Clinical Interventions in Aging最新文献

{"title":"The Protective Activity of Apigenin Against Bone and Cartilage Diseases.","authors":"Jincai Chen, Xiaofei Liao, Longhuo Wu","doi":"10.2147/CIA.S529148","DOIUrl":"10.2147/CIA.S529148","url":null,"abstract":"<p><p>Bone and cartilage diseases have become the leading causes of joint disability due to the destruction of bone and cartilage. No effective drugs are available to cure bone and cartilage diseases. Exploring natural compounds as therapeutic alternatives shows promise. Apigenin, a naturally occurring flavonoid, exhibits various pharmacological activities, such as anti-inflammation, antioxidant, and immune modulation. Apigenin acts as a phytoestrogen and mediates the balance of bone remodeling by inducing osteogenic differentiation, promoting osteoblast-associated bone formation, and inhibiting osteoclast-related bone resorption. In addition, apigenin exhibits protective effects against osteoporosis (OP), rheumatoid arthritis (RA), osteoarthritis (OA), gouty arthritis (GA), and intervertebral disc degeneration (IDD). Apigenin can be a promising agent in treating bone and cartilage. However, the application of apigenin is limited due to its low water solubility and bioavailability. More efforts are still needed.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1235-1251"},"PeriodicalIF":3.7,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional Relationship Between Hypoalbuminemia and Postoperative Pneumonia in Elderly Hip Fracture Patients: A Retrospective Cohort Study.","authors":"Junxiang Wang, Hui Yu, Xin Xu, Junfei Guo","doi":"10.2147/CIA.S523802","DOIUrl":"10.2147/CIA.S523802","url":null,"abstract":"<p><strong>Background: </strong>Postoperative pneumonia is a common and severe complication following hip fracture (HF) surgery in the elderly. Hypoalbuminemia, a marker of poor nutritional status and systemic inflammation, is widely recognized as a predictor of adverse outcomes. However, their bidirectional relationship in elderly HF patients remains underexplored.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted in China enrolling elderly patients (≥65 years) with HFs between Mar 2020 and Feb 2023. After predefined participants selection inclusion and exclusion criteria, 1661 surgically treated HF patients were included and analyzed utilizing multiple statistical models, including univariate logistic regression, Lasso regression, and Boruta algorithm for variable selection, while multivariate logistic regression and propensity score matching (PSM) for assess the bidirectional relationship between hypoalbuminemia and postoperative pneumonia. All participants' demographics, injury-related data, surgery-related data, perioperative complications, and two-year follow-up mortality rates were collected and compared.</p><p><strong>Results: </strong>A total of 1,661 patients were included, of whom 144 developed postoperative pneumonia (8.67%). Preoperative hypoalbuminemia was identified as an independent risk factor for postoperative pneumonia (OR: 7.96, 95% CI: 4.08-15.53, <i>P</i><0.001), while postoperative pneumonia itself was associated with an increased risk of developing hypoalbuminemia (OR: 2.34, 95% CI: 1.62-3.38, <i>P</i><0.001). PSM, as sensitivity analyses, further confirmed that postoperative pneumonia itself exacerbates hypoalbuminemia, creating a detrimental cycle. In addition, postoperative pneumonia significantly prolonged hospital stays, increased complication, and elevated mortality rates at 3 months to 2 years (OR: 1.83-3.43, all <i>P</i><0.05) follow-up period.</p><p><strong>Conclusion: </strong>Preoperative hypoalbuminemia is a significant predictor of postoperative pneumonia in elderly patients with HFs, and postoperative pneumonia, in turn, exacerbates hypoalbuminemia, creating a deleterious cycle. Early nutritional assessment and intervention are essential in breaking this cycle and improving outcomes. These findings support the incorporation of routine nutritional screening and optimization into the preoperative care of elderly HF patients to reduce complications and enhance recovery.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1205-1221"},"PeriodicalIF":3.7,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Propensity-Score Matched Analysis to Evaluate Local Treatment Modalities for Esophageal Squamous Cell Carcinoma in Over 80 years on A SEER Database.","authors":"Qiaofang Li, Mengchang Gao, Yitong Li, Lei Tian, Kuo Wang, Xiaolu Yan","doi":"10.2147/CIA.S511737","DOIUrl":"10.2147/CIA.S511737","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to investigate the impact of Local treatment modalities on the survival of≥80 years older patients with squamous cell esophageal cancer, including cancer-directed surgery (CDS) or radiotherapy (RT).