Clinical Interventions in Aging最新文献

{"title":"Time-Lagged Effects of Hyperglycemia on Inflammation in Older Adults with Community-Acquired Pneumonia: Nutritional Insights and Personalized Intervention Windows.","authors":"Lei Miao, Qing Xiao, Jingxian Liao, Chunhui Xie, Xiaozhu Shen","doi":"10.2147/CIA.S533728","DOIUrl":"10.2147/CIA.S533728","url":null,"abstract":"<p><strong>Purpose: </strong>The dynamic interplay between glucose metabolism and systemic inflammation is increasingly recognized as a pivotal factor influencing outcomes in older adults with community-acquired pneumonia (CAP), yet its temporal patterns and the modifying role of nutritional status remain insufficiently understood.</p><p><strong>Patients and methods: </strong>In this retrospective cohort study, 507 older adults (≥65 years) hospitalized with CAP were included. Serial measurements of blood glucose (GLU), C-reactive protein (CRP), and neutrophil-to-lymphocyte ratio (NLR) were obtained at admission, 24 hours, and 72 hours. Cross-correlation function (CCF) analysis was used to characterize lagged temporal relationships among biomarkers, while autoregressive integrated moving average (ARIMA) models predicted biomarker trends. Subgroup analyses were conducted according to 28-day survival, diabetes status, nutritional status, and age.</p><p><strong>Results: </strong>Patients who died within 28 days had higher CRP, NLR, and GLU levels across all time points compared to survivors, with pronounced delays in normalization of inflammatory markers and persistent hyperglycemia (all P<0.001). CCF analyses demonstrated that glucose elevations often preceded increases in CRP and NLR, particularly at a lag of -1, indicating early metabolic perturbations can foreshadow subsequent inflammatory surges. Survivors showed evidence of timely feedback regulation, with negative correlations at subsequent lags, while non-survivors, malnourished patients, and those aged ≥85 years exhibited disrupted, delayed, or reversed cross-correlation patterns. ARIMA models provided robust predictions, identifying critical intervention windows based on biomarker trends.</p><p><strong>Conclusion: </strong>These findings reveal the systemic impact of hyperglycemia on inflammation and suggest potential benefits of nutritional interventions targeting glucose control to modulate inflammatory responses in elderly CAP patients. Overall, this study underscores the importance of integrating metabolic monitoring with nutritional strategies to improve outcomes in this vulnerable population.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1359-1380"},"PeriodicalIF":3.7,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malnutrition and Muscle Loss Mediate the Association Between NT-proBNP and Mortality in Hospitalized Older Adults.","authors":"Jun Tao, Xiaoyan Zhang, Niansong Wang, Dongsheng Cheng","doi":"10.2147/CIA.S523073","DOIUrl":"https://doi.org/10.2147/CIA.S523073","url":null,"abstract":"<p><strong>Background & aims: </strong>Elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP), a biomarker of cardiac stress, predicts mortality in heart failure. Its association with outcomes in older hospitalized patients without overt heart failure, and potential mediation by malnutrition and muscle loss, remains unclear. The purpose of this study was to assess the association between NT-proBNP and mortality in hospitalized oldest-old adults (≥80 years) and to explore the mediating role of malnutrition and muscle loss.</p><p><strong>Methods: </strong>This prospective cohort study was conducted among 360 hospitalized patients ≥ 80 years of age (median age 87 years, 24.4% women) in the Department of Geriatrics (Shanghai, China), between August 2017 and January 2018. The Geriatric Nutritional Risk Index (GNRI) and Mini Nutritional Assessment Short Form (MNA-SF) were used for nutritional assessment, while calf circumference was used as a measure of muscle mass. A Cox proportional hazard model was used to assess the relationship between NT-proBNP levels and mortality. Mediation analysis was used to explore the mediating effects of malnutrition and muscle loss.</p><p><strong>Results: </strong>The median follow-up was 4.1 years with 159 (44.1%) deaths. Mortality risk increased by 32% per 2-fold increase in NT-proBNP levels (full adjusted hazard ratio: 1.32 [95% Confidence Interval (CI), 1.20-1.46]). A mediation analysis showed that a lower GNRI score and decreased calf circumference partially mediated the effects of high NT-proBNP and mortality risk, with an estimated relative effect size of 28.9%, while MNA-SF and calf circumference mediated with an estimated relative effect size of 25.3%.