Anaesthesia Critical Care & Pain Medicine最新文献

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Preoperative anaesthesia and other team meetings for complex cases: a narrative review 复杂病例的术前麻醉和其他团队会议:叙述性回顾。
IF 3.7 3区 医学
Anaesthesia Critical Care & Pain Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.accpm.2024.101421
Antoine Baumann , Dan Benhamou
{"title":"Preoperative anaesthesia and other team meetings for complex cases: a narrative review","authors":"Antoine Baumann ,&nbsp;Dan Benhamou","doi":"10.1016/j.accpm.2024.101421","DOIUrl":"10.1016/j.accpm.2024.101421","url":null,"abstract":"<div><h3>Background</h3><div>The conventional two-step process for surgical procedures – surgical followed by anaesthetic consultation - may not adequately address the needs of complex cases involving high-risk patients or procedures, leading to increased risks of adverse events. Although surgical team meetings (STM) and multidisciplinary team meetings (MDTM) were implemented many years ago, anaesthesia team meetings (ATM) have recently emerged as potential solutions to enhance perioperative management.</div></div><div><h3>Purpose</h3><div>We aim to systematically review and summarize the existing literature that reflects the main theoretical approaches, practices, effects, and clinical relevance of preoperative team meetings - with specific consideration to preoperative ATM - in managing difficult cases.</div></div><div><h3>Methods</h3><div>We performed a narrative review of the literature (1980–2024) to identify studies focusing on the practice and the impact of preoperative meetings on patient outcomes, compliance with treatment plans, and teamwork quality. We provide here a qualitative synthesis of the findings.</div></div><div><h3>Results</h3><div>Fourteen studies were identified: 11 consider preoperative multidisciplinary team meeting (MDTM), 2 consider preoperative surgical team meeting (STM), and only one anaesthesia team meeting (ATM).</div></div><div><h3>Conclusions</h3><div>There is currently not enough robust evidence that preoperative team meetings clearly improve hard patient’s outcome parameters. And the place for ATM does not appear to have been studied to date. There is a need for well-designed studies to explore the impact of preoperative ATM on clinical practice improvement, quality of care, and patient outcomes.</div></div>","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"43 5","pages":"Article 101421"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How green is my reusable bronchoscope? 我的可重复使用支气管镜有多环保?
IF 3.7 3区 医学
Anaesthesia Critical Care & Pain Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.accpm.2024.101420
Nicolas Massart , Christophe Millet , Hélène Beloeil , Pierre Fillatre , Caroline Rouxel , Magalie Daudin , Nicolas Coullier , Véronique Marie , Elodie Peguet , Pierre Bardoult
{"title":"How green is my reusable bronchoscope?","authors":"Nicolas Massart ,&nbsp;Christophe Millet ,&nbsp;Hélène Beloeil ,&nbsp;Pierre Fillatre ,&nbsp;Caroline Rouxel ,&nbsp;Magalie Daudin ,&nbsp;Nicolas Coullier ,&nbsp;Véronique Marie ,&nbsp;Elodie Peguet ,&nbsp;Pierre Bardoult","doi":"10.1016/j.accpm.2024.101420","DOIUrl":"10.1016/j.accpm.2024.101420","url":null,"abstract":"<div><h3>Introduction</h3><div>Single-use bronchoscopes have replaced reusable ones in many institutions. This study aimed to evaluate the environmental and financial impacts of both strategies: reusable and single-use bronchoscopes.</div></div><div><h3>Material and methods</h3><div>We conducted a pragmatic study in a 21-bed polyvalent ICU, in Saint-Brieuc, Bretagne, France. The eco-audit consisted of estimating greenhouse gas (GHG) emissions, considering the life cycle of each strategy. Greenhouse gas (GHG) emissions related to construction, packaging, transport and waste elimination were compared between 2 devices: the reusable bronchoscope, a Pentax® FI-16RBS that was disinfected twice daily; and the single-use bronchoscope, the bronchoflex agile® from TSC.</div></div><div><h3>Results</h3><div>For the reusable bronchoscope, GHG emissions were marginally impacted by the number of bronchoscopies performed (from 185 kg eq.CO<sub>2</sub> per year to 192 kg eq.CO<sub>2</sub> for 10 or 110 bronchoscopies per year). For the reusable device, GHG emissions directly depended on the number of bronchoscopies performed with 3.82 kg eq.CO<sub>2</sub> emitted per bronchoscopy. The breakeven point for the reusable bronchoscope was estimated at 50 bronchoscopies in terms of GHG emissions and 96 bronchoscopies for financial considerations.</div></div><div><h3>Conclusion</h3><div>Considering current practice in our ICU, reusable bronchoscopes have lower GHG emissions when used more than 50 times a year and a lower cost when used more than 96 times a year as compared with single-use bronchoscopes.</div></div>","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"43 5","pages":"Article 101420"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of two different positions of an anaesthesiologist for ease of endotracheal intubation in adult patients: A randomised control trial 比较麻醉师的两种不同体位对成年患者气管插管的易用性:随机对照试验。
