Allergology International最新文献

{"title":"Analysis of the relationship between comorbid obstructive sleep apnea and clinical outcomes in patients with asthma in Japan","authors":"Hitomi Ikegami-Tanaka,&nbsp;Naoya Yasokawa,&nbsp;Koji Kurose,&nbsp;Shonosuke Tajima,&nbsp;Masaaki Abe,&nbsp;Shigeki Katoh,&nbsp;Yoshihiro Kobashi,&nbsp;Toru Oga","doi":"10.1016/j.alit.2024.01.009","DOIUrl":"10.1016/j.alit.2024.01.009","url":null,"abstract":"<div><h3>Background</h3><p>Asthma and obstructive sleep apnea (OSA) are prevalent chronic respiratory disorders, which often coexist and interact with each other. Obesity is an important risk factor shared by them. The rate of obesity is lower in Japan versus Western countries. Hence, the co-existence of asthma and OSA has not been investigated in Japan.</p></div><div><h3>Methods</h3><p>Ninety-seven outpatients with asthma were recruited. Patients wore a portable monitor for sleep study. Background data, pulmonary function, blood tests, and patient-reported outcomes including gastroesophageal reflux disease, sleepiness, sleep quality, asthma control, cough and respiratory symptoms, and health status, were assessed.</p></div><div><h3>Results</h3><p>Of the patients, 19 (19.6 %), 40 (41.2 %), 24 (24.7 %), and 14 (14.4 %) were classified into non-, mild, moderate, and severe OSA groups. Non-OSA patients were younger than those in other groups (p &lt; 0.05). The BMI of patients with moderate and severe OSA, was higher than that of non-OSA patients (p &lt; 0.05). Pulmonary function, FeNO, serum IgE, and the number of peripheral eosinophils were not significantly different between groups. Nonetheless, compared with the other groups, treatment step was the highest, and the Asthma Control Test, Leicester Cough Questionnaire, COPD Assessment Test, and Asthma Health Questionnaire-33 yielded worst scores in the severe OSA group, and predicted the severe OSA after adjustment by BMI.</p></div><div><h3>Conclusions</h3><p>Moderate and severe OSA are highly prevalent among patients with asthma in Japan. Pulmonary function did not differ between groups. However, patients with asthma and severe OSA were linked to more asthma treatment, worse asthma control, more symptoms and cough, and worse health status.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 3","pages":"Pages 390-396"},"PeriodicalIF":6.8,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893024000108/pdfft?md5=7b59586cb4bbcbcbc84e83ee54e67e81&pid=1-s2.0-S1323893024000108-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLEC10A expression defines functionally distinct subsets of conventional type 2 dendritic cells (cDC2) in the mouse lung","authors":"Fumiya Nihashi ,&nbsp;Kazuki Furuhashi ,&nbsp;Ryo Horiguchi ,&nbsp;Yoshihiro Kitahara ,&nbsp;Yusuke Inoue ,&nbsp;Hideki Yasui ,&nbsp;Masato Karayama ,&nbsp;Yuzo Suzuki ,&nbsp;Hironao Hozumi ,&nbsp;Noriyuki Enomoto ,&nbsp;Tomoyuki Fujisawa ,&nbsp;Yutaro Nakamura ,&nbsp;Naoki Inui ,&nbsp;Takafumi Suda","doi":"10.1016/j.alit.2024.01.011","DOIUrl":"10.1016/j.alit.2024.01.011","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 3","pages":"Pages 481-484"},"PeriodicalIF":6.8,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893024000121/pdfft?md5=28e5120f65937abaf4a6598de043f4fb&pid=1-s2.0-S1323893024000121-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current and future perspectives on the consensus guideline for food protein-induced enterocolitis syndrome (FPIES)","authors":"Sara Anvari ,&nbsp;Melanie A. Ruffner ,&nbsp;Anna Nowak-Wegrzyn","doi":"10.1016/j.alit.2024.01.006","DOIUrl":"10.1016/j.alit.2024.01.006","url":null,"abstract":"<div><p>Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE mediated food allergy presenting with delayed onset of projectile vomiting in the absence of cutaneous and respiratory symptoms. The pathophysiology of FPIES remains poorly characterized. The first international consensus guidelines for FPIES were published in 2017 and provided clinicians with parameters on the diagnosis and treatment of FPIES. The guidelines have served as a resource in the recognition and management of FPIES, contributing to an increased awareness of FPIES. Since then, new evidence has emerged, shedding light on adult-onset FPIES, the different phenotypes of FPIES, the