: 15–159 ml). The maintenance OCS dose and the percentage of OCS users decreased from 13.9 mg/day to 6.0 mg/day and from 20.4 % to 9.2 %, respectively. Multivariable analysis identified baseline blood eosinophil count (≥400 cells/μl) and fractional exhaled nitric oxide (≥22 ppb) as independent predictors of therapeutic response to benralizumab. Benralizumab treatment was discontinued due to nonserious adverse events and patient choice in four and three patients, respectively.</div></div><div><h3>Conclusions</h3><div>In a real-world setting in Japan, patients with severe eosinophilic asthma treated with benralizumab demonstrated substantial improvements in asthma control, quality of life, and respiratory function with reduced OCS usage. Trial registration: Japan Registry of Clinical Trials (jRCTs031190237).</div></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 2","pages":"Pages 274-282"},"PeriodicalIF":6.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Japanese cedar pollen sensitization in children with Dermatophagoides pteronyssinus sensitization and maternal sensitization: Insights from the Yamanashi adjunct study within the Japan Environment and Children’s Study (JECS)","authors":"Ayumi Shimamura ,&nbsp;Ryoji Shinohara ,&nbsp;Megumi Kushima ,&nbsp;Sanae Otawa ,&nbsp;Hideki Yui ,&nbsp;Tomokazu Matsuoka ,&nbsp;Daisuke Watanabe ,&nbsp;Hiroshi Yokomichi ,&nbsp;Kunio Miyake ,&nbsp;Reiji Kojima ,&nbsp;Zentaro Yamagata ,&nbsp;Daiju Sakurai ,&nbsp;The Yamanashi Adjunct Study of the Japan Environment and Children’s Study (JECS-Y) Group","doi":"10.1016/j.alit.2024.11.002","DOIUrl":"10.1016/j.alit.2024.11.002","url":null,"abstract":"<div><h3>Background</h3><div>In recent years, the prevalence of allergic rhinitis (AR) in Japanese children has increased significantly. Multiple sensitization and genetic factors are associated with the development of AR, and moreover, multiply sensitized children are more likely to have parents with AR. This research investigated the association of Japanese cedar pollen (JCP) sensitization in children with <em>Dermatophagoides pteronyssinus</em> (DP) sensitization and with maternal JCP sensitization.</div></div><div><h3>Methods</h3><div>This is an Adjunct Study to the Japan Environment and Children’s Study (JECS) in Yamanashi where reports the highest positive rate of JCP sensitization. It included 1469 mother-child pairs who participated in a comprehensive health examination of 8-year-old children (from 2019 to 2022) at the JECS-Yamanashi. Univariate and multivariate logistic regression models were created using the presence/absence of child’s JCP sensitization as the objective variable; mother’s JCP sensitization and child’s DP sensitization as explanatory variables; and child’s sex and BMI, mother’s age, and JCP exposure in the examination year as adjustment variables.</div></div><div><h3>Results</h3><div>Children who were positive for DP sensitization were also more likely to be positive for JCP sensitization (adjusted OR: 6.58; 95%CI: 5.10–8.48; <em>P</em> &lt; 0.001). Children who were positive for DP sensitization were also more likely to be positive for JCP sensitization if their mothers were positive for JCP sensitization (adjusted OR: 1.77; 95%CI: 1.16–2.71; <em>P</em> = 0.008).</div></div><div><h3>Conclusions</h3><div>JCP sensitization is associated with DP sensitization in children. Furthermore, in DP sensitization-positive children, JCP sensitization of the child was associated with JCP sensitization of the mother.