</p><p><strong>Conclusion: </strong>NT-proBNP levels were associated with increased mortality in hospitalized older patients. Moreover, the detrimental effects of NT-proBNP on survival were partly mediated by malnutrition and muscle loss. Consequently, preventive and nutritional strategies should be required for these patients.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1349-1357"},"PeriodicalIF":3.7,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12383006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Longitudinal Effect of an Integrated Nursing Intervention Based on the Integrated Theory of Health Behavior Change (ITHBC) on Multidimensional Health Indicators in Older Radiotherapy Patients.","authors":"Jing Jiang, Luxi Qian, Jie Chen, Juan Lu, Huanfeng Zhu, Bo Zhang, Yalan Zhao, Jing Tian, Qiuping Zhang, Xia He","doi":"10.2147/CIA.S532913","DOIUrl":"https://doi.org/10.2147/CIA.S532913","url":null,"abstract":"<p><strong>Introduction: </strong>The Integrated Theory of Health Behavior Change (ITHBC) offers a structured framework for promoting sustained health behavior change through cognitive beliefs, self-regulation, and social facilitation. However, its application in geriatric oncology remains unexplored.</p><p><strong>Methods: </strong>This quasi-experimental study enrolled 291 older adult patients who underwent radiotherapy at the Jiangsu Cancer Hospital. Patients hospitalized from July to December 2024 (n=146) received ITHBC-guided multidisciplinary nursing intervention, while those treated from January to June 2024 (n=145) received conventional individualized nursing care. Key outcomes, including disease cognition, self-management efficacy, and quality of life, were assessed at baseline and five months post-intervention using validated instruments. Statistical analyses included t-tests, ANCOVA, and effect-size calculations.</p><p><strong>Results: </strong>After 5 months, the intervention group showed significantly greater improvements in disease cognition (Δ=+23.5 vs +16.4), self-management efficacy (Δ=+10.63 vs +3.77), and quality of life scores (Δ=+22.07 vs +6.98), all P < 0.001. The effect size for disease cognition was 1.32 (95% CI: 1.08-1.56).</p><p><strong>Discussion: </strong>These findings confirm the efficacy of the ITHBC-based nursing model in enhancing cognitive, behavioral, and psychosocial outcomes in older patients undergoing radiotherapy. Structuring geriatric oncology care around behavioral theories, such as ITHBC, yields measurable benefits and supports its broader application in nursing interventions.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1293-1304"},"PeriodicalIF":3.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life Space Mobility and Social Frailty for Middle-Aged and Older Adults with Different Levels of Hearing Impairment.","authors":"Jhen Yang You, Ching-Ju Chiu","doi":"10.2147/CIA.S522426","DOIUrl":"https://doi.org/10.2147/CIA.S522426","url":null,"abstract":"<p><strong>Objective: </strong>Life-space mobility reflects daily and social movement, crucial for active aging and independence in older adults. Good mobility is associated with greater vitality and the ability to live independently. This study examines the relationship between hearing loss and life-space mobility using pure tone average (PTA) hearing levels.</p><p><strong>Methods: </strong>This cross-sectional study recruited participants aged 50-79 from January 2023 to May 2024 through community in southern Taiwan. Participants were recruited via electronic bulletin boards and word-of-mouth. Hearing was assessed using pure tone audiometry, and data on socioeconomic status, life-space mobility, cognition, depression, social frailty, and health status were collected via questionnaires. Logistic regression was used to identify predictors of life-space mobility.</p><p><strong>Results: </strong>Ninety participants (mean age 64.21 years) with good cognition completed the study. Pure tone audiometry showed 60% had bilateral hearing loss (better ear hearing level >20 dB), and 15.6% had bilateral hearing disability (bilateral hearing level >50 dB). Low life-space mobility was observed in 5.6%, and social frailty in 13.3%. Bilateral hearing disabilities predicted low life-space mobility (OR = 48.34, CI = 2.06-1136.35). Each decibel increase in worse ear hearing level increased the likelihood of low life-space mobility by 6% (OR = 1.06, CI = 1.0-1.1).</p><p><strong>Conclusion: </strong>Hearing loss is an independent predictor of life-space mobility. Increased worse ear hearing levels are associated with reduced life-space. Routine hearing assessment may support timely identification and intervention to preserve mobility in aging populations.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1337-1347"},"PeriodicalIF":3.