Journal of Orthopaedic Surgery最新文献

{"title":"Letter to the editor regarding \"the analgesic effect and safety of duloxetine in total knee arthroplasty: A systematic review\".","authors":"Xiaomeng Tian, Ying Xu, Ye Yang, Xiaoling Hou","doi":"10.1177/10225536231198768","DOIUrl":"10.1177/10225536231198768","url":null,"abstract":"","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"31 3","pages":"10225536231198768"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10205955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the use of polymethyl-methacrylate cement after intralesional curettage of giant cell tumors of appendicular bone guarantee reduced local recurrence rates? A retrospective analysis.","authors":"Thomas Colding-Rasmussen, Peter F Horstmann, Peter H Jørgensen, Werner Hettwer, Bjarne H Hansen, Christian Nai En Tierp-Wong, Michael M Petersen","doi":"10.1177/10225536231202155","DOIUrl":"10.1177/10225536231202155","url":null,"abstract":"<p><strong>Purpose: </strong>Polymethyl-methacrylate cement (PMMA) is often used as bone defect reconstruction material after surgical removal of giant cell tumors. The purpose of this study was to investigate if the application of PMMA improves the local recurrence rates for giant cell tumors (GCT) of appendicular bone treated with intralesional curettage.</p><p><strong>Methods: </strong>A retrospective analysis of all appendicular GTCs treated at two major Danish sarcoma centres between the 1^st of January 1998 and December 31^st 2013; minimum follow-up of 3.0 years (median: 8.9; 1.3-18.7 years). Kaplan-Meier survival model, log-rank and multivariate Cox regression were used to calculate and compare local recurrence rates. <i>p</i>-values <0.05 were considered statistically significant.</p><p><strong>Results: </strong>102 patients (M59/F43), median age 31Y (11-84) were included in this study. The overall 3-years local recurrence-rate was 19.9% (95%CI: 11.9-27.9%); 91% had occurred within 3 years. In patients treated with intralesional curettage (<i>n</i> = 64), the 3-years recurrence-rate was 30.6% (95%CI: 18.8-42.4%), compared to 2.6% (95%CI: 0.0-7.8%) in patients treated with wide resection or amputation (<i>n</i> = 38), <i>p</i> < .001. The 3-years recurrence-rate for patients treated with intralesional curettage and reconstruction using PMMA was 29.0% (95%CI: 12.6-45.4%) and without PMMA: 31.8% (95%CI: 15.2-48.4%), <i>p</i> = .83.</p><p><strong>Conclusion: </strong>We found that the use of PMMA for bone defect reconstruction after intralesional curettage of GTCs in the appendicular skeleton did not ensure a reduced risk of local recurrence.</p>","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"31 3","pages":"10225536231202155"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10189670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthopaedic surgery academic productivity - how do we measure up?","authors":"Nicholas Croker, Yash Panwar, Zsolt J Balogh","doi":"10.1177/10225536221135471","DOIUrl":"10.1177/10225536221135471","url":null,"abstract":"<p><strong>Purpose: </strong>Research is vital for evidence-based surgery. Understanding scientometric differences among surgical specialties has scope to inform discussions within and across surgical specialities to develop and maintain a culture of research productivity. This study aims to quantify Australian orthopaedic surgical academic productivity compared to the other specialties within the Royal Australasian College of Surgeons' (RACS).</p><p><strong>Methods: </strong>A list of Australian surgeons registered with RACS was compiled using the \"find a surgeon\" function on the RACS Web site. This list was cross-referenced with the specialty databases on their respective websites. A name search of the SCOPUS database for each individual surgeon was performed. For each individual h-index, m-index, total active publishing years, total publications, and total citations were collected.</p><p><strong>Results: </strong>Orthopaedic surgeons had the equal lowest h-index median 2 (interquartile range:3), the shortest duration involved in research median 5 years (14), produced the fewest articles median 2 (7) and attained the second lowest number of citations median 28 (116) of the Australian surgical specialties. When the 10 individuals with highest h-index are compared among specialties, orthopaedic surgeons rank second with a median of 37 (6.5).