Allergology International最新文献

{"title":"Mouse hygiene status–A tale of two environments for mast cells and allergy","authors":"Yu-Wen Yeh,&nbsp;Zou Xiang","doi":"10.1016/j.alit.2023.08.008","DOIUrl":"10.1016/j.alit.2023.08.008","url":null,"abstract":"<div><p>Animal models, including those employing the use of house mice (<em>Mus musculus</em>), are crucial in elucidating mechanisms in human pathophysiology. However, it is evident that the impreciseness of using laboratory mice maintained in super-hygienic barrier facilities to mirror relevant aspects of human physiology and pathology exists, which is a major limitation in translating mouse findings to inferring human medicine. Interestingly, free-living wild mice are found to be substantially different from laboratory-bred, specific pathogen-free mice with respect to various immune system compartments. Wild mice have an immune system that better reflects human immunity. In this review article, we discuss recent experimental findings that address the so-called “wild immunology”, which reveals the contrasting immune features between laboratory-raised mice and their wild companions as well as laboratory mice that have been exposed to a natural rodent habitat. A particular focus will be given to the development of pulmonary mast cells and its possible impact on the use of “naturalized” or “rewilded” laboratory mice as experimental asthma models.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 58-64"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023000849/pdfft?md5=df01058dc93c5f2d7aa1730b9eadf6cd&pid=1-s2.0-S1323893023000849-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10161253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrin and fibrinogen degradation products/D-dimer ratio can be a useful marker for differentiating an acute attack of hereditary angioedema from thrombotic conditions","authors":"Daisuke Honda ,&nbsp;Isao Ohsawa ,&nbsp;Toshiyuki Miyata ,&nbsp;Masayuki Ozaki ,&nbsp;Masashi Aizawa ,&nbsp;Yasuhiko Tomino ,&nbsp;Katsuhiko Asanuma","doi":"10.1016/j.alit.2023.08.001","DOIUrl":"10.1016/j.alit.2023.08.001","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 174-176"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023000771/pdfft?md5=1e3e2f40301a31d7176c047606265349&pid=1-s2.0-S1323893023000771-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10018585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction in ANCA levels associated with mepolizumab add-on treatment in eosinophilic granulomatosis with polyangiitis: Case series and literature review","authors":"Yosuke Kamide ,&nbsp;Kentaro Watai ,&nbsp;Yuto Nakamura ,&nbsp;Maki Iwata ,&nbsp;Yuma Fukutomi ,&nbsp;Masami Taniguchi ,&nbsp;Kiyoshi Sekiya","doi":"10.1016/j.alit.2023.09.001","DOIUrl":"10.1016/j.alit.2023.09.001","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 180-183"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023000850/pdfft?md5=3846c439f11adc35a58f00afee32228f&pid=1-s2.0-S1323893023000850-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49683942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sub-pollen in platelet products: A potential cause of allergic transfusion reactions","authors":"Ryu Yanagisawa ,&nbsp;Manjiro Yamanaka ,&nbsp;Fumihiro Kawakami ,&nbsp;Hideyuki Nakazawa","doi":"10.1016/j.alit.2023.09.006","DOIUrl":"10.1016/j.alit.2023.09.006","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 184-186"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023001041/pdfft?md5=d91d1f7f166f13efb2122110816b2f81&pid=1-s2.0-S1323893023001041-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41144435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growing Up in Singapore with allergies – Lessons learnt from the GUSTO & S-PRESTO cohorts","authors":"Noor H.A. Suaini ,&nbsp;Hugo Van Bever ,&nbsp;Elizabeth Huiwen Tham","doi":"10.1016/j.alit.2023.09.003","DOIUrl":"10.1016/j.alit.2023.09.003","url":null,"abstract":"<div><p>Healthcare systems across the world face major challenges due to allergic diseases, known to affect people of all ages. In Singapore, two prominent cohort studies, Growing Up in Singapore Towards healthy Outcomes (GUSTO) and the Singapore PREconception Study of long-Term maternal and child Outcomes (S-PRESTO), have made notable advancements to our knowledge and understanding of allergic diseases. These cohorts, which comprised of healthy mother-infant dyads recruited from the healthy Singapore population, have shed light on the complex connections between factors influencing health in early life, preconception and pregnancy, on the pathogenesis of allergic disorders in offspring.