</p><p><strong>Patients and methods: </strong>Patients in the Surveillance Epidemiology and End Results (SEER) database were divided into CDS Group and RT Group D according to different Local treatment modalities. Propensity score matching (PSM) was performed to adjust for baseline differences between the two groups. Overall survival (OS) and cancer-specific survival (CSS) was calculated using the Kaplan-Meier method and compared using the Log rank test.</p><p><strong>Results: </strong>A total of 1588 esophageal squamous cell cancer patients of ≥80 years older between 1975 and 2021 were included in the final study cohort, including 165 (10.4%) patients who underwent CDS and 1423 (89.6%) patients who received radiotherapy (RT) therapy. Univariate and multivariate analyses showed that local treatment modalities were prognostic factors for cause-specific survival (CSS) and overall survival (OS). Patients who received CDS had better CSS (HR = 0.674; 95% CI = 0.544-0.836; P < 0.000) and OS (HR = 0.717; 95% CI = 0.595-0.863; P < 0.000). In the propensity-score matched (PSM) dataset, CDS was associated with better CSS (P < 0.008) and OS (P < 0.011) for patients with ≥80 years older; Subgroup analyses showed the prognostic effect of local treatment modalities was significantly influenced by Age. Nevertheless, no differences were observed in CSS (P = 0.584) and OS (P = 0.434) for patients with ≥85 years old.</p><p><strong>Conclusion: </strong>In conclusion, CDS was the preferred treatment for esophageal squamous cell cancer patients with 80-84 years older, and there was no difference between CDS and RT for patients with≥85 years older. This study highlight the value of different local treatments for esophageal squamous cell carcinoma over 80 years patients, especially for ≥85 years older. Further studies are needed to understand drivers of this bias and enhance equality in old patient treatment.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1223-1234"},"PeriodicalIF":3.7,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-State fMRI Reveals the Neural Correlates of Acupuncture in the Treatment of Vascular Cognitive Impairment.","authors":"Qiuping Liu, Kang Xiao, Ping Wan, Qinghua Zou","doi":"10.2147/CIA.S529416","DOIUrl":"10.2147/CIA.S529416","url":null,"abstract":"<p><p>Vascular cognitive impairment (VCI) represents a spectrum of cognitive deficits caused by cerebrovascular pathology, affecting multiple cognitive domains including memory, executive function, and attention. While pharmacological interventions for VCI remain limited, growing evidence supports acupuncture as an effective and safe therapeutic approach that improves both global cognition and activities of daily living in affected patients. Nevertheless, the neurobiological mechanisms underlying acupuncture's therapeutic effects require further elucidation. Resting-state functional magnetic resonance imaging (rs-fMRI) has emerged as a powerful neuroimaging tool for investigating brain function in cognitive disorders. This technique detects blood oxygen level-dependent (BOLD) signals that reflect spontaneous neuronal activity during rest, providing insights into functional connectivity patterns and regional brain activity. In neurodegenerative conditions, rs-fMRI has successfully characterized alterations in functional networks and identified potential biomarkers of cognitive impairment. This review not only summarizes the existing evidence on the efficacy of acupuncture in treating VCI, but also synthesizes the current evidence from rs-fMRI studies to elucidate how acupuncture improves cognitive function in VCI patients through central mechanisms.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1191-1204"},"PeriodicalIF":3.7,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral Amyloid Angiopathy-Related Inflammation: Clinical Characteristics and Treatment Experience.","authors":"Xue Wang, Jiaqi Li, Qichang Fu, Honglin Zheng, Suying Duan, Yuan Gao, Haiyang Luo, Yuming Xu","doi":"10.2147/CIA.S513320","DOIUrl":"10.2147/CIA.S513320","url":null,"abstract":"<p><strong>Objective: </strong>The present study aims to analyze the clinical manifestations, laboratory results, neuroimaging features, treatment interventions, and outcomes in a cohort of patients with cerebral amyloid angiopathy-related inflammation (CAA-ri), providing a deeper understanding of this rare subtype of CAA and enhancing diagnostic precision in clinical practice.