Journal of Orthopaedic Surgery最新文献

{"title":"Nationwide partial knee replacement uptake is influenced by volume and supplier--A Dutch arthroplasty register study.","authors":"Iris Koenraadt-van Oost,&nbsp;Koen Lm Koenraadt,&nbsp;Alexander Hoorntje,&nbsp;Liza N van Steenbergen,&nbsp;Stefan Bt Bolder,&nbsp;Rutger Ci van Geenen","doi":"10.1177/10225536221144726","DOIUrl":"https://doi.org/10.1177/10225536221144726","url":null,"abstract":"<p><strong>Background: </strong>Despite the established advantages of partial knee replacements (PKR), their usage remains limited. We investigated the effect of hospital knee arthroplasty (KA) volume and the availability of a frequently used PKR by the total KA supplier on the use of PKRs in a hospital.</p><p><strong>Methods: </strong>A total of 190,204 total knee replacements (TKR) and 18,134 PKRs were identified in the Dutch Arthroplasty Register (LROI) from 2007 to 2016. For each hospital we determined the annual absolute KA volume (TKR+PKR) into quartiles (<103, 103-197, 197-292, >292 knee replacements/year), and determined whether the TKR supplier provided a frequently used PKR. Hospitals were divided in routine PKR users (≥13 PKRs/year) or occasional/non PKR users (<13 PKRs/year). Based on these parameters, the effect of total KA volume and supplier on PKR usage was investigated, using chi-square tests. Logistic regression analysis was performed to evaluate the influence of the combination of these factors.</p><p><strong>Results: </strong>In the lowest volume group, around 15% of the hospitals used PKRs, compared to 75% in the highest volume group. Having a TKR supplier that also provides a frequently used PKR resulted in a higher likelihood of performing PKR, especially in low volume hospitals.</p><p><strong>Conclusions: </strong>Hospitals' total KA volume and the availability of a frequently used PKR appear to influence the use of PKR.</p>","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"30 3","pages":"10225536221144726"},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10403349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute correction of distal femoral deformities by retrograde femoral nail using preoperative planning.","authors":"Mesut Kariksiz,&nbsp;Ozgur Karakoyun","doi":"10.1177/10225536221143552","DOIUrl":"https://doi.org/10.1177/10225536221143552","url":null,"abstract":"<p><strong>Purpose: </strong>This study presents the technique and results of acute correction of distal femoral deformities using retrograde femoral nailing based on preoperative planning without using a fixator.</p><p><strong>Methods: </strong>Twenty-eight patients (34 limbs: 22 left-sided, 12 right-sided, mean age = 36 years) undergoing distal femoral deformity correction with retrograde femoral nailing between 2013 and 2020 were examined retrospectively. The osteotomy line, block screw location and number were identified by detailed preoperative planning. Osteotomy was performed using the percutaneous multiple drill method, and the retrograde femoral nail was placed.</p><p><strong>Results: </strong>The average follow-up period was 62.7 months (range: 13-84 months). Postoperatively, the mean mechanical axis deviation was corrected to 6.8 mm (range: 0-8 mm) and the mean mechanical lateral distal femoral angle to 87.42° (range: 84-90°). The Association for the Study an Application of the Method of Ilizarov (ASAMI) score was excellent for all patients. None of the patients had fracture, infection, implant failure, or non-union.</p><p><strong>Conclusion: </strong>Distal femoral deformities can be corrected acutely, without applying external fixators, with good preoperative planning and using the retrograde femoral nail. This technique is safe and effective, with a low complication rate.</p>","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"30 3","pages":"10225536221143552"},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10398688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of intermediate stage varus ankle arthritis treated by supramalleolar osteotomy.","authors":"Liangpeng Lai,&nbsp;Yan Wang,&nbsp;Yong Wu,&nbsp;Ning Sun,&nbsp;Ying Li,&nbsp;Hui Du,&nbsp;Xiaofeng Gong","doi":"10.1177/10225536221132769","DOIUrl":"https://doi.org/10.1177/10225536221132769","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the outcomes of intermediate stage varus ankle arthritis treated by supramalleolar osteotomy.</p><p><strong>Methods: </strong>Clinical data of 57 patients with varus arthritis who underwent supramalleolar osteotomy at our hospital between March 2018 and December 2019 were retrospectively analyzed. The patients were grouped according to the Takakura classification, and assessed using the American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Score and the Visual Analogue Score (VAS). Tibial anterior surface (TAS) angle and talar tilt (TT) angle were measured at the weight-bearing anteroposterior view. Tibial lateral surface (TLS) angle was measured at the weight-bearing lateral view. The differences in the above indicators of patients with different stages of varus ankle arthritis before and after treatment were analyzed.