Infectious Diseases of Poverty最新文献

{"title":"Live attenuated RHΔtkl1 and PruΔpp2a-c mutants of Toxoplasma gondii are promising vaccine candidates conferring protection in pigs.","authors":"Ze-Xuan Wu, Yu Kang, Zhi Zheng, Wen-Bo Hao, Shi-Bo Huang, Yu-Xuan Wang, Xiao-Nan Zheng, Xing-Quan Zhu","doi":"10.1186/s40249-026-01451-8","DOIUrl":"10.1186/s40249-026-01451-8","url":null,"abstract":"<p><strong>Background: </strong>Toxoplasma gondii is an apicomplexan parasite which infects nearly all warm-blooded animals and humans, causing zoonotic toxoplasmosis. Pork infected with T. gondii is considered a significant source of human infection. Currently, no commercial vaccines are available for porcine toxoplasmosis globally, thus a safe and effective vaccine is urgently needed. This study evaluated the immuno-protective effects of two T. gondii gene knockout attenuated strains, RHΔtkl1 and PruΔpp2a-c, in pigs.</p><p><strong>Methods: </strong>Pigs immunized by intramuscular injection with 1 × 10⁷ tachyzoites of attenuated RHΔtkl1 or PruΔpp2a-c strains were challenged orally with 1.000 sporulated oocysts of the Pru strain at 28 days post-vaccination (dpv), followed by a secondary challenge via intraperitoneal injection of 1 × 10⁷ Pru strain tachyzoites at 70 dpv. Clinical signs were monitored. T. gondii-specific antibody levels were examined by enzyme-linked immunosorbent assay. The protective efficacy was evaluated by analyzing pathological lesions, pathological score, parasite load, brain cyst burden, and by mouse bioassay. GraphPad Prism software was employed to perform the log-rank (Mantel Cox) test, Student's t test and one-way ANOVA.</p><p><strong>Results: </strong>Pigs immunized with either RHΔtkl1 or PruΔpp2a-c exhibited only low-grade fever. Combined with pathological changes and pathological scores, these findings support the moderate safety of both strains. Pigs immunized with either RHΔtkl1 or PruΔpp2a-c and subsequently challenged with T. gondii Pru oocysts and tachyzoites exhibited a sharp increase in T. gondii-specific antibodies, which remained high for 5 weeks (P < 0.01). Pathological lesions were alleviated after immunization, with a significant reduction in parasite load observed in tissues including the brain, heart, gastrocnemius, longissimus dorsi, psoas major, and diaphragm (P < 0.01). Furthermore, a marked decrease in brain cyst burden was recorded (P < 0.0001). Mouse bioassay results confirmed a significant reduction in the proportion of mouse brain tissues positive for T. gondii genomic DNA in the group immunized and then challenged, compared to the non-immunized challenged group (P < 0.0001).</p><p><strong>Conclusions: </strong>The two live attenuated RHΔtkl1 and PruΔpp2a-c mutants of demonstrated moderate safety, immunogenicity, and protective efficacy in pigs, identifying them as potential candidate vaccines against porcine toxoplasmosis.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"15 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influenza vaccine hesitancy versus uptake in seven Chinese megacities: a cross-sectional survey.","authors":"Tao Li, Qian Xiong, Peixin Wu","doi":"10.1186/s40249-026-01445-6","DOIUrl":"10.1186/s40249-026-01445-6","url":null,"abstract":"<p><strong>Background: </strong>Influenza vaccine hesitancy remains a major barrier to achieving adequate vaccination coverage, particularly in densely populated urban areas with aging populations. Seven Chinese megacities are especially vulnerable to influenza transmission, yet evidence on drivers of vaccine hesitancy in these contexts remains limited. This study aimed to assess the prevalence and determinants of influenza vaccine hesitancy (IVH) among urban populations to inform strategies for improving vaccine uptake in China.</p><p><strong>Methods: </strong>We conducted a multi-city cross-sectional survey from March to June 2025 across seven Chinese megacities (Beijing, Shanghai, Guangzhou, Shenzhen, Tianjin, Chongqing, and Chengdu). Participants were selected using a stratified sampling strategy within communities; eligible participants were residents (aged ≥ 18 years) who had lived in the selected communities for at least six months. Data on demographic, socioeconomic, attitudinal factors, and behavioural factors were collected. Multivariable logistic regression was used to identify factors associated with IVH and pre-season influenza vaccine uptake.