Clinical Interventions in Aging最新文献

{"title":"A Preliminary Screening Tool for High-Risk Frailty in Older Adults Patients with Pulmonary Tuberculosis.","authors":"Hui-Juan Li, Yue-Ying Zhou, He-He Yu, Jian Jiang, Yu-Wei Cai","doi":"10.2147/CIA.S493887","DOIUrl":"10.2147/CIA.S493887","url":null,"abstract":"<p><strong>Objective: </strong>To understand the current status and analyse the factors influencing frailty in older adults patients with pulmonary tuberculosis.</p><p><strong>Methods: </strong>This retrospective case-control study included 204 older adults patients with pulmonary tuberculosis. The enrolled patients were divided into a frailty group (n = 101) and a non-frailty group (n = 103). The study further collected and compared the data of various scores.</p><p><strong>Results: </strong>The total frailty score among the patients ranged from 0 to 15 points, with an average score of 5.23 ± 2.31 points. The total social support score ranged from 15 to 47 points, with an average of 33.43 ± 6.11 points. The physical function level scores ranged from 10 to 100 points, with an average of 84.58 ± 14.48 points. Additionally, univariate analysis showed significant differences between the groups in terms of age, body mass index (BMI), duration of disease, types of long-term medication and the number of complications and comorbidities (<i>P</i> < 0.05). Correlation analysis revealed negative correlations of social support (<i>P</i> < 0.001) and physical function (<i>P</i> < 0.001) with the overall frailty score and a positive correlation of depression levels (<i>P</i> < 0.001) with the overall frailty score. Further regression analysis indicated that being over 80 years old, having a low BMI, long-term polypharmacy and a high depression score were risk factors. High social support and physical function scores were protective factors against frailty in older adults patients with pulmonary tuberculosis.</p><p><strong>Conclusion: </strong>In older adults patients with pulmonary tuberculosis, the overall frailty score shows negative correlations with social support and physical function and a positive correlation with depression level.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"57-68"},"PeriodicalIF":3.5,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"U-Shaped Relationship Between MSpO2 Levels and the Incidence of Frailty in Elderly OSA Patients: Findings from a Multicenter Cohort Study [Letter].","authors":"Hanqin Zhu, Lei Dong","doi":"10.2147/CIA.S513894","DOIUrl":"10.2147/CIA.S513894","url":null,"abstract":"","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"55-56"},"PeriodicalIF":3.5,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intervention for Social Frailty Focusing on Physical Activity and Reducing Loneliness: A Randomized Controlled Trial.","authors":"Aki Gen, Yumi Higuchi, Tetsuya Ueda, Tomoko Hashimoto, Wataru Kozuki, Tatsunori Murakami, Mio Ishigami","doi":"10.2147/CIA.S491979","DOIUrl":"10.2147/CIA.S491979","url":null,"abstract":"<p><strong>Purpose: </strong>During the COVID-19 pandemic, older adults living in the community experienced reduced physical activity (PA) and heightened loneliness, particularly those with less frequent outings-a key factor of social frailty. Promoting PA may foster social participation, increase outings, and reduce loneliness. This study investigates the effects of a multi-component intervention on PA and loneliness in socially frail older adults.</p><p><strong>Materials and methods: </strong>This single-blind, randomized controlled trial included 64 participants aged ≥ 60 years with social frailty and pre-frailty defined according to Makizako's Social Frailty Index. Participants were randomly assigned to either the intervention (n = 34) or the control (n = 30) group. Over eight weeks, the intervention group attended a weekly 60-min multi-component program that included health education, exercise, and self-monitoring. A simple exercise booklet was distributed to the control group at baseline. For both groups, outcome measures were assessed at baseline and after eight weeks. PA was assessed using a triaxial accelerometer. Loneliness was measured using the three-item version of the UCLA Loneliness Scale. We used repeated-measures analysis of variance with group-by-time interactions to estimate the intervention effects following the intention-to-treat approach.