recognition of new food triggers, center-specific food challenge protocols and management of acute FPIES. Emerging evidence indicates that FPIES impacts both pediatric and adult population. As a result, there is growing need to tailor the consensus guidelines to capture diagnoses in both patient groups. Furthermore, it is crucial to provide food challenge protocols that meet the needs of both pediatric and adult FPIES patients, as well as the subset of patients with atypical FPIES. This review highlights the evolving clinical evidence relating to FPIES diagnosis and management published since the 2017 International FPIES Guidelines. We will focus on areas where recent published evidence may support evolution or revision of the guidelines.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 2","pages":"Pages 188-195"},"PeriodicalIF":6.8,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893024000078/pdfft?md5=a30dff50061d598041fff07f721bbb90&pid=1-s2.0-S1323893024000078-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin care by washing with water is not inferior to washing with a cleanser in children with atopic dermatitis in remission in summer: WASH study","authors":"Yukiko Katoh ,&nbsp;Osamu Natsume ,&nbsp;Ryuhei Yasuoka ,&nbsp;Satoshi Hayano ,&nbsp;Eisaku Okada ,&nbsp;Yutaka Ito ,&nbsp;Akira Sakai ,&nbsp;Yoko Monna ,&nbsp;Fumitaka Takayanagi ,&nbsp;Yusuke Inuzuka ,&nbsp;Yuji Sakakura","doi":"10.1016/j.alit.2024.01.007","DOIUrl":"10.1016/j.alit.2024.01.007","url":null,"abstract":"<div><h3>Background</h3><p>Washing with water is not inferior to washing with soaps and detergents in children with atopic dermatitis (AD) in remission during the fall-winter seasons. We investigated whether this finding varies during summer based on the type of cleanser (soaps and detergents).</p></div><div><h3>Methods</h3><p>This evaluator-blinded, pragmatic, randomized, and non-inferiority study enrolled patients with AD whose eczema was controlled following regular steroid ointment application 2 days/week. For 8 ± 4 weeks, participants washed their upper and lower limbs with a cleanser on one side and with water alone on the other. Each participant chose either a weakly alkaline soap or an acidic detergent. The primary outcome was the Eczema Area and Severity Index (EASI) score at week 8 ± 4.</p></div><div><h3>Results</h3><p>The data of 43 of the 47 registered participants were analyzed. The median patient age was 44 (23–99) months; 28 and 15 participants chose weakly alkaline and acidic cleansers, respectively. At week 8 ± 4, EASI scores of the water and cleanser sides were 0.00 (0.00–0.40) and 0.15 (0.00–0.40), respectively (<em>p</em> = 0.74). The difference between both sides was 0.00 (−0.07 to 0.14); the limits of the 95 % confidence interval did not reach the pre-specified non-inferiority margin. No difference was observed in the median Patient-Oriented Eczema Measure score, number of additional steroid ointment applications, and occurrences of skin infections. There were no differences between the cleanser types in any of the results.</p></div><div><h3>Conclusions</h3><p>We demonstrated that washing with water was not inferior to that with a cleanser in patients with AD in the maintenance phase during summer, regardless of the type of cleanser.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 3","pages":"Pages 428-435"},"PeriodicalIF":6.8,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S132389302400008X/pdfft?md5=bbbac75fdd1f53e3708e6efa4ff40775&pid=1-s2.0-S132389302400008X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139679674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of atopic conditions on development and recurrences of infectious keratitis","authors":"Yutaka Omatsu,&nbsp;Yumiko Shimizu,&nbsp;Tomoko Haruki,&nbsp;Yoshitsugu Inoue,&nbsp;Dai Miyazaki","doi":"10.1016/j.alit.2024.01.008","DOIUrl":"10.1016/j.alit.2024.01.008","url":null,"abstract":"<div><h3>Background</h3><p>Atopic conditions are known to be associated with viral and bacterial infections. The purpose of this study was to determine the relationship between the effects of atopic conditions on the severity and recurrence of ocular infections including herpes simplex virus (HSV).