Journal of Oral & Facial Pain and Headache最新文献

{"title":"Sensitivity, specificity and prevalences<b>-</b>comparison of four screening tests for temporomandibular disorders.","authors":"Maria Ertl, Florian Beuer, Axel Bumann","doi":"10.22514/jofph.2025.069","DOIUrl":"10.22514/jofph.2025.069","url":null,"abstract":"<p><strong>Background: </strong>This prospective clinical study investigates whether functionally compensated but clinically inapparent temporomandibular disorder (TMD) findings can be detected in individuals without pre-existing medical conditions.</p><p><strong>Methods: </strong>A total of 200 participants (10-50 years) without a medical history were examined using screening methods: Craniomandibular Disorders (CMD)-Short Finding, CMD-Screening, Preventive Manual Structural Analysis (PMSA), and Preventive Structural Stress Screening (PSSS). The Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) Axis I served as the reference standard. Five diagnoses were analyzed based on prevalence, sensitivity, specificity, predictive values, 95% confidence intervals, and <i>p</i>-values (McNemar, Cochran Q).</p><p><strong>Results: </strong>TMD findings were detectable. PMSA and PSSS always produced identical results (<i>p</i> = 1.000), differing significantly from CMD-Short Finding for arthralgia and disc displacement (<i>p</i> < 0.001), and from CMD-Screening for myogenic pain (<i>p</i> < 0.001). No significant differences were found between PMSA/PSSS and CMD-Screening for arthralgia (<i>p</i> = 0.528) or CMD-Short Finding for myogenic pain (<i>p</i> = 0.490). Not all tests achieved a 70% sensitivity and a 95% specificity. The most important results are summarized here: arthralgia (0.0%-15.0%) by PMSA/PSSS (sensitivity 96.00% [79.65-99.90], specificity 96.57% [92.69-98.73], <i>p</i> = 0.125); myogenic pain (34.5%-49.5%) by CMD-Screening (excluding digastric muscle: sensitivity 84.15% [74.42-91.28], specificity 100.00% [96.92-100.00], <i>p</i> < 0.001) and by PMSA/PSSS (including digastric muscle: sensitivity 98.02% [93.03-99.76], specificity 100.00% [96.34-100.00], <i>p</i> = 0.500); disc displacement (14.5%-20.5%) by CMD-Short Finding (sensitivity 100.00% [85.18-100.00], specificity 96.61% [92.77-98.75], <i>p</i> = 0.031); degenerative joint disease and disc displacement without reduction with limited opening showed very low prevalence (0.0%-1.0%), which results in limiting reliability.</p><p><strong>Conclusions: </strong>TMD findings were detectable in asymptomatic individuals. PMSA and PSSS were the most suitable screening tools. The results support the need for regular screening, and further studies.</p><p><strong>Clinical trial registration: </strong>DRKS00035175, https://drks.de/search/en/trial/DRKS00035175, retrospectively registered.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"39 4","pages":"100-121"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12727190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antinociceptive and anti-inflammatory effects of a formulation based on <i>Alpinia zerumbet</i> essential oil: an <i>in vivo</i> and <i>in vitro</i> approach.","authors":"Wagner Hummig, Julia Maria Zortea, Victor Augusto Benedicto Dos Santos, Luiz Eduardo Nunes Ferreira, Juliana Geremias Chichorro","doi":"10.22514/jofph.2025.077","DOIUrl":"10.22514/jofph.2025.077","url":null,"abstract":"<p><strong>Background: </strong>Current pharmacological treatments for acute orofacial pain present limitations, risks, and side effects. Thus, the search for safer alternatives is justified. The essential oil of <i>Alpinia zerumbet</i> (EOAz) has been used in the treatment of several medical conditions, including pain and inflammation, but scientific validation is scarce. The aim of this study was to investigate the antinociceptive and anti-inflammatory effects of EOAz in models of acute orofacial pain in rats and in inflammatory parameters <i>in vitro</i>.</p><p><strong>Methods: </strong>Adult male Wistar rats were subjected to intraoral incision surgery, a model of postoperative pain. The effect of the facial topical application (1 to 3 times a day for 3 days) of EOAz or a formulation based on EOAz (Fb-EOAz) was assessed on heat and mechanical hyperalgesia. The same rats were tested in the open field test (OFT) to assess the influence of the treatments on rats' locomotion. Moreover, the effects of the treatments were evaluated on facial heat hyperalgesia induced by lipopolysaccharide (LPS), a model of myofascial pain, and <i>in vitro</i>, in the release of nitric oxide (NO) and interleukin-6 in macrophages stimulated by LPS.</p><p><strong>Results: </strong>EOAz and Fb-EOAz reduced postoperative heat hyperalgesia, but only Fb-EOAz reduced postoperative mechanical hyperalgesia and heat hyperalgesia induced by LPS. Fb-EOAz reduced NO and interleukin-6 release by macrophages stimulated by LPS. None of the treatments affected the rat's locomotion.