</p><p>GUSTO highlighted significant risk factors in antenatal and early life, such as maternal diet, health and lifestyle choices, as well as infant environmental influences, that contributed to the risk of allergic diseases in the Asian Singaporean population. It also identified differential patterns of allergic disease in comparison to other populations, particularly the role of the microbiome in predicting atopic outcomes. Meanwhile, S-PRESTO further explores the long-term maternal and child outcomes associated with preconception health. Findings seem to suggest that prevention of offspring allergic conditions can be achieved through optimizing maternal health and lifestyle choices before conception.</p><p>Both studies underscore the significance of early life interventions, preconception health, and personalized approaches to effectively manage and prevent allergies. By leveraging the insights and promising findings from GUSTO and S-PRESTO, future work can drive development of preventative strategies and personalized interventions to reduce burden of allergic diseases in the Singapore population.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 13-19"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023000874/pdfft?md5=82dcd34cfe290a78a87c4d453aae9283&pid=1-s2.0-S1323893023000874-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophil extracellular trap formation in the giant papillae of atopic keratoconjunctivitis and vernal keratoconjunctivitis","authors":"Miki Onoue ,&nbsp;Akiko Saga ,&nbsp;Keisuke Adachi ,&nbsp;Yosuke Asada ,&nbsp;Toshiaki Hirakata ,&nbsp;Satoshi Iwamoto ,&nbsp;Shigeharu Ueki ,&nbsp;Nobuyuki Ebihara ,&nbsp;Akira Matsuda","doi":"10.1016/j.alit.2023.10.002","DOIUrl":"10.1016/j.alit.2023.10.002","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 177-179"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023001065/pdfft?md5=29fe718ff7f1d9ec02c03f5d940f651f&pid=1-s2.0-S1323893023001065-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49693302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exacerbation rates in Japanese patients with obstructive lung disease: A subanalysis of the prospective, observational NOVELTY study","authors":"Tomotaka Kawayama ,&nbsp;Kenichi Takahashi ,&nbsp;Toshikazu Ikeda ,&nbsp;Kenya Fukui ,&nbsp;Naoyuki Makita ,&nbsp;Naoki Tashiro ,&nbsp;Junpei Saito ,&nbsp;Toshihiro Shirai ,&nbsp;Hiromasa Inoue","doi":"10.1016/j.alit.2023.08.003","DOIUrl":"10.1016/j.alit.2023.08.003","url":null,"abstract":"<div><h3>Background</h3><p>Although clinical trials including asthma and COPD patients have revealed much about exacerbation frequencies, most studies are limited in that they recruited patients only with a clear diagnosis of one disease or the other, based on conventional diagnostic criteria, which may exclude many real-world patients with mixed symptoms.</p></div><div><h3>Methods</h3><p>NOVELTY is a global prospective observational study of patients with asthma and/or COPD from real-world practice. In this subanalysis, we compared patient characteristics of obstructive pulmonary diseases between the Japanese population (n = 820) and the overall population excluding Japanese patients (n = 10,406).</p></div><div><h3>Results</h3><p>The Japanese population had fewer exacerbations than the overall population across most of the physician-assessed disease severities and all diagnoses. The difference in exacerbation frequencies was more prominent in patients with COPD and asthma + COPD. The Japanese population was older, had higher former smoking rates, lower BMI, fewer respiratory symptoms, and better health-related quality of life compared with the overall population across all diagnoses.</p></div><div><h3>Conclusions</h3><p>We clarified differences in patient characteristics among patients with asthma and/or COPD in Japan compared with non-Japanese patients. Importantly, we found that Japanese patients with asthma and/or COPD had significantly fewer exacerbations compared with patients overall. The results from our study may contribute to the development of precision medicine and guidelines specific to Japan.