International Journal of Radiation Research最新文献_第10页

Increased second primary liver cancer risk in young breast cancer patients undergoing radiotherapy and chemotherapy: a nationwide population-based study 在接受放疗和化疗的年轻乳腺癌患者中，第二原发性肝癌的风险增加:一项基于全国人群的研究

IF 0.6 4区医学

International Journal of Radiation Research Pub Date : 2022-04-01 DOI: 10.52547/ijrr.20.2.6

I. Seo, H. Jang

{"title":"Increased second primary liver cancer risk in young breast cancer patients undergoing radiotherapy and chemotherapy: a nationwide population-based study","authors":"I. Seo, H. Jang","doi":"10.52547/ijrr.20.2.6","DOIUrl":"https://doi.org/10.52547/ijrr.20.2.6","url":null,"abstract":"Background : Although chemotherapy (CT) and radiotherapy (RT) are important breast cancer (BC) treatment modalities, they can cause other cancers. However, second cancers of liver and stomach tend to be ignored during BC treatment. In this study, the incidence patterns of second primary cancer of liver and stomach were analyzed. Materials and Methods : The insurance claim data of patients that underwent definitive surgery from 2009 to 2010 were analyzed. Standardized incidence ratios (SIRs) were used to estimate the relative risks of second primary liver cancer (SPLC) and second primary stomach cancer (SPSC). In addition, hazard ratios (HRs) of risk factors were analyzed. Data were obtained on 21,024 BC patients that underwent definitive mastectomy. Results : The median follow - up period was 105.5 months. Overall SIRs for SPLC and SPSC were 7.26 (p<0.01) and 2.92 (p<0.01). In the young age group (aged 20–39 years), the crude HR for CT was 2.27 (p < 0.05) and the age/RT adjusted HR was 2.37 (p<0.05). RT also showed a tendency to induce SPLC. The effect of CT peaked within 5 years after treatment, whereas the effect of RT gradually increased after 5 years. Conclusion : This study shows CT and RT both increase the risk of SPLC in BC patients and that these increases are greater in young BC patients. Times to SPLC occurrence after RT and CT were found to differ.","PeriodicalId":48815,"journal":{"name":"International Journal of Radiation Research","volume":"51 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75557609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complementary killing effect of tirapazamine in combination with radiation therapy on cells with high aldehyde dehydrogenase activity in SAS cell line 替拉帕嗪联合放疗对SAS细胞系高醛脱氢酶活性细胞的补充杀伤作用

IF 0.6 4区医学

International Journal of Radiation Research Pub Date : 2022-04-01 DOI: 10.52547/ijrr.20.2.3

K. Ichise, K. Hirose, M. Sato, F. Komai, M. Tanaka, I. Fujioka, H. Kawaguchi, Y. Hatayama, Y. Takai, M. Aoki

{"title":"Complementary killing effect of tirapazamine in combination with radiation therapy on cells with high aldehyde dehydrogenase activity in SAS cell line","authors":"K. Ichise, K. Hirose, M. Sato, F. Komai, M. Tanaka, I. Fujioka, H. Kawaguchi, Y. Hatayama, Y. Takai, M. Aoki","doi":"10.52547/ijrr.20.2.3","DOIUrl":"https://doi.org/10.52547/ijrr.20.2.3","url":null,"abstract":"Background : Tumor cells with high aldehyde dehydrogenase activity (ALDH high cells) are induced by an intratumoral hypoxic condition and lead to radioresistance, tumor recurrence, and metastasis. Therefore, to enhance the anti - tumor effect of radiotherapy, it is reasonable to efficiently control ALDH high cells by targeting them. In this study, we evaluated the effect of tirapazamine, a hypoxic toxin, combined with irradiation on ALDH high cells. Materials and Methods : Human tongue squamous cell carcinoma SAS cells were used in this study. Spheroids were irradiated with 6 Gy following treatment with 40 μ M tirapazamine. After 24, 48, and 72 hours, the populations of ALDH high cells were analyzed. The frozen sections of spheroids were prepared, and hypoxia - inducible factor - 1 α- positive areas and ALDH1 - positive areas were detected. Results : Compared with the cells grown in monolayer culture, the SAS cells grown in spheroids exhibited radioresistance. Furthermore, the proportion of ALDH high cells was significantly higher in spheroids than in monolayer culture. The ALDH high cells were sustained in a hypoxic fraction localized at the center of the spheroids after irradiation. Tirapazamine effectively reduced these ALDH high cells. The combination of tirapazamine with irradiation showed an additive cytotoxic effect in spheroids, but not in parental cells, which was consistent with a preferential killing effect of tirapazamine on ALDH high cells. Conclusion : Combined tirapazamine and radiotherapy administration appeared to be a reasonable approach to control ALDH high cells in hypoxic regions that may be involved in recurrence and metastasis.","PeriodicalId":48815,"journal":{"name":"International Journal of Radiation Research","volume":"66 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83248625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytogenetic and immunological efficacy of nicotiflorin and rutin combination on gamma irradiated rats 烟碱与芦丁联合对γ辐照大鼠细胞遗传学和免疫学的影响

