European Annals of Otorhinolaryngology-Head and Neck Diseases最新文献

{"title":"Association of nasal mucus cystatin SN levels with disease severity in patients with uncontrolled chronic rhinosinusitis","authors":"X. Pan ,&nbsp;Y. Li ,&nbsp;Z. Liu ,&nbsp;S. Xu ,&nbsp;D. Wu","doi":"10.1016/j.anorl.2025.11.006","DOIUrl":"10.1016/j.anorl.2025.11.006","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to measure and compare nasal mucus cystatin SN levels in patients with controlled and uncontrolled chronic rhinosinusitis, and to evaluate its diagnostic performance in distinguishing between these disease states.</div></div><div><h3>Material and methods</h3><div>A total of 98 CRS patients were prospectively enrolled and evaluated for disease control based on the EPOS criteria. Specimens of nasal mucus and tissue from patients with CRS and 15 healthy controls undergoing surgery for the deviated septum were obtained to measure cystatin SN levels. Disease severity was evaluated using the 22-item Sinonasal Outcome Test (SNOT-22), Questionnaire of Olfactory Disorders Negative Statements (QOD-NS) score, Lund-Kennedy score, Lund-Mackay score, olfactory cleft endoscopy scale (OCES), and olfactory cleft computed tomography (CT) score. Multivariable logistic regression analysis was used to determine the risk factors associated with uncontrolled CRS.</div></div><div><h3>Results</h3><div>Among the patients with CRS, 42.86% were uncontrolled. Cystatin SN expression in the nasal epithelium was significantly increased among patients with uncontrolled CRS compared to those with controlled CRS and healthy controls (both <em>P</em> <!-->&lt;<!--> <!-->0.001). Furthermore, the uncontrolled CRS exhibited significantly higher blood eosinophil counts (BEC) (<em>P</em> <!-->=<!--> <!-->0.001), SNOT-22 score (<em>P</em> <!-->=<!--> <!-->0.001), QOD-NS score (<em>P</em> <!-->=<!--> <!-->0.004), Lund-Mackay score (<em>P</em> <!-->=<!--> <!-->0.022), OCES (<em>P</em> <!-->=<!--> <!-->0.004), and olfactory cleft CT score (<em>P</em> <!-->=<!--> <!-->0.012) than controlled CRS. Additionally, mucus cystatin SN levels showed a positive correlation with BEC (R<!--> <!-->=<!--> <!-->0.126, <em>P</em> <!-->=<!--> <!-->0.012) in patients with CRS. Multivariable logistic regression analysis showed that nasal mucus cystatin SN was identified as an independent predictor of uncontrolled CRS (OR<!--> <!-->=<!--> <!-->1.011, <em>P</em> <!-->=<!--> <!-->0.028). Mucus cystatin SN levels with a cutoff point greater than 106.050<!--> <!-->pg/mL had a superior predictive value for uncontrolled CRS compared to BEC (area under the curve, 0.886 vs. 0.782, <em>P</em> <!-->&lt;<!--> <!-->0.001).</div></div><div><h3>Conclusion</h3><div>Mucus cystatin SN levels were highly associated with disease severity in patients with uncontrolled CRS.</div></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"143 3","pages":"Pages 167-174"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145744369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extended high-frequency audiometry for detecting early hearing effects of personal listening devices: A narrative review","authors":"M. Škerková ,&nbsp;E. Mrázková ,&nbsp;M. Kovalová ,&nbsp;L. Kocurková ,&nbsp;N. Gottfriedová","doi":"10.1016/j.anorl.2026.01.011","DOIUrl":"10.1016/j.anorl.2026.01.011","url":null,"abstract":"<div><div>Personal listening devices (PLDs) are widely used among young adults, raising concern about early noise-induced hearing loss (NIHL). Conventional audiometry (≤<!--> <!-->8<!--> <!-->kHz) may not detect the earliest signs of cochlear damage. Extended high-frequency audiometry (EHFA, ≥<!--> <!-->9<!--> <!-->kHz) has been suggested as a more sensitive approach for identifying early auditory changes. This narrative review examined the potential role of EHFA in detecting PLD-related hearing effects. A structured search of PubMed and Academic Search Ultimate through 30 September 2024 identified nine eligible studies (sample sizes 20–282; ages 13–31 years). Most studies reported significantly elevated thresholds in the 9–16<!--> <!-->kHz range, particularly at 12–14<!--> <!-->kHz, among participants with prolonged PLD use (&gt;<!--> <!-->4–5 years) or higher listening levels (≥<!--> <!-->75 dBA). These threshold shifts often occurred despite normal conventional audiograms, suggesting that EHFA may capture early changes not identified by standard testing. Two studies, however, found no significant group differences, likely due to small control samples, short exposure duration, or limited statistical power. Considerable heterogeneity in exposure definitions, calibration, and reliance on self-reported listening habits further limits comparability. Current evidence indicates that EHFA may hold promise as an early indicator of NIHL in young adult PLD users, but further methodological refinements, objective exposure monitoring, and longitudinal research are required to establish normative data and clarify its prognostic and clinical utility.