Archivos Espanoles De Urologia最新文献

{"title":"Vitamin E Supplementation is Effective in Improving Clinical Symptoms and Reducing Renal Scarring in Children with Acute Pyelonephritis: A Retrospective Study.","authors":"Xiaomei Zhong, Juan Tang, Hong Jiang, Mingcheng Zhang, Yuanwei Zhai","doi":"10.56434/j.arch.esp.urol.20257806.95","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.95","url":null,"abstract":"<p><strong>Background: </strong>Urinary tract infection (UTI) is common in children. In particular, acute pyelonephritis (APN) may cause irreversible renal scarring (RS). This retrospective study aimed to evaluate the effects of vitamin E (VE) supplementation on children with APN.</p><p><strong>Methods: </strong>A retrospective analysis was performed on the medical records of children with APN who were admitted to our hospital from January 2022 to January 2024. The patients were divided into two groups according to treatment method: The conventional group (received conventional antibiotic treatment) and the VE group (received vitamin E supplement on the basis of antibiotic treatment). Symptom improvement time, laboratory indices and RS were compared between the two groups.</p><p><strong>Results: </strong>This study enrolled 86 patients, including 41 in the VE group and 45 in the conventional group. Baseline characteristics were not significantly different between the two groups (<i>p</i> > 0.05). The improvement time of fever and other clinical symptoms in the VE group was shorter than that in the conventional group (<i>p</i> < 0.05). Before treatment, the levels of red blood cells, white blood cells, squamous epithelial cells, bacteria, interleukin-6, interleukin-8 and heparin-binding protein in urine were not significantly different between the two groups (<i>p</i> > 0.05). After treatment, these values in the VE group were lower than those in the conventional group (<i>p</i> < 0.05). After 6 months of follow-up, the incidence of RS in the VE group was significantly lower than that in the conventional group (<i>p</i> < 0.05). Further subgroup analyses showed that vitamin E reduced the incidence of RS in children of all ages and genders (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>Vitamin E can effectively shorten the time to improvement of clinical symptoms and laboratory indicators in children with APN and reduce the incidence of RS.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"710-715"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Re: Research Progress on the Correlation between PI-RADS v2.1 Combined with ADC Values and Prostate Gleason Risk Stratification.","authors":"Guangling Kou, Zhiyun Wang, Lin Chen, Fei Gao","doi":"10.56434/j.arch.esp.urol.20257806.105","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.105","url":null,"abstract":"","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"788-789"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Selenoprotein P and Glutathione Expression in Relation to Sperm Kinetic Parameters in Patients with Asthenospermia.","authors":"Qianjin Xu, Ning Zhao","doi":"10.56434/j.arch.esp.urol.20257806.96","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.96","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the relationship amongst serum selenoprotein P (SeP), glutathione (GSH) expression and sperm kinetic parameters in patients with asthenospermia.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on men of reproductive age who underwent preconception testing at the Center for Reproductive Medicine between October 2022 and October 2024. The study subjects were divided into a case group and a healthy group based on the percentage of progressive motile sperm. Comparative analysis was performed to analyse the serum SeP of the two groups, GSH and spermatozoa kinetic parameters.