Journal of Endocrinological Investigation最新文献

{"title":"Reevaluating potassium supplementation in pediatric DKA: Is routine KPO₄ use necessary?","authors":"Öznur Eser, Emel Ulusoy, Anıl Er, Zeynep Ölmez Mart, Sezen Arslan, Korcan Demir, Ayhan Abacı, Murat Duman","doi":"10.1007/s40618-025-02686-2","DOIUrl":"https://doi.org/10.1007/s40618-025-02686-2","url":null,"abstract":"<p><strong>Purpose: </strong>Diabetic ketoacidosis (DKA) is a serious complication in pediatric patients with type 1 diabetes, requiring careful management of electrolyte imbalances, particularly for hypokalemia. This study evaluates the clinical outcomes of different potassium supplementation strategies during DKA treatment.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed pediatric DKA cases treated in a pediatric emergency department over a 13-year period. Outcomes included serum electrolyte imbalances, hyperchloremic acidosis contribution, time to acidosis resolution, and time to transition to subcutaneous (SC) insulin.</p><p><strong>Results: </strong>A total of 113 pediatric DKA individuals were included, with a median age of 9.23 (± 4.15) years; 58.4% (n = 66) were female. Among these 113 individuals, 36 (31.9%) were administered both potassium chloride (KCL) and potassium phosphate (KPO₄), whereas, 77 (68.1%) were administered KCL exclusively. No significant difference was observed between these two groups in terms of the severity of acidosis, the duration of acidosis recovery, and the incidence of hypokalemia and hyperchloremia.</p><p><strong>Conclusion: </strong>The omission of KPO₄ supplementation in DKA treatment did not increase the risk of hyperchloremic metabolic acidosis, prolong acidosis resolution, delay transition to SC insulin therapy, or cause clinically significant hypophosphatemia. These findings suggest that KCl may be a valid alternative in the management of pediatric diabetic ketoacidosis when KPO₄ is unavailable; however, prospective randomized controlled trials are needed to confirm this observation.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone loss and increased bone marrow adiposity in ovary-intact and ovariectomized rats with chronic obstructive pulmonary disease.","authors":"Jingzheng Fan, Yuyan Jiang, Lechang Yu, Xu Lu, Qiang Zhang","doi":"10.1007/s40618-025-02635-z","DOIUrl":"https://doi.org/10.1007/s40618-025-02635-z","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Osteoporosis is a major clinically significant extrapulmonary comorbidity that can arise in individuals with chronic obstructive pulmonary disease (COPD). While there have been reports of a negative correlation between bone marrow adiposity and bone integrity, the role of such adiposity in COPD-induced bone loss is not well understood. This study was developed with the aim of clarifying how COPD affects bone and bone marrow fat in both ovary-intact and ovariectomized (OVX) rats.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study utilized 32 five-month-old female Wistar rats that either underwent bilateral OVX or Sham surgical procedures. Beginning 7 days after surgery, these rats were regularly exposed to cigarette smoke (CS) or room air (RA) for 5 months. At baseline, 3 months, and 5 months, a series of parameters were analyzed including the bone marrow fat fraction (FF) and bone mineral density (BMD) for the left proximal femur and L4-L5 vertebrae, as measured through water/fat MRI and dual-energy X-ray absorptiometry. Moreover, pulmonary function, lung morphometry, marrow adipocyte characteristics detected via histopathology, trabecular bone microarchitectural features detected by micro-CT scanning, changes in adipogenic and osteogenic marker gene expression detected by qPCR, and serum levels of bone turnover biomarkers detected by ELISA were also analyzed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;CS exposure for 5 months was associated with the significant exacerbation of fat expansion in the bone marrow together with overall bone deterioration in the ovary-intact and OVX rats. Relative to rats exposed to RA, those exposed to CS presented with: (1) Increased marrow FF, larger marrow adipocyte diameter, greater adipocyte density, and a higher adipocyte volume percentage; (2) an increase in the expression of adipogenic genes (PPARγ2, FABP4) in the bone marrow; (3) trabecular bone microstructural deterioration, reduced BMD, lower levels of osteogenic gene expression (Runx2), and changes in the levels of serum bone biomarkers including decreased bone formation marker levels together with increased levels of markers of bone resorption. The combination of chronic CS exposure and OVX was associated with even more pronounced fat expansion in the bone marrow and bone loss relative to CS exposure in isolation. Over time, CS exposure was associated with the progressive accumulation of fat in the bone marrow and the deterioration of bone tissue, with marrow FF differing significantly within 3 months of CS exposure, while BMD was significantly decreased by month 5 relative to RA-exposed control rats.