</div></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"143 3","pages":"Pages 195-200"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147628978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REFCOR guidelines for sinonasal adenocarcinoma","authors":"L. de Gabory ,&nbsp;C. Monnot ,&nbsp;A.-C. Baglin ,&nbsp;B. Baujat ,&nbsp;V. Coste-Martineau ,&nbsp;G. de Bonnecaze ,&nbsp;L. Digue ,&nbsp;C. Dupin ,&nbsp;C. Even ,&nbsp;F.-R. Ferrand ,&nbsp;J. Michel ,&nbsp;A. Moya-Plana ,&nbsp;T. Radulesco ,&nbsp;J. Thariat ,&nbsp;S. Vergez ,&nbsp;B. Vérillaud ,&nbsp;M. Kérimian ,&nbsp;C. Rumeau","doi":"10.1016/j.anorl.2026.04.007","DOIUrl":"10.1016/j.anorl.2026.04.007","url":null,"abstract":"<div><h3>Introduction</h3><div>Since 2009, management of sinonasal adenocarcinoma (ADK) was governed by general guidelines. The present paper presents an update.</div></div><div><h3>Method</h3><div>The formalized expert consensus methodology was applied. A literature analysis for the period 2009–2020 in the PubMed and Cochrane Library databases selected 60 studies meeting the PRISMA criteria. Eighteen recommendations were drawn up and validated.</div></div><div><h3>Results</h3><div>For T1 and T2N0M0 intestinal ADK and low-grade non-intestinal ADK, isolated surgery with negative margins is recommended (Relative agreement). For pT2 and pT3N0M0 intestinal ADK with negative resection margins, tumor-board discussion of adjuvant radiotherapy is recommended (Relative agreement). Complete resection with negative margins followed by radiotherapy to the tumor bed is the curative treatment for T4N0M0 intestinal ADK (Strong agreement) and N0M0 high-grade non-intestinal ADK of whatever stage (Relative agreement). Prophylactic cervical lymph-node treatment is not recommended in N0 sinonasal ADK (Relative agreement).</div></div><div><h3>Conclusion</h3><div>The present update defines specific recommendations for this histologic family.</div></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"143 3","pages":"Pages 212-218"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REFCOR guidelines for sinonasal adenoid cystic carcinoma","authors":"D. Ebode ,&nbsp;T. Radulesco ,&nbsp;J. Michel","doi":"10.1016/j.anorl.2026.04.003","DOIUrl":"10.1016/j.anorl.2026.04.003","url":null,"abstract":"<div><div>Sinonasal adenoid cystic carcinoma (ACC) is a rare seromucosal gland tumor, accounting for 7.5% of sinonasal cavity cancers. It is a distinct entity, with slow progression, strong perineural tropism and high risk of late recurrence. Since the time of the 2009 French guidelines, large multicenter studies have been reported, enabling more precise clinical, pathologic and therapeutic analysis. To update the previous guidelines, a systematic review was performed, using PRISMA guidelines and the PubMed, Scopus and Web of Science databases for the period 2009–2020. English and French language articles were selected on strict inclusion criteria, resulting in 23 studies analyzed out of 283. Data were classified according to the French Health Authority levels of evidence, as a scientific basis for the new REFCOR guidelines published in 2022. We here present a short version of the scientific rationale. Results confirmed frequently late clinical presentation, with most tumors staged T3 or T4 at diagnosis. Histologically, solid tumors and perineural or bone infiltration were of poorer prognosis. Overall 5-year survival ranges from 61% to 87%, but risk of recurrence beyond 20 years requires prolonged monitoring. Treatment is based on complete surgical resection. Adjuvant radiotherapy, preferably with intensity modulation, is indicated in case of risk factors. In unresectable or recurrent forms, exclusive hadron therapy is a good option. Systemic treatments show limited efficacy, with no neoadjuvant forms or current recommendations for concomitant chemoradiotherapy. Targeted therapies, on the other hand, are promising.</div></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"143 3","pages":"Pages 201-206"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory laryngeal reaction after medialization by hyaluronic acid","authors":"R. Haddad,&nbsp;A. Mattei,&nbsp;A. Giovanni","doi":"10.1016/j.anorl.2026.01.003","DOIUrl":"10.1016/j.anorl.2026.01.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Injection laryngoplasty with hyaluronic acid (HA) is currently the first-line treatment for glottic insufficiency, significantly improving vocal function. Some rare inflammatory laryngeal reactions have been reported, managed conservatively by corticosteroids and antibiotics.</div></div><div><h3>Case report</h3><div>An 83-year-old woman with longstanding dysphonia due to left laryngeal paralysis was treated by medialization with hyaluronic acid injection under local anesthesia. Postoperative course featured onset of dyspnea 42<!--> <!-->h after injection, with a large laryngeal edema, unimproved by conservative medical treatment. CT showed edematous infiltration of the left hemilarynx, greater than the injected volume. Given the lack of clinical improvement, emergency tracheotomy was performed. Progressive absorption of the edema allowed decannulation 3<!--> <!-->weeks later.