Joyce Duarte, Patrícia Pauletto, Carla Massignan, Michele Bolan, Fabio Luíz Domingos, Ana Luiza Curi Hallal, Graziela De Luca Canto
{"title":"Association Between Sleep Bruxism and Quality of Life: A Systematic Review.","authors":"Joyce Duarte, Patrícia Pauletto, Carla Massignan, Michele Bolan, Fabio Luíz Domingos, Ana Luiza Curi Hallal, Graziela De Luca Canto","doi":"10.11607/ofph.2687","DOIUrl":"https://doi.org/10.11607/ofph.2687","url":null,"abstract":"<p><strong>Aims: </strong>To evaluate the association between sleep bruxism (SB) and quality of life (QoL) in the general population.</p><p><strong>Methods: </strong>A systematic review was conducted, and studies were included with no restrictions regarding age, gender, or language. SB and general health-related QoL and/or oral health-related QoL (OHRQoL) measures in the included studies needed to be based on validated tools. The databases searched were Google Scholar, LILACS, OpenGrey, ProQuest, PubMed, Science Direct, Scopus, and Web of Science. Quality of evidence was evaluated using the Joanna Briggs Institute critical appraisal checklists and GRADE (Grading of Recommendations Assessment, Development, and Evaluation) criteria.</p><p><strong>Results: </strong>Fourteen studies met the inclusion criteria. Ten studies were published in English, and four in Portuguese. All studies evaluating the association of SB with health-related QoL showed no statistical significance when overall scores were considered. The overall quality of evidence was considered very low due to high heterogeneity among the studies. SB seemed not to be associated with health-related QoL, but did have a negative impact on some characteristics of OHRQoL.</p><p><strong>Conclusion: </strong>There is insufficient scientific evidence to support or disprove the association between SB and QoL/OHRQoL in the general population.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"34 4","pages":"341-352"},"PeriodicalIF":2.5,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38348034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuanxiu Zhang, Fernando G Exposto, Anastasios Grigoriadis, Frank Lobbezoo, Michail Koutris, Jinglu Zhang, Lin Wang, Peter Svensson
{"title":"Comparison of Pain-Generated Functional Outcomes in Experimental Models of Delayed-Onset Muscle Soreness and Nerve Growth Factor Injection of the Masticatory Muscles.","authors":"Yuanxiu Zhang, Fernando G Exposto, Anastasios Grigoriadis, Frank Lobbezoo, Michail Koutris, Jinglu Zhang, Lin Wang, Peter Svensson","doi":"10.11607/ofph.2623","DOIUrl":"https://doi.org/10.11607/ofph.2623","url":null,"abstract":"<p><strong>Aims: </strong>To compare two pain models of myalgic TMD, delayed-onset muscle soreness (DOMS) and injections of nerve growth factor (NGF), in terms of pain-related and motor function outcomes, as well as activity-related temporal summation.</p><p><strong>Methods: </strong>Fifty age- and gender-matched healthy participants were recruited and randomized into one of three groups: to a repeated eccentric contraction task to cause DOMS (n = 20), to receive NGF injections into the masseter muscle (n = 20), or to a control group (n = 10). Mechanical sensitivity of masticatory muscles, chewing parameters, jaw function limitation, maximum bite force, and activity-related temporal summation were assessed at baseline and at days 1, 2, and 7 following the intervention.</p><p><strong>Results: </strong>Compared to baseline, both model groups showed increased mechanical sensitivity, jaw function limitation, pain on chewing, and decreased chewing efficiency, lasting longer in the NGF group than in the DOMS group (P < .05). Furthermore, also compared to baseline, the NGF group showed increased pain on maximum bite and decreased pain-free maximum opening (P < .05). No increases in activity-related temporal summation were shown for any of the model groups when compared to baseline or the control group (P > .05).</p><p><strong>Conclusion: </strong>Both models produced similar pain-related outcomes, with the NGF model having a longer effect. Furthermore, the NGF model showed a more substantial effect on motor function, which was not seen for the DOMS model. Finally, neither of the models were able to provoke activity-related temporal summation of pain.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"34 4","pages":"311-322"},"PeriodicalIF":2.5,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38348031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jia Yu, Sakari Laaksonen, Eerika Mursu, Matleena Typpö, Paula Pesonen, Hanna-Marja Voipio, Simo Saarakkala, Aune Raustia, Pertti Pirttiniemi