</p><p><strong>Results: </strong>PA was not affected by the intervention. A significant group-by-time interaction was observed for loneliness, with a medium effect size (p < 0.05), indicating that loneliness was significantly reduced in the intervention group compared to the control group.</p><p><strong>Conclusion: </strong>The multi-component program aimed at promoting PA may contribute to the building of social relationships and reducing loneliness in older adults with social frailty and pre-frailty.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"43-53"},"PeriodicalIF":3.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11740606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Outcomes of Arthroscopic Tenotomy versus Tenodesis with Medium-to-Massive Rotator Cuff Tear in the Elderly: A Retrospective Study.","authors":"Kaihang Song, Guanghua Lu, Ming Cai, Qi Sun","doi":"10.2147/CIA.S493029","DOIUrl":"10.2147/CIA.S493029","url":null,"abstract":"<p><strong>Purpose: </strong>Shoulder arthroscopic repair of rotator cuff tears with simultaneous treatment of lesions of the long head of the biceps tendon has become increasingly accepted. However, the clinical outcomes between tenotomy and tenodesis remain unclear. This study aimed to compare the efficacy of tenotomy and tenodesis combined with rotator cuff repair in elderly patients with medium-to-massive rotator cuff tears.</p><p><strong>Patients and methods: </strong>We conducted a retrospective trial of patients aged > 60 years with medium-to-massive rotator cuff tears who underwent arthroscopic rotator cuff repair with tenotomy or tenodesis. This study included 96 patients: 47 in the tenotomy group and 49 in the tenodesis group. At 3 and 6 months after surgery and at the last follow-up, the American Shoulder and Elbow Surgeons (ASES) score, Constant-Murley score (CS score), anterior shoulder pain (VAS score), elbow flexion strength and supination strength, and complications were recorded.</p><p><strong>Results: </strong>At 3 months postoperatively, ASES score, CS score and strength of elbow flexion of the tenodesis group were significantly better than those of the tenotomy group. In addition, the VAS score is 4.4 ± 1.4 and 3.3 ± 1.3 in the tenodesis and tenotomy respectively (p = 0.039). At the final follow-up, despite no significant statistical differences in ASES scores, CS scores, VAS scores, and flexion strength between the two groups, the variation in the above items in the tenodesis group was statistically lower than that in the tenotomy group. No difference was observed in the rates of complications and revision between the groups.</p><p><strong>Conclusion: </strong>For people over 60 years of age with medium to massive rotator cuff tears, postoperative shoulder function of tenodesis is superior to tenotomy, and functional recovery is relatively more stable after tenodesis than after tenotomy.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"33-42"},"PeriodicalIF":3.5,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Four Non-Insulin-Based Insulin Resistance Indices and the Risk of Post-Stroke Depression.","authors":"Ping Wang, Mengchao Wang, Zhe Xie, Zhongwen Zhi, Yuqian Wang, Fan Liu, Yufeng Liu, Liandong Zhao","doi":"10.2147/CIA.S501569","DOIUrl":"https://doi.org/10.2147/CIA.S501569","url":null,"abstract":"<p><strong>Purpose: </strong>Research suggests that insulin resistance (IR) is associated with acute ischemic stroke (AIS) and depression. The use of insulin-based IR assessments is complicated. Therefore, we explored the relationship between four non-insulin-based IR indices and post-stroke depression (PSD).</p><p><strong>Patients and methods: </strong>A total of 638 consecutive AIS patients were enrolled in this prospective cohort study. Clinical data were collected to compute indices such as the triglyceride glucose (TyG) index, triglyceride glucose-body mass index (TyG-BMI), insulin resistance metabolic score (METS-IR), and triglyceride/high-density lipoprotein cholesterol ratio (TG/HDL-C). One month post-stroke, neuropsychological assessments were conducted using the 17-item Hamilton Depression Scale. Binary logistic regression analysis was performed to explore the relationship between the four non-insulin-based IR indices and PSD.