</p><p><strong>Methods: </strong>We conducted a systematic retrospective review of clinical records from 13 consecutive patients who met the diagnostic criteria for probable CAA-ri and were evaluated at the First Affiliated Hospital of Zhengzhou University between January 2021 and August 2024.</p><p><strong>Results: </strong>The study cohort comprised 13 patients (7 males, 6 females; mean age 65.2 years, range 42-81), predominantly presenting with subacute onset (53.8%, n=7). Cognitive impairment (61.5%, n=8) emerged as the most frequent clinical manifestation, followed by headache (46.2%, n=6), epileptic seizures (30.8%, n=4), and focal neurological deficits (23.1%, n=3). Neuroimaging findings across all patients demonstrated asymmetric white matter hyperintensities in conjunction with cortical-subcortical cerebral microbleeds. A subset of patients exhibited cortical superficial siderosis lobar hemorrhage, and/or punctate acute infarction. Among the nine patients who underwent lumbar puncture, five showed elevated cerebrospinal fluid (CSF) pressure and protein levels. All four patients assessed for CSF Alzheimer's disease biomarkers showed reduced Aβ42 and Aβ40 levels, alongside elevated total tau and phosphorylated tau levels. Furthermore, over 70% of the patients who treated with immunosuppressive therapy achieved favorable clinical outcomes.</p><p><strong>Conclusion: </strong>Clinical manifestations and neuroimaging abnormalities serve as pivotal non-invasive criteria for guiding clinicians in the diagnosis of CAA-ri. Timely initiation of immunosuppressive therapy in CAA-ri patients can lead to favorable outcomes.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1181-1190"},"PeriodicalIF":3.7,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12338093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Safety of Blood Flow Restriction Combined with Stepping Aerobic Exercise in Older Adults with Sarcopenia.","authors":"Hui Zhang, Shulian Liu, Zhiyu Mao, Kewen Niu, Xinwei Li, Tongtong Yin, Fangfang Wang, Li Wang","doi":"10.2147/CIA.S520775","DOIUrl":"10.2147/CIA.S520775","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to explore the safety of blood flow restriction combined stepping aerobic exercise (BFR-SAE) using elastic and non-elastic cuffs at varying pressures in older adults with sarcopenia.</p><p><strong>Methods: </strong>Older adults with sarcopenia were selected by convenience sampling method and underwent BFR-SAE using elastic and non-elastic cuffs at 20%, 40%, and 60% limb occlusion pressure (LOP). Exercise response and adverse events were recorded.</p><p><strong>Results: </strong>Thirty-one participants (84.81 ± 6.19 years old) completed the tests. During the non-elastic cuffs test, 31 participants completed at 20% LOP, and 4 (12.9%) dropped from 40% to 20% LOP. At 60% LOP, 19 (61.3%) and 3 (9.7%) dropped to 40% and 20% LOP, respectively. In the elastic cuffs tests all participants completed at 20% and 40% LOP. At 60% LOP, 9 (29.0%) dropped to the interface pressure corresponding to 40% LOP. General exercise responses were lower with elastic cuffs at 40% LOP (22.6% vs 45.2%) and 60% LOP (41.9% vs 51.6%), with higher completion rate than non-elastic cuffs (40% LOP: 100% vs 87.1%; 60% LOP: 71.0% vs 29.0%). Among the results of systolic and diastolic blood pressure (SBP and DBP), pulse rate (P) and pulse oxygen saturation (SpO₂), differences were found in BP and P at different time points (<i>P</i><0.05) within each pressure, but no significant difference between different pressures. Non-elastic cuffs caused significant increases in SBP, DBP, and P from rest, while only SBP and P showed significant increases in elastic cuffs group. Pain scores were 0 for both cuffs after tests, the adverse events rate was 1.1% and rating of perceived exertion all reached moderate-intensity of exercise.</p><p><strong>Conclusion: </strong>Elastic cuffs for BFR-SAE induced milder exercise responses and higher completion rates, suggesting better safety and feasibility than non-elastic cuffs in older adults with possible sarcopenia.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1165-1179"},"PeriodicalIF":3.