</p></div><div><h3>Methods</h3><p>This study was performed on 474 consecutive patients with infectious keratitis caused by bacteria, fungus, acanthamoeba, HSV, or varicella-zoster virus. The relationships between the atopic condition and specific infectious pathogens and HSV were determined using real-time PCR.</p></div><div><h3>Results</h3><p>Our findings showed that atopic dermatitis (AD) was significantly associated with the incidence of HSV keratitis (odds ratio (OR), 10.2; <em>P</em> = 0.000). Other associations with AD were observed only with bacteria in an adverse manner. HSV proliferation in the lesions of patients with HSV keratitis whose AD was associated with non-infectious atopic blepharitis were significantly greater by 145-folds (<em>P</em> = 0.000). The presence of asthma or allergic rhinitis also increased the HSV DNA copy numbers.</p><p>A recurrence of HSV keratitis was observed in 70 patients (43.2 %), and mean time to recurrence was 1647 days. Cox proportional hazard model indicated that the epithelial type of HSV recurrence but not the stromal type was associated with atopic conditions especially with AD. The factors significantly associated with a recurrence was AD associated with non-infectious atopic blepharitis (HR: 6.11, <em>P</em> = 0.000) and asthma (HR: 3.03, <em>P</em> = 0.025).</p></div><div><h3>Conclusions</h3><p>Atopic conditions, especially AD with atopic blepharitis, are significantly associated with the development, increased proliferation, and shorter time to a recurrence on HSV keratitis.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 3","pages":"Pages 445-452"},"PeriodicalIF":6.8,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893024000091/pdfft?md5=d84db142059e31636e8d5270112ecd33&pid=1-s2.0-S1323893024000091-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139679455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of household pet ownership and filaggrin loss-of-function mutations on eczema prevalence in children: A birth cohort study","authors":"Kenji Toyokuni ,&nbsp;Kiwako Yamamoto-Hanada ,&nbsp;Limin Yang ,&nbsp;Kouhei Hagino ,&nbsp;Daisuke Harama ,&nbsp;Marei Omori ,&nbsp;Yasuaki Matsumoto ,&nbsp;Daichi Suzuki ,&nbsp;Kotaro Umezawa ,&nbsp;Kazuma Takada ,&nbsp;Mami Shimada ,&nbsp;Seiko Hirai ,&nbsp;Fumi Ishikawa ,&nbsp;Sayaka Hamaguchi ,&nbsp;Mayako Saito-Abe ,&nbsp;Miori Sato ,&nbsp;Yumiko Miyaji ,&nbsp;Shigenori Kabashima ,&nbsp;Tatsuki Fukuie ,&nbsp;Emiko Noguchi ,&nbsp;Yukihiro Ohya","doi":"10.1016/j.alit.2024.01.003","DOIUrl":"10.1016/j.alit.2024.01.003","url":null,"abstract":"<div><h3>Background</h3><p>The association between pet exposure in infancy, early childhood eczema, and <em>FLG</em> mutations remains unclear.</p></div><div><h3>Methods</h3><p>This was a birth cohort study performed in Tokyo, Japan. The primary outcome was current eczema based on questionnaire responses collected repeatedly from birth to 5 years of age. Generalized estimating equations and generalized linear modeling were used to evaluate the association.</p></div><div><h3>Results</h3><p>Data from 1448 participants were used for analyses. Household dog ownership during gestation, early infancy, and 18 months of age significantly reduced the risk of current eczema. Household cat ownership also reduced the risk of current eczema, albeit without statistical significance. The combined evaluation of children from households with pets, be it cats, dogs or both, the risk of current eczema at 1–5 years of age was lower in those with household pet exposure ownership during gestation (RR = 0.59, 95 % CI 0.45–0.77) and at 6 months (RR = 0.49, 95 % CI 0.36–0.68). , Reduced risks of eczema were also observed at 2–5 (RR = 0.52, 95 % CI 0.37–0.73) and 3–5 years of age (RR = 0.50 95 % CI 0.35–0.74) when the respective household pet ownership were evaluated at 18 months and 3 years of age. These protective associations of reduced risk of eczema were only observed in children without <em>FLG</em> mutations.</p></div><div><h3>Conclusions</h3><p>Household dog and pet (dog, cat, or both) ownership was protective against early childhood eczema in a birth cohort dataset. This protective association was observed only in children without <em>FLG</em> mutations, which should be confirmed in studies with larger cohorts.