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;These results suggest that bone marrow adiposity is closely associated with the onset of osteoporosis among female rats in this model of COPD, with likely effects on the activity of both osteoblasts and osteoclasts. These results underscore the importance of targeting adipose cells in the bone marrow when seeki","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144856726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metanephrines-corrected adrenal vein sampling in primary aldosteronism concurrent with autonomous cortisol secretion.","authors":"Xizi Zhang, Yiyang Fu, Hang Shen, Qinglian Zeng, Aipin Zhang, Zhipeng Du, Ying Song, Jinbo Hu, Linqiang Ma, Yi Yang, Yifan He, Qianna Zhen, Jiayu Li, Junlong Li, Qi Zhang, Qifu Li, Shumin Yang","doi":"10.1007/s40618-025-02660-y","DOIUrl":"https://doi.org/10.1007/s40618-025-02660-y","url":null,"abstract":"<p><strong>Purpose: </strong>Whether metanephrines (MNs)-corrected indices in adrenal venous sampling (AVS) would be useful in subtyping primary aldosteronism (PA) concurrent with autonomous cortisol secretion (ACS) remains unclear.</p><p><strong>Methods: </strong>This retrospective study included PA patients concurrent with (PA/ACS) or without (isolated PA) ACS who underwent AVS. Firstly, optimal cut-offs for the metanephrine-based selectivity index (SI_MN) and normetanephrine-based SI (SI_NMN) were determined using cortisol-corrected SI (SI_cort≥2) as the reference in the isolated PA group. Subsequently, the accuracy of MNs-corrected indices was evaluated in the PA/ACS group.</p><p><strong>Results: </strong>130 isolated PA patients and 65 PA/ACS patients were included. In isolated PA, the optimal cut-off values of SI_MN and SI_NMN were 3.4 and 1.6, respectively. Eleven PA/ACS patients had unsuccessful cannulation (SI_cort<2), of whom, the diagnoses of 8 and 6 patients were rescued by SI_MN and SI_NMN, respectively. Using lateralization index (LI) ≥ 4 to diagnose unilateral PA, 28 out of 65 PA/ACS were identified by cortisol- or NMN-corrected indices, and five more patients were identified by MN-corrected indices. Among 25 PA/ACS patients with a final subtyping diagnosis based on post-surgery outcomes, 52.0% (13/25) were correctly identified by both cortisol- and MNs-corrected indices. In the remaining 12 patients, four were correctly identified by MNs-corrected indices, one was correctly identified by cortisol-corrected indices alone, two were judged as unsuccessful cannulation by SI and all three indicators were wrongly subtyped in the five patients.</p><p><strong>Conclusion: </strong>For patients with PA/ACS, MN-corrected AVS serves as a complementary approach to cortisol-corrected AVS.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Art, diet and thyroid disease: interpreting the goiter motif in the trivulzio tapestries.","authors":"Valentino Marino Picciola, Maria Chiara Zatelli, Luigi Massimino Sena","doi":"10.1007/s40618-025-02685-3","DOIUrl":"https://doi.org/10.1007/s40618-025-02685-3","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective Study to Determine Trimester-Specific Thyroid Function Reference Intervals.","authors":"Li-Hsin Pan, Chang-Ching Yeh, Shun-Jie Yang, Chen-Chang Yang, Chii-Min Hwu, Harn-Shen Chen, Fan-Fen Wang, Chun-Jui Huang","doi":"10.1007/s40618-025-02651-z","DOIUrl":"https://doi.org/10.1007/s40618-025-02651-z","url":null,"abstract":"<p><strong>Purpose: </strong>Precise thyroid function assessment during pregnancy prevents inaccurate diagnosis of thyroid disease. This study aimed to establish trimester-specific reference intervals for thyroid function tests (TFTs) in Taiwanese pregnant women and analyze thyroid hormone and anti-thyroid antibody changes through gestation.