</p><p><strong>Results: </strong>Ultimately, 381 patients completed the 1-month follow-up, including 112 (29.4%) with PSD. The PSD group exhibited significantly higher levels of the four IR indices compared to the non-PSD group. Logistic regression analysis demonstrated that these indicators were independently associated with PSD occurrence, both before and after adjusting for potential confounders (all P < 0.001). Tertile analyses indicated that the highest tertile group had a greater risk of PSD occurrence than the lowest tertile group for four IR indicators, even after adjusting for potential confounders (all P < 0.05). Restricted cubic spline analysis revealed a linear dose-response relationship between the four IR indices and PSD. In the subgroup analysis, only the TyG index showed a significant interaction with diabetes (P for interaction = 0.014). The area under curve values for the TyG index, TyG-BMI, METS-IR, and TG/HDL-C were 0.700, 0.721, 0.711, and 0.690, respectively.</p><p><strong>Conclusion: </strong>High TyG index, TyG-BMI, METS-IR, and TG/HDL-C at baseline were independent risk factors for PSD in AIS. Each of these indicators exhibits predictive value for PSD occurrence, aiding in the early identification of high-risk groups.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"19-31"},"PeriodicalIF":3.5,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Self-Management Behavior Profiles in Patients with Multimorbidity: A Sequential, Explanatory Mixed-Methods Study.","authors":"Yujia Fu, Jingjie Wu, Zhiting Guo, Yajun Shi, Binyu Zhao, Jianing Yu, Dandan Chen, Qiwei Wu, Erxu Xue, Haoyang Du, Huafang Zhang, Jing Shao","doi":"10.2147/CIA.S488890","DOIUrl":"10.2147/CIA.S488890","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to identify self-management behavior profiles in multimorbid patients, and explore how workload, capacity, and their interactions influence these profiles.</p><p><strong>Patients and methods: </strong>A sequential explanatory mixed-methods design was employed. In the quantitative phase (August 2022 to May 2023), data were collected from 1,920 multimorbid patients across nine healthcare facilities in Zhejiang Province. Latent Profile Analysis (LPA) was used to identify distinct self-management behavior profiles. Multinomial logistic regression was then used to assess the influence of workload and capacity dimensions (independent variables in Model 1), as well as their interaction (independent variables in Model 2), on these profiles (dependent variables in two models). The qualitative phase (May to August 2023) included semi-structured interviews with 16 participants, and the Giorgi analysis method was used for data categorization and coding.</p><p><strong>Results: </strong>Quantitative analysis revealed three self-management behavior profiles: Symptom-driven Profile (8.0%), Passive-engagement Profile (29.5%), and Active-cooperation Profile (62.5%). Compared to the Active-cooperation Profile, both the Symptom-driven and Passive-engagement Profiles were associated with a higher workload (<i>OR</i> > 1, <i>P</i> < 0.05) and lower capacity (<i>OR</i> < 1, <i>P</i> < 0.05). An interaction of the overall workload and capacity showed a synergistic effect in the Passive-engagement Profile (<i>OR</i> = 1.08, 95% <i>CI</i> = 1.03-1.13, <i>P</i> < 0.05). Qualitative analysis identified six workload themes, and related coping strategies of three self-management behavior profiles. The integrated results highlighted distinct characteristics: Symptom-driven Profile patients exhibited reactive behaviors with limited health awareness, Passive-engagement Profile patients reduced engagement once symptoms stabilized, while Active-cooperation Profile patients proactively managed their conditions.