骨关节炎患者滑液中整合素-2的表达及诊断意义。

IF 1.3 4区 医学 Q3 ORTHOPEDICS
Weiwei Qian, Zhen Li
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引用次数: 0

摘要

目的:骨关节炎(OA)以滑膜软骨退行性变为特征,是世界范围内致残和疼痛的主要原因。本研究旨在探讨整合素β -2 (ITGB2)在OA患者滑液中的表达及其临床意义。方法:共入组110例OA患者,按照Kellgren-Lawrence分级分为ⅰ级(N = 35)、ⅱ级(N = 42)、ⅲ级(N = 33),并以110例健康者为对照,比较其临床资料。RT-qPCR检测ITGB2水平。采用受试者工作特征曲线分析ITGB2对OA发生的预测价值。采用Pearson法分析ITGB2与骨代谢指标前胶原I型n端肽(PINP)、骨釉蛋白(BGP)、骨碱性磷酸酶(BALP)、β-胶原I端肽(β-CTX)的相关性。采用Logistic回归模型分析OA的影响因素。结果:OA患者红细胞、白细胞、PINP、BGP、BALP含量降低,β-CTX升高。ITGB2在OA患者中高表达,与PINP、BGP、BALP呈负相关,与β-CTX呈正相关。ITGB2水平随OA等级的升高而升高。ITGB2水平>1.375对OA有一定的诊断价值。ITGB2水平与OA严重程度相关,可能是OA分类的生物标志物。ITGB2是OA的独立危险因素。结论:滑液中ITGB2的高表达有助于OA的诊断,可能是OA分级的生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Expression and diagnostic significance of integrin beta-2 in synovial fluid of patients with osteoarthritis.

Objective: Osteoarthritis (OA) is characterized by synovial cartilage degeneration and is the leading cause of disability and pain worldwide. This study sought to investigate the expression of integrin beta-2 (ITGB2) in synovial fluid of OA patients and its clinical significance.

Methods: A total of 110 OA patients were enrolled, who were classified into grade I (N = 35), II (N = 42), and III (N = 33) according to the Kellgren-Lawrence classification, with 110 healthy subjects as controls, and their clinical data were compared. ITGB2 level was detected by RT-qPCR. The receiver operating characteristic curve was used to analyze the predictive value of ITGB2 on OA occurrence. The correlation between ITGB2 and bone metabolism indexes procollagen type I N-terminal peptide (PINP), bone glaprotein (BGP), bone alkaline phosphatase (BALP), and β-collagen I telopeptide (β-CTX) was analyzed by the Pearson method. Logistic regression model was performed to analyze the influencing factors of OA.

Results: The content of red blood cells, white blood cells, PINP, BGP, and BALP was lowered in OA patients, while β-CTX was elevated. ITGB2 was highly-expressed in OA patients, negatively-correlated with PINP, BGP, and BALP, but positively-correlated with β-CTX. ITGB2 level increased with the elevation of OA grade. The ITGB2 level >1.375 had certain diagnostic values for OA. ITGB2 level is related to OA severity and may be a biomarker for OA classification. ITGB2 was an independent risk factor for OA.

Conclusion: High expression of ITGB2 in synovial fluid can assist OA diagnosis and may be a biomarker for OA grade.

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来源期刊
Journal of Orthopaedic Surgery
Journal of Orthopaedic Surgery ORTHOPEDICS-SURGERY
CiteScore
3.10
自引率
0.00%
发文量
91
审稿时长
13 weeks
期刊介绍: Journal of Orthopaedic Surgery is an open access peer-reviewed journal publishing original reviews and research articles on all aspects of orthopaedic surgery. It is the official journal of the Asia Pacific Orthopaedic Association. The journal welcomes and will publish materials of a diverse nature, from basic science research to clinical trials and surgical techniques. The journal encourages contributions from all parts of the world, but special emphasis is given to research of particular relevance to the Asia Pacific region.
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