European Annals of Otorhinolaryngology-Head and Neck Diseases最新文献_第7页

Nivolumab immunotherapy rechallenge for progressive laryngeal squamous cell carcinoma after failure of conventional treatment: A CARE case report 常规治疗失败后，Nivolumab 免疫疗法再挑战治疗进展期喉鳞癌：CARE病例报告

IF 1.9 4区医学

European Annals of Otorhinolaryngology-Head and Neck Diseases Pub Date : 2024-08-01 DOI: 10.1016/j.anorl.2024.02.003

{"title":"Nivolumab immunotherapy rechallenge for progressive laryngeal squamous cell carcinoma after failure of conventional treatment: A CARE case report","authors":"","doi":"10.1016/j.anorl.2024.02.003","DOIUrl":"10.1016/j.anorl.2024.02.003","url":null,"abstract":"<div><h3>Objective</h3><p>Analysis of rechallenge with nivolumab<span> as 5th-line therapy for locally and nodally failed laryngeal squamous cell carcinoma<span> following conventional therapeutic modalities: radiotherapy, surgery and chemotherapy.</span></span></p></div><div><h3>Observation</h3><p><span><span>A 70-year-old male, with local and nodal progression of laryngeal squamous cell carcinoma after treatment with </span>chemoradiotherapy<span> and surgery, was initially treated for recurrence with carboplatin<span>, 5-fluorouracile (FU) and cetuximab<span><span>, followed by second-line nivolumab<span>, and then two lines of conventional chemotherapy with paclitaxel and </span></span>cetuximab<span> followed by carboplatin and cetuximab. He underwent rechallenge with nivolumab in 5th line, achieving 12</span></span></span></span></span>  <!-->months’ survival since initiation of exclusive systemic management after failure of conventional treatment.</p></div><div><h3>Conclusion</h3><p>This case report highlights the benefit of nivolumab rechallenge in 5th line following previous failure as stand-alone therapy in 2nd line for a patient with laryngeal squamous cell carcinoma locally and nodally uncontrolled after conventional treatment. Clinical trials evaluating the efficacy of this approach are necessary to assess its contribution, as it is currently not a standard therapeutic option.</p></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139987774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smoke in the operating room 手术室内的烟雾

IF 1.9 4区医学

European Annals of Otorhinolaryngology-Head and Neck Diseases Pub Date : 2024-08-01 DOI: 10.1016/j.anorl.2024.02.010

引用次数: 0

Spontaneous resorption of geniculate ganglion arachnoid cyst 膝状神经节蛛网膜囊肿自发吸收。

IF 1.9 4区医学

European Annals of Otorhinolaryngology-Head and Neck Diseases Pub Date : 2024-08-01 DOI: 10.1016/j.anorl.2024.02.002

引用次数: 0

Myomucosal island flaps for oropharyngeal reconstruction 用于口咽重建的粘膜岛状皮瓣

IF 1.9 4区医学

European Annals of Otorhinolaryngology-Head and Neck Diseases Pub Date : 2024-08-01 DOI: 10.1016/j.anorl.2023.11.015

引用次数: 0

Total laryngectomy in children: Madness or method? 儿童全喉切除术：疯狂还是方法？

IF 1.9 4区医学

European Annals of Otorhinolaryngology-Head and Neck Diseases Pub Date : 2024-08-01 DOI: 10.1016/j.anorl.2023.11.013

引用次数: 0

Neither hear or see, what's happening? 既听不见也看不见，到底发生了什么？

IF 1.9 4区医学

European Annals of Otorhinolaryngology-Head and Neck Diseases Pub Date : 2024-08-01 DOI: 10.1016/j.anorl.2023.12.004

引用次数: 0

Risk factors for laryngeal lesions in adult acute respiratory distress syndrome: A STROBE-compliant French case-control study 成人急性呼吸窘迫综合征喉部病变的风险因素：符合 STROBE 标准的法国病例对照研究。

IF 1.9 4区医学

European Annals of Otorhinolaryngology-Head and Neck Diseases Pub Date : 2024-08-01 DOI: 10.1016/j.anorl.2024.02.011