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 3","pages":"Pages 422-427"},"PeriodicalIF":6.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893024000042/pdfft?md5=202c0a6ec3a7cfef59bd87cde6b87e60&pid=1-s2.0-S1323893024000042-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139657030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-year prognosis after low-dose oral food challenge for children with wheat allergy","authors":"Takaaki Itonaga ,&nbsp;Noriyuki Yanagida ,&nbsp;Ken-ichi Nagakura ,&nbsp;Tomoyuki Asaumi ,&nbsp;Mai Tokunaga ,&nbsp;Makoto Nishino ,&nbsp;Kyohei Takahashi ,&nbsp;Kiyotake Ogura ,&nbsp;Sakura Sato ,&nbsp;Motohiro Ebisawa","doi":"10.1016/j.alit.2024.01.004","DOIUrl":"10.1016/j.alit.2024.01.004","url":null,"abstract":"<div><h3>Background</h3><p>Low-dose oral food challenge (LD-OFC) is an approach to avoid complete elimination in high-risk patients with wheat allergy (WA). We examined the 3-year prognosis after LD-OFC among patients who passed and failed LD-OFC.</p></div><div><h3>Methods</h3><p>Children with immediate-type WA aged ≤6 years with a history of reaction to ≤390 mg of wheat protein underwent their first LD-OFC with 52 mg (baseline LD-OFC). After passing the LD-OFC, children stepped up to 390, 1300, and 5200 mg step-by-step every 3–6 months. After failing LD-OFC, children repeated LD-OFC every 6–12 months. We assessed wheat tolerance defined as consuming 5200 mg without symptoms for 3 years after baseline LD-OFC.</p></div><div><h3>Results</h3><p>The median age of 124 children was 2.4 years, and the wheat- and ω-5-gliadin-specific immunoglobulin E (IgE) levels (kU_A/L) were 23.6 and 2.1, respectively. Upon baseline LD-OFC, 57% passed (LD-tolerant), whereas 43% failed (LD-reactive). Within 3 years, 38% of the LD-reactive group passed re-administered LD-OFC, and 70% of all participants avoided complete elimination. The percentage of the participants who became capable of consuming 390 mg (87% vs. 18%), 1300 mg (78% vs. 13%), and acquired tolerance (70% vs. 13%) was significantly higher in the LD-tolerant group than in the LD-reactive group (<em>p</em> &lt; 0.001). Predictors of persistent WA in the LD-tolerant group were older age (adjusted odds ratio, 1.63), ω-5-gliadin-specific IgE level (1.62 per 10-fold increase), and other food allergies (1.94).</p></div><div><h3>Conclusions</h3><p>LD-tolerant patients frequently acquired wheat tolerance within 3 years. Even if once positive, one-third could pass the re-administered LD-OFC within 3 years.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 3","pages":"Pages 416-421"},"PeriodicalIF":6.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893024000054/pdfft?md5=0621f6990616f6bcdc79301e95b7e6a5&pid=1-s2.0-S1323893024000054-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139651976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of nasal polyp-derived innate lymphoid cells in staphylococcal enterotoxin-induced cellular responses","authors":"Kengo Kanai ,&nbsp;Aiko Oka ,&nbsp;Shin Kariya ,&nbsp;Tazuko Fujiwara ,&nbsp;Takaya Higaki ,&nbsp;Seiichiro Makihara ,&nbsp;Takenori Haruna ,&nbsp;Maki Akamatsu ,&nbsp;Kazunori Nishizaki ,&nbsp;Mizuo Ando ,&nbsp;Mitsuhiro Okano","doi":"10.1016/j.alit.2024.01.005","DOIUrl":"10.1016/j.alit.2024.01.005","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 3","pages":"Pages 477-480"},"PeriodicalIF":6.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893024000066/pdfft?md5=28fc8826d759d6bf1041a1700b2c7da6&pid=1-s2.0-S1323893024000066-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139656859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis of macrolides in the management of adult patients with asthma","authors":"Hiroshi Ohnishi ,&nbsp;Toshihito Otani ,&nbsp;Yoshihiro Kanemitsu ,&nbsp;Tatsuya Nagano ,&nbsp;Johsuke Hara ,&nbsp;Masamitsu Eitoku","doi":"10.1016/j.alit.2024.01.002","DOIUrl":"10.1016/j.alit.2024.01.002","url":null,"abstract":"<div><h3>Background</h3><p>The efficacy of macrolides in the management of asthma has been studied but remains controversial. We conducted a systematic review and meta-analysis of macrolides in the management of adult patients with asthma.