</p><p><strong>Results: </strong>A total of 8689 participants were included. Overall, 45% of participants were classified as vaccine hesitant, while the self-reported influenza vaccination coverage for the 2024 season was 30%. Substantial variation in hesitancy was observed across megacities. Older adults (≥ 65 years) were less likely to report IVH than younger adults (18-44 years) [adjusted odds ratio (aOR) = 0.72, 95% confidence interval (CI): 0.55-0.93] and more likely to be vaccinated (aOR = 1.63, 95% CI: 1.35-1.96). Psychosocial factors were the strongest predictors of hesitancy, particularly low perceived vaccine benefit (aOR = 11.18, 95% CI: 8.45-14.64) and low trust in health authorities (aOR = 17.13, 95% CI: 13.51-21.71). Vaccination uptake was primarily associated with behavioural factors, especially prior COVID-19 vaccination (aOR = 0.32, 95% CI: 0.25-0.39).</p><p><strong>Conclusions: </strong>Influenza vaccination in Chinese megacities is driven by a mix of demographic, psychosocial, and behavioural factors. Targeted strategies addressing both hesitancy and uptake are needed to improve coverage and reduce influenza transmission.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"15 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13137521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First imported case of New World leishmaniasis in Romania: diagnostic and therapeutic challenges in a non-endemic country.","authors":"Andrei Daniel Mihalca, Ioana Bianca Mitrea, Mihaela Sorina Lupșe, Angela Monica Ionică, Gad Baneth, Yaarit Nachum-Biala, Jaideep Kumar, Marian Taulescu, Filipe Dantas-Torres, Felipe Marinho Rocha de Macedo, Simona Corina Șenilă","doi":"10.1186/s40249-026-01448-3","DOIUrl":"10.1186/s40249-026-01448-3","url":null,"abstract":"<p><strong>Background: </strong>Leishmaniasis is a vector-borne protozoan disease with cutaneous, mucocutaneous, and visceral forms. In Europe, most cases involve Old World species, while imported New World infections are rare. We report the first imported human case of New World cutaneous leishmaniasis in Romania.</p><p><strong>Case presentation: </strong>A 25-year-old woman developed progressive ulcerative lesions on her left arm after travel to Panama and Costa Rica. Initial biopsy revealed granulomatous inflammation without identifying the agent. A second biopsy detected amastigotes within macrophages, and molecular analyses (ITS1 sequencing, hsp70 phylogenetic analysis) identified Leishmania panamensis. The patient received oral miltefosine for 28 days, with gradual improvement and complete healing with atrophic scars. No relapse occurred 473 days post-treatment.</p><p><strong>Conclusions: </strong>This case highlights diagnostic challenges in non-endemic regions, emphasizing the need to raise clinical awareness and improve access to molecular tools for prompt recognition and management of imported leishmaniasis in Eastern Europe.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"15 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate drivers and winter constraints of dengue epidemics: a 10-year epidemiological perspective study in the Lao People's Democratic Republic.","authors":"Souphatsone Houatthongkham, Jae Hyun Kim, Bouaphanh Khamphaphongphane, Phonepadith Xangsayarath, Jong-Hun Kim, Sung Hye Kim","doi":"10.1186/s40249-026-01438-5","DOIUrl":"10.1186/s40249-026-01438-5","url":null,"abstract":"<p><strong>Background: </strong>Dengue fever is hyperendemic in the Lao People's Democratic Republic (PDR), where transmission is driven by Aedes mosquitoes and influenced by large-scale climatic phenomena, including the El Niño-Southern Oscillation (ENSO) and the Indian Ocean Dipole (IOD). As a landlocked nation, the Lao PDR experiences sharper winter temperature declines than coastal regions, which may impose a seasonal \"bottleneck\" on vector survival and dengue transmission. This study examined whether winter minimum temperatures act as a seasonal transmission bottleneck, alongside the Oceanic Niño Index (ONI) and the Dipole Mode Index (DMI), during 2014-2023.</p><p><strong>Methods: </strong>Monthly dengue case counts reported to the National Center for Laboratory and Epidemiology, Ministry of Health, Lao PDR, from January 2014 to December 2023 were analyzed using region-specific quasi-Poisson distributed lag nonlinear models. Models incorporated 3-month-lagged ONI/DMI cross-basis functions, winter minimum temperature hinges, long-term trends, and seasonality, with population as an offset. Region-specific estimates were pooled using multivariate meta-analysis to generate best linear unbiased predictions (BLUPs). Optimal lag structures and temperature thresholds were selected by minimizing the quasi-Akaike information criterion and residual sum of squares.