</p><p><strong>Conclusion: </strong>Our objective data provides a factual comparison and baseline assessment of one aspect of research productivity. It can challenge currently held perceptions of performance and can inform conversations about strategic development. We recommend this assessment to other international Colleges and Societies on regular basis. These accurate academic productivity metrics provide opportunity for developing and maintaining a culture of sustained, significant contribution to surgical research.</p>","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"31 3","pages":"10225536221135471"},"PeriodicalIF":1.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10212567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three dimensional finite element analysis of biomechanics of osteotomy ends with three different fixation methods after hallux valgus minimally invasive osteotomy.","authors":"Qiang Xie,&nbsp;Xiaodong Li,&nbsp;Pei Wang","doi":"10.1177/10225536231175235","DOIUrl":"https://doi.org/10.1177/10225536231175235","url":null,"abstract":"PURPOSE Biomechanical study of fixation methods post hallux valgus minimally invasive osteotomy using finite element technology hasn't been reported. This study aimed to compare maximum displacement and stress distribution of osteotomy ends after minimally invasive osteotomy fixed by bandage, Kirschner wire, Herbert screw. METHODS Foot CT images of a patient with mild-moderate hallux valgus were collected. Three-dimensional finite element model of hallux valgus was established through CT image. This study simulated bandage, Kirschner wire and Herbert screw fixation, and analyzed maximum displacement and stress distribution of osteotomy ends in plantar flexion position of foot after fixation. RESULTS Maximum equivalent stress of osteotomy end fixed with bandage, Kirschner wire, Herbert screw was 7.8615, 14.253, 8.3156 MPa, respectively. Total displacement of osteotomy end fixed by bandage, Kirschner wire, Herbert screw was 0.26,896, 0.022,779, 0.029,195 mm, respectively. Maximum stress of Kirschner wire and Herbert screw near osteotomy end was 154.7 and 46.404 MPa, respectively. Fixation strength and stability of Kirschner wire and Herber screw were better than bandage. Kirschner wire had stress concentration phenomenon, with potential fracture risk. Stress of Herbert screw was evenly distributed around osteotomy end, and there was a certain stress concentration, playing an important role in maintaining fracture end stability. CONCLUSIONS Herbert screw showed good fixation strength and stability, and stress distribution was uniform, which can well maintain stability of minimally invasive osteotomy ends. Findings of this study would provide a theoretical basis for selection of fixation methods after clinical minimally invasive osteotomy for hallux valgus.","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"31 2","pages":"10225536231175235"},"PeriodicalIF":1.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10053966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression and diagnostic significance of integrin beta-2 in synovial fluid of patients with osteoarthritis.","authors":"Weiwei Qian,&nbsp;Zhen Li","doi":"10.1177/10225536221147213","DOIUrl":"https://doi.org/10.1177/10225536221147213","url":null,"abstract":"<p><strong>Objective: </strong>Osteoarthritis (OA) is characterized by synovial cartilage degeneration and is the leading cause of disability and pain worldwide. This study sought to investigate the expression of integrin beta-2 (ITGB2) in synovial fluid of OA patients and its clinical significance.</p><p><strong>Methods: </strong>A total of 110 OA patients were enrolled, who were classified into grade I (<i>N</i> = 35), II (<i>N</i> = 42), and III (<i>N</i> = 33) according to the Kellgren-Lawrence classification, with 110 healthy subjects as controls, and their clinical data were compared. ITGB2 level was detected by RT-qPCR. The receiver operating characteristic curve was used to analyze the predictive value of ITGB2 on OA occurrence. The correlation between ITGB2 and bone metabolism indexes procollagen type I N-terminal peptide (PINP), bone glaprotein (BGP), bone alkaline phosphatase (BALP), and β-collagen I telopeptide (β-CTX) was analyzed by the Pearson method. Logistic regression model was performed to analyze the influencing factors of OA.