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 71-80"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023000795/pdfft?md5=be10da29b2ced0ae540b40dff2426a29&pid=1-s2.0-S1323893023000795-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10500248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pretreatment circulating MAIT cells, neutrophils, and periostin predicted the real-world response after 1-year mepolizumab treatment in asthmatics","authors":"Hitoshi Sasano ,&nbsp;Norihiro Harada ,&nbsp;Sonoko Harada ,&nbsp;Tomohito Takeshige ,&nbsp;Yuuki Sandhu ,&nbsp;Yuki Tanabe ,&nbsp;Ayako Ishimori ,&nbsp;Kei Matsuno ,&nbsp;Tetsutaro Nagaoka ,&nbsp;Jun Ito ,&nbsp;Asako Chiba ,&nbsp;Hisaya Akiba ,&nbsp;Ryo Atsuta ,&nbsp;Kenji Izuhara ,&nbsp;Sachiko Miyake ,&nbsp;Kazuhisa Takahashi","doi":"10.1016/j.alit.2023.06.001","DOIUrl":"10.1016/j.alit.2023.06.001","url":null,"abstract":"<div><h3>Background</h3><p>Mepolizumab treatment improves symptom control and quality of life and reduces exacerbations in patients with severe eosinophilic asthma. However, biomarkers that predict therapeutic effectiveness must be determined for use in precision medicine. Herein, we elucidated the dynamics of various parameters before and after treatment as well as patient characteristics predictive of clinical responsiveness to mepolizumab after 1-year treatment.</p></div><div><h3>Methods</h3><p>Twenty-seven patients with severe asthma were treated with mepolizumab for one year. Asthma control test scores, pulmonary function tests, fractional exhaled nitric oxide levels, and blood samples were evaluated. Additionally, we explored the role of CD69-positive mucosal-associated invariant T (MAIT) cells as a candidate biomarker for predicting treatment effectiveness by evaluating an OVA-induced asthma murine model using MR1 knockout mice, where MAIT cells were absent.</p></div><div><h3>Results</h3><p>The frequencies of CD69-positive group 1 innate lymphoid cells, group 3 innate lymphoid cells, natural killer cells, and MAIT cells decreased after mepolizumab treatment. The frequency of CD69-positive MAIT cells and neutrophils was lower and serum periostin levels were higher in responders than in non-responders. In the OVA-induced asthma murine model, CD69-positive MAIT cell count in the whole mouse lung was significantly higher than that in the control mice. Moreover, OVA-induced eosinophilic airway inflammation was exacerbated in the MAIT cell-deficient MR1 knockout mice.</p></div><div><h3>Conclusions</h3><p>This study shows that circulating CD69-positive MAIT cells, neutrophils, and serum periostin might predict the real-world response after 1-year mepolizumab treatment. Furthermore, MAIT cells potentially have a protective role against type 2 airway inflammation.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 94-106"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023000503/pdfft?md5=27f97540f020f3cfefd9482bf6d7bdcc&pid=1-s2.0-S1323893023000503-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9663455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CYP27A1-27-hydroxycholesterol axis in the respiratory system contributes to house dust mite-induced allergic airway inflammation","authors":"Tatsunori Ito ,&nbsp;Tomohiro Ichikawa ,&nbsp;Mitsuhiro Yamada,&nbsp;Yuichiro Hashimoto,&nbsp;Naoya Fujino,&nbsp;Tadahisa Numakura,&nbsp;Yusaku Sasaki,&nbsp;Ayumi Suzuki,&nbsp;Katsuya Takita,&nbsp;Hirohito Sano,&nbsp;Yorihiko Kyogoku,&nbsp;Takuya Saito,&nbsp;Akira Koarai,&nbsp;Tsutomu Tamada,&nbsp;Hisatoshi Sugiura","doi":"10.1016/j.alit.2023.08.005","DOIUrl":"10.1016/j.alit.2023.08.005","url":null,"abstract":"<div><h3>Background</h3><p>27-Hydroxycholesterol (27-HC) derived from sterol 27-hydroxylase (CYP27A1) has pro-inflammatory biological activity and is associated with oxidative stress and chronic inflammation in COPD. However, the role of regulation of CYP27A1- 27-HC axis in asthma is unclear. This study aimed to elucidate the contribution of the axis to the pathophysiology of asthma.