</p><p><strong>Results: </strong>A total of 147 cases were included in the case group and 151 cases into the healthy group. Significant differences in body mass index (BMI), smoking addicted population, regular drinking behavioural population and daily sleep hours were observed between the two groups (<i>p</i> < 0.001). Forward-moving spermatozoa, sperm concentration and total sperm survival were significantly higher in the healthy group than in the case group, whereas the number of non-anterior motion force was significantly lower in the healthy group than in the case group (<i>p</i> < 0.001). The serum SeP and GSH levels of the case group were significantly lower than those in the healthy group (<i>p</i> < 0.001). SeP was negatively correlated with non-anterior motion force (r = -0.476) and positively correlated with other sperm kinetic parameters (r_{forward-moving spermatozoa} = 0.473/r_{sperm concentration} = 0.485/r_{Total sperm viability} = 0.518). GSH was negatively correlated with non-anterior motion force (r = -0.601) and positively correlated with other sperm kinetic parameters (r_{forward-moving spermatozoa} = 0.518/r_{sperm concentration} = 0.554/r_{Total sperm viability} = 0.524), with all correlations being statistically significant (<i>p</i> < 0.001). Multivariate linear regression analyses showed that the BMI (β = -0.217, <i>p</i> < 0.001), daily sleep time (β = 0.236, <i>p</i> < 0.001), SeP (β = 0.253, <i>p</i> < 0.001), GSH (β = 0.325, <i>p</i> < 0.001), presence of smoking addictive behaviours (β = -0.085, <i>p</i> = 0.031) and presence of regular alcohol consumption behaviours (β = -0.083, <i>p</i> = 0.034) were the factors influencing forward-moving spermatozoa. Malondialdehyde showed a negative correlation with SeP and GSH (r = -0.471, -0.543, <i>p</i> < 0.001). SeP and GSH showed good efficacy in the diagnosis of asthenospermia (area under curve (AUC) = 0.824, 0.852).</p><p><strong>Conclusions: </strong>Serum SeP and GSH levels are closely associated with sperm kinetic parameters in patients with asthenospermia, and the mechanism may be related to an imbalance in the antioxidant defence system and oxidative stress damage.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"716-725"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between Mini-Percutaneous Nephrolithotomy and Flexible Ureteroscopy for Patients with Upper Calyceal Calculi Larger than 2 cm.","authors":"Zafer Gokhan Gurbuz, Kadir Karkin, Mubariz Aydamirov, Bugra Aksay, Ediz Vuruskan","doi":"10.56434/j.arch.esp.urol.20257806.88","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.88","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare the results of flexible ureteroscopy with holmium laser lithotripsy (FURSL) and mini-percutaneous nephrolithotomy (mini-PNL) for the treatment of >2 cm upper calyceal stones.</p><p><strong>Methods: </strong>The data of patients who underwent FURSL and mini-PNL surgery for kidney stones between May 2011 and June 2023 were retrospectively examined. Patients with single or multiple kidney stones located in the upper calyx and varying in diameter from 2 cm to 4 cm were included in the study. Operation time, hospitalisation time, complication rates and 1 month stone-free rate (SFR) were compared between the two surgical methods. Stone-free status was evaluated by performing non-contrast computed tomography 1 month after the surgery.</p><p><strong>Results: </strong>A total of 73 (49.3%) and 75 (50.7%) patients were included in the FURSL and mini-PNL groups, respectively. The mean operation time (72.5 vs. 89.7 min) and hospital stay (1.2 vs. 2.1 days) were shorter in the FURSL group (<i>p</i> < 0.001). Although complications were less common in the FURSL group, the difference was not statistically significant (12.3% vs. 21.3%, <i>p</i> = 0.199). The 1 month SFRs were 83.6% and 90.7% in the FURSL and mini-PNL groups, respectively, without statistically significant difference between the groups (<i>p</i> = 0.461).</p><p><strong>Conclusions: </strong>Both surgical approaches are equally effective and safe for the treatment of >2 cm upper calyceal stones. Short surgery and hospitalisation times are the most important advantages of FURSL. This type of surgery can be recommended as an alternative treatment to mini-PNL, with lower complication rates in selected patients.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"653-659"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Preoperative Education Provided by Operating Room Nurses on the Preoperative and Postoperative Anxiety Levels of Patients Undergoing Radical Prostatectomy.","authors":"Ranran Zhao, Yutong Li, Ling Sun","doi":"10.56434/j.arch.esp.urol.20257806.93","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.93","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer is a common malignancy amongst males worldwide. Radical prostatectomy (RP) is a standard treatment, but preoperative anxiety, which affects about 69.5% of patients, negatively affects postoperative outcomes. This study evaluates the effect of preoperative education provided by operating room nurses on the anxiety levels of patients before and after RP.