Allergology International最新文献

{"title":"Addictive behavior is not a comorbidity of chronic spontaneous urticaria","authors":"Sophia Neisinger , Lea Kiefer , Pascale Salameh , Hanna Bonnekoh , Thomas Buttgereit , Annika Gutsche , Leonie Herzog , Melba Munoz , Anne Pankow , Marcus Maurer , Frank Siebenhaar","doi":"10.1016/j.alit.2024.09.005","DOIUrl":"10.1016/j.alit.2024.09.005","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 2","pages":"Pages 325-326"},"PeriodicalIF":6.2,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing the solubility of the major birch pollen allergen Bet v 1 by particle-loading mitigates Th2 responses","authors":"Amin Kraiem ,&nbsp;Erica Pelamatti ,&nbsp;Sophie Grosse-Kathoefer ,&nbsp;Hilal Demir ,&nbsp;Ute Vollmann ,&nbsp;Caroline Ehgartner ,&nbsp;Maria Stigler ,&nbsp;Benjamin Punz ,&nbsp;Litty Johnson ,&nbsp;Nicola Hüsing ,&nbsp;Barbara Bohle ,&nbsp;Lorenz Aglas","doi":"10.1016/j.alit.2024.07.007","DOIUrl":"10.1016/j.alit.2024.07.007","url":null,"abstract":"<div><h3>Background</h3><div>Solubility is a common feature of allergens. However, the causative relationship between this protein-intrinsic feature and sensitization capacity of allergens is not fully understood. This study aimed to proof the concept of solubility as a protein intrinsic feature of allergens.</div></div><div><h3>Methods</h3><div>The soluble birch pollen allergen Bet v 1 was covalently coupled to 1 μm silica particles. IgE-binding and -cross-linking capacity was assessed by inhibition ELISA and mediator release assay, respectively. Alterations in adjuvanticity by particle-loading were investigated by activation of dendritic cells, mast cells and the Toll-like receptor 4 pathway as well as by Th2 polarization in an IL-4 reporter mouse model. In BALB/c mice, particle-loaded and soluble Bet v 1 were compared in a model of allergic sensitization. Antigen uptake and presentation was analysed by restimulating human Bet v 1-specific T cell lines.</div></div><div><h3>Results</h3><div>Covalent coupling of Bet v 1 to silica particles resulted in an insoluble antigen with retained IgE-binding and -cross-linking capacity and no increase in adjuvanticity. <em>In vivo</em>, particle-loaded Bet v 1 induced significantly lower Bet v 1-specific (s)IgE, whereas sIgG1 and sIgG2a levels remained unaffected. The ratio of Th2 to Th1 cells was significantly lower in mice sensitized with particle-loaded Bet v 1. Particle-loading of Bet v 1 resulted in a 24-fold higher T cell activation capacity in Bet v 1-specific T cell lines, indicating more efficient uptake and presentation than of soluble Bet v 1.</div></div><div><h3>Conclusions</h3><div>Our results show that solubility is a decisive factor contributing to the sensitization capacity of allergens. The reduction in sensitization capacity of insoluble, particle-loaded antigens results from enhanced antigen uptake and presentation compared to soluble allergens.</div></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 1","pages":"Pages 126-135"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspiration of acidified milk induces milk allergy by activating alveolar macrophages in mice","authors":"Akiko Nakaoka ,&nbsp;Takayasu Nomura ,&nbsp;Atsushi Suzuki ,&nbsp;Kazuyoshi Ozeki ,&nbsp;Hirohito Kita ,&nbsp;Shinji Saitoh","doi":"10.1016/j.alit.2024.08.001","DOIUrl":"10.1016/j.alit.2024.08.001","url":null,"abstract":"<div><h3>Background</h3><div>Epidemiological studies have identified associations between gastroesophageal reflux (GER) and cow's milk allergy (CMA) in infants. However, the role of GER in the development of CMA remains poorly understood. Our primary objectives were to develop a mouse model that suggests GER as a potential pathogenic mechanism for CMA and to elucidate the immunological mechanisms that connect lung innate immunity with CMA.</div></div><div><h3>Methods</h3><div>Mice were exposed to cow's milk (CM) treated with hydrochloric acid through repeated aspiration into their airways. Subsequently, they were challenged by intraperitoneal injection of CM extract. The immunological mechanisms were investigated using comprehensive single-cell RNA sequencing (scRNA-seq) analysis of the lungs, combined with the use of genetically modified mice.