</p></div><div><h3>Methods</h3><p>Randomized controlled trials of macrolides used in adult patients with asthma were searched for in MEDLINE, EMBASE, PsycINFO, Cochrane Library, CINAHL, and Igaku Chuo Zasshi databases to evaluate the efficacy and safety of macrolides.</p></div><div><h3>Results</h3><p>Seventeen reports with macrolide treatment durations ranging from 6 to 48 weeks were included. Macrolides did not reduce exacerbations requiring hospitalization, severe exacerbations, or rescue use of short-acting beta-2 agonist inhalers; improve lung function; decrease peripheral blood or sputum neutrophil counts; or decrease fractional exhaled nitric oxide compared to placebo. Macrolides statistically improved asthma control and quality of life but by less than the minimal clinically important difference. Peripheral blood eosinophil counts as well as serum and sputum eosinophilic cationic protein concentrations were significantly decreased with macrolides compared to placebo. The improvement of asthma symptoms and airway hyperresponsiveness varied by study. The safety profile of macrolides was comparable to that of placebo.</p></div><div><h3>Conclusions</h3><p>Although macrolides have some useful clinical aspects, there is not sufficient evidence to recommend their use in the management of adult patients with asthma.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 3","pages":"Pages 382-389"},"PeriodicalIF":6.8,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893024000030/pdfft?md5=a7301f6e2f48b386084da43a70b70cbe&pid=1-s2.0-S1323893024000030-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139649337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cluster analysis of phenotypes, job exposure, and inflammatory patterns in elderly and nonelderly asthma patients","authors":"Yung-Chi Chuang ,&nbsp;Hsin-Hua Tsai ,&nbsp;Meng-Chih Lin ,&nbsp;Chao-Chien Wu ,&nbsp;Yuan-Chung Lin ,&nbsp;Tsu-Nai Wang","doi":"10.1016/j.alit.2024.01.001","DOIUrl":"10.1016/j.alit.2024.01.001","url":null,"abstract":"<div><h3>Background</h3><p>Asthma has been identified as different phenotypes due to various risk factors. Age differences may have potential effects on asthma phenotypes. Our study aimed to identify potential asthma phenotypes among adults divided by age as either younger or older than 65 years. We also compared differences in blood granulocyte patterns, occupational asthmagens, and asthma control-related outcomes among patient phenotype clusters.</p></div><div><h3>Methods</h3><p>We recruited nonelderly (&lt;65 years old) (n = 726) and elderly adults (≥65 years old) (n = 201) with mild-to-severe asthma. We conducted a factor analysis to select 17 variables. A two-step cluster analysis was used to classify subjects with asthma phenotypes, and a discriminant analysis was used to verify the classification of cluster results.</p></div><div><h3>Results</h3><p>There were three clusters with different characteristics identified in both the nonelderly and elderly asthmatic adults. In the nonelderly patient group, cluster 2 (obese, neutrophilic phenotypes) had a 1.85-fold significantly increased risk of asthma exacerbations. Cluster 3 (early-onset, atopy, and smoker with an eosinophil-predominant pattern) had a 2.37-fold risk of asthma exacerbations and higher oral corticosteroid (OCS) use than cluster 1 (late-onset and LMW exposure with paucigranulocytic blood pattern). Among elderly patients, cluster 2 had poor lung function and more ex-smokers. Cluster 3 (early-onset, long asthma duration) had the lowest paucigranulocytic blood pattern percentages in the elderly group.</p></div><div><h3>Conclusions</h3><p>The novelty of the clusters was found in age-dependent clusters. We identified three distinct phenotypes with heterogeneous characteristics, asthma exacerbations and medicine use in nonelderly and elderly asthmatic patients, respectively. Classification of age-stratified asthma phenotypes may lead to precise identification of patients, which provides personalized disease management.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 2","pages":"Pages 214-223"},"PeriodicalIF":6.8,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893024000017/pdfft?md5=398fe5a8aa343aacaee3ce4bfcaff518&pid=1-s2.0-S1323893024000017-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139586082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}