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awake Flexible Bronchoscopy Intubation Practice Among Otorhinolaryngology Surgery: An Observation Study Based on Practice Video Recordings and Clinical Data.","authors":"Mannan Abdul, Lili Feng, Xiuwen Yi, Yan Zhuang, Yingjie Wang, Jiali Jiao, Shuang Shuang Li, Yuan Han, Wenxian Li","doi":"10.2147/CIA.S530162","DOIUrl":"10.2147/CIA.S530162","url":null,"abstract":"<p><strong>Background: </strong>Patients with airway pathologies are at higher risk for difficult intubation, making Awake flexible bronchoscopy intubation (AFBI) an essential technique. This study aimed to describe the baseline characteristics, procedural details, and outcomes of AFBI regarding otorhinolaryngology surgery.</p><p><strong>Methods: </strong>This single-centre, observational study included 147 adult patients who underwent a standardised AFBI protocol for otorhinolaryngology surgery patients at Eye & ENT Hospital of Fudan University between January 1, 2022 and July 31, 2023. Data were collected from procedural video recordings and clinical database. Baseline characteristics, oxygenation methods, topicalisation, sedation levels, and procedural outcomes were documented. Comparisons between the first-attempt success group and the multiple-attempts success group were further performed.</p><p><strong>Results: </strong>The median age of the patients was 66.00 years (IQR: 59.00-70.00), and 85.03% were male. The median body mass index (BMI) was 22.20 kg.m^-² (IQR: 19.80-24.60) and the most common indication for AFBI was pathological obstruction of the supra-glottic region (79.59%). Nasal cannula was the most frequently used oxygenation method (94.56%). The minimum SpO₂ during the procedure was 95.00% (IQR: 92.00-97.00), and median procedure duration was 20.45 minutes (IQR: 18.55-24.41). Lidocaine was the most commonly used topical anesthetic (78.23%, median dose: 3.27 mg.kg^-¹, IQR: 2.79-3.94), followed by a combination of lidocaine and tetracaine (20.41%). Dexmedetomidine was administered 100% of cases (median dose: 0.71 µg.kg^-¹, IQR: 0.51-0.88), and fentanyl was used in 97.28% of cases (median dose: 0.87 µg.kg^-¹, IQR: 0.72-1.00). One hundred and twenty-eight (87.07%) were successfully intubated on the first attempt, while 19 (12.93%) required multiple attempts. Patients in the multiple-attempts group had a longer procedure duration [23.33 minutes (IQR: 20.80-26.86) vs 20.01 minutes (IQR: 18.33-24.09), <i>P</i> = 0.007].</p><p><strong>Conclusion: </strong>This study highlights the high first-attempt success rate of the optimized AFBI protocol. Tailored airway management strategies are essential, particularly for older patients, to ensure safety and procedural outcomes.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1325-1336"},"PeriodicalIF":3.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Recovery After Surgery (ERAS) Program for InterTAN Nail Surgery in Intertrochanteric Femoral Fracture (ITF) Patients Over 75 years Old.","authors":"Jingwei Wu, Peng Wang, Zhihua Gao, Shibao Lu","doi":"10.2147/CIA.S527660","DOIUrl":"https://doi.org/10.2147/CIA.S527660","url":null,"abstract":"<p><strong>Background: </strong>Enhanced Recovery After Surgery (ERAS) has been extensively applied across numerous surgical specialties. However, there remains a paucity of research regarding the implementation of ERAS in advanced age patients (≥75 years) who undergo InterTAN nail surgery for intertrochanteric femoral fractures (ITF). This study aimed to assess if our ERAS protocol improves satisfaction and clinical outcomes in such patients.</p><p><strong>Methods: </strong>This was a retrospective cohort study included advanced age patients who underwent InterTAN nail surgery. The ERAS group included patients who underwent surgery between January 2022 and December 2024, while the non - ERAS group consisted of those who had the same surgery between January 2019 and December 2023. Demographics, comorbidities, surgical details, ERAS compliance, outcomes, complications, and length of stay (LOS) were evaluated.</p><p><strong>Results: </strong>A total of 144 patients were included in the ERAS group and 135 in the non - ERAS group. Analysis of demographic data showed no statistically significant intergroup differences. ERAS compliance was 100%. There were no significant differences between the ERAS and non - ERAS groups in terms of operative side, anesthesia type, operating time, intraoperative blood loss, and postoperative Visual Analogue Scale scores. Moreover, 30 - day follow - up revealed no significant differences in readmission rates and mortality between the two groups. However, the LOS was significantly shorter in the ERAS group (5.68±2.34 days vs 6.54±2.04 days in the non - ERAS group; p = 0.03). The overall complication rate was also significantly lower in the ERAS group (10/144 vs 23/135; P < 0.01).