</div></div><div><h3>Results</h3><div>Mice exposed to CM mixed with hydrochloric acid via airway sensitization developed CMA, as evidenced by the production of antigen-specific IgE and IgG antibodies, and the induction of anaphylaxis upon systemic antigen administration. In contrast, aspiration of CM alone did not induce CMA. scRNA-seq analysis revealed potential roles of alveolar macrophages in response to hydrochloric acid. Mice lacking the TLR4 pathway were protected from developing CMA.</div></div><div><h3>Conclusions</h3><div>We have developed a novel mouse model for CMA that utilizes the natural antigen and follows the physiological airway sensitization pathway, thus potentially resembling clinical scenarios. This model, named the acidified milk aspiration-induced allergy model, has the potential to shed light on the role of early innate immunity by analyzing a more physiological model.</div></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 1","pages":"Pages 97-104"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A message from the new Editor-in-Chief","authors":"Atsuhito Nakao (Editor-in-Chief, Allergology International)","doi":"10.1016/j.alit.2024.12.002","DOIUrl":"10.1016/j.alit.2024.12.002","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 1","pages":"Page 1"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspergillus fumigatus extract modulates human eosinophils via NOD2 and oxidative stress","authors":"Hisashi Sasaki ,&nbsp;Jun Miyata ,&nbsp;Yusuke Kawashima ,&nbsp;Ryo Konno ,&nbsp;Masaki Ishikawa ,&nbsp;Yoshinori Hasegawa ,&nbsp;Ryuta Onozato ,&nbsp;Yo Otsu ,&nbsp;Emiko Matsuyama ,&nbsp;Keeya Sunata ,&nbsp;Katsunori Masaki ,&nbsp;Hiroki Kabata ,&nbsp;Yoshifumi Kimizuka ,&nbsp;Tomoe Abe ,&nbsp;Shigeharu Ueki ,&nbsp;Koichiro Asano ,&nbsp;Akihiko Kawana ,&nbsp;Koichi Fukunaga","doi":"10.1016/j.alit.2024.08.009","DOIUrl":"10.1016/j.alit.2024.08.009","url":null,"abstract":"<div><h3>Background</h3><div><em>Aspergillus fumigatus</em> is a pathogenic fungus known to be associated with severe asthma and allergic bronchopulmonary mycosis. However, the precise mechanisms underlying airway inflammation remain unclear. In this study, we investigated the direct modulation of human eosinophils by <em>A. fumigatus</em> and identified the specific mechanism of airway inflammation.</div></div><div><h3>Methods</h3><div>Eosinophils isolated from healthy subjects were stimulated with extracts of <em>A. fumigatus</em>. Multi-omics analysis, comprising transcriptomic and proteomic analyses, was performed. The expression of specific factors was evaluated using quantitative real-time polymerase chain reaction and flow cytometry. Mechanistic analyses were performed using NOD2 inhibitor and N-acetyl-<span>l</span>-cysteine (NAC).</div></div><div><h3>Results</h3><div>The <em>A. fumigatus</em> extract changed the expression of adhesion molecules (CD62L and CD11b) and CD69 on the surface of eosinophils, without affecting their viability, via nucleotide-binding oligomerization domain-containing protein 2 (NOD2) but not protease activity. Investigation using kinase inhibitors showed that <em>A. fumigatus</em> extract-induced modulation was partly mediated via p38 mitogen-activated protein kinases. Multi-omics analysis revealed that <em>A. fumigatus</em>-induced gene and protein expression profiles were characterized by the upregulation of oxidative stress-related molecules, including heat shock proteins (HSP90AA1, HSP90AB1, SRXN1, and HMOX1). NOD2 inhibitor and NAC differentially inhibited <em>A. fumigatus</em>-induced inflammatory changes. Additional multi-omics analysis identified that NOD2 signaling induced gene signatures different from those of interleukin (IL)-5 and elicited synergistic change with IL-5.</div></div><div><h3>Conclusions</h3><div><em>A. fumigatus</em> modulates human eosinophils via NOD2 and oxidative stress-mediated signaling. NOD2 signaling potentiated IL-5-induced activation, suggesting its pathogenic role in type 2 inflammation. NOD2 inhibitors and antioxidants can have therapeutic potential against <em>A. fumigatus</em>-related allergic disorders.