Archivos Espanoles De Urologia最新文献

{"title":"Identification of SLC3A2 as a Potential Therapeutic Target of Ferroptosis in Bladder Cancer.","authors":"Qi Yang, Dewang Zhou, Aaron Beasley, Yujun Liu, Zeqin Yan, Hu Fang, Yuqing Li, Elin S Gray","doi":"10.56434/j.arch.esp.urol.20267901.5","DOIUrl":"10.56434/j.arch.esp.urol.20267901.5","url":null,"abstract":"<p><strong>Background: </strong>Bladder cancer (BC) represents the most prevalent malignancy within the urinary system. Mounting evidence underscores the critical involvement of ferroptosis in cancer pathogenesis; Consequently, this study delves into its molecular underpinnings and therapeutic potential specifically in BC.</p><p><strong>Methods: </strong>We analyzed gene expression profiles from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) repositories. Ferroptosis-related genes (FRGs) were selected from the FerrDb database. Utilizing systematic bioinformatics analyses, we identify differentially expressed and prognostic FRGs and construct an FRGs prognostic model. Combined with protein-protein interaction (PPI) analysis, solute carrier family 3 member 2 (<i>SLC3A2</i>) was selected for further study. Following targeted small interfering RNA (siRNA)-mediated knockdown of <i>SLC3A2</i> in BC cell lines, we conducted comprehensive functional assays to evaluate its effect on malignant phenotypes, ferroptosis, and cisplatin sensitivity.</p><p><strong>Results: </strong><i>SLC3A2</i> expression was significantly elevated in BC cells ( <i>p</i> < 0.001). Its knockdown inhibited the proliferation, migration, and invasion abilities and promoted erastin-induced ferroptosis, as evidenced by increased reactive oxygen species (ROS), lipid peroxidation, and iron accumulation (all <i>p</i> < 0.05). <i>SLC3A2</i> depletion also enhanced cisplatin sensitivity.</p><p><strong>Conclusions: </strong>Collectively, these findings establish <i>SLC3A2</i> as playing a vital oncogenic role in BC tumorigenesis and progression. Its function in inhibiting ferroptosis-especially during cisplatin-based chemotherapy-makes it a promising therapeutic target.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 1","pages":"36-48"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRUS-Clinical Nomogram: A Tool for Predicting Bone Metastasis in Prostate Cancer.","authors":"Yu Li, Wensheng Yue, Fang Yang, Xuebin Liu, Jiping Luo, Siyu Dan, Xiuli He, Ling He, Guihao Hu","doi":"10.56434/j.arch.esp.urol.20267901.15","DOIUrl":"10.56434/j.arch.esp.urol.20267901.15","url":null,"abstract":"<p><strong>Background: </strong>Bone metastasis (BM) is a common complication associated with advanced prostate cancer (PCa). The multiparametric features of transrectal ultrasound (TRUS) in PCa patients with BM remain poorly characterized. This study examined the presence of TRUS in patients with BM and developed a clinical nomogram for risk assessment.</p><p><strong>Methods: </strong>From December 2021 to September 2023, 114 consecutive patients with pathologically confirmed PCa were enrolled in this study. Based on the bone scan results, the patients were classified into BM (n = 56) and non-BM (n = 58) groups. Clinical, baseline TRUS, and transrectal contrast-enhanced ultrasound (TR-CEUS) data were recorded. Predictors of BM were identified using univariate and multivariate logistic regression. A nomogram was developed and internally validated via bootstrap resampling (1000 repetitions). The performance of the model was assessed using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA).</p><p><strong>Results: </strong>The results of the multivariate analysis revealed three independent predictors of BM, which included elevated total prostate-specific antigen (T-PSA) (odds ratio (OR) = 4.745, 95% CI: 2.177-10.344, <i>p</i> = 0.018), higher Gleason score (GS) (OR = 1.844, 95% CI: 1.144-2.970, <i>p</i> = 0.012), and TR-CEUS wash-in presence (OR = 3.268, 95% CI: 1.014-10.538, <i>p</i> = 0.047). The nomogram that incorporated these predictors showed strong discrimination, with an area under the curve (AUC) of 0.899 (95% CI: 0.841-0.96) in the development cohort and 0.859 (95% CI: 0.765-0.968) upon internal validation. Calibration was satisfactory, and the model offered significant net clinical benefits.</p><p><strong>Conclusions: </strong>We found that TR-CEUS wash-in is an independent predictor of BM in PCa patients. Based on the clinical parameters T-PSA, GS, and TR-CEUS, a nomogram might provide a clinical reference for accurately assessing BM.</p><p><strong>Clinical trial registration: </strong>This study was registered in the Chinese Clinical Trial Registry (http://www.chictr.org.cn) (Registration No. ChiCTR 2400082813).