</div></div><div><h3>Discussion</h3><div>We report a rare complication after medialization by HA injection: a severe inflammatory laryngeal reaction significantly impairing airway function and threatening vital prognosis. The case highlights the critical need for close monitoring after medialization and for appropriate management in case of dyspnea onset.</div></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"143 3","pages":"Pages 219-222"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An unusual velar ulceration?","authors":"A. Dubray-Vautrin,&nbsp;N. Badois,&nbsp;O. Choussy,&nbsp;M. Lesnik","doi":"10.1016/j.anorl.2026.01.004","DOIUrl":"10.1016/j.anorl.2026.01.004","url":null,"abstract":"","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"143 3","pages":"Pages 238-239"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Louis Hubert Farabeuf: A renowned anatomist, and a strong character","authors":"C.-A. Righini","doi":"10.1016/j.anorl.2026.04.002","DOIUrl":"10.1016/j.anorl.2026.04.002","url":null,"abstract":"<div><div>In the 19th century, human anatomy was badly taught, in poorly suited run-down premises, by teachers with very uneven levels of knowledge. Louis Hubert Farabeuf came from a poor family, and abandoned his ambition to train as a surgeon, due to poor health. He turned his focus to anatomy, and had modern premises constructed in the Paris Medical School. He also set out the operating rules of anatomy labs that have come down to us today. He was a brilliant anatomist and an exceptional teacher of operative medicine, wrote several books and developed several surgical instruments that are still in use. His career was no bed of roses, but distinctly thorny – which by no means prevented his legacy from enduring.</div></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"143 3","pages":"Pages 234-237"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of two quality-of-life questionnaires in cochlear implanted children","authors":"C. Chandrakumar,&nbsp;F.-X. Bétolaud,&nbsp;N. Noël-Petroff,&nbsp;T. Deray,&nbsp;T. Van Den Abbeele,&nbsp;E. Bois","doi":"10.1016/j.anorl.2025.10.006","DOIUrl":"10.1016/j.anorl.2025.10.006","url":null,"abstract":"<div><div>The present cross-sectional study compared efficacy between two quality-of-life questionnaires for cochlear implanted children: CIQOL-10 Global and PEACH. Forty cochlear implanted children, aged 18 months to 15 years, were included over a 3-month period. Children not wearing the implant, from non-French-speaking families, with psychomotor retardation or neurologic deficit were excluded. Ease of filling out the questionnaires and their relevance were assessed on Visual Analog Scales. The aim was to select the questionnaire better adapted to an implanted pediatric population. PEACH scored significantly better than CIQOL for ease of use and relevance, particularly for under-6 year-olds. On average, 3 of the 10 CIQOL questions went unanswered for children aged<!--> <!-->≤<!--> <!-->6 years, versus just 1 out of 13 for PEACH. PEACH, being easier to answer and more relevant, particularly for younger children, can optimize follow-up of cochlear implanted children.</div></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"143 2","pages":"Pages 95-98"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145355783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulsatile tinnitus with pulsatile tympanic membrane without retrotympanic mass: A CARE case report","authors":"D. Moreau ,&nbsp;O. Heck ,&nbsp;S. Schmerber ,&nbsp;R. Quatre","doi":"10.1016/j.anorl.2026.01.002","DOIUrl":"10.1016/j.anorl.2026.01.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Giant arachnoid granulation can induce lateral sinus stenosis with sigmoid sinus dehiscence, causing pulsatile tinnitus with pulsatile tympanic membrane without retrotympanic mass.</div></div><div><h3>Case report</h3><div>A 78 year-old man presented unilateral left pulsatile tinnitus since 2009, with recent aggravation. Otoendoscopy showed a pulsatile tympanic membrane, in which movement was halted by jugular compression or Valsalva maneuver. CT angiography and MRI found large arachnoid granulation causing left lateral sinus stenosis and eroding the sigmoid sinus wall. Stenting resolved the tinnitus, while the eardrum remained pulsatile.</div></div><div><h3>Discussion</h3><div>Giant arachnoid granulation can induce lateral sinus stenosis and sigmoid sinus dehiscence, with turbulent venous flow and pulsatile tinnitus. The erosion can transmit cerebrospinal fluid pulsation to the sigmoid sinus and then to the tympanic membrane, where it is visible on otoscopy when the membrane is fragile.</div></div>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"143 2","pages":"Pages 131-133"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral epistaxis and nasal obstruction in a middle-aged woman","authors":"S. Moon ,&nbsp;E. Shin ,&nbsp;J.W. Kang","doi":"10.1016/j.anorl.2025.12.002","DOIUrl":"10.1016/j.anorl.2025.12.002","url":null,"abstract":"","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":"143 2","pages":"Pages 142-144"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}