</p><p><strong>Results: </strong>The content of red blood cells, white blood cells, PINP, BGP, and BALP was lowered in OA patients, while β-CTX was elevated. ITGB2 was highly-expressed in OA patients, negatively-correlated with PINP, BGP, and BALP, but positively-correlated with β-CTX. ITGB2 level increased with the elevation of OA grade. The ITGB2 level >1.375 had certain diagnostic values for OA. ITGB2 level is related to OA severity and may be a biomarker for OA classification. ITGB2 was an independent risk factor for OA.</p><p><strong>Conclusion: </strong>High expression of ITGB2 in synovial fluid can assist OA diagnosis and may be a biomarker for OA grade.</p>","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"31 2","pages":"10225536221147213"},"PeriodicalIF":1.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9689676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical model of pulmonary metastasis in patients with osteosarcoma: A new multiple machine learning-based risk prediction.","authors":"Zhiping Su,&nbsp;Feihong Huang,&nbsp;Chunyue Yin,&nbsp;Yuezhao Yu,&nbsp;Chaojie Yu","doi":"10.1177/10225536231177102","DOIUrl":"https://doi.org/10.1177/10225536231177102","url":null,"abstract":"<p><strong>Background: </strong>Metastasis is one of the most significant prognostic factors in osteosarcoma (OS). The goal of this study was to construct a clinical prediction model for OS patients in a population cohort and to evaluate the factors influencing the occurrence of pulmonary metastasis.</p><p><strong>Methods: </strong>We collected data from 612 patients with osteosarcoma (OS), and 103 clinical indicators were collected. After the data were filtered, the patients were randomly divided into training and validation cohorts by using random sampling. The training cohort included 191 patients with pulmonary metastasis in OS and 126 patients with non-pulmonary metastasis, and the validation cohort included 50 patients with pulmonary metastasis in OS and 57 patients with non-pulmonary metastasis. Univariate logistics regression analysis, LASSO regression analysis and multivariate logistic regression analysis were performed to identify potential risk factors for pulmonary metastasis in patients with osteosarcoma. A nomogram was developed that included risk influencing variables selected by multivariable analysis, and used the concordance index (C-index) and calibration curve to validate the model. Receiver operating characteristic curve (ROC), decision analysis curve (DCA) and clinical impact curve (CIC) were employed to assess the model. In addition, we used a predictive model on the validation cohort.</p><p><strong>Results: </strong>Logistic regression analysis was used to identify independent predictors [N Stage + Alkaline phosphatase (ALP)+Thyroid stimulating hormone (TSH)+Free triiodothyronine (FT3)]. A nomogram was constructed to predict the risk of pulmonary metastasis in patients with osteosarcoma. The performance was evaluated by the concordance index (C-index) and calibration curve. The ROC curve provides the predictive power of the nomogram (AUC = 0.701 in the training cohort, AUC = 0.786 in the training cohort). Decision curve analysis (DCA) and clinical impact curve (CIC) demonstrated the clinical value of the nomogram and higher overall net benefits.</p><p><strong>Conclusions: </strong>Our study can help clinicians effectively predict the risk of lung metastases in osteosarcoma with more readily available clinical indicators, provide more personalized diagnosis and treatment guidance, and improve the prognosis of patients.</p><p><strong>Mini abstract: </strong>A new risk model was constructed to predict the pulmonary metastasis in patients with osteosarcoma based on multiple machine learning.</p>","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"31 2","pages":"10225536231177102"},"PeriodicalIF":1.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9701152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustentaculum tali in Chinese population: anatomy and clinical significance.","authors":"Li-Qing Liao,&nbsp;Zi-Yu Feng,&nbsp;Han Yang,&nbsp;Yi-Kai Li","doi":"10.1177/10225536231178354","DOIUrl":"https://doi.org/10.1177/10225536231178354","url":null,"abstract":"BACKGROUND Previous studies lacked adequate quantitative data on sustentaculum tali (ST), especially in Chinese population. The aims of this study are to explore the quantitative morphology of ST in dried bone specimens, and to discuss its implications related to ST screw fixation, talar articular facet variation, as well as subtalar coalitions. METHODS A total of 965 dried intact calcanei from Chinese