{"title":"Effects of Estrogen Level, Dietary Loading, and Aging on Types I, II, and X Collagen Expression and Structure of Rat Mandibular Condylar Cartilage.","authors":"Jia Yu, Sakari Laaksonen, Eerika Mursu, Matleena Typpö, Paula Pesonen, Hanna-Marja Voipio, Simo Saarakkala, Aune Raustia, Pertti Pirttiniemi","doi":"10.11607/ofph.2636","DOIUrl":"https://doi.org/10.11607/ofph.2636","url":null,"abstract":"<p><strong>Aims: </strong>To investigate how estrogen level, dietary loading, and aging affect cartilage structure and the expression of major collagens (types I, II, and X) in rat mandibular condylar cartilage (MCC).</p><p><strong>Methods: </strong>A total of 96 outbred Sprague Dawley female rats were randomly divided into two groups by ovariectomy (OVX) at 7 weeks old. One week later, the rats in each group were further divided into three subgroups on the basis of food hardness: hard food (diet board), normal food (pellet), and soft food (powder). The rats were sacrificed at the age of 5 or 14 months. The thickness of the fibrous, proliferative, and chondroblastic layers of the mandibular condylar cartilage were measured after toluidine blue staining. Immunohistochemical analysis was performed to evaluate the expression levels of types I, II, and X collagen. A linear regression model was used to investigate the main factors affecting changes in thickness and collagen expression.</p><p><strong>Results: </strong>The expression levels of types II and X collagen were decreased by ovarian estrogen deficiency and increased by dietary loading. Increased dietary loading was the main factor affecting an increase in thickness of the cartilage layers, while aging was the main factor affecting a decrease in thickness of the fibrous layer. A significant age-related increase was found in the expression of type I collagen. There was some degree of interaction between aging and dietary loading that affected the thickness of the chondroblastic layer and the expression of type X collagen.</p><p><strong>Conclusion: </strong>The physiologic level of estrogen plays a role in MCC development by promoting the expression of types II and X collagen. Dietary loading is essential to increase the expression of types II and X collagen, as well as the thickness of cellular layers, to maintain the integrity of the MCC. Aging seems to reduce the ability of the MCC to withstand occlusal loading.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"34 4","pages":"331-340"},"PeriodicalIF":2.5,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38348033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dejan Z Aleksic, Svetlana Miletic Drakulic, Srdjan Ljubisavljevic
{"title":"Recurrent Painful Ophthalmoplegic Neuropathy: Migraine, Neuralgia, or Something Else?","authors":"Dejan Z Aleksic, Svetlana Miletic Drakulic, Srdjan Ljubisavljevic","doi":"10.11607/ofph.2656","DOIUrl":"https://doi.org/10.11607/ofph.2656","url":null,"abstract":"<p><p>Recurrent painful ophthalmoplegic neuropathy (RPON) is a very rare disease characterized by recurrent attacks (at least two) of unilateral headache associated with ipsilateral ophthalmoplegia due to paresis of one or more cranial motor nerves, not due to any orbital, parasellar, or posterior fossa lesions. The differential diagnoses for this condition are broad. In addition to disability during an acute attack, this disease could also cause a permanent neurologic deficit. The understanding of RPON pathogenesis has changed over time, leading to a change in the classification of this disorder between editions of the International Classification of Headache Disorders, in which the condition was moved from the chapter on migraine to the chapter on cranial neuralgias and central causes of facial pain. There is no consensus on the pathogenesis of RPON. It is possible that multiple pathogenic mechanisms underlie various clinical forms of the disease. A depiction of pathologic analyses of patients with radiologically confirmed changes in the affected nerves during and outside of attacks would significantly contribute to knowledge of its pathogenesis. Brain imaging should be performed in each patient during an acute RPON attack and at a regular schedule between attacks. Further case reports and case series are required before further conclusions can be made regarding RPON pathogenesis and proposals for treatment options.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"34 4","pages":"374-378"},"PeriodicalIF":2.5,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11607/ofph.2656","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38689664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohd Khairul Anwar Mohd Tahir, Kathreena Kadir, Muzaffar Apipi, Siti Mazlipah Ismail, Zamros Yuzadi Mohd Yusof, Adrian Ujin Yap
{"title":"Translation and Adaptation of the Diagnostic Criteria for Temporomandibular Disorders into the Malay Language: Psychometric Evaluation of Contents.","authors":"Mohd Khairul Anwar Mohd Tahir, Kathreena Kadir, Muzaffar Apipi, Siti Mazlipah Ismail, Zamros Yuzadi Mohd Yusof, Adrian Ujin Yap","doi":"10.11607/ofph.2624","DOIUrl":"https://doi.org/10.11607/ofph.2624","url":null,"abstract":"<p><strong>Aims: </strong>To develop the Malay DC/TMD through a formal cross-cultural adaptation (CCA) process for use in non-English speaking populations and to determine the reliability and validity of the Malay Graded Chronic Pain Scale (M-GCPS) and Malay Jaw Functional Limitation Scale (M-JFLS).</p><p><strong>Methods: </strong>The English DC/TMD was translated into the Malay language using the forward-backward translation procedures specified in the INfORM guideline. The initial Malay instrument was pre-tested, and any discrepancies were identified and reconciled before producing the final Malay DC/TMD. Psychometric properties of the M-GCPS and M-JFLS were evaluated using a convenience sample of 252 subjects and were assessed using internal consistency and test-retest reliability, as well as face, content, concurrent, and construct validity testing. Internal consistency was assessed using Cronbach's alpha, while test-retest reliability was examined using intraclass correlation coefficient (ICC). Concurrent and construct validity of both domains were performed using Spearman ρ correlation test. In addition, construct and discriminant validity were appraised using Kruskal-Wallis and Mann-Whitney U tests, respectively.