</p><p><strong>Methods: </strong>A single-centre retrospective cohort study was conducted, including 169 patients who underwent RP between January 2020 and June 2024. The patients were divided into two groups: The control group, which received routine preoperative counselling, and the intervention group, which received enhanced preoperative education. Anxiety levels were assessed at three time points by using the State-Trait Anxiety Inventory (STAI): 24 h before surgery (T1), upon entering the operating room (T2) and 24 h after surgery (T3). Statistical analyses included <i>t</i>-tests, chi-squared tests and repeated measures Analysis of Variance (ANOVA).</p><p><strong>Results: </strong>The control group included 102 patients, whilst the intervention group included 67 patients. Repeated measures ANOVA revealed no significant differences in the trait-anxiety levels between groups in terms of group effect, time effect or group × time interaction (<i>p</i> > 0.05). Trait-anxiety levels remained stable across all time points. For state-anxiety levels, group effect (<i>p</i> < 0.001) and time effect (<i>p</i> < 0.001) were statistically significant, but group × time interaction effect was not (<i>p</i> = 0.076). A simple effect analysis showed that state-anxiety levels significantly increased at T2 in both groups, but the increase was less pronounced in the intervention group (<i>p</i> < 0.05). At T3, state-anxiety levels significantly decreased in both groups, with a more substantial reduction observed in the intervention group (<i>p</i> < 0.05). Between-group analysis revealed no significant difference in state-anxiety levels at T1 (<i>p</i> > 0.05). At T2 and T3, however, the intervention group exhibited significantly lower state-anxiety levels than the control group (<i>p</i> < 0.05), with the difference being more pronounced at T2.</p><p><strong>Conclusions: </strong>Preoperative education provided by operating room nurses significantly reduces preoperative and postoperative anxiety levels in patients undergoing RP. These findings suggest that integrating enhanced educational strategies into perioperative care can improve patient outcomes.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"693-702"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Vitamin D₃ Supplementation on Androgens and Semen Parameters in Infertile Men: A Systematic Review and Meta-Analysis Based on Prospective Randomised Controlled Trials.","authors":"Yangtian Jiao, Zhaohan Feng, Tianyu Zhang, Xing Chen","doi":"10.56434/j.arch.esp.urol.20257806.103","DOIUrl":"10.56434/j.arch.esp.urol.20257806.103","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the effects of vitamin D₃ supplementation on androgen levels and semen parameters in infertile men.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across multiple databases, including PubMed, Web of Science, Cochrane Library, Scopus and Embase, to identify studies investigating the effects of vitamin D₃ supplementation on androgen levels and semen parameters in infertile males. Data pertaining to changes in testosterone, sex hormone-binding globulin (SHBG), total sperm count and percentage of motile sperm before and after intervention were extracted and analysed.</p><p><strong>Results: </strong>Six studies, involving 945 subjects, were included in the quantitative analysis. With regard to testosterone levels, vitamin D₃ supplementation was found to increase testosterone, although this change was not statistically significant (standard mean difference (SMD) = 0.07, 95% confidence interval (CI): -0.11, 0.25). Similarly, an increase in SHBG levels was observed after vitamin D₃ supplementation, but the change was not statistically significant (SMD = 0.42, 95% CI: -0.38, 1.22). By contrast, an increase in total sperm count was observed (SMD = 1.04, 95% CI: 0.11, 2.19). Additionally, vitamin D₃ supplementation significantly increased the percentage of motile sperm (SMD = 0.82, 95% CI: 0.00, 1.64).</p><p><strong>Conclusions: </strong>In infertile men, vitamin D₃ supplementation does not significantly affect androgen levels. Nevertheless, it may contribute to improvements in total sperm count and the percentage of motile sperm, potentially enhancing reproductive function.