adult donors were evaluated. All linear parameters were measured by two observers with a digital sliding vernier caliper. RESULTS Most parts of ST body can accommodate a commonly-used 4-mm-diameter screw, but the minimum height of anterior ST is only 4.02 mm. The shapes of the STs are slightly affected by left-right, subtalar facet, but the subtalar coalition may potentially increase the sizes of STs. The incidence of tarsal coalition is 14.09%. Among the osseous connection, there are 58.8% of type A articular surface and 76.5% of middle and posterior talar facet (MTF and PTF) involvement. ROC curve shows that subtalar coalition will be detected when ST length is greater than 16.815 mm. CONCLUSIONS Theoretically, all the STs can accommodate 4 mm diameter screw, but a 3.5 mm diameter screw is recommended to be placed in the middle or posterior of the small ST for safety. The shapes of the STs are greatly influenced by the subtalar coalition, while they are less affected by left-right, subtalar facet. The osseous connection is common in type A articular surface and always involved in the MTF and PTF. The cut-off value of the length of STs was confirmed as 16.815 mm for predicting subtalar coalition.","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"31 2","pages":"10225536231178354"},"PeriodicalIF":1.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9697344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studies on intramedullary nailing over 40 years by science mapping method.","authors":"Levent Horoz, Mehmet Fevzi Cakmak","doi":"10.1177/10225536231181707","DOIUrl":"10.1177/10225536231181707","url":null,"abstract":"<p><strong>Background and objective: </strong>As the amount of knowledge in literature continues to increase. Seeing research as a whole and determining its development and direction has become increasingly difficult. To overcome this challenge, new methods are needed. Among the methods developed, bibliometric methods that allow for evaluating research models from different perspectives and identifying collaborations stand out. This article it is aimed to identify the main research themes and trends, highlight the gaps in the literature, and explore the potential for research in this field.</p><p><strong>Methods: </strong>Bibliometric analyses are conducted in databases that contain high-quality data. In this regard, the Web of Science Core Collection (WoS) was chosen in our study. The search was covered the years between 1982-2022. A total of 2556 articles. In our research, articles were examined in two sections. The first section provides an overview of articles on the intramedullary nailing. In the second stage, content analyses were conducted.</p><p><strong>Results: </strong>A total of 2556 articles were published in 352 journals. The total number of authors is 8992, and the average citation per article is 18.87. The United States, China, and England are the top three countries. Based on the H-index most influential authors are Schemitsch EH and Bhandari M. The Injury-International Journal of the Care of the Injured journal has published 10.44% of all articles.</p><p><strong>Conclusion: </strong>Our study sheds light on the 40-year development dynamics of intramedullary nailing.</p>","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"31 2","pages":"10225536231181707"},"PeriodicalIF":1.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9735483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effect of C-type natriuretic peptide on persistent pain in a rat knee arthritis model.","authors":"Shoichi Hasegawa,&nbsp;Jae-Sung An,&nbsp;Jun Hino,&nbsp;Yusuke Amano,&nbsp;Yusuke Nakagawa,&nbsp;Kazumasa Miyatake,&nbsp;Hiroki Katagiri,&nbsp;Tomomasa Nakamura,&nbsp;Ichiro Sekiya,&nbsp;Hideyuki Koga,&nbsp;Kunikazu Tsuji","doi":"10.1177/10225536231181708","DOIUrl":"https://doi.org/10.1177/10225536231181708","url":null,"abstract":"<p><strong>Background: </strong>Intra-articular injection of C-type natriuretic peptide (CNP) at the acute inflammatory stage suppressed fibrotic changes in the infrapatellar fat pad (IFP), articular cartilage degeneration, and persistent pain in a monoiodoacetic acid (MIA)-induced rat knee arthritis model. In this study, we administered CNP during the inflammation subsiding period to evaluate CNP effectiveness in knees with osteoarthritis (OA) pathology.