</p><p><strong>Results: </strong>The patients were followed up for an average of 31.9 ± 5.8 months. Upon the last follow-up, the AOFAS score was 84.1 ± 9.7, the VAS score 2.2 ± 1.3, the TAS angle 92.4 ± 5.5°, the TLS angle 79.3 ± 5.3°, and the TT angle 3.7±3.4°, which were significantly different from the preoperative levels (64.2 ± 14.6, 4.5 ± 1.8, 80.5 ± 6.7°, 74.9 ± 4.6°, and 5.2 ± 64.1°, respectively) (<i>p</i> < .05). There were significant differences in AOFAS and VAS scores before surgery and upon the last follow-up in each group (<i>p</i> < .05). The postoperative TT angle was significantly different from the preoperative level in stage IIIb patients (<i>p</i> = .003).</p><p><strong>Conclusions: </strong>Supramalleolar osteotomy achieved good short-to mid-term clinical outcomes for intermediate stage varus ankle arthritis. This procedure could significantly improve the TAS and TLS angles of the patients at any stage and the TT angle of stage IIIb patients.</p>","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"30 3","pages":"10225536221132769"},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10411614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Denosumab versus zoledronic acid in elderly patients after hip fracture.","authors":"Seung-Ju Kim,&nbsp;Ji Woon Kim,&nbsp;Dong-Woo Lee","doi":"10.1177/10225536221147082","DOIUrl":"https://doi.org/10.1177/10225536221147082","url":null,"abstract":"<p><strong>Background: </strong>Two injectable anti-osteoporosis medications, denosumab and zoledronic acid, have been widely used to treat patients with severe osteoporosis. The purpose of this study was to evaluate the real-world effectiveness and adherence of denosumab compared to zoledronic acid in geriatric patients after a hip fracture.</p><p><strong>Methods: </strong>A total of 282 patients treated with osteoporotic hip fracture between March 2014 and Aug 2022 were retrospectively reviewed. The patients were asked to select the anti-osteoporosis medication after surgery. Treatment persistence was monitored by follow-up visit to the outpatient clinic at postoperative 2 years.</p><p><strong>Results: </strong>Of 282 individuals with baseline data, 162 patients took subcutaneous denosumab and 120 patients took intravenous zoledronic acid. At postoperative 2 years, the change in bone mineral density (BMD) from baseline was greater in the denosumab group compared with the zoledronic acid group (<i>p</i> < 0.001). The rate of persistence to denosumab was significantly higher than that for 12-months zoledronic acid (<i>p</i> = 0.01). Serious adverse events were similar in the two groups.</p><p><strong>Conclusions: </strong>Our study revealed the effectiveness and patients' persistence for two commonly used anti-osteoporosis agents after hip fracture. In this frail, elderly population, half-yearly denosumab was superior to yearly zoledronic acid in BMD and demonstrated significant higher persistence rate, indicating a potential therapeutic advantage that warrants further validation.</p>","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"30 3","pages":"10225536221147082"},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10540033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative midflexion medial laxity using navigation affects patient expectations following posterior stabilized total knee arthroplasty.","authors":"Masahiro Hasegawa, Shine Tone, Yohei Naito, Akihiro Sudo","doi":"10.1177/10225536221119512","DOIUrl":"10.1177/10225536221119512","url":null,"abstract":"<p><strong>Background: </strong>Patient satisfaction and expectations are now recognized as an outcome measure for successful total knee arthroplasty (TKA). The purpose of this study was to determine which factors including soft tissue balance during surgery affect patient satisfaction and expectations after TKA.</p><p><strong>Methods: </strong>A total of 135 patients (157 knees) with knee osteoarthritis who underwent primary TKA with a posterior stabilized design were studied. After implantation of all components, varus/valgus laxity of the knee was measured intraoperatively with the knee at 0°, 30°, 60°, 90°, and 120° guided by an image-free navigation system. Factors that affected patient satisfaction and expectations, including lateral and medial laxities, were evaluated using the 2011 Knee Society score.