</p></div><div><h3>Methods</h3><p>House dust mite (HDM) extract was intranasally administered to C57BL/6 mice and the expression of CYP27A1 in the airways was analyzed by immunostaining. The effect of pre-treatment with PBS or CYP27A1 inhibitors on the cell fraction in the bronchoalveolar lavage fluid (BALF) was analyzed in the murine model. In vitro, BEAS-2B cells were treated with HDM and the levels of CYP27A1 expression were examined. Furthermore, the effect of 27-HC on the expressions of E-cadherin and ZO-1 in the cells was analyzed. The amounts of RANTES and eotaxin from the 27-HC-treated cells were analyzed by ELISA.</p></div><div><h3>Results</h3><p>The administration of HDM increased the expression of CYP27A1 in the airways of mice as well as the number of eosinophils in the BALF. CYP27A1 inhibitors ameliorated the HDM-induced increase in the number of eosinophils in the BALF. Treatment with HDM increased the expression of CYP27A1 in BEAS-2B cells. The administration of 27-HC to BEAS-2B cells suppressed the expression of E-cadherin and ZO-1, and augmented the production of RANTES and eotaxin.</p></div><div><h3>Conclusions</h3><p>The results of this study suggest that aeroallergen could enhance the induction of CYP27A1, leading to allergic airway inflammation and disruption of the airway epithelial tight junction through 27-HC production.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 151-163"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023000813/pdfft?md5=ee80527c3459bce46463add890d50d27&pid=1-s2.0-S1323893023000813-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10041930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of elevated plasma fatty acids as relevant factors for adult-onset asthma: The Nagahama Study","authors":"Noriyuki Tashima ,&nbsp;Hisako Matsumoto ,&nbsp;Kenta Nishi ,&nbsp;Satoru Terada ,&nbsp;Mariko Kogo ,&nbsp;Natsuko Nomura ,&nbsp;Chie Morimoto ,&nbsp;Hironobu Sunadome ,&nbsp;Tadao Nagasaki ,&nbsp;Tsuyoshi Oguma ,&nbsp;Yoshinari Nakatsuka ,&nbsp;Kimihiko Murase ,&nbsp;Takahisa Kawaguchi ,&nbsp;Yasuharu Tabara ,&nbsp;Kazuo Chin ,&nbsp;Kazuhiro Sonomura ,&nbsp;Fumihiko Matsuda ,&nbsp;Toyohiro Hirai","doi":"10.1016/j.alit.2023.04.005","DOIUrl":"10.1016/j.alit.2023.04.005","url":null,"abstract":"<div><h3>Background</h3><p>Obesity and increased body mass index (BMI) are the known risk factors for adult-onset asthma. Serum free fatty acid (FFA) and other blood lipid levels are generally elevated in patients with obesity and may be involved in the onset of asthma. However, it remains largely unknown. This study aimed to elucidate the relationship between plasma fatty acids and new-onset asthma.</p></div><div><h3>Methods</h3><p>This community-based Nagahama Study in Japan enrolled 9804 residents. We conducted self-reporting questionnaires, lung function tests, and blood tests at baseline and 5 years later as follow-up. At the follow-up, plasma fatty acids were measured using gas chromatography-mass spectrometry. Body composition analysis was also measured at the follow-up. The associations between fatty acids and new-onset asthma were evaluated using a multifaceted approach, including targeted partial least squares discriminant analysis (PLS-DA).</p></div><div><h3>Results</h3><p>In PLS-DA for new-onset asthma, palmitoleic acid was identified as the fatty acid most associated with asthma onset. In the multivariable analysis, higher levels of FFA, palmitoleic acid, or oleic acid were significantly associated with new-onset asthma, independent of other confounding factors. The high body fat percentage itself was not the relevant factor, but showed a positive interaction with plasma palmitoleic acid for new-onset asthma. When stratified by gender, the impacts of higher levels of FFA or palmitoleic acid on new-onset asthma remained significant in females, but not in males.</p></div><div><h3>Conclusions</h3><p>Elevated levels of plasma fatty acids, particularly palmitoleic acid, may be a relevant factor for new-onset asthma.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 65-70"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023000448/pdfft?md5=00213bd9df23e55eef72b178935b8503&pid=1-s2.0-S1323893023000448-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9534025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}