IF 0.6 4区医学

International Journal of Radiation Research Pub Date : 2022-04-01 DOI: 10.52547/ijrr.20.2.29

M. R. Mohammed, M. M. Ahmed, S. A. Montaser

{"title":"Cytogenetic and immunological efficacy of nicotiflorin and rutin combination on gamma irradiated rats","authors":"M. R. Mohammed, M. M. Ahmed, S. A. Montaser","doi":"10.52547/ijrr.20.2.29","DOIUrl":"https://doi.org/10.52547/ijrr.20.2.29","url":null,"abstract":"Background : Cytogenetic and immunological damages after ionizing radiation exposure are critical factors that lead to many different events and consequences cascade reactions starting from inflammation, ending with cell damage. These biological events if not well controlled will lead to deleterious effects and cancer. The present study aimed to evaluate the efficacy of the Nicotiflorin and Rutin (NR) combination against drastic effects resulted from γ-irradiation. Materials and Methods : Rats were divided into four groups. (Control) group, (NR) group: treated with 20mg/kg body weight orally daily one dose for two weeks, (Irrad) group: rats exposed to 6Gy as a single dose, and (NR+ Irrad) group which treated with NR combination before irradiation. Detection of DNA damage was done with the Micronucleus test (MN) and Comet assay. Immunological responses were detected by assessing inflammatory cytokines Interluekines-1β (IL-1β), tumor necrosis factor (TNF-α), and homeostasis maintenance cytokines (IL-6 & IL-10). Results : Irradiated group recorded a significant increase in micronuclei (MNi) incidences and significant DNA fragmentation. As well, immunological parameters displayed a significant increase in all measured interleukins except IL-10 which recorded a significant decline. The group injected with NR before irradiation showed significant improvement in all measured parameters. Conclusion : The efficacy of the NR combination may be attributed to its dual protective effects (cytogenetic and immunological enhancement) against damage caused by γ-irradiation.","PeriodicalId":48815,"journal":{"name":"International Journal of Radiation Research","volume":"181 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74323937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Tumor size impacts the performance of ultrasound BI-RADS classification in breast cancer patients 肿瘤大小影响超声BI-RADS在乳腺癌患者中的分类效果

IF 0.6 4区医学

International Journal of Radiation Research Pub Date : 2022-04-01 DOI: 10.52547/ijrr.20.2.13

Q. Guo, Z. Dong, L. Jiang, L. Zhang, Z. Li, D. Wang

引用次数: 0

A preliminary application research of dual-energy spectral CT in breast cancer diagnosis 双能谱CT在乳腺癌诊断中的初步应用研究

IF 0.6 4区医学

International Journal of Radiation Research Pub Date : 2022-04-01 DOI: 10.52547/ijrr.20.2.5