</p><p><strong>Results: </strong>The mean intraoperative lateral laxity was 1.1°, 1.6°, 0.9°, 1.3°, and 1.7° with the knee at 0°, 30°, 60°, 90°, and 120°, respectively. The mean intraoperative medial laxity was 1.1°, 1.4°, 1.1°, 1.1°, and 1.7° with the knee at 0°, 30°, 60°, 90°, and 120°, respectively. Patient satisfaction after TKA correlated positively with symptom (R = 0.61, <i>p</i> < 0.01) and functional activity (R = 0.47, <i>p</i> < 0.01) scores. Patient expectations after TKA weakly positively correlated with symptom (R = 0.29, <i>p</i> < 0.01) and functional activity (R = 0.20, <i>p</i> = 0.01) scores, and weakly negatively with medial laxity at 30° (R = -0.21, <i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>Midflexion medial laxity was associated with worse patient expectations after TKA. Avoiding medial laxity could be one of the important techniques during TKA.</p>","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"30 3","pages":"10225536221119512"},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10006529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimum 3-year experience with vertebral body tethering for treating scoliosis: A systematic review and single-arm meta-analysis.","authors":"Feng Zhu,&nbsp;Xin Qiu,&nbsp;Shunan Liu,&nbsp;Kenneth Man-Chee Cheung","doi":"10.1177/10225536221137753","DOIUrl":"https://doi.org/10.1177/10225536221137753","url":null,"abstract":"<p><strong>Purpose: </strong>Over the past 12 years, vertebral body tethering (VBT) has been gradually promoted for treating scoliosis, but there are few published studies, with only short-term follow-up. This study aimed to systematically review VBT efficacy and safety for treating scoliosis.</p><p><strong>Methods: </strong>PubMed, Web of Science, Embase, and the Cochrane Library were searched for studies on VBT treatment of scoliosis published up to November 2021. Two researchers independently screened the literature, extracted data, and assessed the risk of bias in included studies. Data on clinical efficacy, unplanned reoperations, and complications were extracted. The meta-analysis was performed with R 4.1.0.</p><p><strong>Results: </strong>Twenty-six studies involving 1045 patients were included in the meta-analysis. The correction rate of major curve immediately post-operation was 46.6% ± 13.8% (16%-69%) and that at final follow-up was 53.2% ± 17.9% (16%-79%). The single-arm meta-analysis results of all included studies showed that VBT was effective in general. The overall clinical success rate was 73.02% (95% confidence interval [CI]: 68.31%-78.05%). The pooled overall unplanned reoperation rate was 8.66% (95% CI: 5.53%-13.31%). The overall incidence rate of complications was 36.8% (95% CI: 23.9%-49.7%). The subgroup analysis based on follow-up time indicated that patients with follow-up time >36 months had increased clinical success rate, unplanned reoperation rate, and incidence rate of complications compared with those with <36 months' follow-up time. The preliminary results showed that after 36 months of follow-up, only 7.17% (95% CI: 4.81%-10.55%) of patients required posterior spinal fusion (PSF) surgery and nearly 93% of patients avoided spinal fusion surgeries.</p><p><strong>Conclusions: </strong>The current evidence from at least 3-year follow-up in different countries indicates that VBT is an effective surgical approach for treating scoliosis, with 73.88% of patients achieving clinical success. Nevertheless, about one in seven patients (15.8%) required unplanned reoperations, but only 7.17% required PSF. About half (52.17%) of the patients experienced complications. Due to the limitation of the study number and quality, our conclusion may be biased and requires verification by further studies with longer follow-up times.</p>","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"30 3","pages":"10225536221137753"},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10398672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermediate-term results and risk factors analysis of tumor endoprosthesis in paediatric patients after the resection of lower extremity bone sarcoma.","authors":"Man Lung Moses Li,&nbsp;Kwok Chuen Wong,&nbsp;Wang Kei Chiu,&nbsp;Shekhar-Madhukar Kumta","doi":"10.1177/10225536221132403","DOIUrl":"https://doi.org/10.1177/10225536221132403","url":null,"abstract":"<p><strong>Background: </strong>Mechanical failure of the endoprostheses is a concern in paediatric patients with primary bone sarcoma. Their long-term results are variable in the Asian population, thus we aim to investigate the outcome by assessing the mechanical failure, its risk factors and the functional results.