IF 3.7 3区 医学
Anaesthesia Critical Care & Pain Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.accpm.2024.101422
Poonam Kumari, Amarjeet Kumar, Chandni Sinha, Ajeet Kumar, Kunal Singh
{"title":"Comparison of two different positions of an anaesthesiologist for ease of endotracheal intubation in adult patients: A randomised control trial","authors":"Poonam Kumari,&nbsp;Amarjeet Kumar,&nbsp;Chandni Sinha,&nbsp;Ajeet Kumar,&nbsp;Kunal Singh","doi":"10.1016/j.accpm.2024.101422","DOIUrl":"10.1016/j.accpm.2024.101422","url":null,"abstract":"<div><h3>Background and aims</h3><div>Maintaining the airway with a cuffed endotracheal tube (ETT) in the trachea remains one of the most essential anaesthesia skills. Many parameters were described to assess the difficulty of intubation in the preoperative period, but none allow the prediction of all difficult intubations. The correct posture of the anaesthesiologist is also an important factor for successful endotracheal intubation. The aim of this study was. This study aimed to compare the impact of two different positions of an anaesthesiologist (sitting <em>vs</em>. standing) at the time of endotracheal intubation.</div></div><div><h3>Methods</h3><div>One hundred ten American Society of Anaesthesiologists (ASA) Physical Status I/II patients, aged between 17 to 65 years, Mallampati grade I/II, mouth opening 39–70 mm, thyromental distance (TMD) 6–6.5 cm, and sternomental distance (SMD) &gt;13 cm, scheduled for elective laparoscopic cholecystectomy, were recruited. Patients were divided into two groups; Group I consisted of patients who underwent endotracheal intubation by an anaesthesiologist in a sitting posture, while Group II encompassed patients who underwent endotracheal intubation by anaesthesiologists in a standing posture. Assessment parameters include ease of intubation (IDS score), intubation time, intubation success rate, number of attempts, grade of laryngoscopy (Cormack Lehane score, POGO score), and complications like tooth and soft tissue damage.</div></div><div><h3>Results</h3><div>The ease of intubation was higher in group I, 1(0–1), than in group II, 1(1−2) (<em>p</em> =  0.02), and there was a significant difference between the two groups. The Cormack Lehane grade (CL) was I/IIa/IIb/III in 19/23/13/0 in group I and I/IIa/IIb/III in 13/21/18/3 in group II. The first-attempt intubation success rate for groups I and II was 94.54 % and 92.72 % respectively.</div></div><div><h3>Conclusion</h3><div>The sitting posture of an anaesthesiologist at the time of laryngoscopy provides a better intubating condition when compared with the standing posture.</div></div><div><h3>Registration</h3><div>Clinical Trial Registry - India (CTRI) CTRI/2023/03/050371.</div></div>","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"43 5","pages":"Article 101422"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methodological challenges in rapid molecular testing for pneumonia: Insights and future directions for performing “the perfect” study 肺炎快速分子检测的方法挑战:开展 "完美 "研究的启示和未来方向。
IF 3.7 3区 医学
Anaesthesia Critical Care & Pain Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.accpm.2024.101415
Antoni Torres , Laia Fernández-Barat
{"title":"Methodological challenges in rapid molecular testing for pneumonia: Insights and future directions for performing “the perfect” study","authors":"Antoni Torres ,&nbsp;Laia Fernández-Barat","doi":"10.1016/j.accpm.2024.101415","DOIUrl":"10.1016/j.accpm.2024.101415","url":null,"abstract":"","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"43 5","pages":"Article 101415"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined hypoglossal and lingual nerve palsy: An unrecognized complication after orotracheal intubation for general anaesthesia. A case report of a day surgery patient and a literature review 舌下神经和舌神经联合麻痹:全身麻醉气管插管后一种未被发现的并发症。日间手术患者的病例报告和文献综述。
IF 3.7 3区 医学
Anaesthesia Critical Care & Pain Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.accpm.2024.101418
Laure Cazenave , Philippe Mahiou , John Swan , Philippe Clavert , Johannes Barth
{"title":"Combined hypoglossal and lingual nerve palsy: An unrecognized complication after orotracheal intubation for general anaesthesia. A case report of a day surgery patient and a literature review","authors":"Laure Cazenave ,&nbsp;Philippe Mahiou ,&nbsp;John Swan ,&nbsp;Philippe Clavert ,&nbsp;Johannes Barth","doi":"10.1016/j.accpm.2024.101418","DOIUrl":"10.1016/j.accpm.2024.101418","url":null,"abstract":"<div><div>Cranial nerve injury after orotracheal intubation is a rare complication, which has varied etiology. We present a case of combined unilateral hypoglossal and lingual nerve palsy after orotracheal intubation. The current literature was reviewed for the diagnostic, treatment, follow-up, and preventive measures of this complication.</div></div>","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"43 5","pages":"Article 101418"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Universal use of videolaryngoscope for all intubations in the ICU: The time is now! 在重症监护室的所有插管过程中普遍使用视频喉镜:时不我待!