</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 1","pages":"125-133"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of the COVID-19 Pandemic on Urinary Stone Disease and Treatment Outcomes.","authors":"Mustafa Aydın, Mustafa Koray Kırdağ, Lokman İrkılata, Mesut Berkan Duran, Uğur Öztürk, Mehmet Özen, Mücahit Uğur, Mustafa Kemal Atilla","doi":"10.56434/j.arch.esp.urol.20267901.9","DOIUrl":"10.56434/j.arch.esp.urol.20267901.9","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the characteristics of patients with urinary stone disease before and during the pandemic and to assess the impact of the pandemic on diagnosis-to-treatment intervals and treatment outcomes.</p><p><strong>Materials and methods: </strong>Medical records, laboratory values and radiological images of patients who underwent ureterolithotripsy, retrograde intrarenal surgery and percutaneous nephrolithotomy for ureteral and renal stones before and during the pandemic were retrospectively analysed. Pregnant women and patients under the age of 18 were excluded from the study. The patients' demographic data, number of stones, stone size, stone location, hydronephrosis, impacted stones, creatinine levels, duration of surgery, stone-free rates, hospital stay, complication rates and diagnosis-to-treatment intervals before and during the pandemic were compared.</p><p><strong>Results: </strong>A total of 162 patients with ureteral stones and 129 patients with kidney stones were included in the study. During the pandemic, complication rates and diagnosis-to-treatment intervals were considerably higher in patients with kidney and ureteral stones. Furthermore, the presence of impacted stones for ureteral stones and the presence of hydronephrosis for kidney stones emerged as predictors of complications.</p><p><strong>Conclusions: </strong>During the pandemic, delays were observed in the diagnosis and treatment of patients with both renal and ureteral stones. This delay negatively affected the patients' clinical characteristics at presentation (hydronephrosis) and surgical outcomes (complication rates). Therefore, patients with urolithiasis should be prioritised in exceptional situations, such as pandemics.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 1","pages":"73-79"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Surgical and Serological Risk Factors for Postoperative Urinary Tract Infection Following the Ureteroscopic Treatment of Renal Calculi.","authors":"Xiaoshan Li, Wei Liu, Shiping Wei, Wei Peng","doi":"10.56434/j.arch.esp.urol.20267901.12","DOIUrl":"10.56434/j.arch.esp.urol.20267901.12","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the risk factors of urinary tract infection (UTI) after the ureteroscopic treatment of renal calculi and analyse the correlation amongst serum inflammatory markers, perioperative factors and infection occurrence.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on patients who underwent ureteroscopic lithotripsy and stone extraction at the authors' hospital. On the basis of postoperative diagnostic criteria, patients were categorised into the infection (n = 60) and noninfection (n = 150) groups. The serum levels of C-reactive protein (CRP), procalcitonin (PCT), lipopolysaccharide (LPS), endotoxin (ET) and interleukin-8 (IL-8) were measured preoperatively and postoperatively in both groups. In addition, the maximum stone diameter, operative time and postoperative catheterisation duration were recorded. The correlations amongst serum markers, perioperative factors and UTI were analysed, and univariate and multivariate logistic regression analyses were performed to identify independent risk factors.</p><p><strong>Results: </strong>No significant differences in baseline characteristics or preoperative serum markers were found between the two groups (<i>p</i> > 0.05). The postoperative serum levels of CRP, PCT, LPS, ET and IL-8 were significantly higher in the infection group than in the noninfection group (<i>p</i> < 0.05). Maximum stone diameter did not differ significantly between groups (<i>p</i> > 0.05). However, operative time and postoperative catheterisation duration were markedly longer in the infection group (<i>p</i> < 0.05) than in the noninfection group. Postoperative UTI showed a positive correlation with CRP, PCT, LPS, ET, IL-8, operative time and catheterisation duration (<i>p</i> < 0.001). Multivariate logistic regression analysis identified PCT, IL-8 and postoperative catheterisation duration as independent risk factors for infection (<i>p</i> < 0.05). Although CRP, ET and operative time did not reach statistical significance, all had odds ratio > 1, suggesting a potential association with increased infection risk.</p><p><strong>Conclusions: </strong>Postoperative UTI following ureteroscopic lithotripsy is closely associated with elevated serum inflammatory markers and perioperative factors. Increased PCT and IL-8 levels, as well as prolonged postoperative catheterisation, were identified as independent risk factors. Monitoring perioperative inflammatory indicators and optimising surgical and catheter management may reduce the incidence of postoperative UTI and provide a basis for individualised preventive strategies in clinical practice.