</p><p><strong>Methods: </strong>20 male Wistar rats were randomly divided into two groups. The rats received an intra-articular injection of MIA solution in the right knee to induce inflammation-induced joint degeneration. One group subsequently received an intra-articular CNP injection for six consecutive days from day 8, whereas another group received vehicle solution. Pain avoidance behavior tests and histological analyses were conducted to examine the therapeutic effects of CNP.</p><p><strong>Results: </strong>The incapacitance test indicated that the percent weight on the ipsilateral limb decreased after MIA injection by day 4 and continued to decrease until the end of the experiment in the vehicle group, suggesting persistent pain in the knee. Intra-articular injection of CNP reversed the weight-bearing ratio on day 19. Histological evaluation showed that the CNP group had more residual fat tissue in the IFP and fewer calcitonin gene-related peptide-positive nerve endings compared to the vehicle group. CNP could not reverse articular cartilage degeneration.</p><p><strong>Conclusions: </strong>Intra-articular injection of CNP after the IFP fibrosis onset had no significant effect on OA severity and extent. Nevertheless, CNP might be utilized therapeutically for OA treatment since it can alleviate persistent knee pain and inhibit structural changes in residual fat tissue.</p>","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"31 2","pages":"10225536231181708"},"PeriodicalIF":1.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9689191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of additional cathelicidin antimicrobial peptide PR-39 on prosthetic-joint infections.","authors":"Yongjun Zhu,&nbsp;Xuan Weng,&nbsp;Jian Zhang,&nbsp;Jingxin Mao","doi":"10.1177/10225536231175237","DOIUrl":"https://doi.org/10.1177/10225536231175237","url":null,"abstract":"<p><strong>Background: </strong>Prosthetic-joint infection (PJI) is one of the severest complications after arthroplasty. However, antibiotics are not effective in the bacteria in biofilm outside the prosthetic-joint. Antimicrobial peptides have an efficient antimicrobial activity in <i>staphylococcus aureus</i> compared with conventional antibiotics.</p><p><strong>Methods: </strong>Bone marrow stem cells (BMSCs) were isolated, cultured and transfected with cathelicidins antimicrobial peptides proline-arginine-rich 39 amino acid peptide (PR-39) lentivirus. The expression of PR-39 gene in BMSCs was detected by RT-PCR, and the antibacterial activity of PR-39 was measured by agar diffusion method. The transfection efficiency was detected by fluorescence microscopy. The infection model of artificial knee joint in rabbits were established. Kirschner wire was used as the knee joint implant to implant the distal femur through the femoral intercondylar fossa of rabbits. 24 rabbits were randomly divided into 2 groups for the above operations: group A was inoculated 0.5 mL into the joint cavity immediately after the incision was sutured 1 × 10⁷ <i>Staphylococcus aureus</i> of colony forming unit (CFU), group B was inoculated with <i>Staphylococcus aureus</i> and PR-39. After operation, the wound conditions and histological changes were observed by X-ray and optical microscope respectively, CRP and erythrocyte sedimentation rate were measured by test assay.</p><p><strong>Results: </strong>The transfection efficiency of lentivirus vectortransfected BMSCs was 74.09%. The supernatant of lentivirus vector had obvious inhibitory effect on <i>Staphylococcus aureus</i>, and the antibacterial rate was 98.43%. 100% infection observed in group A while few infection observed in group B; serum CRP and ESR at a high level in group A while decreased in group B after operation. There were no significant difference in CRP and ESR between the pLV/PR-39 group and pLV/EGFP group at day 1 and 3 respectively after surgery. However, CRP and ESR in the pLV/PR-39 groupwere significantly lower than the pLV/EGFP group at day 7 and 14 respectively after operation.</p><p><strong>Conclusions: </strong>Rabbits planted BMSCs expressing PR-39 were significantly increased resistance to <i>Staphylococcus aureus</i> in PJI than control group thus showing great potential for preventing implant-associated infection. It will provide a potential new therapeutic agent for implant-associated infection.</p>","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"31 2","pages":"10225536231175237"},"PeriodicalIF":1.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9698062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}