</p><p><strong>Methods: </strong>This prospective study at Taipei Veterans General Hospital (2019-2022) included 209 pregnant women. After excluding those with positive anti-thyroid antibodies, use of thyroid-related medications, or plans for abortion, 123 participants were eligible for thyroid function reference interval analysis. TFTs including thyroid-stimulating hormone (TSH), free T4, total T4, free T3, and total T3 along with antibodies were measured once per trimester using a Roche electrochemiluminescence immunoassay. One spot urine sample from each woman was collected at baseline to ensure iodine adequacy and urinary iodine concentration was measured by inductively coupled mass spectrometry.</p><p><strong>Results: </strong>The median urinary iodine concentration was 162.5 µg/L, indicating that the analyzed population had sufficient iodine status. TSH levels were significantly lower in the first trimester (0.007-3.08 µIU/mL) compared to the second (0.33-4.55 µIU/mL) and third trimesters (0.29-4.64 µIU/mL) (p < 0.001). Levels of free T4 and free T3 decreased consistently throughout pregnancy (p < 0.001), while total T3 levels remained stable. In contrast, total T4 levels, anti-thyroid peroxidase antibody titers, and the proportion of women with positive anti-thyrotropin receptor antibodies were higher in the first trimester compared to the second and third trimesters.</p><p><strong>Conclusions: </strong>This study underscores the importance of trimester-specific, population-based reference intervals for TFTs using the Roche assay and represents the first investigation in Taiwanese populations.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MASLD-related fibrosis, but not MASLD, is associated with left ventricular concentric hypertrophy in patients with type 2 diabetes.","authors":"Jiayang Lin, Ruxin Chen, Junlin Huang, Yating Liu, Chensihan Huang, Yan Huang, Bingyan Xu, Yunqian Li, Xinyu He, Hongzhen Lv, Xueyun Wei, Peizhen Zhang, Dan Guo, Jinhua Zhang, Huijie Zhang","doi":"10.1007/s40618-025-02682-6","DOIUrl":"https://doi.org/10.1007/s40618-025-02682-6","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of sphingolipid metabolism related genes-SPTLC1, ORMDL3, SPHK1 and S1PR3 polymorphisms on susceptibility to hashimoto's thyroiditis.","authors":"Xin Li, Haixia Zhao, Zhifu Xiao","doi":"10.1007/s40618-025-02666-6","DOIUrl":"https://doi.org/10.1007/s40618-025-02666-6","url":null,"abstract":"<p><strong>Background: </strong>The destruction of thyroid follicles is an important morphological manifestation of Hashimoto's thyroiditis (HT), and sphingolipid (SPL) metabolism is crucial for maintaining the homeostasis of membrane lipid composition and the stability of the cell membrane. Therefore, the pathogenesis of HT may be related to SPL metabolism. This study aimed to evaluate the associations between SPL metabolism related genes polymorphisms and susceptibility to HT.</p><p><strong>Methods: </strong>Seven SNPs in the SPTLC1, ORMDL3, SPHK1, S1PR1 and S1PR3 were genotyped in 600 HT cases and 600 controls using a MassARRAY platform.</p><p><strong>Results: </strong>The mutation alleles of SPTLC1-rs11790991, SPHK1-rs346801 and S1PR3-rs7022797 led to varying degrees of increased HT risk (p < 0.0001), while the ORMDL3-rs8076131 variant was a protective factor for developing HT (p < 0.0001). Carriers of the mutant heterozygous or homozygous genotypes of SPTLC1-rs11790991, SPHK1-rs346801 and S1PR3-rs7022797 exhibited higher risk of HT than those carrying the wild genotypes (p < 0.0001), while the mutant AG/GG genotypes of ORMDL3-rs8076131 resulted in a reduction in HT susceptibility (p < 0.0001). Subgroup analysis showed that the above four potential susceptible SNPs maintained significant in both males and females. However, these significant correlations are manifested under different genetic models.</p><p><strong>Conclusions: </strong>These results can help identify high-risk populations for HT and suggest that studying SPL metabolism may be a promising direction to explore its pathogenesis.