</p><p><strong>Conclusion: </strong>Identifying three distinct self-management behavior profiles and their relationship with workload and capacity provides valuable insights into multimorbid patients' experiences, emphasizing the need for tailored interventions targeting workload and capacity to improve health outcomes.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1-17"},"PeriodicalIF":3.5,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Remimazolam on Intraoperative Frontal Alpha Band Power Spectrum Density and Postoperative Cognitive Function in Older Adults Undergoing Lower Extremity Fractures Surgeries: A Randomized Controlled Trial.","authors":"Hao Wu, Shunping Tian, Hongxia Ma, Wei Zhou, Shantian Feng, Lijun Meng, Jinlei Ou, Fei Xu, Zhuan Zhang","doi":"10.2147/CIA.S496437","DOIUrl":"https://doi.org/10.2147/CIA.S496437","url":null,"abstract":"<p><strong>Purpose: </strong>Low density of electroencephalogram alpha band power was reported to be associated with perioperative cognitive dysfunction. Few studies have conducted to explore the effects of remimazolam on intraoperative frontal alpha band power spectrum density in older adults. Here, we aimed to explore the impact of remimazolam on intraoperative frontal brain wave alpha band activity and postoperative cognitive function in older adults undergoing lower extremity fractures surgeries.</p><p><strong>Methods: </strong>Patients undergoing elective general anesthesia for lower extremity fracture surgery were randomly allocated to remimazolam group (Group R) and midazolam group (Group M). Group R was induced with remimazolam bolus 0.1 mg/kg followed by a maintenance dose of 0.1 mg·kg^-1·h^-1 for general anesthesia. Group M was induced with midazolam 0.05 mg/kg followed by normal saline maintenance of 0.1 mL·kg^-1·h^-1. The rest anesthesia protocol was the same for both groups. Electroencephalogram data was recorded before anesthesia induction till the end of surgery. Cognitive function was assessed preoperatively, and at the first, third, fifth, and seventh day postoperatively.</p><p><strong>Results: </strong>Compared with Group M, Group R had significantly higher intraoperative power spectral density of the frontal alpha band (<i>P</i> < 0.001), and significantly lower incidence of postoperative cognitive dysfunction at T₈ and T₉ (P = 0.031 and P = 0.017, respectively).</p><p><strong>Conclusion: </strong>Remimazolam can increase frontal brain wave alpha band power spectrum density and improve postoperative cognitive function in older adults undergoing lower extremity fractures surgeries.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"19 ","pages":"2195-2205"},"PeriodicalIF":3.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11700878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity and Specificity of Three Measures of Intrinsic Capacity in Older People Aged 80 and Over in Nursing Homes.","authors":"Linlin Ma, Enjie Zheng, Yi Fang, Huixian Chen, Chuncong Zhou, Shuya Cai, Fen Luo, Wen Jiang, Jialu Wang, Xiangxiang Ning, Haixia Tu, Zhiqin Yin","doi":"10.2147/CIA.S486663","DOIUrl":"https://doi.org/10.2147/CIA.S486663","url":null,"abstract":"<p><strong>Purpose: </strong>Intrinsic capacity (IC), a crucial indicator for the United Nations Decade of Healthy Ageing 2021-2030, is defined by WHO as the foundation of functional ability, representing the composite of all physical and mental capacities of an individual. IC spans five function domains: Locomotor, psychological, cognitive, vitality, and sensory (including vision and hearing). Accurate IC assessment is vital for effective interventions, yet comparative analyses of these tools are scarce. Consequently, we evaluated the diagnostic accuracy of three IC assessment tools in individuals aged 80 and above-Integrated care for older people (ICOPE) Step 1, ICOPE Step 2, and the Lopez-Ortiz's IC scoring system.</p><p><strong>Patients and methods: </strong>This cross-sectional analysis included a total of 475 participants aged ≥80 years between July 2023 and January 2024 in 11 nursing homes in Ningbo, Zhejiang Province, China. To assess that included sociodemographic and health-related information alongside the three IC tools. Diagnostic efficacy was gauged using sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), accuracy, Youden index, and the area under the curve (AUC).