IF 3.7 3区 医学
Anaesthesia Critical Care & Pain Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.accpm.2024.101417
Clément Monet , Philippe Richebé , Samir Jaber
{"title":"Universal use of videolaryngoscope for all intubations in the ICU: The time is now!","authors":"Clément Monet ,&nbsp;Philippe Richebé ,&nbsp;Samir Jaber","doi":"10.1016/j.accpm.2024.101417","DOIUrl":"10.1016/j.accpm.2024.101417","url":null,"abstract":"","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"43 5","pages":"Article 101417"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-flow nasal cannula and in-line aerosolised bronchodilator delivery during severe exacerbation of asthma in adults: a feasibility observational study 成人哮喘严重恶化期间的高流量鼻导管和在线气雾支气管扩张剂给药:可行性观察研究。
IF 3.7 3区 医学
Anaesthesia Critical Care & Pain Medicine Pub Date : 2024-10-01 DOI: 10.1016/j.accpm.2024.101414
Nicolás Colaianni-Alfonso , Ada Toledo , Guillermo Montiel , Mauro Castro-Sayat , Claudia Crimi , Luigi Vetrugno
{"title":"High-flow nasal cannula and in-line aerosolised bronchodilator delivery during severe exacerbation of asthma in adults: a feasibility observational study","authors":"Nicolás Colaianni-Alfonso ,&nbsp;Ada Toledo ,&nbsp;Guillermo Montiel ,&nbsp;Mauro Castro-Sayat ,&nbsp;Claudia Crimi ,&nbsp;Luigi Vetrugno","doi":"10.1016/j.accpm.2024.101414","DOIUrl":"10.1016/j.accpm.2024.101414","url":null,"abstract":"<div><h3>Background</h3><div>Asthma is a common chronic respiratory disease affecting 1–29% of the population in different countries. Exacerbations represent a change in symptoms and lung function from the patient's usual condition that requires emergency department (ED) admission. Recently, the use of a High-Flow Nasal Cannula (HFNC) plus an in-line vibrating mesh nebulizer (VMN) for aerosol drug delivery has been advocated in clinical practice. Thus, this pilot observational study aims to investigate the feasibility of HFNC treatment with VMN for in-line bronchodilator delivery in patients with severe asthma.</div></div><div><h3>Methods</h3><div>This study was conducted from May 2022 to May 2023. Subjects ≥18 years old with a previous diagnosis of asthma who were admitted to the ED during severe exacerbation were included. The primary endpoint was the change in peak expiratory flow ratio (PEFR) after 2-h of treatment with bronchodilator delivered by HFNC with in-line VMN. Additional outcomes were changes in forced expiratory volume in 1 s (FEV<sub>1</sub>) and clinical variables before treatment.</div></div><div><h3>Results</h3><div>30 patients, mean age of 43 (SD ± 16) years, mostly female (67%) were studied. A significant change in PEFR (147 ± 31 L/m <em>vs.</em> 220 ± 38 L/m; <em>p</em> &lt; 0.001) was observed after treatment with HFNC and in-line VMN with significant improvement in clinical variables. And no subjects required invasive mechanical ventilation (IMV) during the study.</div></div><div><h3>Conclusions</h3><div>HFNC treatment with in-line VMN for bronchodilator delivery appears feasible and safe for patients with severe asthma exacerbation. These preliminary promising results should be confirmed with appropriately large-designed studies.</div></div>","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"43 5","pages":"Article 101414"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative Pain Management in children: guidance from the Pain Committee of the European Society for Paediatric Anaesthesiology (ESPA Pain Management Ladder Initiative) Part II 儿童术后疼痛管理:欧洲儿科麻醉学会疼痛委员会指南(ESPA 疼痛管理阶梯倡议)第二部分。
IF 3.7 3区 医学
Anaesthesia Critical Care & Pain Medicine Pub Date : 2024-09-17 DOI: 10.1016/j.accpm.2024.101427