L.J. Chen, B. Wang, S.F. Wang, Z.L. Xu, L. Jin, M. Hu, G.Y. Wang, X.P. Yang

{"title":"A preliminary application research of dual-energy spectral CT in breast cancer diagnosis","authors":"L.J. Chen, B. Wang, S.F. Wang, Z.L. Xu, L. Jin, M. Hu, G.Y. Wang, X.P. Yang","doi":"10.52547/ijrr.20.2.5","DOIUrl":"https://doi.org/10.52547/ijrr.20.2.5","url":null,"abstract":"Background : The objective of this study was to retrospectively analyze the application of dual-energy spectral computerized tomography (DECT) to accurately diagnose breast cancer and lymph node metastasis. Materials and Methods : Between May 2018 and December 2019, 37 patients (22 with breast cancer and 15 with normal breast cancer) who underwent spectral CT imaging were analyzed. Metastatic lymph nodes were identified in 14 patients with breast cancer. Twelve patients who underwent traditional CT were included randomly as the control group to compare the radiation dose with spectral CT. Monochromatic levels with an optimal contrast-to-noise ratio for normal breast tissue were obtained. Quantitative parameters of spectral CT were compared between normal breast and breast cancer patients. The spectral curve, histogram, and scatter plot features of metastatic lymph nodes and primary lesions were analyzed. Results : The monochromatic level with the optimal contrast-to-noise ratio of the breast was approximately 65keV. All quantitative parameters, including values at 40keV–140keV, the concentrations of iodine, spectral curve slope (λ HU ), and relative iodine concentration were increased in breast cancer compared to those in healthy breasts. Metastatic lymph nodes were more consistent with primary breast cancer lesions in the spectral curve, histogram, and scatter plot, especially in the venous phase. Additionally, the radiation of spectral CT was decreased compared to that of traditional CT. Conclusion : S pectral CT can be used to identify breast cancer and metastatic lymph nodes.","PeriodicalId":48815,"journal":{"name":"International Journal of Radiation Research","volume":"12 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86680682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radioprotective effect of hesperidin against ovarian toxicity induced by Ionizing radiation through inhibiting oxidative stress in mice 橙皮苷通过抑制氧化应激对小鼠电离辐射卵巢毒性的辐射防护作用

IF 0.6 4区医学

International Journal of Radiation Research Pub Date : 2022-04-01 DOI: 10.52547/ijrr.20.2.24

S. Hosseinpour, A.E. Nejad Moghaddam, F. Talebpour Amir, S. Hosseinimehr, M. Zargari, A. Karimpour Malekshah, A. Ghasemi

{"title":"Radioprotective effect of hesperidin against ovarian toxicity induced by Ionizing radiation through inhibiting oxidative stress in mice","authors":"S. Hosseinpour, A.E. Nejad Moghaddam, F. Talebpour Amir, S. Hosseinimehr, M. Zargari, A. Karimpour Malekshah, A. Ghasemi","doi":"10.52547/ijrr.20.2.24","DOIUrl":"https://doi.org/10.52547/ijrr.20.2.24","url":null,"abstract":"Background : Radiotherapy enhances the risk of ovarian injury induced by oxidative stress in the female patients. Hesperidin, as a natural compound has various biological properties included anti - tumoral, antioxidant, and anti - inflammatory activities. This research evaluated the effects of hesperidin on ovarian damage induced by IR. Materials and Methods : Twenty - eight female mice distributed to four groups randomly: Control, Hesperidin (100mg/kg), ionizing radiated (IR) (3.2 Gy), and ionizing radiated + hesperidin groups (3.2Gy + 100mg/kg). Hesperidin was administrated orally for 7 successive days. Animals were exposed to total body irradiation on the 8th day of study. Biochemical, hormonal (estrogen and progesterone), and histopathological assessments did on day 12. Results : IR group demonstrated necrosis, apoptosis, and atresia in ovaries, decreased estrogen and progesterone and increased oxidative stress. While Hesperidin pre - treatment improved histological features, recovered the number of follicles in ovaries of the irradiated mice. In addition, the Hesperidin increased estrogen and progesterone and decreased oxidative stress (malondialdehyde, Ferric Reducing Antioxidant Power, and catalase). Conclusion : Data of this research indicate that hesperidin is may be useful in female patients with pelvic cancer during radiotherapy for their ovarian conservation.","PeriodicalId":48815,"journal":{"name":"International Journal of Radiation Research","volume":"83 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75970365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Radiological properties and structural morphology of different MAGAT gel dosimeters formulation 不同MAGAT凝胶剂量计配方的放射学性质和结构形态

IF 0.6 4区医学

International Journal of Radiation Research Pub Date : 2022-04-01 DOI: 10.52547/ijrr.20.2.27

