Allergology International最新文献

{"title":"Effects of raw seafood on the risk of hypersensitivity reaction recurrence in patients with an Anisakis allergy: A retrospective observational study in Japan","authors":"Yuto Hamada , Eiji Nakatani , Kentaro Watai , Maki Iwata , Yuto Nakamura , Kai Ryu , Yosuke Kamide , Kiyoshi Sekiya , Yuma Fukutomi","doi":"10.1016/j.alit.2023.08.002","DOIUrl":"10.1016/j.alit.2023.08.002","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 171-173"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023000783/pdfft?md5=9bcfc47dba09f9440ade369fe5523246&pid=1-s2.0-S1323893023000783-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10115413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of MAIT cells to modulate asthma","authors":"Yasuo Shimizu ,&nbsp;Chie Sugimoto ,&nbsp;Hiroshi Wakao","doi":"10.1016/j.alit.2023.07.006","DOIUrl":"10.1016/j.alit.2023.07.006","url":null,"abstract":"<div><p>Despite recent advances in asthma treatments, the search for novel therapies remains necessary because there are still patients with recurrent asthma exacerbations and poor responses to the existing treatments. Since group 2 innate lymphoid cells (ILC2) play a pivotal role in asthma by triggering and exacerbating type 2 inflammation, controlling ILC2s function is key to combating severe asthma. Mucosal-associated invariant T (MAIT) cells are innate-like T cells abundant in humans and are activated both in a T cell receptor-dependent and -independent manner. MAIT cells are composed of MAIT1 and MAIT17 based on the expression of transcription factors T-bet and RORγt, respectively. MAIT cells play pivotal roles in host defense against pathogens and in tissue repair and are essential for the maintenance of immunity and hemostasis. Our recent studies revealed that MAIT cells inhibit both ILC2 proliferation and functions in a mouse model of airway inflammation. MAIT cells may alleviate airway inflammation in two ways, by promoting airway epithelial cell barrier repair and by repressing ILC2s. Therefore, reagents that promote MAIT cell-mediated suppression of ILC2 proliferation and function, or designer MAIT cells (genetically engineered to suppress ILC2s or promote repair of airway damage), may be effective therapeutic agents for severe asthma.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 40-47"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S132389302300076X/pdfft?md5=044b3d2f0cd81953456703437fe17f73&pid=1-s2.0-S132389302300076X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9977188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of subcutaneous allergen immunotherapy on non-targeted allergen-induced immune responses","authors":"Kazuyuki Nakagome ,&nbsp;Tomoyuki Soma ,&nbsp;Takahiro Uchida ,&nbsp;Ryu Sekiya ,&nbsp;Takehito Kobayashi ,&nbsp;Kazuki Katayama ,&nbsp;Hidetoshi Iemura ,&nbsp;Erika Naito ,&nbsp;Yuki Hoshino ,&nbsp;Sachiko Miyauchi ,&nbsp;Yoshitaka Uchida ,&nbsp;Yuki Shiko ,&nbsp;Makoto Nagata","doi":"10.1016/j.alit.2023.07.001","DOIUrl":"10.1016/j.alit.2023.07.001","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 164-167"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023000710/pdfft?md5=f1ca40e0279912d4d4a48923a6e80efe&pid=1-s2.0-S1323893023000710-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10222164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of semaphorins in allergic diseases","authors":"Maiko Naito ,&nbsp;Atsushi Kumanogoh","doi":"10.1016/j.alit.2023.08.006","DOIUrl":"10.1016/j.alit.2023.08.006","url":null,"abstract":"<div><p>Semaphorins were originally identified as guidance molecules in neural development. However, accumulating evidence indicates that ‘immune semaphorins’ are critically involved in regulating immune cell activation, differentiation, mobility and migration. Semaphorins are also intimately associated with the pathogenesis of allergic diseases including asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, and eosinophilic chronic rhinosinusitis. Interestingly, reflecting their function in positive or negative regulation of immune cells, levels of some semaphorins are increased while others are decreased in patients with allergic diseases. This review presents the pathogenic functions of immune semaphorins in allergic inflammation and discusses the potential use of these molecules as therapeutic targets for allergic diseases.