</div></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 2","pages":"Pages 301-307"},"PeriodicalIF":6.2,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Questionnaire survey among ophthalmic allergists on dupilumab-associated ocular surface disease in Japan","authors":"Jun Shoji ,&nbsp;Yousuke Asada ,&nbsp;Rumi Adachi ,&nbsp;Noriko Inada ,&nbsp;Eiichi Uchio ,&nbsp;Yoko Kataoka ,&nbsp;Norito Katoh ,&nbsp;Tatsuma Kishimoto ,&nbsp;Eisuke Shimizu ,&nbsp;Tamaki Sumi ,&nbsp;Etsuko Takamura ,&nbsp;Kenichi Namba ,&nbsp;Yuuko Hara ,&nbsp;Kazuhiro Harada ,&nbsp;Akira Hirota ,&nbsp;Atsuki Fukushima ,&nbsp;Ken Fukuda ,&nbsp;Hiroshi Fujishima ,&nbsp;Moe Matsuzawa ,&nbsp;Akira Matsuda ,&nbsp;Nobuyuki Ebihara","doi":"10.1016/j.alit.2024.10.004","DOIUrl":"10.1016/j.alit.2024.10.004","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 2","pages":"Pages 333-335"},"PeriodicalIF":6.2,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible role for obstructive sleep apnea in nocturnal episodes of idiopathic angioedema","authors":"Evelien Maria Hutten,&nbsp;Annick Augustina Josephina Maria van de Ven,&nbsp;Rick Gert-Jan Pleijhuis","doi":"10.1016/j.alit.2024.11.001","DOIUrl":"10.1016/j.alit.2024.11.001","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 2","pages":"Pages 340-342"},"PeriodicalIF":6.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tristetraprolin-mediated mRNA destabilization regulates basophil inflammatory responses","authors":"Junya Ito ,&nbsp;Kensuke Miyake ,&nbsp;Tomoki Chiba ,&nbsp;Kazufusa Takahashi ,&nbsp;Yutaro Uchida ,&nbsp;Perry J. Blackshear ,&nbsp;Hiroshi Asahara ,&nbsp;Hajime Karasuyama","doi":"10.1016/j.alit.2024.10.005","DOIUrl":"10.1016/j.alit.2024.10.005","url":null,"abstract":"<div><h3>Background</h3><div>Basophils, despite being the least common granulocytes, play crucial roles in type 2 immune responses, such as chronic allergic inflammation and protective immunity against parasites. However, the molecular mechanisms regulating basophil activation and inflammatory molecule production remain poorly understood. Therefore, we investigated the role of RNA-binding proteins, specifically tristetraprolin (TTP), in regulating inflammatory molecule production in basophils.</div></div><div><h3>Methods</h3><div>Using antigen/IgE-stimulated basophils from wild-type (WT) and TTP-knockout (TTP-KO) mice, we performed bulk RNA sequencing, transcriptome-wide mRNA stability assays, and protein analyses. We also examined mRNA expression and protein production of inflammatory molecules in TTP-KO basophils under stimulation with IL-33 or LPS. Furthermore, we evaluated the <em>in vivo</em> significance of TTP in basophils using basophil-specific TTP-deficient mice and a hapten oxazolone-induced atopic dermatitis model.</div></div><div><h3>Results</h3><div>TTP expression was upregulated in basophils following stimulation with antigen/IgE, IL-33, or LPS. Under these stimuli, TTP-KO basophils exhibited elevated mRNA expression of inflammatory molecules, such as <em>Il4</em>, <em>Areg</em>, <em>Ccl3</em>, and <em>Cxcl2</em>, compared to WT basophils. Transcriptome-wide mRNA stability assays revealed that TTP deficiency prolonged the mRNA half-life of these inflammatory mediators. Notably, the production of these inflammatory proteins was significantly increased in TTP-KO basophils. Moreover, basophil-specific TTP-deficient mice showed exacerbated oxazolone-induced atopic dermatitis-like skin allergic inflammation.</div></div><div><h3>Conclusions</h3><div>TTP is a key regulator of basophil activation, controlling the production of inflammatory mediators through mRNA destabilization. Our <em>in vivo</em> findings demonstrate that the absence of TTP in basophils significantly aggravates allergic skin inflammation, highlighting its potential as a therapeutic target for allergic diseases.</div></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 2","pages":"Pages 263-273"},"PeriodicalIF":6.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic utility of Interleukin-22 in ocular surface testing for dupilumab-associated ocular surface disease","authors":"Rumi Adachi ,&nbsp;Jun Shoji ,&nbsp;Akira Hirota ,&nbsp;Akiko Tomioka ,&nbsp;Koremasa Hayama ,&nbsp;Noriko Inada ,&nbsp;Satoru Yamagami","doi":"10.1016/j.alit.2024.10.002","DOIUrl":"10.1016/j.alit.2024.10.002","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 2","pages":"Pages 330-332"},"PeriodicalIF":6.