Allergology International最新文献

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The role of GATA2 in the expression of the soluble decoy receptor ST2/IL1RL1 in human and mouse mast cells. GATA2在人和小鼠肥大细胞中可溶性诱骗受体ST2/IL1RL1表达中的作用
IF 6.2 2区 医学
Allergology International Pub Date : 2025-05-22 DOI: 10.1016/j.alit.2025.04.004
Kazuki Nagata, Kazumi Kasakura, Kenta Ishii, Naoto Ito, Mutsuko Hara, Nobuhiro Nakano, Ko Okumura, Chiharu Nishiyama
{"title":"The role of GATA2 in the expression of the soluble decoy receptor ST2/IL1RL1 in human and mouse mast cells.","authors":"Kazuki Nagata, Kazumi Kasakura, Kenta Ishii, Naoto Ito, Mutsuko Hara, Nobuhiro Nakano, Ko Okumura, Chiharu Nishiyama","doi":"10.1016/j.alit.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.alit.2025.04.004","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exacerbated signs of atopic dermatitis with gut dysbiosis predominate in male than in female adult patients. 伴有肠道生态失调的特应性皮炎症状加重的男性成人患者多于女性成人患者。
IF 6.2 2区 医学
Allergology International Pub Date : 2025-05-19 DOI: 10.1016/j.alit.2025.04.002
Susumu Ichiyama, Kozo Ohkusu-Tsukada, Hidehisa Saeki
{"title":"Exacerbated signs of atopic dermatitis with gut dysbiosis predominate in male than in female adult patients.","authors":"Susumu Ichiyama, Kozo Ohkusu-Tsukada, Hidehisa Saeki","doi":"10.1016/j.alit.2025.04.002","DOIUrl":"https://doi.org/10.1016/j.alit.2025.04.002","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophils predominate as IL1B-expressing cells in Schnitzler syndrome: Insights from the SCan study to evaluate the efficacy and safety of canakinumab in Japanese patients. 中性粒细胞作为表达il1b的细胞在Schnitzler综合征中占主导地位:来自SCan研究的见解,以评估canakinumab在日本患者中的有效性和安全性。
IF 6.2 2区 医学
Allergology International Pub Date : 2025-05-19 DOI: 10.1016/j.alit.2025.04.003
Naotomo Kambe, Norimitsu Inoue, Yoko Ueki, Yuyi Zhou, Satoru Yonekura, Kosuke Katsuo, Satoshi Nakamizo, Hiroshi Tsujimoto, Katsuki Ohtani, Hajime Yoshifuji, Tomoyasu Jo, Kazushi Izawa, Mayuko Yamamoto, Koji Takemura, Shin-Ichiro Kagami, Yoshie Kawahara, Yoko Amino, Yumiko Ibi, Satoshi Morita, Nobuo Kanazawa
{"title":"Neutrophils predominate as IL1B-expressing cells in Schnitzler syndrome: Insights from the SCan study to evaluate the efficacy and safety of canakinumab in Japanese patients.","authors":"Naotomo Kambe, Norimitsu Inoue, Yoko Ueki, Yuyi Zhou, Satoru Yonekura, Kosuke Katsuo, Satoshi Nakamizo, Hiroshi Tsujimoto, Katsuki Ohtani, Hajime Yoshifuji, Tomoyasu Jo, Kazushi Izawa, Mayuko Yamamoto, Koji Takemura, Shin-Ichiro Kagami, Yoshie Kawahara, Yoko Amino, Yumiko Ibi, Satoshi Morita, Nobuo Kanazawa","doi":"10.1016/j.alit.2025.04.003","DOIUrl":"https://doi.org/10.1016/j.alit.2025.04.003","url":null,"abstract":"<p><strong>Background: </strong>Schnitzler syndrome (SchS) is a late-onset autoinflammatory disease characterized by urticarial rash and monoclonal gammopathy. SchS shares clinical features with cryopyrin-associated periodic syndrome, which is driven by gain-of-function mutations in NLRP3, and while IL-1β-targeted therapies have shown efficacy, the underlying pathogenesis of SchS remains unclear.</p><p><strong>Methods: </strong>During a multicenter, single-arm, open-label, investigator-initiated trial evaluating the efficacy and safety of canakinumab in five Japanese patients with SchS (named the SCan Study after SchS and Canakinumab), based on a similar study conducted in Germany, we measured 32 cytokines/chemokines and 11 complement-related factors in plasma and analyzed their correlations with changes in clinical symptoms during treatment. Furthermore, in two cases, single-cell RNA sequencing of peripheral blood and spatial transcriptomic analysis of lesional skin were performed to identify IL1B-expressing cells.