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 1","pages":"98-104"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Who is Next? Impact of Systemic Immune-Inflammation Index and De Ritis Ratio for Predicting 90-Day Survival after Salvage Cystectomy in Advanced Bladder Cancer.","authors":"Yigit Akin, Enis Mert Yorulmaz, Sacit Nuri Gorgel, Serkan Ozcan, Osman Kose, Erbay Tumer, Erhan Ates","doi":"10.56434/j.arch.esp.urol.20267901.8","DOIUrl":"10.56434/j.arch.esp.urol.20267901.8","url":null,"abstract":"<p><strong>Background: </strong>Salvage cystectomy (SC) following failed bladder-preserving therapy shows an association with exceptionally high perioperative morbidity and mortality. Reliable preoperative biomarkers that can predict short-term outcomes are urgently needed. We investigated whether the systemic immune-inflammation index (SII) and De Ritis ratio (aspartate aminotransferase/alanine aminotransferase) can serve as predictors of 90-day postoperative survival following SC.</p><p><strong>Methods: </strong>Of the 139 patients with advanced bladder cancer (cT3b-cT4) who underwent cystectomy between 2010 and 2025 at a tertiary referral centre, we identified 70 individuals who underwent SC. We then aimed to create a matched control group from a pool of primary radical cystectomy (RC) patients. With the use of a nearest-neighbour matching approach based on age, sex and clinical stage, a suitable match was found for 69 of the 70 SC patients. Therefore, the final study cohort consisted of 70 SC patients and 69 primary RC patients. The groups were well-balanced for the matching variables. Preoperative clinical, pathological and laboratory variables-including SII and De Ritis ratio-were assessed. The primary endpoint was 90-day all-cause mortality, and statistical significance was defined as <i>p</i> < 0.05.</p><p><strong>Results: </strong>The 90-day mortality rate reached 49.6%. Nonsurvivors had significantly higher preoperative SII (979.9 vs. 521.5, <i>p</i> < 0.001) and De Ritis ratios (1.52 vs. 1.24, <i>p</i> < 0.001) compared with the survivors. Multivariate analyses confirmed SII (<i>p</i> < 0.001) and De Ritis ratio (<i>p</i> = 0.018) as independent predictors of early mortality. Receiver operating characteristic analysis demonstrated good discrimination with SII (area under the curve (AUC): 0.79) and De Ritis ratio (AUC: 0.68). The combined model demonstrated the highest predictive performance (AUC: 0.80; Sensitivity 69.6%; Specificity 80.0%).</p><p><strong>Conclusions: </strong>Elevated preoperative SII and De Ritis ratio can independently predict 90-day mortality following SC. Their combined use may improve prognostic accuracy and offer a cost-effective and readily available tool for preoperative risk stratification in this high-risk population.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 1","pages":"66-72"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Presentation and Long-Term Outcomes of Prune Belly Syndrome in a Tertiary Hospital.","authors":"Ana Roche-Gomez, Cristina Julia Blázquez Gómez, Daniel Cabezalí Barbancho, Cristina Tordable Ojeda, Alejandra Licero Villanueva, Alvaro Castro Garrido, Mar Espino Hernández","doi":"10.56434/j.arch.esp.urol.20267901.3","DOIUrl":"10.56434/j.arch.esp.urol.20267901.3","url":null,"abstract":"<p><strong>Background: </strong>Prune belly syndrome (PBS) is a rare congenital disorder defined by deficient abdominal musculature, urinary tract anomalies and cryptorchidism. Clinical presentation is variable, and extrarenal malformations are common.</p><p><strong>Materials and methods: </strong>A retrospective descriptive study of seven patients diagnosed with PBS between 1990 and 2024 in a tertiary-care hospital was carried out. Clinical, biochemical, radiological, auxological and surgical data were reviewed.</p><p><strong>Results: </strong>All patients had megacystis and abdominal muscle hypoplasia. Megalourethra was observed in three (43%), cryptorchidism in six (86%), hydronephrosis in all cases and renal dysplasia in four (57%). Extrarenal anomalies included congenital heart disease in three patients (43%), musculoskeletal defects in three (43%) and other malformations in two (28%). Mean serum creatinine level was 0.83 mg/dL at birth and 1.30 mg/dL at the last follow-up. Two patients (28%) required clean intermittent catheterisation, and one (14%) underwent renal transplantation at 14 years. Surgical procedures included orchidopexy in five patients (71%), vesicostomy in four (57%) and Mitrofanoff appendicovesicostomy in one patient.