{"title":"Risk factors for laryngeal lesions in adult acute respiratory distress syndrome: A STROBE-compliant French case-control study","authors":"","doi":"10.1016/j.anorl.2024.02.011","DOIUrl":"10.1016/j.anorl.2024.02.011","url":null,"abstract":"<div><h3>Introduction</h3><p>The global SARS-CoV-2 pandemic led to an increased incidence of post-intubation laryngeal injuries in patients with acute respiratory distress syndrome (ARDS). The primary objective of this study was to identify risk factors for symptomatic laryngeal lesions in patients with Covid-19-related ARDS. The secondary objective was to analyze the progression of these laryngeal lesions.</p></div><div><h3>Methods</h3><p>A 21 month nested case-control study was conducted in 3 university hospital centers of the Hospices Civils de Lyon (France). Cases encompassed all patients intubated for Covid-19-related ARDS who presented symptomatic laryngeal pathology. The control group consisted of all patients enrolled during the same period for Covid-19-related ARDS without evidence of laryngeal lesions (no specific ENT intervention). Uni- and multi-variate analyses were performed to identify risk factors for the occurrence of laryngeal lesions.</p></div><div><h3>Results</h3><p>Forty-nine patients were included in the case group and 50 in the control group. The only significant risk factor for symptomatic laryngeal injury was the number of reintubations, with an odds ratio of 5.08 (95% CI, 1.40–22.12; <em>P</em>  <!-->0.013). No other predictive factors were identified among the variables analyzed: obesity, number of prone sessions, self-extubation, duration of intubation and number of days of curarization.</p></div><div><h3>Conclusion</h3><p>The number of reintubations was the sole independent risk factor associated with the development of symptomatic laryngeal lesions in patients managed for Covid-19-related ARDS.</p></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1879729624000280/pdfft?md5=f29c0ef4ba072ae61b48dd77c0e52f43&pid=1-s2.0-S1879729624000280-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139997993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autologous fat injection for empty-nose syndrome 自体脂肪注射治疗空鼻综合征。

IF 1.9 4区医学

European Annals of Otorhinolaryngology-Head and Neck Diseases Pub Date : 2024-08-01 DOI: 10.1016/j.anorl.2023.10.017

{"title":"Autologous fat injection for empty-nose syndrome","authors":"","doi":"10.1016/j.anorl.2023.10.017","DOIUrl":"10.1016/j.anorl.2023.10.017","url":null,"abstract":"<div><h3>Aims</h3><p>Inferior meatus augmentation by injection or implants is one of the treatments for empty-nose syndrome (ENS), but levels of evidence of efficacy are low. We present the technique and evaluate our experience. The primary objective was to analyze changes in Empty Nose Syndrome 6-item Questionnaire (ENS6Q) scores after treating patients with ENS by autologous fat injection. Secondary objectives were the analysis of the evolution of each of the six ENS6Q items and identification of complications. Eleven patients underwent a minimally invasive approach to limit nasal airflow using fat injection between March 2021 and December 2022.</p></div><div><h3>Results</h3><p>Ten of the 11 patients showed a decrease in overall ENS6Q score (<em>P</em>    <!-->11. Ten were satisfied with the procedure, but remained symptomatic. The procedure did not result in any complications.</p></div><div><h3>Conclusion</h3><p><span>These encouraging results confirm the data in the literature suggesting that fat injection improves symptomatology in </span>empty nose syndrome. However, like other minimally invasive approaches to limit nasal airflow, it does not eliminate all symptoms. These results need to be confirmed by studies on larger cohorts with longer follow-up, preferably in a multicenter setting.</p></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71487791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Closure without epiglottoplasty or tracheotomy after reconstructive frontal anterior laryngectomy. 重建额前喉切除术后无需会厌成形术或气管切开术即可闭合。

IF 1.9 4区医学

European Annals of Otorhinolaryngology-Head and Neck Diseases Pub Date : 2024-06-25 DOI: 10.1016/j.anorl.2024.06.003

M-C Senol, V Bastit, M Humbert, E Babin, M Perréard

{"title":"Closure without epiglottoplasty or tracheotomy after reconstructive frontal anterior laryngectomy.","authors":"M-C Senol, V Bastit, M Humbert, E Babin, M Perréard","doi":"10.1016/j.anorl.2024.06.003","DOIUrl":"https://doi.org/10.1016/j.anorl.2024.06.003","url":null,"abstract":"<p><p>Reconstructive frontal anterior laryngectomy (RFAL) is a partial laryngeal surgery technique for resecting early-stage (T1-T2) glottic squamous cell carcinoma. Indications comprise a lesion of the anterior commissure of the larynx that cannot be adequately exposed by endoscopy, and cases in which radiotherapy is refused or contraindicated. The initial RFAL technique included epiglottoplasty. Here we propose a technique without epiglottoplasty, with the advantage of avoiding need for tracheotomy in most cases. After the first stage of surgical excision, reconstruction consists in placing a vertical brace transepiglottically and below the cricoid. The epiglottis is thus left at its original height and secured in place to prevent flapping in the pharyngolaryngeal lumen. Transverse bracing is then performed through the thyroid wings: one of the key points of this surgery is to control tension to avoid risk of stenosis. The subhyoid muscles are sutured together to achieve satisfactory sealing. This technique offers satisfying functional results and oncological control. The most frequent complications are (1) secondary tracheotomy, which can be avoided by selecting patients who require a primary tracheotomy and optimizing the seal, and (2) stenosis, which can be limited by not bringing the cartilaginous structures too close together during bracing.</p>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare cause of vegetating lesion at a reconstructive surgery site. 整形手术部位植物性病变的罕见病因。

IF 2.5 4区医学

European Annals of Otorhinolaryngology-Head and Neck Diseases Pub Date : 2024-06-18 DOI: 10.1016/j.anorl.2024.06.004

K Al Tabaa, A Walter, M Batttistella, C Mauppin

引用次数: 0