</p><p><strong>Conclusions: </strong>These data provide preclinical evidence of antinociceptive and anti-inflammatory effects of Fb-EOAz. This approach may represent an alternative or adjuvant therapy in the control of inflammatory and myofascial orofacial pain.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"39 4","pages":"207-217"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12727173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applicability of the theory of pain-sensorimotor interactions to orofacial pain and sensorimotor behavior, and implications for orofacial pain research and management.","authors":"Barry J Sessle, Greg M Murray","doi":"10.22514/jofph.2025.066","DOIUrl":"10.22514/jofph.2025.066","url":null,"abstract":"<p><p>The orofacial sensorimotor system encompasses a variety of orofacial tissues as well as several pathways and circuits in the central nervous system (CNS) that participate in orofacial sensorimotor behaviors such as chewing, facial expression, speech, and swallowing. Acute or chronic pain can severely affect these behaviors, but the relationships between sensorimotor behaviors and pain, and the factors influencing the interactions and underlying mechanisms have remained unclear. Several theories proposed to account for the interactions and mechanisms have not provided a comprehensive picture of pain-sensorimotor interactions, nor fully acknowledged the diversity of biopsychosocial factors that may affect pain-related sensorimotor behaviors and the musculoskeletal tissues involved in the behaviors, and that may also contribute to the inter-individual and sex differences in pain-sensorimotor interactions. Such considerations prompted, last year, a review that has provided new perspectives of pain-sensorimotor interactions, and identified the wide range of biological, psychological, and sociocultural factors that may influence the interactions and underlying mechanisms. It also resulted in a novel theory being proposed, the Theory of Pain-Sensorimotor Interactions (TOPSMI), which has provided a more comprehensive mechanistic framework to consider the interactions between sensorimotor behaviors and pain, and their complexity. Since the new perspectives leading to TOPSMI were derived mainly from findings in the spinal sensorimotor system, the present article aims to determine the particular applicability of TOPSMI to orofacial pain-sensorimotor interactions. It reviews orofacial pain-related sensorimotor behaviors and the nociceptive pathways, CNS circuits and their plasticity, and musculoskeletal tissues involved in these behaviors, as well as the influences of psychosocial, genetic, epigenetic, and environmental factors bearing specifically on orofacial pain-sensorimotor interactions. The article concludes that the basic tenets of TOPSMI are applicable to orofacial pain-sensorimotor interactions and that this has implications for the clinical management of orofacial pain and future research in this field.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"39 4","pages":"38-59"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12727179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Up-regulation of peripheral and central CGRP expression combined with subchondral bone remodeling in rat MIA-induced TMJOA model.","authors":"Liqin Xu, Henghua Jiang, Qijun Xu, Wei Fang","doi":"10.22514/jofph.2025.078","DOIUrl":"10.22514/jofph.2025.078","url":null,"abstract":"<p><strong>Background: </strong>Temporomandibular joint osteoarthritis (TMJOA) is a pathological condition marked by subchondral bone remodeling. Osteoarthritis can lead to TMJ pain, nevertheless, the relationship between nociceptive mechanisms and subchondral bone in TMJOA still unclear.</p><p><strong>Methods: </strong>In the present investigation, a rat TMJOA model was established via intra-articular administration of monosodium iodoacetate (MIA). Following the induction of MIA-triggered TMJOA, tissue samples were collected from the TMJ condyle, trigeminal system components including ganglion (TG) and nucleus caudalis (TNC), and hippocampal formation. Micro-computed tomography (Micro-CT) was employed to evaluate subchondral bone degeneration in the TMJ, while tartrate-resistant acid phosphatase (TRAP) staining was conducted to measure the activity of osteoclasts in the subchondral bone. Furthermore, immunofluorescence (IF) staining was performed to detect the expression of calcitonin gene related peptide (CGRP) in the TMJ subchondral bone. Afterwards, immunohistochemistry (IHC) was used to detect the expression of CGRP in the TG, TNC and hippocampus tissues. The experimental results were expressed as mean ± Standard Error of the Mean (SEM) values and two-way Analysis of Variance (ANOVA) with Student-Newman-Keuls <i>post hoc</i> testing was employed for statistical comparisons, adopting a significance threshold of <i>p</i> < 0.05.