</p><p><strong>Conclusions: </strong>PBS is a rare disorder with a heterogeneous clinical spectrum. This cohort revealed a high prevalence of cardiac anomalies. Renal dysplasia, recurrent urinary tract infections and delayed surgical intervention were associated with progressive renal impairment. Management in centres with multidisciplinary teams is essential.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 1","pages":"21-30"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomogram Model for Predicting Clinical Efficacy of Emergency Extracorporeal Shock Wave Lithotripsy in Patients with Upper Urinary Tract Calculi: A Single-Centre Retrospective Study.","authors":"Zhenya Shen, Shaohui Zhang, Yang Gui, Yuhua Wang, Guoqiang Yu","doi":"10.56434/j.arch.esp.urol.20267901.11","DOIUrl":"10.56434/j.arch.esp.urol.20267901.11","url":null,"abstract":"<p><strong>Background and aims: </strong>To explore the factors influencing the clinical efficacy of emergency extracorporeal shock wave lithotripsy (ESWL) in patients with upper urinary tract calculi, construct a nomogram model for predicting stone expulsion outcomes and validate its performance.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of 502 patients with upper urinary tract calculi who underwent emergency ESWL at The First Affiliated Hospital of Henan University of Science and Technology from January 2022 to December 2024. All patients were divided into the effective and ineffective groups based on the complete elimination of calculi within 4 weeks after surgery. Differences in general clinical data, urinalysis, liver and renal function indicators, calculus-related characteristics and treatment-related characteristics between the two groups were compared. Multivariate logistic regression was used to identify independent predictors of ESWL efficacy and construct a nomogram model. The model was evaluated using the receiver operating characteristic curve, calibration curve and decision curve analysis.</p><p><strong>Results: </strong>A total of 140 (27.9%) patients had ineffective treatment. Independent risk factors for failure included long emergency visit-to-ESWL time, high urinary white-blood-cell count, elevated serum creatinine/serum uric acid, large maximum stone diameter, high stone density and severe hydronephrosis; ESWL energy and the number of shocks were mediated associated factors; High estimated glomerular filtration rate and ureteral calculi were protective factors (all <i>p</i> < 0.05). The nomogram showed a good predictive performance (area under the curve = 0.862, 95% confidence interval: 0.793-0.931) with good calibration and net benefit.</p><p><strong>Conclusions: </strong>A validated nomogram based on independent predictors and mediated factors was constructed to provide a reliable tool for emergency ESWL decision-making.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 1","pages":"88-97"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ankaferd versus Immunotherapeutics and Chemotherapeutics in Bladder Cancer.","authors":"Hilmi Sarı, Serdar Celik, Kutsal Yorukoglu, Ilhan Celebi, Mehmet Ugur Mungan, Safiye Aktas","doi":"10.56434/j.arch.esp.urol.20267901.7","DOIUrl":"10.56434/j.arch.esp.urol.20267901.7","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the antineoplastic effects of Ankaferd Blood Stopper (ABS) compared with standard immunotherapeutic and chemotherapeutic agents in primary bladder cancer cell cultures.</p><p><strong>Methods: </strong>Tumour tissues taken from patients who underwent transurethral bladder tumour resection due to primary bladder tumour were grown in primary cell culture (PCC). Each patient was divided into six different groups. Ankaferd Blood Stopper, Bacillus Calmette-Guérin (BCG), gemcitabine (GCB), ABS + BCG and ABS + GCB combinations were applied to the groups. A 24-h viability assay was performed for all groups.</p><p><strong>Results: </strong>Amongst the 24 patients diagnosed with bladder cancer, 4 were excluded due to the detection of muscle invasive bladder cancer on pathological evaluation. Consequently, 20 patients with confirmed non-muscle invasive bladder cancer (NMIBC) were included in the study. Patients treated with BCG, ABS and GCB were compared with the control group, and the average cell viability rates were 39.20%, 32.30% and 42.00%, respectively (<i>p</i> < 0.001). Furthermore, combination treatments (ABS + BCG and ABS + GCB) resulted in significant reductions in viability (<i>p</i> < 0.001). Despite similarities in stages, histological types and grades, the viability outcomes following drug treatment varied.</p><p><strong>Conclusions: </strong>ABS negatively impacted the survival outcomes of bladder cancer cells. Upon examination of the results for each bladder tumour, despite identical stages and grades, the viability responses still varied. These findings support further investigation of personalised treatment and ABS as a potential adjunct in bladder cancer therapy.