</p><p><strong>Results: </strong>Cronbach's alpha values for the M-GCPS and M-JFLS were 0.95 and 0.97, respectively. The ICC was 0.98 for the M-GCPS and 0.99 for M-JFLS. The majority of the tested associations for both domains were found to be statistically significant, with good positive correlations.</p><p><strong>Conclusion: </strong>The M-GCPS and M-JFLS were found to be reproducible and valid. The Malay DC/TMD shows potential for use among Malay-speaking adults.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"34 4","pages":"323-330"},"PeriodicalIF":2.5,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38348032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laila A Machado, Leticia S Fiedler, Yuri M Costa, Leonardo R Bonjardim, Paulo César R Conti
{"title":"Influence of Reported Physical Activity Level and Psychosocial Features on Orofacial Mechanical Sensitivity: A Pilot Study.","authors":"Laila A Machado, Leticia S Fiedler, Yuri M Costa, Leonardo R Bonjardim, Paulo César R Conti","doi":"10.11607/ofph.2559","DOIUrl":"https://doi.org/10.11607/ofph.2559","url":null,"abstract":"<p><strong>Aims: </strong>To evaluate the influence of self-reported physical activity level on painful mechanical somatosensory profile and psychosocial characteristics.</p><p><strong>Methods: </strong>A total of 90 participants, male and female, were divided into three groups based on the frequency, duration, and intensity of physical activity over the last 3 months. The classification followed a modified criterion of the short version of the International Physical Activity Questionnaire (IPAQ). Mechanical quantitative sensory tests were performed in the region of the anterior temporalis muscle and on the thenar area of the dominant hand, and psychosocial aspects were assessed using questionnaires measuring state and trait anxiety, pain catastrophizing, lifestyle, and quality of life.</p><p><strong>Results: </strong>There was no significant main effect of group on any of the somatosensory variables (F < 0.34 and P > .416). As for psychosocial aspects, the low level of physical activity group had the lowest scores on the lifestyle questionnaire (P < .009).</p><p><strong>Conclusion: </strong>Level of physical activity did not significantly influence mechanical somatosensory thresholds or temporal summation in the orofacial region, and worse quality of life was found in participants reporting a low level of physical activity.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"34 4","pages":"303-310"},"PeriodicalIF":2.5,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38348030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial: Where Do We Go From Here?","authors":"E. Eliav","doi":"10.11607/ofph.2020.3.e","DOIUrl":"https://doi.org/10.11607/ofph.2020.3.e","url":null,"abstract":"","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"27 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72736722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chuan Zhang, Hai Hu, Sushant K Das, Mao-Jiang Yang, Bing Li, Yang Li, Xiao-Xue Xu, Han-Feng Yang
{"title":"Structural and Functional Brain Abnormalities in Trigeminal Neuralgia: A Systematic Review.","authors":"Chuan Zhang, Hai Hu, Sushant K Das, Mao-Jiang Yang, Bing Li, Yang Li, Xiao-Xue Xu, Han-Feng Yang","doi":"10.11607/ofph.2626","DOIUrl":"https://doi.org/10.11607/ofph.2626","url":null,"abstract":"<p><strong>Aims: </strong>To evaluate the available literature on structural and functional brain abnormalities in trigeminal neuralgia (TN) using several brain magnetic resonance imaging (MRI) techniques to further understand the central mechanisms of TN.</p><p><strong>Methods: </strong>PubMed and Web of Science databases and the reference lists of identified studies were searched to identify potentially eligible studies through January 2019. Eligible articles were assessed for risk of bias and reviewed by two independent researchers.</p><p><strong>Results: </strong>A total of 17 articles meeting the inclusion criteria were included in this study. The methodologic quality of the included studies was moderate. A total of 10 studies evaluated structural gray matter (GM) changes, and there was reasonable evidence that the GM of some specific brain regions changed in TN patients. In addition, there was a significant change in the root entry zone of the trigeminal nerve and in several regions of white matter. Functional changes in resting state were assessed in 9 studies. TN patients showed increased activation of resting state, and this activation was reduced in specific brain regions. There were several studies that focused on the correlation between functional parameters or strength of functional connectivity and clinical features (eg, visual analog score and pain duration), but each study focused on different brain areas or different functional connectivities within the brain.</p><p><strong>Conclusion: </strong>There is moderate evidence that TN patients show structural brain differences in specific cortical and subcortical regions. In addition, TN patients show changes in pain-related functional connections in the resting state. Future research should focus on longitudinal designs and integration of different brain-imaging techniques.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"34 3","pages":"222-235"},"PeriodicalIF":2.5,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11607/ofph.2626","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38330912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria N Bot, Anton de Wijer, Jan Pool, Ewald M Bronkhorst, Stanimira Sparreboom Kalaykova, Nico Hj Creugers, Elise M van de Putte