</p><p><strong>Results: </strong>The detection of IC decline exceeded 85% across all methods. Using ICOPE Step 2 as a benchmark, ICOPE Step 1 showed robust performance across four domains of locomotion, psychological, cognitive, and vitality, whereas the Lopez-Ortiz's IC scoring system was generally ineffective.</p><p><strong>Conclusion: </strong>All three IC assessment methods have limitations. To save resources, ICOPE Step 1 can be considered for direct assessment in non-sensory domains. Conversely, the ICOPE Step 2 and Lopez-Ortiz's IC scoring systems exhibited overly stringent and lenient thresholds, respectively. At this stage, IC assessment tools cannot balance subjectivity and objectivity; thus, it is recommended that the appropriate tool be selected according to actual application scenarios. Continuous improvement of IC assessment tools remains a requirement for future studies.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"19 ","pages":"2179-2194"},"PeriodicalIF":3.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the Predictive Utility of MHR for Senile Osteoporosis: Unaddressed Considerations and Future Directions [Response to Letter].","authors":"Dang Li, Nan Lin","doi":"10.2147/CIA.S510489","DOIUrl":"10.2147/CIA.S510489","url":null,"abstract":"","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"19 ","pages":"2165-2166"},"PeriodicalIF":3.5,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Cognitive Frailty and Depression: A Prospective Cohort Study of Adults Aged 45 Years and Older in China.","authors":"Jiang Wang, Aizhang Zhu, Jie Chen, Rui Zeng, Siyi Wang, Lihuan Chen, Ying Chen, Qianqian Min, Wei Li, Dongmei Ye, Ruohan Wu, Fayi Xie, Tenghui Fan, Ke Zhu, Wan Zhu, Hongmei Hu, Conghua Wang, Xiaoming Zhang","doi":"10.2147/CIA.S484352","DOIUrl":"10.2147/CIA.S484352","url":null,"abstract":"<p><strong>Background: </strong>The interplay between cognitive frailty and depression remains inadequately understood, with a paucity of evidence from prospective cohort studies. Our study aims to elucidate the relationship between cognitive frailty and the risk of incident depression.</p><p><strong>Methods: </strong>Utilizing data from the China Health and Retirement Longitudinal Study (CHARLS) spanning 2011, 2013, and 2015, subjects were classified according to cognitive frailty criteria established by an international consensus panel. Multiple logistic regression models were employed to examine the cross-sectional and longitudinal associations between frailty, cognitive impairment, cognitive frailty, and depression. Subgroup analyses and interaction tests were conducted to identify potential effect modifiers.</p><p><strong>Results: </strong>In 2011, the study encompassed 4514 participants, with 2330 individuals followed up through 2015. Cross-sectional analyses revealed that participants classified in frailty, cognitive impairment, and cognitive frailty exhibited multivariable-adjusted odds ratios (ORs) for depression of 1.87 (95% CI 1.60-2.18; P < 0.001), 1.97 (95% CI 1.58-2.47; P < 0.001), and 3.38 (95% CI 2.66-4.29; P < 0.001), respectively, compared to no diseased group. Longitudinal analyses from 2011 to 2015 indicated that participants in frailty, cognitive impairment, and cognitive frailty had multivariable-adjusted ORs of 1.28 (95% CI 1.05-1.58; P = 0.0165), 1.39 (95% CI 1.01-1.91; P = 0.0411), and 1.57 (95% CI 1.05-2.35; P = 0.0273), respectively, for new-onset depression relative to no diseased group.</p><p><strong>Limitations: </strong>The definition of depression relied solely on self-reported data.</p><p><strong>Conclusion: </strong>In the middle-aged and elderly Chinese population, patients with cognitive frailty have a higher risk of depression than those with only frailty and cognitive impairment. This may suggest that health care providers should pay more attention to the mental health of those patients with cognitive frailty.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"19 ","pages":"2167-2178"},"PeriodicalIF":3.5,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}