Maria Vittinghoff , Per Arne Lönnqvist , Valeria Mossetti , Stefan Heschl , Dusica Simic , Vesna Colovic , Martin Hözle , Marzena Zielinska , Belen De Josè Maria , Francesca Oppitz , Diana Butkovic , Neil S. Morton
{"title":"Postoperative Pain Management in children: guidance from the Pain Committee of the European Society for Paediatric Anaesthesiology (ESPA Pain Management Ladder Initiative) Part II","authors":"Maria Vittinghoff ,&nbsp;Per Arne Lönnqvist ,&nbsp;Valeria Mossetti ,&nbsp;Stefan Heschl ,&nbsp;Dusica Simic ,&nbsp;Vesna Colovic ,&nbsp;Martin Hözle ,&nbsp;Marzena Zielinska ,&nbsp;Belen De Josè Maria ,&nbsp;Francesca Oppitz ,&nbsp;Diana Butkovic ,&nbsp;Neil S. Morton","doi":"10.1016/j.accpm.2024.101427","DOIUrl":"10.1016/j.accpm.2024.101427","url":null,"abstract":"<div><div>The ESPA Pain Management Ladder Initiative is a clinical practice advisory based upon expert consensus supported by the current literature to help ensure a basic standard of perioperative pain management for all children. In 2018 the perioperative pain management of six common pediatric surgical procedures was summarised. The current Pain Management Ladder recommendations focus on five more complex pediatric surgical procedures and suggest basic, intermediate, and advanced pain management methods. The aim of this paper is to encourage best possible pain management practice and to support institutions to create their own pain management concepts according to their financial and human resources due to the diversity of clinical settings in Europe. Furthermore, the authors underline that these recommendations are intended for inpatients only.</div></div>","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"43 6","pages":"Article 101427"},"PeriodicalIF":3.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of dexmedetomidine versus propofol on outcomes in critically ill patients with different sedation depths: a propensity score-weighted cohort study 右美托咪定与异丙酚对不同镇静深度重症患者预后的影响:倾向得分加权队列研究。
IF 3.7 3区 医学
Anaesthesia Critical Care & Pain Medicine Pub Date : 2024-09-16 DOI: 10.1016/j.accpm.2024.101425
Hao-Chin Wang , Chun-Jen Huang , Shu-Fen Liao , Ru-Ping Lee
{"title":"Effects of dexmedetomidine versus propofol on outcomes in critically ill patients with different sedation depths: a propensity score-weighted cohort study","authors":"Hao-Chin Wang ,&nbsp;Chun-Jen Huang ,&nbsp;Shu-Fen Liao ,&nbsp;Ru-Ping Lee","doi":"10.1016/j.accpm.2024.101425","DOIUrl":"10.1016/j.accpm.2024.101425","url":null,"abstract":"<div><h3>Objective</h3><div>We explored the effects of dexmedetomidine (DEX) versus propofol on outcomes in critically ill patients and to assess whether these effects are dissimilar under different sedation depths.</div></div><div><h3>Methods</h3><div>A stabilized inverse probability of treatment weighting cohort study was conducted using data from the Medical Information Mart for Intensive Care IV database from 2008 to 2019. Adult intensive care unit (ICU) patients who were administered DEX or propofol as the primary sedative were identified. Various statistical methods were used to evaluate the effects of DEX versus propofol on outcomes.</div></div><div><h3>Results</h3><div>Data on 107 and 2318 patients in DEX and propofol groups, respectively, were analyzed. Compared to the propofol group, the DEX group exhibited longer ventilator-free days on day 28 and a shorter ICU stay. Conversely, it showed null associations of DEX with the risk of 90-day ICU mortality, the odds of persistent organ dysfunction on day 14 and acute kidney injury, and the duration of vasopressor-free days on day 28. Subgroup analyses revealed that DEX positively impacted persistent organ dysfunction on day 14, ventilator-free days on day 28, and ICU stay in the subgroup with a Richmond Agitation Sedation Scale (RASS) score of ≥−2. However, DEX negatively impacted 90-day ICU mortality, persistent organ dysfunction on day 14, and ventilator-free days on day 28 in the subgroup with a RASS score of &lt;−2.