{"title":"Physical Treatments Reduce Pain in Children with Tension-Type Headache: A Systematic Review and Meta-Analysis.","authors":"Maria N Bot, Anton de Wijer, Jan Pool, Ewald M Bronkhorst, Stanimira Sparreboom Kalaykova, Nico Hj Creugers, Elise M van de Putte","doi":"10.11607/ofph.2575","DOIUrl":"https://doi.org/10.11607/ofph.2575","url":null,"abstract":"<p><strong>Aims: </strong>To assess the effectiveness of a variety of physical treatments in the management of tension-type headache (TTH) in children.</p><p><strong>Methods: </strong>This review is reported in accordance with the PRISMA guidelines and was registered in the PROSPERO database (CRD42014015290). Randomized and nonrandomized controlled trials that examined the effects of all treatments with a physical component in the management of TTH in children and compared these treatments to a placebo intervention, no intervention, or a controlled comparison intervention were included. The Physiotherapy Evidence Database (PEDro) criteria for bias assessment and the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) Working Group criteria were used to assess the quality of the body of evidence. The outcome measures were pain, functioning, and quality of life. Only RCTs were included in the meta-analyses.</p><p><strong>Results: </strong>An initial search produced 10,464 published articles. Of these, 17 were relevant trials, including 1,815 participants. The overall GRADE rating of the included studies was moderate, and 11 of the 17 studies could be used in the meta-analyses. The effectiveness of physical treatments in terms of a reduction of pain of 50% or more showed a risk ratio (RR) of 2.37 (95% CI: 1.69 to 3.33). Relaxation training was the most evaluated intervention and proved to be significantly effective (RR: 3.00 [95% CI: 1.94 to 4.63]). In children having TTH combined with temporomandibular disorders, occlusal appliances were effective (RR: 2.58 [95% CI: 1.37 to 4.85]).</p><p><strong>Conclusion: </strong>This review supports the use of physical treatments to reduce pain in children with TTH.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"34 3","pages":"240-254"},"PeriodicalIF":2.5,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11607/ofph.2575","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38330906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tinnitus in Temporomandibular Disorders: Axis I and Axis II Findings According to the Diagnostic Criteria for Temporomandibular Disorders.","authors":"Eitan Mijiritsky, Ephraim Winocur, Alona Emodi-Perlman, Pessia Friedman-Rubin, Ehab Dahar, Shoshana Reiter","doi":"10.11607/ofph.2611","DOIUrl":"https://doi.org/10.11607/ofph.2611","url":null,"abstract":"<p><strong>Aims: </strong>To examine the associations of self-reported presence of tinnitus with subtypes of temporomandibular disorders (TMD) as assessed by Axis I of the Diagnostic Criteria for TMD (DC/TMD) and with psychologic characteristics as assessed by Axis II.</p><p><strong>Methods: </strong>This retrospective controlled study included 108 consecutive TMD patients referred to the Tel Aviv University Orofacial Pain Clinic. Each patient received full Axis I and Axis II diagnoses according to the DC/TMD. The patients were asked about currently experiencing tinnitus. Pearson chi-square test and Fisher exact test were used to test the associations between categorical variables. Mann-Whitney test was used to assess differences in continuous variables between categories. A P value < .05 was considered statistically significant.</p><p><strong>Results: </strong>Thirty-three (30.6%) TMD patients reported experiencing tinnitus. There was a significantly higher prevalence of myofascial pain with referral (P = .008) and nonspecific physical symptoms (P = .014) among the TMD patients who reported tinnitus. In addition, those patients reported significantly longer pain duration compared to TMD patients without tinnitus (P = .039).</p><p><strong>Conclusion: </strong>This study emphasizes the necessity of assessing both Axes I and II according to the DC/TMD in future studies and supports creating a standardized tinnitus screener tailored to TMD patients for future studies on tinnitus in TMD patients.</p>","PeriodicalId":48800,"journal":{"name":"Journal of Oral & Facial Pain and Headache","volume":"34 3","pages":"265-272"},"PeriodicalIF":2.5,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11607/ofph.2611","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38330910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}