唾液腺癌(不包括腺样囊性癌)的全身治疗:REFCOR通过正式共识方法推荐。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-01 DOI:10.1016/j.anorl.2023.11.004

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引用次数: 0

摘要

目的:根据临床情况，确定涎腺癌(不包括腺样囊性癌)全身性药物治疗的指征。材料和方法:法国罕见头颈部肿瘤网络(REFCOR)成立了一个指导小组，起草了Medline上发表的文献的叙述性综述，并提出了建议。然后，根据正式的共识方法，由一个评级小组评估对建议的遵守程度。结果:唾液腺癌是罕见的，目前没有足够的证据表明在局部阶段化疗。在转移期，最初的管理可以基于对惰性疾病的监测阶段。一些组织学亚型(唾液管癌和腺癌)更具侵袭性，需要从一开始就进行全身治疗。为了指导全身治疗，建议进行免疫组织化学和分子生物学分析(HER2和雄激素受体的过表达，NTRK融合，下一代测序)。结论:唾液腺癌是一种罕见的肿瘤，目前有效的治疗方法很少。因此，建议将患者纳入临床试验。

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Systemic therapies for salivary gland carcinoma (excluding adenoid cystic carcinoma): REFCOR recommendations by the formal consensus method

Objective

To determine the therapeutic indications for systemic medical treatment in the management of salivary gland carcinoma (excluding adenoid cystic carcinoma) according to the clinical situation.

Materials and methods

The French Network of Rare Head and Neck Tumors (REFCOR) formed a steering group who drafted a narrative review of the literature published on Medline and proposed recommendations. The level of adherence to the recommendations was then assessed by a rating group, according to the formal consensus method.

Results

Salivary gland carcinoma is rare and there is currently insufficient evidence to indicate chemotherapy at the localized stage. At the metastatic stage, initial management can be based on a phase of monitoring for indolent disease. Some histological subtypes (salivary duct carcinoma and adenocarcinoma) are more aggressive and require systemic treatment from the outset. To guide systemic treatment, it is recommended to perform immunohistochemistry and molecular biology analyses (overexpression of HER2 and androgen receptors, NTRK fusion, next-generation sequencing).

Conclusion

Salivary gland carcinoma is a rare tumor for which there are currently few effective medical treatments. It is therefore recommended to include patients in clinical trials.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.