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of progression after surgery in non-functioning pituitary macroadenomas: a Spanish multicenter study.","authors":"Betina Biagetti, Andres Cardona-Arias, Edelmiro Menéndez Torre, Anna Aulinas, Ignacio Ruz-Caracuel, Rogelio García Centeno, Laura González, Ana Irigaray Echarri, María Dolores Moure Rodríguez, Miguel Paja, Fernando Guerrero-Pérez, Justo P Castaño, María Dolores Ollero García, Cristina Novo-Rodríguez, Carmen Tenorio-Jimenéz, Rocío Villar-Taibo, Ignacio Bernabéu, Everardo Díaz-López, María Calatayud, Cristina Alvarez-Escola, Patricia Martín Rojas-Marcos, José María Recio-Córdova, Claudia Lozano-Aida, Queralt Asla Roca, María Dolores Aviles, Elena López Mezquita, María Fernández Argueso, Inmaculada González Molero, Iban Alberoa, Cindy Idrobo, Estefanía Achote, Elena Martínez-Sáez, Mónica Marazuela, Manel Puig-Domingo, Felicia Hanzu, Marta Araujo-Castro","doi":"10.1007/s40618-025-02674-6","DOIUrl":"https://doi.org/10.1007/s40618-025-02674-6","url":null,"abstract":"<p><strong>Background and purpose: </strong>Non-functioning pituitary adenomas (NFPAs) have an unpredictable clinical course, with recurrence and progression posing significant challenges. This study aims to evaluate progression-free survival (PFS) and identify predictors and patterns of tumor progression.</p><p><strong>Methods: </strong>We conducted a retrospective multicenter study including 472 patients with NFPAs > 1 cm from 17 Spanish hospitals (416 surgical, 56 conservative management). Tumor progression was defined as > 20% increase in size, >2 mm growth on imaging, or new/worsening clinical symptoms. Kaplan-Meier analysis was used to estimate PFS for both groups and independent predictors of progression were assessed using Cox proportional hazards regression in the surgical cohort.</p><p><strong>Results: </strong>During a median follow-up of 7.9 years (range: 5.0-46.9), tumor progression occurred in 67 patients (14.2%). Most progression 29/67 (89.6%) events occurred within the first 15 years of follow-up. Multivariate analysis identified residual tumor (HR = 5.1; 95% CI: 2.2-11.9; p < 0.01) and aggressive histopathology (HR = 2.1; 95% CI: 1.1-3.8; p = 0.02) as significant independent predictors of progression. Neither gender, age, radiotherapy nor cabergoline treatment significantly altered progression risk in the multivariate model.</p><p><strong>Conclusion: </strong>NFPAs show a gradual risk of progression over time, particularly during the first 15 years post-diagnosis. Postoperative residual tumor and aggressive histopathological features are the strongest predictors of progression, highlighting the importance of maximal safe resection when feasible and detailed histopathological assessment for risk stratification. These findings support long-term surveillance for high-risk patients.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sweeteners and puberty: investigating genetic and dietary influences on central precocious puberty.","authors":"Yuan-Jen Tsai, Chia-Min Kuo, Jhih-Wei Hsu, Chun-Chang Chen, Chien-Ming Lin, Ying-Chuan Chen, Yang-Ching Chen","doi":"10.1007/s40618-025-02677-3","DOIUrl":"https://doi.org/10.1007/s40618-025-02677-3","url":null,"abstract":"<p><p>Central precocious puberty (CPP) is characterized by the early onset of secondary sexual characteristics caused by premature activation of the hypothalamic-pituitary-gonadal axis. CPP can result in short stature, reproductive health complications, and psychosocial challenges. The rising prevalence of CPP underscores the urgency of investigating the genetic and dietary factors that influence its development to reduce long-term health and developmental effects. CPP was diagnosed in 481 participants. Aspartame, sucralose, glycyrrhizin, and added sugars were significantly linked to increased CPP risk, particularly in genetically predisposed individuals. A dose-dependent relationship was also identified, with higher sweetener intake associated with a greater risk of CPP. Gender-specific effects were also discovered, with sucralose being strongly associated with CPP in boys and glycyrrhizin, sucralose, and added sugar all being strongly associated with CPP in girls. The effects of the interaction between genetic predisposition and sweetener intake on this risk were non-significant. Sweetener consumption and high genetic predisposition independently increase the risk of CPP. Therefore, combining genetic and dietary assessments can guide prevention strategies for at-risk children, reducing the long-term health effects of early puberty.</p>","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The goitrous sponge-bearer in Francesco Bianchi Ferrari's Pala delle Tre Croci (c. 1495).","authors":"Maria Emilia Paladino, Michele Augusto Riva","doi":"10.1007/s40618-025-02681-7","DOIUrl":"https://doi.org/10.1007/s40618-025-02681-7","url":null,"abstract":"","PeriodicalId":48802,"journal":{"name":"Journal of Endocrinological Investigation","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}