</div></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 1","pages":"Pages 156-165"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Follicular T cells and the control of IgE responses","authors":"Pablo F. Cañete ,&nbsp;Di Yu","doi":"10.1016/j.alit.2024.09.007","DOIUrl":"10.1016/j.alit.2024.09.007","url":null,"abstract":"<div><div>Atopy is considered the epidemic of the 21st century, and while decades of research have established a direct link between Th2 cells driving pathogenic IgE-mediated allergic disease, only in the past years have T follicular helper (Tfh) cells emerged as pivotal drivers of these responses. In this review, we will examine the molecular mechanisms governing the IgE response, with a particular emphasis on the key cytokines and signaling pathways. We will discuss the exclusion of IgE-producing B cells from germinal centers and explore the recently established role of follicular T cell function and heterogeneity in driving or curtailing these immune responses. Additionally, we will assess the current state of major monoclonal antibodies and allergen immunotherapies designed to counteract Th2-driven inflammation, as well as reflect on the need to investigate how these biologics impact Tfh cell activity, differentiation, and function, as these insights could pave the way for much-needed therapeutic innovation in the treatment of allergic diseases.</div></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 1","pages":"Pages 13-19"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro cross-reactivity between hen's egg and quail's egg in children with hen's egg allergy","authors":"Mari Takei,&nbsp;Masatoshi Mitomori,&nbsp;Akemi Saito,&nbsp;Kinji Tada,&nbsp;Noriyuki Yanagida,&nbsp;Sakura Sato,&nbsp;Motohiro Ebisawa","doi":"10.1016/j.alit.2024.07.006","DOIUrl":"10.1016/j.alit.2024.07.006","url":null,"abstract":"","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 1","pages":"Pages 166-168"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long term safety and efficacy of ligelizumab in the treatment of Japanese patients with chronic spontaneous urticaria","authors":"Hidetoshi Takahashi ,&nbsp;Atsushi Fukunaga ,&nbsp;Koremasa Hayama ,&nbsp;Takayoshi Sasajima ,&nbsp;Ayako Fujishige ,&nbsp;Ryohei Ichishita ,&nbsp;Naoko Tomimatsu ,&nbsp;Eva Hua ,&nbsp;Vineeth Varanasi ,&nbsp;Alis Burciu ,&nbsp;Michihiro Hide ,&nbsp;Thomas Severin","doi":"10.1016/j.alit.2024.09.002","DOIUrl":"10.1016/j.alit.2024.09.002","url":null,"abstract":"<div><h3>Background</h3><div>In Japan, urticaria is a common skin disorder with chronic spontaneous urticaria (CSU) being the most frequent subtype. This study evaluated the safety of ligelizumab (anti-IgE monoclonal antibody) in Japanese CSU patients.</div></div><div><h3>Methods</h3><div>This was a Phase 3 multicenter, open-label, single-arm 52-week study in adult Japanese patients with CSU inadequately controlled with locally approved doses of H1-antihistamines. The primary objective reported the safety of ligelizumab 120 mg subcutaneously every 4 weeks, by evaluation of treatment emergent adverse events (TEAE). Secondary objectives evaluated efficacy by absolute change from baseline (CFB) in weekly urticaria activity score (UAS7), and the proportion of patients with UAS7 = 0, and dermatology life quality index (DLQI) = 0–1 over time.</div></div><div><h3>Results</h3><div>From a total of 66 CSU patients (80.3% females; mean ± SD age 46.4 ± 13.2 years; mean ± SD baseline UAS7 28.7 ± 6.5) enrolled, 53 patients (80.3%) reported ≥1 TEAE during the study, with no severe or serious adverse events, no anaphylaxis events and low frequency of TEAEs leading to treatment discontinuations (6.1%). Absolute mean CFB of UAS7 showed a rapid onset of response at Week 4 (−14.2) with further improvement until end of treatment at Week 52 (−22.9). The proportion of patients achieving UAS7 = 0 improved over time (14.5% at Week 4; 50.0% at Week 52). A sizable proportion of patients achieved DLQI 0–1 with the first dose of ligelizumab (38.5%), and improvements observed throughout the study until Week 52 (68.8%).</div></div><div><h3>Conclusions</h3><div>Treatment with ligelizumab 120 mg was well-tolerated with mild to moderate adverse events and was efficacious in Japanese patients.