</p><p><strong>Methods: </strong>We retrospectively reviewed 38 paediatric patients (mean 13.29, range 6-18) with primary bone sarcoma of lower extremity undergone chemotherapy and limb salvage surgery with tumor endoprosthesis between 2003 and 2016. All hospital notes were reviewed for any type of failures. Risk factors for implant loosening like stem size, remaining bone length, stem length, extracortical bone bridge ingrowth (EBBI), the ratio of resected bone length to whole bone length, bone stem ratio and custom-made versus modular were analyzed. The limb function was recorded by Musculoskeletal Tumor Society (MSTS) score. Median follow-up time was 7.42 years (3.0-15.4 years) and minimum follow-up for surviving patients was 2 years.</p><p><strong>Results: </strong>Endoprosthesis survivorship, according to Kaplan Meier was 94.7%, 85.4% and 66.2% at 2, 5 and 10 years respectively. Type II failure occurred in three patients (7.9%). Type III failure occurred in four patients (10.5%). Type IV failure occured in two patients (5.2%). Only EBBI independently predicted implant loosening (<i>p</i> = .007). Risk factors like stem size, remaining bone length, stem length, the ratio of resected bone length to whole bone length and custom-made versus modular were not associated with increase in implant loosening (<i>p</i> > .05). The mean stem size was 9.41 mm in asymptomatic group, comparable with 9.22 mm in the failure group (<i>p</i> = .79). The MSTS score was 29.62.</p><p><strong>Conclusions: </strong>Our data suggests that paediatric Chinese patients with small body built had good and excellent mid-term results in implant survival and limb function respectively. EBBI is important in preventing loosening in tumor endoprosthesis. In contrast to the reported higher failure risk with stem size <12 mm, we found no increased loosening rate with smaller stem size endoprosthesis.</p><p><strong>Level of evidence: </strong>Class III.</p>","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"30 3","pages":"10225536221132403"},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10411856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alignment prior to total knee arthroplasty in high tibial osteotomy patients has no effect on subsequent functional outcomes.","authors":"Joshua Song,&nbsp;Don Thong Siang Koh,&nbsp;Lincoln Ming Hand Liow,&nbsp;Shi-Lu Chia,&nbsp;Ngai Nung Lo,&nbsp;Seng Jin Yeo,&nbsp;Jerry Yongqiang Chen","doi":"10.1177/10225536221132052","DOIUrl":"https://doi.org/10.1177/10225536221132052","url":null,"abstract":"<p><strong>Introduction: </strong>The influence of prior high tibial osteotomy (HTO) on total knee arthroplasty (TKA) functional outcomes remains widely debated. Alignment of failed HTO can pose technical challenges with subsequent TKA. The primary aim of this study was to evaluate the influence of HTO alignment on the clinical outcomes of subsequent TKA. The secondary aim was to compare the time to TKA for each HTO alignment type.</p><p><strong>Methods: </strong>Patients who underwent TKA post lateral closing-wedge HTO for symptomatic medial compartment osteoarthritis between 2001 and 2014 were prospectively followed up for 2 years. A total of 159 patients were assigned to three groups based on their pre-TKA femora tibia angles using long lower limb radiographs: varus alignment (VrA) ≤ 3^o valgus, neutral alignment (NA) 3-9^o valgus alignment, valgus alignment (VlA) ≥ 9^o valgus. Functional outcomes were quantified using Knee Society Function Score and Knee Scores (KSFS and KSKS respectively), modified Oxford Knee Score (OKS), Short Form 36 Physical Component Score (SF-36 PCS), and SF-36 Mental Component Score (SF-36 MCS). Pre-operative and post-operative knee range of motion were also measured.</p><p><strong>Results: </strong>Mean pre-TKA KSKS in VrA patients (35 ± 18) was significantly lower than both NA (51 ± 19) and VlA (40 ± 21) patients (<i>p</i> < .05). Otherwise, there was no significant difference in functional outcome scores (KSFS, KSKS, OKS, SF-36 PCS and SF-36 MCS) or range of motion at 6 months and 2 years post-TKA. The mean duration from HTO to TKA was 12 ± 7 years with no significant differences between VrA, NA, and VlA HTO to TKA (13 ± 7 years, 13 ± 6 years and12 ± 8 years respectively, <i>p</i> > .05).</p><p><strong>Conclusion: </strong>HTO alignment did not influence time to subsequent TKA. HTO alignment did not influence early outcomes as well as radiological outcomes of subsequent TKA.</p><p><strong>Level of evidence: </strong>III.