A. Al-Asady, N. Razak, M. Zin, S. Mahmud

{"title":"Radiological properties and structural morphology of different MAGAT gel dosimeters formulation","authors":"A. Al-Asady, N. Razak, M. Zin, S. Mahmud","doi":"10.52547/ijrr.20.2.27","DOIUrl":"https://doi.org/10.52547/ijrr.20.2.27","url":null,"abstract":"Background : : One of the most important qualities of a radiation dosimeter is tissue-equivalent, which represents radiation absorption and scattering that is similar to that of human tissue. The goal of this study is to determine the radiological and structural properties of several MAGAT gel dosimeter formulations prior to irradiation. This will provide a basis on how radiation properties altered prior to irradiation, which will later affect radiation absorption behaviour . Materials and Methods : Radiological properties of different MAGAT gel formulations (MAGAT, MAGAT doped methylene blue, MAGAT doped zinc oxide nanoparticles, MAGAT dope methylene blue and zinc oxide nanoparticles) were measured from density, linear attenuation coefficients, mass attenuation coefficients and CT values. The results were compared to soft tissue and water as references. The gel’s morphological structures were investigated using electron microscopy for better understanding of gel’s absorption mechanism. Results : The mass density of all MAGAT gel formulations differed by up to 2.5% from that of water and are very close to that of muscle tissue. This is due to the high gelatin and monomer concentration used in MAGAT gel formulation. The CT-values, furthermore, are within the soft tissue range. The MAGAT doped with methylene blue and ZnO NPs demonstrated the greatest increase in linear attenuation value, as well as having a nano spider-web morphological structure with a large surface area, which may have increased gel sensitivity and attenuation coefficients of MAGAT gel. Conclusion : Different MAGAT gel formulations were found to exhibit similar radiological properties to soft tissues and water.","PeriodicalId":48815,"journal":{"name":"International Journal of Radiation Research","volume":"56 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84541127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changing the entrance surface dose and image quality by applying an air mattress to the table commonly used in computed tomography 通过在计算机断层扫描中常用的桌子上应用气垫来改变入口表面剂量和图像质量

IF 0.6 4区医学

International Journal of Radiation Research Pub Date : 2022-04-01 DOI: 10.52547/ijrr.20.2.25

J. Park, S. Kim

{"title":"Changing the entrance surface dose and image quality by applying an air mattress to the table commonly used in computed tomography","authors":"J. Park, S. Kim","doi":"10.52547/ijrr.20.2.25","DOIUrl":"https://doi.org/10.52547/ijrr.20.2.25","url":null,"abstract":"Background : In this study, the changes in the entrance surface dose (ESD) and image quality were examined when an air mattress was used to reduce the X-ray scattering caused by treatment tables commonly used for computed tomography (CT). Materials and Methods : Dual-energy CT (DECT) was used, with the ESD of Alderson Radiation Therapy (ART) phantom measured by scanning with different X-ray tube voltages and X -ray tube currents for three scenarios: when no air mattress was employed, and when a 5 cm or 10 cm thick air mattress was employed. The statistical significance of the changes in ESD and image quality were based on the presence and thickness of the air mattress. Additionally, the variations of the X-ray tube voltage and current for different air mattress thicknesses were investigated using paired t-test . Results : For all X-ray tube voltages and currents, applying an air mattress significantly improved both the ESD and image quality, with the 5 cm air mattress improving both the ESD and image quality. Conclusion : The 5 cm air mattress produced no artifacts in the diagnostic images, and demonstrated a statistically significant reduction in patient ESD during DECT imaging.","PeriodicalId":48815,"journal":{"name":"International Journal of Radiation Research","volume":"14 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87496731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of natural radioactivity in mango, the influence of soil radioactivity, its radiation hazard indices and the overall excess lifetime cancer risk 芒果天然放射性评价、土壤放射性影响、辐射危害指标及总体超寿命致癌风险

IF 0.6 4区医学

International Journal of Radiation Research Pub Date : 2022-04-01 DOI: 10.52547/ijrr.20.2.33