</p><p><strong>Results: </strong>The improvement in clinical symptoms and quality of life was maintained for 48 weeks following canakinumab treatment. Notably, these changes in clinical symptoms strongly correlated with WBC count, neutrophil count, CRP, and serum amyloid A levels, which were used as evaluation parameters in this study. In contrast, IL-1β and most other cytokines/chemokines exhibited distinct patterns and were not useful as markers of disease activity. IgM levels remained stable without an upward trend. Additionally, IL1B-expressing cells were predominantly neutrophils in both peripheral blood and lesional skin. Furthermore, neutrophil counts in peripheral blood decreased following canakinumab administration.</p><p><strong>Conclusions: </strong>This study demonstrated that the primary source of IL1B-expressing cells in SchS is neutrophils. Moreover, canakinumab improves clinical symptoms by regulating neutrophil dynamics in peripheral blood.</p>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examining effects of race and chronic rhinosinusitis on asthma; more evidence for unified-airway diseases. 种族和慢性鼻窦炎对哮喘的影响更多关于统一气道疾病的证据。
IF 6.2 2区 医学
Allergology International Pub Date : 2025-04-23 DOI: 10.1016/j.alit.2025.03.006
Donyea L Moore, Evan A Patel, Bobby A Tajudeen, Pete S Batra, Mahboobeh Mahdavinia
{"title":"Examining effects of race and chronic rhinosinusitis on asthma; more evidence for unified-airway diseases.","authors":"Donyea L Moore, Evan A Patel, Bobby A Tajudeen, Pete S Batra, Mahboobeh Mahdavinia","doi":"10.1016/j.alit.2025.03.006","DOIUrl":"https://doi.org/10.1016/j.alit.2025.03.006","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in the diagnosis and treatment of DIHS/DRESS in 2025. 2025年DIHS/DRESS诊断和治疗的最新进展。
IF 6.2 2区 医学
Allergology International Pub Date : 2025-04-17 DOI: 10.1016/j.alit.2025.03.007
Yoshiko Mizukawa, Tetsuo Shiohara
{"title":"Recent advances in the diagnosis and treatment of DIHS/DRESS in 2025.","authors":"Yoshiko Mizukawa, Tetsuo Shiohara","doi":"10.1016/j.alit.2025.03.007","DOIUrl":"https://doi.org/10.1016/j.alit.2025.03.007","url":null,"abstract":"<p><p>Drug-induced hypersensitivity syndrome (DIHS) or drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe drug reaction characterized by a range of clinical manifestations. These range from mild cases resolving upon cessation of the causative drug to severe cases involving complex disease progression and potential fatality. A hallmark of DIHS/DRESS is the sequential reactivation of herpesviruses, particularly human herpesvirus 6 (HHV-6), during the disease course, contributing to recurrent symptoms. Viral reactivation can lead to critical complications, including infectious DIHS/DRESS-associated complications (iDACs) and autoimmune sequelae (aDACs). Managing DIHS/DRESS remains challenging due to its complexity, requiring precise prediction and tailored treatment strategies. Recent studies suggest that early-stage classification using the DIHS/DRESS Severity (DDS) score may help identify refractory cases, including DACs. Furthermore, early intervention with anti-cytomegalovirus (anti-CMV) therapy can mitigate iDACs caused by CMV reactivation, preventing progression to severe CMV-related diseases. Long-term follow-up is crucial, as aDACs can manifest even 3 years postonset. Serial monitoring is recommended, particularly in patients treated with intravenous immunoglobulin or corticosteroid pulse therapy, which are recognized risk factors for aDAC development. This review highlights DIHS/DRESS management strategies, focusing on its clinical features, the role of viral reactivation, and therapeutic interventions.</p>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medical treatment recipient ratio for metal allergy among Japanese children and adolescents: A retrospective cohort study using health insurance claims data (2016-2020). 日本儿童和青少年金属过敏的医疗接受率:2016-2020年健康保险索赔数据的回顾性队列研究