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"772-781"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence and Human Factors in Urology.","authors":"Abdullah Altunhan, Selim Soyturk, Burak Akgul, Theodoros Tokas, Mehmet Balasar, Selcuk Guven, Kamran Ahmed","doi":"10.56434/j.arch.esp.urol.20257806.86","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.86","url":null,"abstract":"<p><strong>Background: </strong>This review focuses on the critical role of human factors in the integration of artificial intelligence (AI) into urology. Whilst AI holds promise for enhancing diagnostics, surgical precision and personalised care, its success depends considerably on the cognitive, physical and psychosocial dimensions of human interaction with these systems.</p><p><strong>Objectives: </strong>Key human factors, such as cognitive load, trust, collaboration and communication, directly influence the adoption and effectiveness of AI technologies. For instance, clinicians must balance leveraging AI's insights with maintaining critical thinking to avoid automation bias.</p><p><strong>Methods: </strong>The design and ergonomics of AI tools, and their seamless integration into clinical workflows, play pivotal roles in optimising efficiency and minimising disruptions. Psychosocial elements like transparency, team dynamics and patient-centric communication are vital to fostering trust and ensuring ethical use of AI in sensitive contexts.</p><p><strong>Results: </strong>Training and continuous professional development tailored to human factors are essential to empower clinicians to work effectively alongside AI. Ethical considerations, including accountability and fairness, further emphasise the need for transparent processes and diverse datasets to address algorithmic biases.</p><p><strong>Conclusions: </strong>This review highlights the path toward a responsible and patient-centred integration of AI in urology by prioritising human factors, ultimately bridging the gap between technological innovation and compassionate healthcare delivery.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"632-641"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Postural Care on Postoperative FLACC Score and Incision Recovery in Children Undergoing High Hernia Sac Ligation.","authors":"Hongling Yu, Qin Bai, Ling Yang","doi":"10.56434/j.arch.esp.urol.20257806.102","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.102","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of postural nursing on the postoperative Face, Legs, Activity, Cry, Consolability (FLACC) scores and incision recovery of children undergoing high hernia sac ligation, which is an effective method for the treatment of inguinal hernia in children.</p><p><strong>Methods: </strong>Clinical data were collected from paediatric patients who underwent laparoscopic high hernia sac ligation during the observation period in our hospital. According to different postoperative nursing methods, the children were divided into an observation group (postoperative position nursing) and a control group (postoperative routine nursing). The FLACC scores of the two groups of paediatric patients were obtained at 4, 12 and 24 h postoperatively. Data on the recovery time of relevant functions and surgical incision healing status for the two groups of paediatric patients were collected during the postoperative care period.</p><p><strong>Results: </strong>A total of 207 paediatric patients' clinical data were collected and divided into an observation group (n = 103) and a control group (n = 104). The results of repeated measures analysis of variance (ANOVA) indicated a significant interaction effect between measurement time and group on the FLACC scores (<i>p</i> < 0.001). Further simple effect analysis revealed no statistically significant difference in FLACC scores between the two groups at time T0 (<i>p</i> > 0.05). However, at time points T1 and T2, the FLACC scores in the observation group were significantly lower than those in the control group (<i>p</i> < 0.001). The postoperative recovery indexes of the observation group were better than those of the control group (<i>p</i> < 0.001), and the total incidence of postoperative surgical incision complications was lower than that of the control group (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Positional care has a significant effect on postoperative pain and incision recovery in children undergoing hernia sac ligation.