</p><p><strong>Conclusion: </strong>In this cohort of advanced age patients with ITF managed via our ERAS program, it was evidenced that this program is safe and can effectively reduce the LOS and the incidence of complications.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1305-1313"},"PeriodicalIF":3.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superpath is Superior to Posterolateral Approach for Hemiarthroplasty in Geriatric Patients with High Risk for Dislocation.","authors":"Yuhui Yang, Hong Zhang, Qing Dai, Dapeng Zhang, Zhaohong Zhou, Hai Jiang, Yunzhi Peng, Jianhua Huang, Linyong Hu, Qianyue Sun","doi":"10.2147/CIA.S532656","DOIUrl":"https://doi.org/10.2147/CIA.S532656","url":null,"abstract":"<p><strong>Background: </strong>Dislocation following hemiarthroplasty (HA) for femoral neck fractures in the elderly was a rare but severe complication. Tissue-sparing SuperPATH approach for HA had been described with promising results in terms of function recovery, transfusion and dislocation rate. The aim of the present study was to investigate the clinical outcomes, perioperative complications, and mortality rate through SuperPATH (SP) and posterolateral (PL) approach in geriatric patients with high dislocation risk.</p><p><strong>Methods: </strong>A total of 621 patients from January 2015 to January 2024 were retrospectively reviewed. According to high-dislocated risk, 39 patients through SuperPATH approach and 42 patients through posterolateral approach met the inclusion criteria. All the surgeries were performed by the same hip surgery team. The operation time, surgery incision, intraoperative blood loss and complications were evaluated. The postoperative outcomes, especially dislocation and mortality were assessed at 1-month, 6-month, and 1-year follow-up intervals postoperatively.</p><p><strong>Results: </strong>Compared with PL group, the surgery incision and blood transfusion rate in SP group was significantly decreased. The early Harris hip score in SP group was significantly higher than that of PL group (t = 7.587, p < 0.001) at 1-week postoperatively, without statistic difference at one month and one year. Totally, the one-year mortality for all patients with high risk of dislocation was 18/81 (22.22%). 8 patients sustained one or more dislocations in PL group, while no patients in the SP group did (OR = 1.235, p = 0.004). The incidence of reoperation was significantly lower in SP group. While there was no significant difference of complication and one-year mortality between groups.</p><p><strong>Conclusion: </strong>SuperPATH approach for bipolar HA was associated with reducing dislocation and accelerating early hip function recovery in high-risk dislocation population. Once predictors of dislocation risk following HA in the elderly were detected, tissue-sparing invasive approach or constrained THA prosthesis might be considered to avoid evitable complications.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1315-1324"},"PeriodicalIF":3.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Clinical Management Pathway for Perioperative Nutritional Risk in Elderly Patients with Hip Fractures.","authors":"Weiyu Pan, Yu Xie, Junjuan Zhang, Huimin Yang, Cheng Cheng, Hongmei Zhang","doi":"10.2147/CIA.S534553","DOIUrl":"https://doi.org/10.2147/CIA.S534553","url":null,"abstract":"<p><strong>Objective: </strong>The nutritional challenges faced by elderly patients with hip fractures during the perioperative period are significantly associated with clinical outcomes. This study aims to develop a clinical management pathway tailored for elderly hip fracture patients at nutritional risk during the perioperative period, with the objectives of enhancing patient management precision, reducing the duration of hospitalization, and minimizing associated healthcare costs.</p><p><strong>Methods: </strong>Based on the perioperative time sequence, nursing process framework, and the five-step principle of nutritional diagnosis and treatment, literature review, Delphi method, and priority graph method were employed to determine the content and hierarchical weight indicators of the clinical management pathway for this patient population.</p><p><strong>Results: </strong>A total of 20 experts participated in two rounds of Delphi consultation, with effective response rates of 100% in both rounds. The authority coefficients of the experts were 0.890 and 0.923; the coefficient of variation ranged from 0.045 to 0.226 and 0 to 0.247, and the Kendall's W coefficients were 0.575 and 0.22 (P < 0.001), respectively. The finalized clinical management pathway included 6 primary indicators, 18 secondary indicators, and 103 tertiary indicators.