S. Ibikunle

{"title":"Assessment of natural radioactivity in mango, the influence of soil radioactivity, its radiation hazard indices and the overall excess lifetime cancer risk","authors":"S. Ibikunle","doi":"10.52547/ijrr.20.2.33","DOIUrl":"https://doi.org/10.52547/ijrr.20.2.33","url":null,"abstract":"Background : Radionuclide ingestion has raised a global concern due to its radiological implication on man. Materials and Methods : Activity concentration of natural radionuclides ( 226 Ra, 232 Th and 40 K) in soil, leaf and fruit samples of mango plants from Akure, Nigeria has been estimated using gamma ray spectrometer NaI (Tl) detector. Spectra analyses were performed with the Genie2K spectrometry software, version 2.1 (Canberra industries Inc). Results : The mean activities concentration of 40 K, 226 Ra and 232 Th in soils were 469.72 ± 86.44, 25.17 ± 9.87 and 19.33 ± 6.98 Bq kg - 1 respectively. The mean activities concentration of 40 K, 226 Ra and 232 Th in leaves were 444.76 ± 89.10, 20.43 ± 7.47 and 17.23 ± 7.39 Bq kg - 1 respectively. The mean activities concentration of 40 K, 226 Ra and 232 Th in fruits were 439.54 ± 87.39, 18.96 ± 6.80 and 15.43 ± 5.64 Bq kg - 1 respectively. The mean total absorbed dose rate in air and the mean annual effective dose equivalent for soil sample were estimated at 39.37 ± 11.43 nGy h - 1 and 48.28 ± 14.01 µSv y - 1 . Conclusion : The mean radium equivalent, hazard indices and excess lifetime cancer risks (ELCR) through soil exposures are below the world average, but the mean annual effective dose equivalent and ELCR for different age groups, from radionuclide ingestion through mango consumption in the area are above the world average.","PeriodicalId":48815,"journal":{"name":"International Journal of Radiation Research","volume":"26 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73827147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Do auto-planning intensity modulated radiotherapy treatment plans for central lung cancer have improved quality over manual plans? 中枢性肺癌的自动计划调强放疗治疗方案是否比人工计划质量更高?

IF 0.6 4区医学

International Journal of Radiation Research Pub Date : 2022-04-01 DOI: 10.52547/ijrr.20.2.35

H. Chen, Y. Shao, H. Wang, H. Gu, Y. Duan, A. Feng, Y. Huang, C. Chen, Z. Xu

{"title":"Do auto-planning intensity modulated radiotherapy treatment plans for central lung cancer have improved quality over manual plans?","authors":"H. Chen, Y. Shao, H. Wang, H. Gu, Y. Duan, A. Feng, Y. Huang, C. Chen, Z. Xu","doi":"10.52547/ijrr.20.2.35","DOIUrl":"https://doi.org/10.52547/ijrr.20.2.35","url":null,"abstract":"Background : To investigate the performance of Auto - Planning intensity modulated radiation therapy (IMRT) plans for patients with central lung cancer and to determine whether Auto - Planning improves the quality of IMRT plans. Materials and Methods : Thirty patients treated with IMRT for central lung cancer were replanned with the Pinnacle 3 Auto - Planning module. The dose distribution at the target, organ at risk (OAR) sparing, dose falloff in the five rings outside of target, monitor units (MUs), planning time, and dosimetric verification in terms of the γ passing rate were evaluated. A Wilcoxon signed - rank test was performed to assess differences between groups (p<0.05). Results : The target homogeneity in the Auto - Planning were significantly better than that in the manual plans, the target conformity in both groups were similar. The Auto - Planning plans yielded lower V 5 , V 10 , V 13 , V 20 , V 30 , V 40 values, mean lung dose of total lung (p<0.01), and D max of spinal cord (p<0.01) and V 30 of heart (p<0.01). No significant difference was found for the V 40 of the heart (p=0.203). The Auto - Planning module reduced the D mean , D 2 and D 5 values in all rings outside of PTV. The planning time was 52.5% shorter for Auto - Planning plans than for manual plans (p<0.01), and 4.4% additional MUs were required with Auto - Planning. No difference was observed for the γ passing rate. Conclusion : Auto - Planning for central lung cancer could improve homogeneity of target volumes, significantly delivery lower dose to OARs and steeper dose falloff outside of tumors while reducing the planning time.","PeriodicalId":48815,"journal":{"name":"International Journal of Radiation Research","volume":"4 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73490001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0