IF 6.2 2区 医学
Allergology International Pub Date : 2025-04-16 DOI: 10.1016/j.alit.2025.04.001
Daigo Kato, Takako Miyamae, Yuzaburo Inoue
{"title":"Medical treatment recipient ratio for metal allergy among Japanese children and adolescents: A retrospective cohort study using health insurance claims data (2016-2020).","authors":"Daigo Kato, Takako Miyamae, Yuzaburo Inoue","doi":"10.1016/j.alit.2025.04.001","DOIUrl":"https://doi.org/10.1016/j.alit.2025.04.001","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishment of a novel human basophil cell line for functional analysis and in vitro allergy testing. 一种用于功能分析和体外过敏试验的新型人嗜碱性细胞系的建立。
IF 6.2 2区 医学
Allergology International Pub Date : 2025-04-04 DOI: 10.1016/j.alit.2025.03.003
Ryo Kurita, Takaaki Abe, Kanako Maebara, Daisuke Takahashi, Shigeki Miyata, Masahiro Satake, Yoshihiko Tani
{"title":"Establishment of a novel human basophil cell line for functional analysis and in vitro allergy testing.","authors":"Ryo Kurita, Takaaki Abe, Kanako Maebara, Daisuke Takahashi, Shigeki Miyata, Masahiro Satake, Yoshihiko Tani","doi":"10.1016/j.alit.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.alit.2025.03.003","url":null,"abstract":"<p><strong>Background: </strong>Basophils are the rarest granulocytes and play diverse roles, e.g., in protective immunity and allergic inflammatory reactions. However, the underlying molecules and mechanisms involved in basophil differentiation and functions, particularly in humans, remain largely unknown. This may be due to the lack of high-quality research tools.</p><p><strong>Methods: </strong>We established a novel, immortalized, human basophil cell line by introducing human papillomavirus 16-E6/E7, c-MYC, and BCL-xL gene expression systems into cultured basophils, and evaluated whether this cell line is useful as a research tool, compared with KU812, which is the most commonly-used human basophil cell line.</p><p><strong>Results: </strong>This cell line expressed various basophil markers, including CD123, CD203c, and the high-affinity immunoglobulin (Ig)E receptor α-chain and can mature into more differentiated cells under specific culture conditions. The differentiated cells stimulated with anti-IgE antibodies showed increased CD203c expression in a dose-dependent manner, whereas the differentiated KU812 cells showed little activation after the stimulation. The established cell line also demonstrated increased sensitivity to allergic activation when stimulated with an allergen (NP-BSA) and allergen-specific IgE (anti-NP-IgE). Furthermore, histamine- and interleukin-4-releasing abilities were also confirmed. These allergic activation profiles were similar to those of basophils from healthy individuals, although the activation levels of the established cells were lower than those of basophils from highly-sensitive individuals.</p><p><strong>Conclusions: </strong>These findings suggest that the established basophil cell line has substantially different characteristics from a conventional cell line and could serve as a new tool for investigating basophil differentiation and functions, as well as for testing allergic reactions.</p>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacogenetic biomarkers associated with risk of developing severe drug eruptions and clinical implementation of HLA genetic testing. 与发生严重药疹风险相关的药物遗传学生物标志物和HLA基因检测的临床实施。
IF 6.2 2区 医学
Allergology International Pub Date : 2025-04-04 DOI: 10.1016/j.alit.2025.03.002
Taisei Mushiroda