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potentially Inappropriate Medication and Associated Factors Among Older Patients with HIV/AIDS: A Multicenter Cross-Sectional Study.","authors":"Jia Li, Dongsheng Hong, Jiankun Dong, Qingwei Zhao, Hongmei Wang","doi":"10.2147/CIA.S519649","DOIUrl":"10.2147/CIA.S519649","url":null,"abstract":"<p><strong>Purpose: </strong>This study sought to characterize the prevalence, patterns, and associated risk factors for Potentially Inappropriate Medication use among older patients living with HIV/AIDS. The ultimate goal of this study is to inform strategies to increase medication safety in this vulnerable population.</p><p><strong>Patients and methods: </strong>Using the 2023 American Geriatrics Society Beers Criteria, we performed a comprehensive retrospective analysis of medication use patterns among HIV/AIDS patients aged ≥65 years, drawing data from 21 hospitals across eight Chinese cities between 2019 and 2023. The analytical framework incorporated descriptive statistics, negative binomial regression for trend analysis, and multivariable logistic regression to evaluate PIM prevalence and identify associated risk factors.</p><p><strong>Results: </strong>The analysis included 2,642 patients (80.28% male; median age 71 years, IQR: 67~75). The PIM prevalence was 23.20% (613/2,642) in the cohort, with medications contraindicated in older adults constituting the largest category (51.87%), followed by disease-related PIMs (19.88%) and medications requiring cautious use (27.80%). Type 3 PIMs demonstrated a consistent and statistically significant downward trend throughout the study period (<i>P</i><0.001). Conversely, using a single PIM exhibited a statistically significant upward trajectory (<i>P</i>=0.020). In multivariate modeling, polypharmacy emerged as the strongest predictor of PIM use (adjusted OR=9.05, 95% CI: 7.20~11.38), followed by hospitalization (adjusted OR=1.38, 95% CI: 1.05~1.80), with consistent associations observed across the 65~84 year age range (all <i>P</i><0.05).</p><p><strong>Conclusion: </strong>The substantial and increasing burden of PIM use among elderly patients living with HIV/AIDS underscores the urgent need for enhanced medication oversight. Targeted intervention strategies should prioritize patients with polypharmacy, those requiring hospitalization, and those with specific age demographics.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1155-1164"},"PeriodicalIF":3.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Risk Prediction Tool for Bleeding and Adverse Cardiovascular Events in Patients with Pre-Existing Coronary Stents Undergoing Gastrointestinal Cancer Surgery.","authors":"Zi-Yao Xu, Xin-Yu Hao, Zhongyong Zhang, Junjun Zhang, Lei Gao, Tian Li, Xin-Xin Wang","doi":"10.2147/CIA.S516475","DOIUrl":"10.2147/CIA.S516475","url":null,"abstract":"<p><strong>Background: </strong>Aged patients with coronary stents facing gastrointestinal cancer surgery are encountered more and more frequently in clinical practice, and such patients are at high risk of both bleeding and ischemia, requiring effective risk assessment. Therefore, this study will establish a prediction tool that can predict both bleeding events and major adverse cardiovascular events (MACEs).</p><p><strong>Methods: </strong>Multicenter clinical data from 3127 gastrointestinal cancer surgery patients with a history of coronary stent implantation were utilized to establish and validate our prediction tool. We introduced the revised cardiac risk index (RCRI) score and the subsequent dual antiplatelet therapy (PRECISE-DAPT) score to be contrast. Net reclassification index (NRI) and integrated discrimination improvement (IDI) were used to interpret the strengths. Within 30 days post-surgery, we compared the bleeding events and MACEs.</p><p><strong>Results: </strong>Among 3127 patients, 437 (13.9%) developed MACEs and 565 (18.1%) developed bleeding events. The MACEs model achieved good prediction performance both in the internal set (AUC: 0.924, 95% CI: 0.910-0.939) and the external set (AUC: 0.908, 95% CI: 0.880-0.937). The bleeding model also achieved good prediction performance both in the internal set (AUC: 0.862, 95% CI: 0.843-0.882) and the external set (AUC: 0.852, 95% CI: 0.818-0.886). The nomogram score greater than 131 indicates a high risk, with a postoperative MACEs incidence exceeding 23%. Similarly, the score exceeding 124 signifies a high risk, with a postoperative bleeding incidence above 21%.</p><p><strong>Conclusion: </strong>The novel predictive instrument provides the online risk calculator, which could accurately quantify the risk of bleeding and ischemia in patients with coronary stent undergoing gastrointestinal cancer surgery.