不同MAGAT凝胶剂量计配方的放射学性质和结构形态

IF 0.4 4区 医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
A. Al-Asady, N. Razak, M. Zin, S. Mahmud
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引用次数: 0

摘要

背景:辐射剂量计最重要的特性之一是组织等效,它表示与人体组织类似的辐射吸收和散射。本研究的目的是在辐照前确定几种MAGAT凝胶剂量计配方的放射学和结构特性。这将为辐照前的辐射特性如何改变提供基础,这将在以后影响辐射吸收行为。材料与方法:从密度、线性衰减系数、质量衰减系数和CT值等方面对不同MAGAT凝胶配方(MAGAT、MAGAT掺杂亚甲基蓝、MAGAT掺杂氧化锌纳米粒子、MAGAT掺杂亚甲基蓝和氧化锌纳米粒子)的放射学性质进行了测定。结果与软组织和水作对照。为了更好地了解凝胶的吸收机理,利用电子显微镜对凝胶的形态结构进行了研究。结果:所有MAGAT凝胶制剂的质量密度与水的质量密度相差2.5%,与肌肉组织的质量密度非常接近。这是由于在MAGAT凝胶配方中使用了高明胶和单体浓度。此外,ct值在软组织范围内。亚甲基蓝和ZnO NPs掺杂的MAGAT线性衰减值增加最大,并且具有大表面积的纳米蜘蛛网形态结构,这可能增加了MAGAT凝胶的凝胶敏感性和衰减系数。结论:不同配方的MAGAT凝胶对软组织和水具有相似的放射学特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Radiological properties and structural morphology of different MAGAT gel dosimeters formulation
Background : : One of the most important qualities of a radiation dosimeter is tissue-equivalent, which represents radiation absorption and scattering that is similar to that of human tissue. The goal of this study is to determine the radiological and structural properties of several MAGAT gel dosimeter formulations prior to irradiation. This will provide a basis on how radiation properties altered prior to irradiation, which will later affect radiation absorption behaviour . Materials and Methods : Radiological properties of different MAGAT gel formulations (MAGAT, MAGAT doped methylene blue, MAGAT doped zinc oxide nanoparticles, MAGAT dope methylene blue and zinc oxide nanoparticles) were measured from density, linear attenuation coefficients, mass attenuation coefficients and CT values. The results were compared to soft tissue and water as references. The gel’s morphological structures were investigated using electron microscopy for better understanding of gel’s absorption mechanism. Results : The mass density of all MAGAT gel formulations differed by up to 2.5% from that of water and are very close to that of muscle tissue. This is due to the high gelatin and monomer concentration used in MAGAT gel formulation. The CT-values, furthermore, are within the soft tissue range. The MAGAT doped with methylene blue and ZnO NPs demonstrated the greatest increase in linear attenuation value, as well as having a nano spider-web morphological structure with a large surface area, which may have increased gel sensitivity and attenuation coefficients of MAGAT gel. Conclusion : Different MAGAT gel formulations were found to exhibit similar radiological properties to soft tissues and water.
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来源期刊
International Journal of Radiation Research
International Journal of Radiation Research RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
1.10
自引率
33.30%
发文量
42
期刊介绍: International Journal of Radiation Research (IJRR) publishes original scientific research and clinical investigations related to radiation oncology, radiation biology, and Medical and health physics. The clinical studies submitted for publication include experimental studies of combined modality treatment, especially chemoradiotherapy approaches, and relevant innovations in hyperthermia, brachytherapy, high LET irradiation, nuclear medicine, dosimetry, tumor imaging, radiation treatment planning, radiosensitizers, and radioprotectors. All manuscripts must pass stringent peer-review and only papers that are rated of high scientific quality are accepted.
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