</div></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 1","pages":"Pages 136-143"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-CT-derived lung volumes and mortality risk in patients with fibrotic hypersensitivity pneumonitis","authors":"Shusuke Yazawa ,&nbsp;Yuzo Suzuki ,&nbsp;Yuko Tanaka ,&nbsp;Koshi Yokomura ,&nbsp;Masato Kono ,&nbsp;Dai Hashimoto ,&nbsp;Atsuki Fukada ,&nbsp;Yusuke Inoue ,&nbsp;Hideki Yasui ,&nbsp;Hironao Hozumi ,&nbsp;Masato Karayama ,&nbsp;Kazuki Furuhashi ,&nbsp;Noriyuki Enomoto ,&nbsp;Tomoyuki Fujisawa ,&nbsp;Naoki Inui ,&nbsp;Takafumi Suda","doi":"10.1016/j.alit.2024.07.002","DOIUrl":"10.1016/j.alit.2024.07.002","url":null,"abstract":"<div><h3>Background</h3><div>Hypersensitivity pneumonitis (HP) is a complex and heterogenous interstitial lung disease (ILD) that occurs in susceptible individuals due to certain inhaled antigens. Fibrotic-HP is a major underlying disease of progressive pulmonary fibrosis. Therefore, in addition to the radiological features of HP, quantitatively measuring fibrosis is important to evaluate disease severity and progression. The present study aimed to compare three-dimensional computed tomography (3D-CT)-derived lung volumes (LVs) of patients with HP and determine its association with mortality risk.</div></div><div><h3>Methods</h3><div>In this retrospective and multicenter cohort study, 126 patients diagnosed with HP (fibrotic, n = 72 and non-fibrotic, n = 54) with a confidence level higher than moderate were enrolled. Each lobe LV was measured using 3D-CT at the time of diagnosis and standardized using predicted forced vital capacity. The 3D-CT LV was compared with those of 42 controls and 140 patients with idiopathic pulmonary fibrosis (IPF).</div></div><div><h3>Results</h3><div>Compared to patients with fibrotic-HP, the standardized total LV was significantly higher in controls and patients with non-fibrotic-HP and was similar in patients with IPF. Longitudinal analyses demonstrated that approximately half of the patients with fibrotic-HP had an annual decrease in total LV. Decreased total and lower-lobe LVs were associated with shorter survival, and were independently associated with mortality together with ongoing exposure to inciting antigens. A composite model consisting of ongoing exposure to inciting antigens and total or lower-lobe LV successfully classified mortality risk into three groups.</div></div><div><h3>Conclusions</h3><div>Quantitatively measuring standardized LV can help determine disease severity, progression, and mortality risk in patients with fibrotic-HP.</div></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 1","pages":"Pages 78-85"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive review of pollen-food allergy syndrome: Pathogenesis, epidemiology, and treatment approaches","authors":"Yukinori Kato,&nbsp;Taiyo Morikawa,&nbsp;Shigeharu Fujieda","doi":"10.1016/j.alit.2024.08.007","DOIUrl":"10.1016/j.alit.2024.08.007","url":null,"abstract":"<div><div>Pollen-food allergy syndrome (PFAS) is caused by cross-reaction of a specific pollen antigen with the corresponding food allergen in sensitized individuals. The manifestations are usually limited to oral symptoms; however, sometimes, rhinitis, respiratory and skin symptoms, and anaphylactic shock may occur. In PFAS pathogenesis, when food containing protein antigens (pan-allergens) with high homology to pollen antigens is ingested, mast cells bound to pollen antigen-specific IgE distributed in the oral mucosa cross-react with the food antigen, causing a local type I allergic reaction. The prevalence of PFAS depends on the geographic conditions, such as the type and amount of pollen in the area. PFAS is prevalent in all regions owing to the wide variety of pollen antigens implicated in the disease, such as alder and grass pollen, even outside of the birch habitat area. Basic research on PFAS is expected to significantly contribute to elucidating the pathogenesis and development of therapeutic strategies for PFAS. Currently, effective treatment for patients with PFAS that allows safe consumption of raw foods is lacking, and avoiding the intake of causative foods is the basis of prevention. Furthermore, allergen immunotherapy for PFAS has not yet been established, but various attempts are underway to develop it into a novel treatment strategy. This review highlights the current research landscape on the pathophysiology, epidemiology, and clinical aspects of PFAS. We outline the research gaps that should be addressed to improve the outcomes of patients with PFAS.</div></div>","PeriodicalId":48861,"journal":{"name":"Allergology International","volume":"74 1","pages":"Pages 42-50"},"PeriodicalIF":6.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}