</p><p><strong>Results: </strong>A total of 134,093 dengue cases were reported, with substantial regional heterogeneity. The Capital Region had the highest burden (40,672 cases; annual incidence 35.4 per 100,000), followed by the Southern Mountains and Tropical Rainforests region (20,176 cases; 23.3 per 100,000). Annual incidence in each region appeared constrained by region-specific winter minimum temperature thresholds. Pooled BLUPs analyses adjusted for covariates revealed monotonic cumulative relative risk increases with ONI [RR = 2.83 at ONI = 2.0; 95% confidence interval (CI): 1.46-5.49) and decreases with DMI (RR = 0.37 at DMI = 1.5; 95% CI: 0.24-0.59).</p><p><strong>Conclusions: </strong>Winter cold functions as a primary bottleneck for dengue transmission in the Lao PDR, with ENSO amplifying and IOD suppressing outbreak risk. These findings support the development of climate-integrated, region-specific early warning systems. Incorporating 3-month-lagged climate indices may enhance public health preparedness for future dengue outbreaks.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"15 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress and challenges in development of minimum essential dataset for disease surveillance through a One Health lens: a scoping review.","authors":"Tianyun Li, Lijun Jia, Ne Qiang, Jinxin Zheng, Jinjun Ran, Xiaoxi Zhang, Lefei Han","doi":"10.1186/s40249-026-01437-6","DOIUrl":"10.1186/s40249-026-01437-6","url":null,"abstract":"<p><strong>Background: </strong>Minimum essential dataset (MED) enables One Health surveillance by facilitating cross-sectoral data sharing. Yet, existing MED research represents insufficient integration of the One Health concept, and its progress in disease surveillance remains unclear. This study aims to evaluate the current progress and gaps in MED research in disease surveillance through a One Health lens.</p><p><strong>Methods: </strong>This scoping review systematically searched Embase, PubMed, Scopus, and Web of Science from the inception of databases to November 30th, 2024 to identify studies published in English. Studies were independently screened by two reviewers for inclusion based on their relevance to the development of MEDs for disease surveillance. The progress and challenges were synthesized based on data extracted from eligible studies.</p><p><strong>Results: </strong>This review includes 28 eligible studies for analysis, all of which focused on infectious diseases. MED development is predominantly concentrated on the human health interface (89.3%), whereas animal and environmental interfaces are comparatively limited (≤ 10.7%). The One Health concept has been adopted in 16 of the eligible studies; however, there is still insufficient interdisciplinary and cross-sectoral collaboration (57.1%). Meanwhile, numerous methods have been employed in the development of MEDs, with qualitative approaches being the most prevalent (42.9%), while data-driven approaches remain scarce. The absence of a standardized approach is recognized as a primary barrier. Thus, we propose a pathway and operational tool to detail the specific steps, which could facilitate future research on MED.</p><p><strong>Conclusion: </strong>This review highlights critical gaps in MED development at the human-animal-environment interface, and proposes a pathway and operational tool to inform future development of MED, including scope identification, establishment, modification and improvement. This study promotes the improvement of disease surveillance system and provides insights to enhance future preparedness for reducing the global public health burden.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"15 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13093924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147730376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ecological environmental management program promotes Schistosomiasis control in Erhai Lake of China: an analysis based on SWOT-ANP-ADAM approach.","authors":"Hongqiong Wang, Jing Song, Shizhu Li, Xinping Shi, Siqi Ning, Yuwan Hao, Chunhong Du, Yi Dong","doi":"10.1186/s40249-026-01442-9","DOIUrl":"10.1186/s40249-026-01442-9","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The transmission of Schistosoma japonicum is closely related to the surrounding natural environment and socio-economic factors. In recent years, the ecological environmental management program has been implemented in S. japonicum endemic areas around Erhai Lake of China. Relevant protection and governance measures affected the transmission of S. japonicum. This study was conducted to assess the impact of ecological environmental management program on S. japonicum control, and proposed strategic alternatives with a prioritized order of implementation in Erhai Lake.