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1137-1153"},"PeriodicalIF":3.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Safety and Effectiveness of Multi-Segment Cortical Bone Trajectory Screws in Adult Degenerative Scoliosis with Stenosis Among the Elderly: Minimum 5-year Follow-up Study.","authors":"Jie Wang, Zihao Ding, Yuzeng Liu, Yong Hai","doi":"10.2147/CIA.S527306","DOIUrl":"10.2147/CIA.S527306","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the long-term efficacy and safety of multi-segment cortical bone trajectory screws for treating mild adult degenerative scoliosis with stenosis among the elderly.</p><p><strong>Patients and methods: </strong>From January 2018 to December 2019, a total of 41 patients of mild adult degenerative scoliosis with stenosis underwent posterior lumbar decompression, bone graft fusion, and internal fixation, which were retrospectively divided into pedicle screw (PS) group and cortical bone trajectory (CBT) screw group according to different internal fixation methods. The operation time, intraoperative blood loss, immobilization, and length of hospital stay were compared between the two groups. The visual analog score (VAS) of low back and leg pain, Oswestry disability index (ODI), Cobb angle, lumbar lordosis (LL) angle, apex vertebral translation (AVT), coronal balance distance (CBD) and sagittal vertical axis (SVA) were compared between the two groups preoperatively and 6 months, 1 year, 5 years postoperatively. Perioperative and follow-up complications were observed.</p><p><strong>Results: </strong>The CBT group was superior to PS group in operation time, intraoperative blood loss, immobilization, length of hospital stay (<i>P</i><0.05). The low back VAS and ODI in CBT group were significantly lower than those in PS group at 6 months, 1 year and 5 years postoperatively (<i>P</i><0.05). The leg VAS in CBT group was lower than PS group at 5 years postoperatively (<i>P</i><0.05). The incidence of screw loosening and adjacent segment disease 5 years postoperatively in CBT group was significantly lower than that in PS group (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>Multi-segment cortical bone trajectory screws is a safe and effective treatment option for mild adult degenerative scoliosis with stenosis among the elderly. This technique features miniinvasive trauma and quick recovery, which might lead to improved long-term quality of life and a reduction in screw loosening and adjacent segment disease rates.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1125-1135"},"PeriodicalIF":3.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mediating Role of Activities of Daily Living in the Relationship Between Depressive Symptoms and Multidimensional Frailty in the Elderly with Multimorbidity.","authors":"Dongmei Mei, Yan Yang, Defang Meng, Yaoyao Hu, Xiaoyan Wang","doi":"10.2147/CIA.S518492","DOIUrl":"10.2147/CIA.S518492","url":null,"abstract":"<p><strong>Purpose: </strong>Previous studies have shown an association between depression and frailty in older adults, but the psychological and social dimensions of frailty are often overlooked, especially in the context of multimorbidity. This study aims to explore the association of depressive symptoms with multidimensional frailty and the mediating role of ADL.</p><p><strong>Patients and methods: </strong>Data were collected using a general information questionnaire, Tilburg Frailty Indicator (TFI), ADL was assessed with Barthel index, and Elderly Depression Rating Scale.</p><p><strong>Results: </strong>Depressive symptoms were significantly correlated with multidimensional frailty (including each dimension) and ADL (<i>p</i> <0.05). Regression analysis showed that depressive symptoms were directly associated with multidimensional frailty (β = 0.484, <i>p</i> < 0.001) and indirectly through ADL (β = 0.442, <i>p</i> < 0.001). Dimensions showed that depressive symptoms directly associated with physical frailty and mental frailty (β = 0.454, 0.542, 0.118, <i>p</i> < 0.001) indirectly through ADLs (β = 0.250, 0.492, <i>p</i> < 0.001). Bootstrap tests confirmed the robustness of these findings.</p><p><strong>Conclusion: </strong>The findings confirm the importance of interventions targeting mental health and restoration of physical function to prevent multidimensional frailty in older adults with multimorbidity.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1109-1123"},"PeriodicalIF":3.7,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}