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 31-39"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023000825/pdfft?md5=b4b553f1564a6763d689360410cef444&pid=1-s2.0-S1323893023000825-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10139235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of obesity in asthma: Possible future therapies","authors":"Hiroki Tashiro,&nbsp;Yuki Kurihara,&nbsp;Yuki Kuwahara,&nbsp;Koichiro Takahashi","doi":"10.1016/j.alit.2023.08.007","DOIUrl":"10.1016/j.alit.2023.08.007","url":null,"abstract":"<div><p>Obesity is one of the factors associated with the severity of asthma. Obesity is associated with aggravation of the pathophysiology of asthma, including exacerbations, airway inflammation, decreased pulmonary function, and airway hyperresponsiveness. The present review addresses the characteristics of asthma with obesity, focusing especially on the heterogeneity caused by the degree of type 2 inflammation, sex differences, the onset of asthma, and race differences. To understand the severity mechanisms in asthma and obesity, such as corticosteroid resistance, fatty acids, gut microbiome, and cytokines, several basic research studies are evaluated. Finally, possible future therapies, including weight reduction, microbiome-targeted therapies, and other molecular targeted therapies are addressed. We believe that the present review will contribute to better understanding of the severity mechanisms and the establishment of novel treatments for severe asthma patients with obesity.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 48-57"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023000837/pdfft?md5=1991b883c5554acf3dc890d793552e26&pid=1-s2.0-S1323893023000837-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10140016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for allergy documentation in electronic health record: A retrospective study in a tertiary health center in Switzerland","authors":"Maxime Ringwald ,&nbsp;Laura Moi ,&nbsp;Alexandre Wetzel ,&nbsp;Denis Comte ,&nbsp;Yannick D. Muller ,&nbsp;Camillo Ribi","doi":"10.1016/j.alit.2023.06.006","DOIUrl":"10.1016/j.alit.2023.06.006","url":null,"abstract":"<div><h3>Background</h3><p>Most hospitals use electronic health records (EHR) to warn health care professionals of drug hypersensitivity (DH) and other allergies. Indiscriminate recording of patient self-reported allergies may bloat the alert system, leading to unjustified avoidances and increases in health costs. The aim of our study was to analyze hypersensitivities documented in EHR of patients at Lausanne University Hospital (CHUV).</p></div><div><h3>Methods</h3><p>We conducted a retrospective study on patients admitted at least 24 h to CHUV between 2011 and 2021. After ethical clearance, we obtained anonymized data. Because culprit allergen could be either manually recorded or selected through a list, data was harmonized using a reference allergy database before undergoing statistical analysis.</p></div><div><h3>Results</h3><p>Of 192,444 patients, 16% had at least one allergy referenced. DH constituted 60% of all allergy alerts, mainly beta-lactam antibiotics (BLA) (30%), NSAID (11%) and iodinated contrast media (ICM) (7%). Median age at first hospitalization and hospitalization length were higher in the allergy group. Female to male ratio was 2:1 in the allergic group. Reactions were limited to the skin in half of patients, and consistent with anaphylaxis in 6%. In those deemed allergic to BLA, culprit drug was specified in 19%, ‘allergy to penicillin’ otherwise. It was impossible to distinguish DH based on history alone or resulting from specialized work-up.</p></div><div><h3>Conclusions</h3><p>Older age, longer hospital stays, and female sex increase the odds of in-patient allergy documentation. Regarding DH, BLA were referenced in 4% of inpatient records. Specific delabeling programs should be implemented to increase data reliability and patient safety.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 143-150"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023000709/pdfft?md5=f16df0b56c54b7e116a4c2163338f878&pid=1-s2.0-S1323893023000709-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10157032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overviewing allergy epidemiology in Japan - Findings from birth cohorts (JECS and T-Child study)","authors":"Kiwako Yamamoto-Hanada ,&nbsp;Yukihiro Ohya","doi":"10.1016/j.alit.2023.11.005","DOIUrl":"10.1016/j.alit.2023.11.005","url":null,"abstract":"<div><p>The escalating global allergy epidemic has emerged as a pressing and persistent challenge, exerting a profound impact on human health systems across centuries. This burgeoning predicament can be attributed to contemporary lifestyles, environmental influences, and genetic predispositions. The manifestation of allergy-related factors exhibits dynamic fluctuations contingent on temporal shifts, geographical distinctions, cultural variances, and diverse demographic strata. In this review, we present recent epidemiological insights derived from two distinct birth cohorts: the Japan Environment and Children's Study (JECS), encompassing the entirety of Japan, and the Tokyo Children's Health, Illness, and Development Study (T-Child Study) within Tokyo. Through this comprehensive review, we offer a comprehensive overview of the latest epidemiological discoveries stemming from these pivotal Japanese birth cohorts, thereby affording a unique opportunity to deliberate on imperative strategies for the optimal management of the allergy epidemic.