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;An integrated SWOT-ANP-ADAM analysis is performed to accomplish the set objective in this study. The strengths, weaknesses, opportunities, and threats (SWOT) analysis is conducted to identify the impact factors of ecological environmental management program on S. japonicum control and strategic alternatives. The Analytical Network Process (ANP) was used to evaluate the impact factors, and the Axial Distance-Based Aggregated Measurement (ADAM) method was applied to constructed multi-faceted polyhedron for the ranking the strategic alternatives, thereby better informing decisions for synergistic ecological-disease management.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 14 impact factors and 12 strategic alternatives were obtained. The relative importance of the group of impact factors is ranked as strengths, opportunities, weaknesses, and threats, with weights equal to 0.3092, 0.2610, 0.2324, and 0.1975, respectively. The Chinese central government's prioritization of S. japonicum control and ecological environmental management (weight equal to 0.1562), as well as the lack of a top-level cooperative mechanism designed to integrate S. japonicum control and ecological environmental management (weight equal to 0.1424), are the most noteworthy factors. In ecological environmental management program of Erhai Lake, management of agricultural non-point source pollution (weight equal to 0.1209), construction of high-efficiency water-saving irrigation systems(weight equal to 0.0853) reduce the risk of S. japonicum transmission, while the wetland restoration may create more favorable habitats for Oncomelania hupensis, as well as increase the number of wildlife populations posing challenges for S. japonicum control(weight equal to 0.0700). Additionally, construction of the ecological management- S. japonicum control model in an integrated manner is the most important strategy (volume of complex polyhedron equal to 0.0693).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Ecological environmental management program in the Erhai Lake has significant strengths and opportunities in promoting S. japonicum control, but also faces certain weaknesses and threats according to the weight of impact factors. This study confirms ecological environmental management as a viable complementary strategy to conventional S. japonicum control. Scientific planning and com","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"15 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13072597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Access to praziquantel in Italy: persistent gaps and ongoing responses amid a Europe-wide shortage.","authors":"Rosalia Marrone, Cristiano Camponi, Silvia Cammarata, Domenico Di Giorgio, Robert Giovanni Nisticò, Christian Napoli","doi":"10.1186/s40249-026-01435-8","DOIUrl":"10.1186/s40249-026-01435-8","url":null,"abstract":"<p><p>In Italy, praziquantel (PZQ) is not registered for human use and can be imported from European countries where it is authorized, according to a specific ministerial decree. Recent Europe-wide shortages, however, have made this route impractical, resulting in the unavailability of this essential medicine. This editorial summarizes historical gaps in supply, the actions undertaken, and the interim solutions implemented to restore PZQ access in Italy. The Italian experience highlights broader challenges related to essential medicines and underscores the need for coordinated national and European strategies to ensure stable and equitable availability.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"15 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13072471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whipple's disease with multiple serous effusions as the clinical manifestation: a case report and literature review.","authors":"Luan Zhang, Tianyi Wu, Nannan Xu, Gang Wang, Lintao Sai, Lili Wang, Hui Yang, Shanshan Wang, Ke Xu","doi":"10.1186/s40249-026-01441-w","DOIUrl":"10.1186/s40249-026-01441-w","url":null,"abstract":"<p><strong>Background: </strong>Whipple's disease, caused by Tropheryma whipplei, is a rare multisystem infectious disorder with diverse clinical manifestations. Typical symptoms include arthralgia, nausea, vomiting, diarrhoea, and weight loss, while nonspecific features such as fever, anaemia, and lymphadenopathy may also occur. Presentations with multiple serous effusions are exceedingly rare. Diagnosis remains particularly challenging in resource-limited regions because of nonspecific symptoms and limited access to advanced diagnostic techniques.