</p><p><strong>Results: </strong>Compared with the control group, Micro-CT results revealed progressive condylar degeneration over time. Consistently, MIA-induced TMJOA rats demonstrated a pronounced accumulation of TRAP-positive osteoclasts in the subchondral bone. The expression of CGRP in the TMJ subchondral bone, TG, TNC and hippocampus tissues was also obviously increased in MIA-induced TMJOA rats.</p><p><strong>Conclusions: </strong>MIA-induced rat TMJOA pain could be attributed to the augmented exprssion of CGRP in the TMJ subchondral bone, TG, TNC and hippocampus tissues. An elevated level of CGRP stimulated nociception which was implicated in the development of peripheral and central sensitization in TMJOA pain.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"39 4","pages":"218-226"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12727174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of acupuncture for tension-type headache: a systematic review and meta-analysis of randomized controlled trials.","authors":"Pen-Ting Lin, Sheng-Yu Su, Chia-Lung Shih","doi":"10.22514/jofph.2025.067","DOIUrl":"10.22514/jofph.2025.067","url":null,"abstract":"<p><strong>Background: </strong>Tension-type headache (TTH) is a common primary headache disorder characterized by bilateral, non-pulsating, mild-to-moderate pressing or tightening pain. The objective of this study was to investigate the efficacy of acupuncture for TTH using meta-analysis.</p><p><strong>Methods: </strong>We adhered to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines to conduct this research. A systematic search of multiple electronic databases, including PubMed, EMBASE, and the Cochrane Library, was conducted, covering all literature from their inception to August 2024. The articles investigating the efficacy of acupuncture for patients with TTH were included. Meta-analyses were used to pooled the effect size using RevMan 5.4.</p><p><strong>Results: </strong>A total of six randomized controlled trials (including 927 patients) were included. The results revealed the acupuncture group showing significant decrease in headache frequency at 6 weeks post-treatment (standardized mean difference (SMD) = -0.23; 95% confidence interval (CI): -0.43 to -0.03; <i>p</i> = 0.03), while the acupuncture group had higher odds of headache relief when compared with the sham-acupuncture group (odds ratio (OR) = 1.85; 95% CI: 1.34 to 2.57; <i>p</i> < 0.001). In subgroup analysis, acupuncture showed significant decrease in pain level compared to sham-acupuncture when patients received more than one month or 10 treatment sessions (SMD = -0.32; 95% CI: -0.56 to -0.09; <i>p</i> = 0.006).</p><p><strong>Conclusions: </strong>Our results suggest that acupuncture could be effective for TTH when the treatment period extends beyond one month or includes more than 10 sessions.</p><p><strong>The prospero registration: </strong>Registration number CRD42024602270.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"39 4","pages":"60-69"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12727187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying symmetry in mandibular condyle motion: a real-time MRI approach.","authors":"Justine Leclère, Karyna Isaieva, Guillaume Drouot, Romain Gillet, Jacques Felblinger, Pierre-André Vuissoz, Xavier Dubernard","doi":"10.22514/jofph.2025.079","DOIUrl":"10.22514/jofph.2025.079","url":null,"abstract":"<p><strong>Background: </strong>The temporomandibular joints (TMJs) are essential for daily function and must operate in synergy to ensure optimal jaw movement. Real-time magnetic resonance imaging (RT-MRI) enables direct visualization of mandibular condyle motion; however, its application for symmetry assessment remains insufficiently studied. This exploratory study focuses on the consistency of condylar motion symmetry assessments, including visual evaluation of raw image series and 3D trajectories calculated from RT-MRI, as well as automatically extracted quantitative parameters. Given that well-correlated parameters are more likely to be reliable, this work aims to identify optimal methods for assessing symmetry of the condylar pathway using RT-MRI.</p><p><strong>Methods: </strong>The study includes 18 volunteers. A 2D real-time fast low angle shot (FLASH) sequence was used to acquire two sagittal and one axial planes. For quantitative analysis, mandibular condyles were segmented using a neural network. The extracted symmetry parameters were maximum displacement difference and maximum difference of amplitudes for spatial assessments, and latency and velocity peak delay for temporal evaluations. 3D trajectories were automatically generated using a previously validated method. Qualitative scoring of raw image series was conducted by two experts, and the 3D trajectories were evaluated by a dental surgeon. The agreement between qualitative scores was assessed using Cohen's kappa test, while correlations among quantitative parameters were analyzed using Spearman's test.