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 1","pages":"58-65"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aetiological Description of Urinary Tract Infections in Patients with Type 2 Diabetes and Construction of a Clinical Prediction Model: A Retrospective Study.","authors":"Chaofei Zhao, Yue Li, Ao Wu, Dayong Jiang","doi":"10.56434/j.arch.esp.urol.20267901.14","DOIUrl":"10.56434/j.arch.esp.urol.20267901.14","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to describe the aetiology and risk factors of urinary tract infection in patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>The clinical data of patients with T2DM treated in our hospital from January 2023 to January 2025 were retrospectively analysed. The patients were divided into the infection group and control group based on the occurrence of urinary tract infection (UTI). The incidence and risk factors of T2DM associated with UTI were analysed. Multivariate logistic regression analysis was conducted to establish a risk prediction model, and a receiver operating characteristic (ROC) curve was drawn. All patients were randomly divided into a training set and a validation set at a ratio of 7:3 to evaluate the stability of the prediction model.</p><p><strong>Results: </strong>This study comprised 269 patients with T2DM, of whom 50 had UTI, resulting in an incidence rate of 18.59%. Multivariate logistic regression analysis showed that the duration of diabetes and levels of glycosylated haemoglobin (HbA1c), sodium-dependent glucose transporter 2 (SGLT2) inhibitor and albumin (ALB) were independent risk factors for T2DM complicated by UTI (<i>p</i> < 0.05). The area under the ROC curve for the training set was 0.806 (95% CI 0.723-0.888), the specificity was 0.845 and the sensitivity was 0.833. In the validation set, the area under the ROC curve was 0.877 (95% CI 0.793-0.960), the specificity was 0.829 and the sensitivity was 0.882. The calibration curve indicated that the prediction curve fit well with the ideal curve (45-degree diagonal). This suggested a strong correlation between the predicted and actual probabilities, indicating a good model.</p><p><strong>Conclusions: </strong>Duration of diabetes and levels of HbA1c, SGLT2 inhibitor and ALB may be independent risk factors for UTI in patients with T2DM. These indicators should be monitored in clinical practice to prevent UTIs.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 1","pages":"114-124"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of Central Sarcopenia for Perioperative and Postoperative Outcomes in Patients with Testicular Germ Cell Cancer Undergoing Post-Chemotherapy Retroperitoneal Lymph Node Dissection.","authors":"Muhammed Fatih Simsekoglu, Ahmet Vural, Feyyaz Irmak, Furkan Kuzucu, Ugur Aferin, Göktug Kalender, Sinharib Citgez, Cetin Demirdag","doi":"10.56434/j.arch.esp.urol.20267901.6","DOIUrl":"10.56434/j.arch.esp.urol.20267901.6","url":null,"abstract":"<p><strong>Background: </strong>Retroperitoneal lymph node dissection (RPLND) is an effective treatment option for testicular cancer with retroperitoneal lymph node metastasis. The accurate prediction of surgical and oncological outcomes after RPLND is essential. In the present study, we aim to evaluate the effect of central sarcopenia on surgical and oncological outcomes in patients undergoing RPLND.</p><p><strong>Methods: </strong>This retrospective cohort study was approved by the institutional ethics committee. Patients diagnosed with metastatic testicular germ cell cancer treated with three or four cycles of bleomycin, etoposide and platinum chemotherapy followed by RPLND between 2010 and 2023 were enrolled. Demographic factors (age, gender, body mass index, comorbidities and cancer characteristics), RPLND pathology, postoperative complications and survival data were evaluated, and the relationship between the psoas lumbar vertebral index (PLVI) calculated from axial computed tomography images and clinical outcomes was examined.</p><p><strong>Results: </strong>The median follow-up duration for the 48 patients was 81.5 months (interquartile range (IQR): 32-150). The median age at RPLND was 26 years (IQR: 21-30). The median PLVI was 0.79 (IQR: 0.65-0.91), and low PLVI values were significantly associated with high postoperative complication rates (<i>p</i> = 0.013). Furthermore, low PLVI (<i>p</i> = 0.007) and large tumour size (<i>p</i> = 0.018) were independently associated with short metastasis-free survival (MFS).</p><p><strong>Conclusions: </strong>Low PLVI is significantly associated with short MFS and an increased risk of postoperative complications. In addition, large tumour size predicts short MFS, and the PLVI is a potentially valuable predictive marker for surgical and oncological outcomes for patients undergoing post-chemotherapy RPLND.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"79 1","pages":"49-57"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}