</p><p><strong>Case presentation: </strong>A 34-year-old male presented with fever, vomiting, diarrhoea, mild dry cough, and anorexia. Whole-body computed tomography revealed systemic inflammatory changes that mimicked vasculitis, including multiple serous effusions (pleural, peritoneal, pericardial, and pelvic) and omental thickening. Initial anti-infective therapy failed. Serological tests, pleural fluid analysis, and thoracoscopic pleural biopsy excluded systemic vasculitis and pleural malignancy. Given the diagnostic uncertainty, subsequently 18F-fluorodeoxyglucose positron emission tomography demonstrated diffuse peritoneal thickening accompanied by hypermetabolism, which prompted a biopsy. Definitive diagnosis was achieved via laparoscopic omental biopsy with histopathology, periodic acid-Schiff staining, and polymerase chain reaction. Despite receiving targeted antibiotic therapy for T. whipplei, the patient showed suboptimal clinical improvement. We speculated that the recurrence of the patient's condition was more likely attributable to immune reconstitution inflammatory syndrome. Combination therapy with doxycycline, hydroxychloroquine, and short-term glucocorticoids induced sustained remission. After more than 2 years of targeted anti-T. whipplei therapy, the patient demonstrated a favourable recovery.</p><p><strong>Conclusions: </strong>Multiple serous effusions are uncommon clinical manifestations of Whipple's disease. Early identification of T. whipplei infection and timely targeted therapy are critical for improving patient prognosis.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"15 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13072459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dengue transmission dynamics in China's border regions adjacent to Myanmar.","authors":"Yanshu Ke, Hongjie Wei, Chunhai Luo, Jiahui Li, Fang Xie, Bingbing Wang, Hong Liu, Hongning Zhou, Qiuping Chen, Jia Rui, Tianmu Chen","doi":"10.1186/s40249-026-01440-x","DOIUrl":"10.1186/s40249-026-01440-x","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Dengue fever is a major mosquito-borne disease that is spreading rapidly from endemic regions to previously low-incidence regions. The regions at the interface between Southeast Asia and China represent critical hotspots for the cross-border and subsequent local transmission of dengue fever. In this study, a cross-population transmission model was constructed to characterize the transmission dynamics in China's border regions adjacent to Myanmar.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Dengue case data from the dengue fever case reporting system were collected for Dehong Dai and Jingpo Autonomous Prefecture (DH) and Lincang City (LC), which are situated along the China-Myanmar border in southwestern China (2014-2023). We analyzed spatiotemporal patterns of dengue transmission and developed a transmission dynamics model that accounts for vertical transmission in mosquitoes to quantify transmission dynamics at three levels: the overall disease system, mosquito-to-human, and human-to-mosquito. Model parameters were estimated using least-squares fitting to observed case data, and model performance was evaluated using the coefficient of determination (R&lt;sup&gt;2&lt;/sup&gt;).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;From 2014 to 2023, a total of 10,180 dengue cases were documented across two China's border prefectures adjacent to Myanmar, 83.1% of which were locally acquired infections. There were 7,893 cases reported in DH (906 international imports, 6,961 local) and 2,287 cases reported in LC (717 international imports, 1,497 local). Transmission exhibited pronounced seasonality, peaking between July and November, and a strong temporal correlation between imported and local cases was observed. By using a dynamic transmission model incorporating mosquito vertical transmission, we achieved statistically significant model fits (P &lt; 0.001) and quantified temporal changes in transmissibility. During the rising phases of the outbreak, the overall transmissibility consistently exceeded 1. Analysis of directional transmission revealed a marked temporal shift: human-to-mosquito transmissibility was predominant in earlier outbreak years (2017: 1-5 in DH, 10-15 in LC), whereas mosquito-to-human transmissibility has increased substantially in recent years (2023: 5-15 in DH, 10-20 in LC). Sensitivity analyses demonstrated that while overall transmissibility estimates remained robust across different initial mosquito population assumptions, the directional transmission components were sensitive to the ratio of exposed to infected mosquitoes, reflecting the inherent identifiability challenges of the model in the absence of entomological surveillance data.