</p>","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"30 3","pages":"10225536221132052"},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10760633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Goals, challenges and strategies for wound and bleeding management in total knee arthroplasty: A modified Delphi method.","authors":"Matthew Lyons,&nbsp;Ryan M Nunley,&nbsp;Amran Ahmed Shokri,&nbsp;Tyson Doneley,&nbsp;Hyuk-Soo Han,&nbsp;Kengo Harato,&nbsp;Ayano Kuwasawa,&nbsp;Dae-Hee Lee,&nbsp;Xin Qi,&nbsp;Wenwei Qian,&nbsp;Siripong Ratanachai,&nbsp;Weijun Wang,&nbsp;Brian Po-Han Chen,&nbsp;Walter Danker","doi":"10.1177/10225536221138985","DOIUrl":"https://doi.org/10.1177/10225536221138985","url":null,"abstract":"<p><strong>Background: </strong>Surgical techniques related to soft tissue management play critical roles in optimizing surgical outcomes and patient satisfaction in total knee arthroplasty (TKA). Despite the importance of wound closure and bleeding management approaches, no published guidelines/consensus are available.</p><p><strong>Methods: </strong>Twelve orthopedic surgeons participated in a modified Delphi panel consisting of 2 parts (each part comprising two rounds) from September-October 2018. Questionnaires were developed based on published evidence and guidelines on surgical techniques/materials. Questionnaires were administered via email (Round 1) or at a face-to-face meeting (subsequent rounds). Panelists ranked their agreement with each statement on a five-point Likert scale. Consensus was achieved if ≥70% of panelists selected 4/5, or 1/2. Statements not reaching consensus in Round 1 were discussed and repeated or modified in Round 2. Statements not reaching consensus in Round 2 were excluded from the final consensus framework.</p><p><strong>Results: </strong>Consensus was reached on 13 goals of wound management. Panelists agreed on 38 challenges and 71 strategies addressing surgical techniques or wound closure materials for each tissue layer, and management strategies for blood loss reduction or deep vein thrombosis prophylaxis in TKA. Statements on closure of capsular and skin layers, wound irrigation, dressings and drains required repeat voting or modification to reach consensus.</p><p><strong>Conclusion: </strong>Consensus from Asia-Pacific TKA experts highlights the importance of wound management in optimizing TKA outcomes. The consensus framework provides a basis for future research, guidance to reduce variability in patient outcomes, and can help inform recommendations for wound management in TKA.</p>","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"30 3","pages":"10225536221138985"},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10389474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MiR-362-5p inhibits cartilage repair in osteoarthritis via targeting plexin B1.","authors":"Qian Li,&nbsp;Ping Xu,&nbsp;Chi Zhang,&nbsp;Yang Gao","doi":"10.1177/10225536221139887","DOIUrl":"https://doi.org/10.1177/10225536221139887","url":null,"abstract":"<p><strong>Background and objectives: </strong>Chondrogenesis of bone marrow mesenchymal stem cells (BMSCs) exerts great function during the pathogenesis of osteoarthritis (OA). Studies have reported the association of plexin B1 (PLXNB1) with OA pathogenesis. In this study, the upstream mechanism and function of PLXNB1 in this disease were explored.</p><p><strong>Methods: </strong>Flow cytometry was applied to test BMSC characterization. Chondrogenic differentiation of BMSCs was evaluated by Alcian blue staining. The expression of PLXNB1, miR-362-5p, miR-501-5p, miR-1827, miR-500-5p was measured using RT-qPCR analysis. The protein levels of PLXNB1, Aggrecan, and Silent information regulator factor 2-related enzyme 1 (SIRT1) were determined by western blotting. Binding relationship between miR-362-5p and PLXNB1 was confirmed using bioinformatics analysis and luciferase reporter assay. The in vivo model of OA was established in Sprague-Dawley rats which received medial meniscus instability surgery. For histopathological examination, cartilage tissues in the knee joint of rats were stained with hematoxylin and eosin. Micro-CT analysis was employed to observe the changes of morphometric indices including average trabecular separation, average trabecular thickness, and bone volume fraction.</p><p><strong>Results: </strong>BMSCs were identified to possess the characteristics of mesenchymal stem cells. PLXNB1 was observed to be highly expressed during chondrogenic differentiation of BMSCs and PLXNB1 overexpression promoted BMSC chondrogenic differentiation. Mechanically, PLXNB1 was targeted by miR-362-5p. In rescue assays, miR-362-5p reversed the effects of PLXNB1 on chondrogenic differentiation of BMSCs. In the in vivo experiments, upregulated PLXNB1 expression alleviated joint injury of OA rats. Additionally, overexpressed miR-362-5p and downregulated PLXNB1 expression levels were detected in OA rats.</p><p><strong>Conclusion: </strong>MiR-362-5p promotes OA progression by suppressing PLXNB1.</p>","PeriodicalId":48794,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"30 3","pages":"10225536221139887"},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10397524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}