</p><p><strong>Results: </strong>Results showed higher agreement in the axial plane (intra-observer κ = 0.68; inter-observer κ = 0.44) than in the sagittal plane (κ = 0.51 and 0.20, respectively). Inter-planar correlations were weak to moderate (ρ = 0.21-0.48), with latency showing the strongest correlation.</p><p><strong>Conclusions: </strong>For our dataset, latency emerged as the most robust temporal parameter. Additionally, motion analysis in the axial plane demonstrated greater consistency in both quantitative measurements and visual scoring. These findings suggest that the axial plane may be preferable for assessing motion symmetry in RT-MRI.</p><p><strong>Clinical trial registration: </strong>\"METHODO\" ClinicalTrials.gov Identifier: NCT02887053, approval: CPP EST-III, 08.10.01; \"EDEN\" ClinicalTrials.gov Identifier: NCT05218460, approval: CPP SUD-EST IV, 26.07.21.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"39 4","pages":"227-234"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12727175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burning mouth syndrome: updates on pathogenesis and diagnostic algorithms.","authors":"Federica Canfora, Elena Calabria, Niccolò Giuseppe Armogida, Giulia Ottaviani, Michele Davide Mignogna, Gianrico Spagnuolo, Daniela Adamo","doi":"10.22514/jofph.2025.064","DOIUrl":"10.22514/jofph.2025.064","url":null,"abstract":"<p><p>Burning Mouth Syndrome (BMS) is a complex, chronic neuropathic orofacial pain disorder characterized by a persistent burning or dysesthetic sensation in the oral cavity without an identifiable organic cause. Accurate diagnosis and effective management of BMS pose significant challenges to clinicians, necessitating a comprehensive and multidisciplinary approach. This review delves into BMS's pathogenesis and diagnostic algorithms, highlighting the latest advancements in understanding the underlying mechanisms and diagnostic strategies. Utilizing specific diagnostic algorithms assists clinicians in assessing and selecting appropriate treatment strategies, thereby minimizing diagnostic delays. These algorithms are crucial for excluding other causes of oral burning by focusing on symptomatology, patient history, and clinical examination. They involve ruling out oral infections, nutritional deficiencies, hormonal imbalances, autoimmune disorders, and medication side effects as potential causative factors. Supporting the diagnostic process, additional tests such as blood tests (including a thrombophilic panel and Neuron-Specific Enolase), neurosensory assessments, neuroradiological examinations, and evaluations of psychological profiles and cognitive function may be employed. Neurosensory assessments and neuroradiological examinations can provide insights into possible neuropathic causes, while psychological and cognitive assessments can identify any psychological factors and the extent to which cognitive decline may contribute to the condition. A comprehensive diagnostic approach not only aids in the accurate identification of BMS but also helps differentiate it from other oral conditions with similar presentations. This thorough evaluation is essential for developing a tailored treatment plan that addresses each patient's specific needs, ultimately improving clinical outcomes and enhancing the quality of life for individuals suffering from BMS.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"39 4","pages":"1-30"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12738272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating risk of reported versus theoretical drug-drug interactions in headaches medicine: an exhaustive comparison between DrugBank and FAERS database for abortive and preventive combinations.","authors":"Victor Kaytser, Ian Hakkinen, Jay Dave, Pengfei Zhang","doi":"10.22514/jofph.2025.073","DOIUrl":"10.22514/jofph.2025.073","url":null,"abstract":"<p><strong>Background: </strong>Polypharmacy is common in headache medicine. This project uses DrugBank and Food and Drug Administration's (FDA) Adverse Event Reporting System (FAERS) to determine the likelihood of a theoretical and empirically reported interaction between a given number of headache abortive and preventive medications.</p><p><strong>Methods: </strong>All headache medications referenced in \"The American Headache Society Position Statement on Integrating New Migraine Treatments into Clinical Practice\" and Szperka's \"Migraine care in the era of COVID-19: clinical pearls and plea to insurers\" were included. All possible combinations of up to three abortives and preventatives were screened for drug-drug interactions through searches in DrugBank and FAERS. If at least one drug-drug interaction was listed, then it was included in our analysis. The percentage of combinations containing an interaction was then compared across the two databases.