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 20-30"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S132389302300117X/pdfft?md5=a23fb9eebf67cb2ea65b96b8c2ea5971&pid=1-s2.0-S132389302300117X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138478937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipocalin-2 promotes neutrophilic inflammation in nasal polyps and its value as biomarker","authors":"Chen Zhang ,&nbsp;Huan Wang ,&nbsp;Li Hu ,&nbsp;Qianqian Zhang ,&nbsp;Jiani Chen ,&nbsp;Le Shi ,&nbsp;Xiaole Song ,&nbsp;Juan Liu ,&nbsp;Kai Xue ,&nbsp;Jingjing Wang ,&nbsp;Dehui Wang ,&nbsp;Xicai Sun","doi":"10.1016/j.alit.2023.07.004","DOIUrl":"10.1016/j.alit.2023.07.004","url":null,"abstract":"<div><h3>Background</h3><p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common chronic inflammatory disease of the nasal cavity and paranasal sinuses. The role of neutrophils in the pathogenesis of CRSwNP has attracted more attention in recent years, due to its association with more severe disease and reduced steroid responsiveness. Lipocalin-2 (LCN2) has been found to modulate neutrophils infiltration in other neutrophilic inflammation including inflammatory bowel disease, rheumatoid arthritis, and psoriasis. The aim was to evaluate the expression and regulator role of LCN2 in neutrophilic inflammation in CRSwNP, and its role as a potential biomarker predicting non-eosinophilic CRSwNP (neCRSwNP).</p></div><div><h3>Methods</h3><p>Bioinformatic analysis, immunostainings, real-time PCR and ELISA were used to analyze the expression and location of LCN2 in nasal tissues. The expression of proinflammatory mediators were assessed in nasal tissues and secretions. LCN2 production in human nasal epithelial cells (HNECs) and neutrophils, as well as its role in neutrophilic inflammation was evaluated by in vitro experiments.</p></div><div><h3>Results</h3><p>LCN2 was mainly located in neutrophils and HNECs of nasal polyps. LCN2 expression was also significantly higher in the polyp tissue and nasal secretions from patients with neCRSwNP. The LCN2 levels were positively correlated with type 3 inflammation markers, including G-CSF, IL-8, and IL-17. LCN2 expression could be upregulated by IL-17 A and TNF-α in HNECs, and LCN2 could also promote the expression of IL-8 in dispersed polyp cells and HNECs.</p></div><div><h3>Conclusions</h3><p>LCN2 could serve as a novel biomarker predicting patients with neCRSwNP, and the increased expression of LCN2 may participate in the pathogenesis of neCRSwNP.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 115-125"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023000746/pdfft?md5=9665fcc2b90c78aabfdbd37d6ad976e2&pid=1-s2.0-S1323893023000746-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9970718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mouse hygiene status–A tale of two environments for mast cells and allergy","authors":"Yu-Wen Yeh,&nbsp;Zou Xiang","doi":"10.1016/j.alit.2023.08.008","DOIUrl":"10.1016/j.alit.2023.08.008","url":null,"abstract":"<div><p>Animal models, including those employing the use of house mice (<em>Mus musculus</em>), are crucial in elucidating mechanisms in human pathophysiology. However, it is evident that the impreciseness of using laboratory mice maintained in super-hygienic barrier facilities to mirror relevant aspects of human physiology and pathology exists, which is a major limitation in translating mouse findings to inferring human medicine. Interestingly, free-living wild mice are found to be substantially different from laboratory-bred, specific pathogen-free mice with respect to various immune system compartments. Wild mice have an immune system that better reflects human immunity. In this review article, we discuss recent experimental findings that address the so-called “wild immunology”, which reveals the contrasting immune features between laboratory-raised mice and their wild companions as well as laboratory mice that have been exposed to a natural rodent habitat. A particular focus will be given to the development of pulmonary mast cells and its possible impact on the use of “naturalized” or “rewilded” laboratory mice as experimental asthma models.</p></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 58-64"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023000849/pdfft?md5=df01058dc93c5f2d7aa1730b9eadf6cd&pid=1-s2.0-S1323893023000849-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10161253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrin and fibrinogen degradation products/D-dimer ratio can be a useful marker for differentiating an acute attack of hereditary angioedema from thrombotic conditions","authors":"Daisuke Honda ,&nbsp;Isao Ohsawa ,&nbsp;Toshiyuki Miyata ,&nbsp;Masayuki Ozaki ,&nbsp;Masashi Aizawa ,&nbsp;Yasuhiko Tomino ,&nbsp;Katsuhiko Asanuma","doi":"10.1016/j.alit.2023.08.001","DOIUrl":"10.1016/j.alit.2023.08.001","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"73 1","pages":"Pages 174-176"},"PeriodicalIF":6.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1323893023000771/pdfft?md5=1e3e2f40301a31d7176c047606265349&pid=1-s2.0-S1323893023000771-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10018585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}