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"766-771"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circumaortic Left Renal Vein Causing Combined Nutcracker Syndrome: A Case Report and Literature Review.","authors":"David Luengo Gómez, María Rabadán Caravaca, Francisco Javier Contreras Matos, Antonio Jesús Láinez Ramos-Bossini","doi":"10.56434/j.arch.esp.urol.20257806.104","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.104","url":null,"abstract":"<p><strong>Background: </strong>Nutcracker syndrome is a rare clinical condition characterised by the compression of the left renal vein (LRV). This syndrome results in venous hypertension and a variety of symptoms, including haematuria and abdominal pain. We reported an unusual case of combined nutcracker syndrome caused by the compression of both branches of a circumaortic LRV, an anatomical variant.</p><p><strong>Methods: </strong>An 18-year-old female presented with chronic abdominal pain and intermittent haematuria. Laboratory tests and imaging studies including contrast-enhanced computed tomography (CT) of the abdomen and pelvis were performed to investigate the cause. A comprehensive literature review of similar cases was conducted using PubMed.</p><p><strong>Results: </strong>CT showed circumaortic LRV with the anterior branch compressed between the superior mesenteric artery and the aorta, and the posterior branch compressed between the aorta and the spine. This finding confirmed the diagnosis of combined nutcracker syndrome. The patient opted for conservative management, which improved her symptoms. Literature review identified only five other cases of combined nutcracker syndrome owing to circumaortic LRV.</p><p><strong>Conclusions: </strong>Combined nutcracker syndrome is primarily diagnosed through imaging and should be considered in patients with chronic abdominal pain and haematuria, especially when anatomic variants such as circumaortic LRV are present. CT allows accurate visualisation of venous compression and the anatomic structures involved.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"782-787"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of Preoperative Inflammatory Burden Index in Predicting Overall Survival and Progression in Nonmetastatic Muscle-Invasive Bladder Cancer.","authors":"Rıdvan Kayar, Kemal Kayar, Emre Tokuç, Ramazan Topaktaş, Muhammet Çiçek, Samet Demir, Metin Öztürk","doi":"10.56434/j.arch.esp.urol.20257806.89","DOIUrl":"https://doi.org/10.56434/j.arch.esp.urol.20257806.89","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluates the prognostic significance of the inflammatory burden index (IBI) and related systemic inflammatory markers, namely, C-reactive protein-to-albumin ratio (CAR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic inflammation response index (SIRI), neutrophil-to-lymphocyte ratio (NLR), and pan-immune inflammation value (PIV), in predicting survival outcomes in patients with nonmetastatic muscle-invasive bladder cancer (MIBC) undergoing radical cystectomy (RC).</p><p><strong>Methods: </strong>A total of 115 patients treated between January 2014 and January 2023 were included. IBI, CAR, SII, PLR, MLR, SIRI, NLR, and PIV were calculated. Kaplan-Meier, Cox regression, and receiver operating characteristic (ROC) curve analyses were performed to determine the impact of these biomarkers on overall survival (OS) and progression-free survival (PFS).</p><p><strong>Results: </strong>ROC analysis for OS prediction revealed the highest predictive accuracy for PIV (area under curve (AUC) = 0.784, <i>p</i> < 0.001), followed by SIRI (AUC = 0.751) and IBI (AUC = 0.747). For PFS prediction, IBI demonstrated the strongest predictive value (AUC = 0.672, <i>p</i> = 0.002), followed by CAR (AUC = 0.663, <i>p</i> = 0.003) and PIV (AUC = 0.662, <i>p</i> = 0.003). Multivariate Cox regression analysis identified PIV (hazard ratio (HR) = 3.673, <i>p</i> < 0.001), SIRI (HR = 3.074, <i>p</i> < 0.001), and IBI (HR = 2.209, <i>p</i> = 0.002) as independent predictors of OS. High IBIs were significantly associated with advanced tumor stage (T stage) (<i>p</i> = 0.025), lymphovascular invasion (<i>p</i> = 0.002), and perineural invasion (<i>p</i> = 0.023) but not with lymph node metastasis (<i>p</i> = 0.713).</p><p><strong>Conclusions: </strong>IBI and associated hematological markers are valuable for predicting survival outcomes in patients with MIBC. The findings support the integration of these biomarkers with other prognostic tools to enhance the accuracy of treatment outcome predictions.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 6","pages":"660-670"},"PeriodicalIF":0.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}