</p><p><strong>Conclusion: </strong>The constructed clinical management pathway for elderly hip fracture patients at nutritional risk during the perioperative period is scientifically sound, comprehensive in content, and highly specialized. It offers a valuable reference for nutritional management and represents a meaningful step toward precise clinical care in this patient population.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1267-1282"},"PeriodicalIF":3.7,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12366635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Preoperative Frailty and Post-Induction Hypotension in Elderly Patients Undergoing Major Non-Cardiac Surgery: A Prospective Observational Cohort Study.","authors":"Jiawen Yu, Lu Che, Ruoxi Wang, Quexuan Cui, Li Xu, Yuguang Huang","doi":"10.2147/CIA.S535277","DOIUrl":"https://doi.org/10.2147/CIA.S535277","url":null,"abstract":"<p><strong>Purpose: </strong>Post-induction hypotension (PIH) is one of the most common complications during general anesthesia, especially in elderly patients. Frailty, which describes age-related decrease of physiological capacity with increased susceptibility to stress, may be associated with PIH, when stress is brought by anesthetics. This study aimed to explore the association between preoperative frailty and PIH as well as postoperative complications.</p><p><strong>Patients and methods: </strong>This study was a prospective observational cohort study. Elderly patients scheduled for elective non-cardiac surgery under general anesthesia were recruited from December 2019 to April 2022 in Peking Union Medical College Hospital. Preoperative frailty was assessed by FRAIL scale. The primary outcome was post-induction hypotension. Secondary outcome included postoperative complications, functional recovery, length of stay and hospital cost.</p><p><strong>Results: </strong>A total of 147 patients were included in the final analysis, of which 25 (17.0%) were considered frail. Frailty patients were generally older and suffered more from anemia, hypoalbuminemia, weakness, and orthostatic hypotension. The incidence of PIH was significantly higher in frail patients than non-frail elderly (80.0% vs 37.7%). Multivariable analysis revealed that frailty was associated with higher risk of PIH (aRR 1.72, 95% CI 1.20-2.47, P=0.003) after adjusting for baseline characteristics, surgical type and intraoperative medications. Comprehensive complication index within 30 days after surgery was significantly higher in frail patients.</p><p><strong>Conclusion: </strong>Frailty is associated with post-induction hypotension during general anesthesia in elderly patients undergoing non-cardiac surgery. Preoperative frailty assessment may help identify high-risk patients for better anesthesia plan.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1283-1292"},"PeriodicalIF":3.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Interdisciplinary Approach to Assistive Technology for Parkinson's Disease Dementia.","authors":"Sara Munzesheimer, Tin Wai Tiffany Siu, Dudley Yacinthe, Michelle Garcia-Casals, Ihtsham Ul Haq, Danielle S Shpiner","doi":"10.2147/CIA.S516786","DOIUrl":"https://doi.org/10.2147/CIA.S516786","url":null,"abstract":"<p><p>Parkinson's Disease Dementia (PDD) and Parkinson's Disease-Mild Cognitive Impairment (PD-MCI) are common non-motor complications that can manifest as Parkinson's disease (PD) progresses. Cognitive impairment associated with PDD/PD-MCI can degrade patients' functional communication, safety, independence in activities of daily living, relationships with others, and increase caregivers' burden. Assistive Technology (AT) can help the PDD/PD-MCI population and their families to improve daily functioning, safety, and quality of life. This review highlights the breadth, functionality, effectiveness, and utilization of currently available AT in PDD and PD-MCI from an interdisciplinary rehabilitative perspective, including insights from physical therapy, occupational therapy, and speech-language pathology. Some larger AT studies that were reviewed offer meaningful perspectives on realistic patient implementation; however, other AT studies had limitations including small sample sizes, insufficient focus on PDD/PD-MCI population needs, and underrepresentation of patients with cognitive deficits. Nevertheless, this review aims to serve as one of the first interdisciplinary clinical guides for determining appropriate use, timing, and individualized adaptation of AT, allowing clinicians to maximize functional outcomes in the PDD/PD-MCI population. Additional studies are required to gain a deeper understanding of practical application, training, and implementation of AT for individuals with PDD/PD-MCI from an interdisciplinary perspective.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1253-1265"},"PeriodicalIF":3.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}