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of local nasal immunotherapy using hypoallergenic birch pollen ointment in patients with pollen-food allergy syndrome: A preliminary study of five cases","authors":"Keiko Komatsuzaki ,&nbsp;Yoshio Otani ,&nbsp;Hiroki Kageshima ,&nbsp;Yuki Sekino ,&nbsp;Yasuhiro Suzuki ,&nbsp;Tsukasa Ugajin ,&nbsp;Meiyo Tamaoka ,&nbsp;Pariko Yorozu ,&nbsp;Ryoichi Hanazawa ,&nbsp;Akihiro Hirakawa ,&nbsp;Daisuke Murakami ,&nbsp;Yasunari Miyazaki","doi":"10.1016/j.alit.2024.10.006","DOIUrl":"10.1016/j.alit.2024.10.006","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 2","pages":"Pages 336-339"},"PeriodicalIF":6.2,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of severe asthma during the COVID-19 pandemic: A retrospective study using a Japanese database","authors":"Kazuto Matsunaga ,&nbsp;Hayato Oka ,&nbsp;Hitomi Uchimura ,&nbsp;Yoshifumi Arita ,&nbsp;Takehiro Hirai ,&nbsp;Naoyuki Makita ,&nbsp;Hiroyuki Nagase","doi":"10.1016/j.alit.2024.09.003","DOIUrl":"10.1016/j.alit.2024.09.003","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 2","pages":"Pages 327-329"},"PeriodicalIF":6.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin health survey on atopic dermatitis among Japanese children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study","authors":"Chikana Kawaguchi ,&nbsp;Maki Ozawa ,&nbsp;Takanori Hidaka ,&nbsp;Keiko Murakami ,&nbsp;Mami Ishikuro ,&nbsp;Fumihiko Ueno ,&nbsp;Aoi Noda ,&nbsp;Tomomi Onuma ,&nbsp;Genki Shinoda ,&nbsp;Masatsugu Orui ,&nbsp;Taku Obara ,&nbsp;Yumiko Ito ,&nbsp;Takashi Kakinuma ,&nbsp;Kazuhiro Kudoh ,&nbsp;Hiroaki Ozawa ,&nbsp;Satoshi Nakagawa ,&nbsp;Masato Mizuashi ,&nbsp;Ryoko Omori ,&nbsp;Masatoshi Deguchi ,&nbsp;Yumi Kanbayashi ,&nbsp;Setsuya Aiba","doi":"10.1016/j.alit.2024.09.008","DOIUrl":"10.1016/j.alit.2024.09.008","url":null,"abstract":"<div><h3>Background</h3><div>Precise skin phenotypic data are indispensable in accurately diagnosing atopic dermatitis (AD). Therefore, this study examined the interobserver concordance for AD and non-AD diagnoses between two dermatologists. AD prevalence determined by the self-reported physician diagnoses and the diagnoses determined from the United Kingdom (UK) diagnostic criteria were compared with the diagnoses made by the two dermatologists, using data from a skin health survey.</div></div><div><h3>Methods</h3><div>This study included 1,638 children that participated in the skin health survey, which was part of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. AD was assessed using dermatologist assessments, self-reported physician diagnoses, and the UK diagnostic criteria. The concordance for diagnoses was evaluated using kappa. The sensitivity and specificity of the self-reported physician diagnoses and the UK diagnostic criteria were calculated by comparing them with the two dermatologists’ diagnoses.</div></div><div><h3>Results</h3><div>Among the 1,638 children, 393 (24.0 %), 194 (11.9 %), and 597 (37.2 %) were diagnosed with AD by the two dermatologists, physicians, and the UK diagnostic criteria, respectively. The kappa (95 % CI) of the interobserver concordance for AD or non-AD diagnoses between the two dermatologists was 0.78 (0.75–0.81). The sensitivity and specificity of the self-reported physician diagnoses were 26.7 % and 94.1 %, respectively. The sensitivity and specificity of the UK diagnostic criteria were 85.0 % and 82.4 %, respectively.</div></div><div><h3>Conclusions</h3><div>Interobserver concordance for AD or non-AD diagnoses between the two dermatologists was substantial. Self-reported physician diagnoses exhibited low sensitivity that potentially indicated underdiagnosis of AD, whereas the UK diagnostic criteria might overdiagnose AD.</div></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 2","pages":"Pages 246-253"},"PeriodicalIF":6.2,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}