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Our findings reveal the dengue transmission dynamics in China's border regions adjacent to Myanmar over the 2014-2023 study period. Our results underscore the necessity of integrating entomological monitoring with case-based surveillance and support enhanced cross-border ","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"15 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13055008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of human population movement on mass drug administration for neglected tropical diseases: a scoping review.","authors":"Moussa Sangare, Oumar Coulibaly, Claudia Duguay, Abdoul Fatao Diabate, Dukharmel Nazaire, Kiflom Hailu, Yaya Ibrahim Coulibaly, Carol Vlassoff, Manisha A Kulkarni, Alison Krentel","doi":"10.1186/s40249-026-01433-w","DOIUrl":"10.1186/s40249-026-01433-w","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Neglected tropical diseases (NTDs), including but not limited to lymphatic filariasis, onchocerciasis, trachoma, schistosomiasis, and soil-transmitted helminths, remain a major public health challenge in Africa. Mass drug administration (MDA) is a key strategy for NTD control and elimination. However, mobile populations such as internally displaced persons (IDPs), nomadic groups, and seasonal workers often face major constraints that reduce MDA effectiveness defined by coverage. Understanding how mobility and its underlying drivers affect MDA implementation is therefore critical to designing inclusive, effective, and equitable intervention strategies. In this review, we aim to map existing evidence on how human population movement influences the outcomes of MDA programs in Africa.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Following PRISMA-ScR guidelines, we searched using electronic databases Medline (Ovid), Embase, Web of Science, and manually screened additional sources for studies published in English or French between January 2000 and February 19, 2025. Two authors independently extracted data, resolving discrepancies through discussion, or with a third reviewer. We included studies reporting on MDA interventions and mobile or migrant populations in Africa. Data were extracted using a standardized template and synthesized thematically to describe mobility patterns, barriers to access, implementation gaps, and strategies used to improve MDA reach among mobile groups. The thematic synthesis consisted of organizing the extracted data into recurring themes, comparing trends across studies, and grouping similar observations to develop broader themes that reflect common challenges and approaches related to mobile populations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;From 6814 studies identified, twenty (20) met the inclusion criteria. The review identified multiple challenges likely to affect MDA equity and effectiveness. Mobility, particularly among nomad pastoralists, seasonal workers, IDPs, and cross-border populations leads to systematic exclusion from MDA campaigns. Barriers included geographic inaccessibility, limited tailored communication, lack of cross-border collaboration/coordination, and rigid campaign schedules. Promising strategies documented were mobility-informed microplanning, cross-border collaboration/coordination, flexible delivery models, enhanced community engagement and integration with other health interventions. The evidence emphasizes the need for adaptive, equity-focused MDA approaches to effectively reach mobile populations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Population mobility has a significant impact on equitable MDA delivery and can hinder progress toward NTD elimination targets in Africa. Tailored, flexible, and inclusive strategies are urgently needed to ensure mobile populations are reached. Future efforts should focus on developing mobility indicators, pilot-testing adaptive MDA delivery models alig","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"15 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13054986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}