</p><p><strong>Results: </strong>Of the 38 abortives and 23 preventives included, once more than 3 drugs are used in any combination, a drug-drug interaction was >99% likely, per DrugBank. However, per FAERS, the reported interaction was 39% to 60% likely once 3 or 4 drugs are used in any combination. In FAERS, the likelihood of interaction rised most dramatically once 3 or more drugs are used.</p><p><strong>Conclusions: </strong>Theoretical interactions, based on DrugBank, maybe overstated when compared to actual observed interactions in FAERS. Future direction is needed delving into the types of interactions recorded in each database.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"39 4","pages":"165-172"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12727184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between temporomandibular disorders/bruxism and head and neck pains: a bidirectional Mendelian randomization study.","authors":"Shan-Shan Du, Yuan-Yuan Hu, Yu-Ming Niu","doi":"10.22514/jofph.2025.070","DOIUrl":"10.22514/jofph.2025.070","url":null,"abstract":"<p><strong>Background: </strong>Temporomandibular disorders (TMDs) and bruxism are the most common disorders affecting the oral and maxillofacial system. Patients with TMDs or bruxism frequently suffer from chronic head and neck pains (HNPs); however, the etiology between TMDs/bruxism and HNPs remains unclear.</p><p><strong>Methods: </strong>We explore the association between TMDs/bruxism and HNPs with a bidirectional Mendelian randomization (MR) method with public online genome-wide association study (GWAS) data from the Integrative Epidemiology Unit (IEU) open GWAS project, FinnGen consortium and GWAS Catalog website. Inverse variance weighted (IVW) and other four statistical approaches were employed to investigate the associations. Furthermore, Cochran's Q, Mendelian randomization (MR)-Egger intercept test, MR pleiotropy residual sum and outlier test, and leave-one-out tests were conducted as sensitivity analyses to ensure the robustness of results. Multivariable MR (MVMR) analyses were adopted to validate the significant effects observed in the two-sample MR analyses while adjusting for potential confounders.</p><p><strong>Results: </strong>Overall, our analysis revealed a reciprocal significant association between TMDs and neck/shoulder pain (NSP) in both forward (<i>p</i> = 0.023) and reverse (<i>p</i> = 0.004) analyses, which were corroborated by subsequent MVMR analyses adjusted for anxiety, body mass index (BMI) and sleeplessness. All results were confirmed robust under current sensitivity analysis.</p><p><strong>Conclusions: </strong>These findings suggest a potential causal association between TMDs and HNPs. The bidirectional relationship highlight the importance of preventing TMDs and HNPs as a health strategy for mitigating each other's risks.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"39 4","pages":"122-137"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12727188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the efficacy of connective tissue massage and manual lymphatic drainage in patients with migraine: a randomized controlled trial.","authors":"Betü Yıldırım Bulut, Özlem Çinar Özdemir","doi":"10.22514/jofph.2025.054","DOIUrl":"10.22514/jofph.2025.054","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate and compare the effects of connective tissue massage (CTM) and manual lymphatic drainage (MLD) on neck pain, disability, quality of life, and pain thresholds in patients with migraine.</p><p><strong>Methods: </strong>A total of 40 migraine patients were randomly assigned to either the CTM or MLD group. Quality of life was assessed using the Short Form-36 (SF-36); pain sensitivity and perception were measured using an algometer, and neck pain was evaluated using the Neck Pain and Disability Scale (NPAD). Patients tracked their headaches in a pain diary for 15 days before and after the intervention. Both groups received 45 min of treatment twice a week for six weeks.</p><p><strong>Results: </strong>After treatment, the pain threshold increased significantly, whereas total medication use and the number of pain days decreased in both groups. However, while CTM led to a greater reduction in NPAD scores (<i>p</i> < 0.001), MLD was more effective in improving overall pain management and enhancing quality of life (<i>p</i> = 0.017).</p><p><strong>Conclusions: </strong>These findings suggest that CTM and MLD can help migraine patients, with MLD showing a stronger effect on pain relief and well-being, whereas CTM being more effective in reducing neck pain and disability.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov/NCT05976399.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"39 3","pages":"121-132"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}