{"title":"Pharmacogenetic biomarkers associated with risk of developing severe drug eruptions and clinical implementation of HLA genetic testing.","authors":"Taisei Mushiroda","doi":"10.1016/j.alit.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.alit.2025.03.002","url":null,"abstract":"<p><p>The association of human leukocyte antigen (HLA) with the risk of drug-induced skin eruptions has been extensively studied. The sensitivity of the association of specific HLA alleles with drug eruptions ranges from approximately 50 to 100%, indicating a significant influence of HLA alleles on the risk of developing such reactions. Consequently, HLA testing holds substantial clinical potential as a genetic diagnostic tool to avoid drug eruptions. For instance, when prescribing drugs like carbamazepine and lamotrigine, which are known to cause severe drug eruptions, preemptive HLA genetic testing can help predict an individual's risk. This approach enables clinicians to reduce the overall incidence of drug eruptions by selecting alternative therapeutic agents or adjusting dosages based on the results of HLA genetic testing.</p>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two cases of edible cricket allergy: Antigen analysis and cross-reactivity with shrimp and mite allergens. 食用蟋蟀过敏2例:抗原分析及与虾、螨过敏原的交叉反应。
IF 6.2 2区 医学
Allergology International Pub Date : 2025-04-03 DOI: 10.1016/j.alit.2025.03.005
Masaki Yamamoto, Tomofumi Kawabe, Yasuhiro Osugi, Nayu Sato, Masashi Nakamura, Kayoko Matsunaga, Takahiko Horiguchi, Akiko Yagami
{"title":"Two cases of edible cricket allergy: Antigen analysis and cross-reactivity with shrimp and mite allergens.","authors":"Masaki Yamamoto, Tomofumi Kawabe, Yasuhiro Osugi, Nayu Sato, Masashi Nakamura, Kayoko Matsunaga, Takahiko Horiguchi, Akiko Yagami","doi":"10.1016/j.alit.2025.03.005","DOIUrl":"https://doi.org/10.1016/j.alit.2025.03.005","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pre-clinical strategies and emerging technologies driving advances in the alpha-gal syndrome. 推动alpha-gal综合征进展的临床前策略和新兴技术。
IF 6.2 2区 医学
Allergology International Pub Date : 2025-04-02 DOI: 10.1016/j.alit.2025.03.004
Loren D Erickson, Jeffrey M Wilson, Kayla Cramton, Claudia M Rival
{"title":"Pre-clinical strategies and emerging technologies driving advances in the alpha-gal syndrome.","authors":"Loren D Erickson, Jeffrey M Wilson, Kayla Cramton, Claudia M Rival","doi":"10.1016/j.alit.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.alit.2025.03.004","url":null,"abstract":"<p><p>Alpha-gal syndrome (AGS) is a unique allergic condition triggered by IgE antibody production against the mammalian oligosaccharide galactose-α-1,3-galactose (α-gal). The syndrome, acquired by bites from multiple tick species, leads to delayed allergic reactions after consuming mammalian-derived products containing α-gal, including red meat, dairy, and select medications. AGS is especially prevalent in regions with high tick exposure and has become a global public health concern, with rising cases across continents. Despite growing research, including recent findings suggesting that asymptomatic α-gal sensitization may contribute to coronary artery disease, the precise immune mechanisms-particularly B cell-mediated IgE production following tick bites-remain poorly understood. Additionally, the tick saliva components that trigger sensitization and the role of the skin-gut axis in food allergy development are knowledge gaps. AGS research has benefited from animal models like mice, zebrafish, and pigs, which replicate key syndrome features, though have limitations. Humanized mouse models and human organoid systems now offer promising tools for investigating AGS pathogenesis and testing potential therapies. This review explores current pre-clinical methodologies, challenges, and the future of AGS research, emphasizing innovative models that may bridge knowledge gaps and advance therapeutic development.</p>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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