</div></div><div><h3>Conclusion</h3><div>Our results indicated that, compared with propofol, DEX had beneficial and adverse impacts on certain ICU outcomes in critically ill patients, and these impacts appeared to depend on sedation depths.</div></div>","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"43 6","pages":"Article 101425"},"PeriodicalIF":3.7,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prophylactic application of dexmedetomidine reduces the incidence of emergence delirium in children: A systematic review and meta-analysis 预防性使用右美托咪定可降低儿童出现谵妄的几率:系统回顾与元分析。
IF 3.7 3区 医学
Anaesthesia Critical Care & Pain Medicine Pub Date : 2024-09-16 DOI: 10.1016/j.accpm.2024.101426
Sai-hao Fu , Meng-rong Miao , Lu-yao Zhang , Jing Bian , Yun-xiang Fu , Jia-qiang Zhang , Ming-yang Sun
{"title":"Prophylactic application of dexmedetomidine reduces the incidence of emergence delirium in children: A systematic review and meta-analysis","authors":"Sai-hao Fu ,&nbsp;Meng-rong Miao ,&nbsp;Lu-yao Zhang ,&nbsp;Jing Bian ,&nbsp;Yun-xiang Fu ,&nbsp;Jia-qiang Zhang ,&nbsp;Ming-yang Sun","doi":"10.1016/j.accpm.2024.101426","DOIUrl":"10.1016/j.accpm.2024.101426","url":null,"abstract":"<div><h3>Background</h3><div>Emergence delirium (ED) is a common postoperative cognitive dysfunction in children. ED may cause distress to patients and their families in the early post-anesthesia period and have long-term adverse effects on children.</div></div><div><h3>The primary purpose</h3><div>was to verify whether dexmedetomidine can reduce the occurrence of ED in children.</div></div><div><h3>Research type</h3><div>Systematic review and meta-analysis of RCTs.</div></div><div><h3>Data acquisition</h3><div>A search was conducted on Web of Science, WHO Trials, Cochrane Library, Clinical Trials.gov, and PubMed for all published studies from inception to 23 Oct. 2022.</div></div><div><h3>Eligibility criteria</h3><div>Randomized clinical trials that met the following criteria: patients aged 1–18 years, study site in the PACU (Post-anesthesia care unit), incidence of ED as the primary outcome, and prophylactic use of dexmedetomidine defined as injected before admission to the PACU.</div></div><div><h3>Results</h3><div>A total of 7 randomized trials were included (6 studies during eye and neck surgery, 1 during hernia surgery), involving 512 patients (257 (50.1%) with dexmedetomidine, and 250 (49.9%) with control. ED was observed in 17.51% of the patients treated with dexmedetomidine and in 43.14% of those receiving control (risk ratio (RR) = 0.40, 95 % confidence interval [CI] [0.30−0.55], <em>P</em> &lt; 0.00001). Additionally, the prophylactic application of dexmedetomidine also reduced the occurrence of Post-Operating Nausea and Vomiting (RR = 0.24, 95%CI [0.12−0.49], <em>P</em> = 0.0001) and PACU stay time after extubation (mean difference (MD) = −1.57, 95%CI [−3.07 to −0.07], <em>P</em> = 0.04). However, sensitivity analysis of RCTs showed that our effect estimates were not stable (MD = −1.78, 95%CI [−4.18−0.62], <em>P</em> = 0.15).</div></div><div><h3>Conclusion</h3><div>The prophylactic use of dexmedetomidine was associated with a reduction of ED. However, our findings only apply to eye and neck surgery.</div></div><div><h3>Trial registration</h3><div>PROSPERO: CRD42022371840.</div></div>","PeriodicalId":48762,"journal":{"name":"Anaesthesia Critical Care & Pain Medicine","volume":"43 6","pages":"Article 101426"},"PeriodicalIF":3.7,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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