Journal of Evidence-Based Dental Practice最新文献

{"title":"Statement of Purpose/Levels of Evidence","authors":"","doi":"10.1016/S1532-3382(25)00094-6","DOIUrl":"10.1016/S1532-3382(25)00094-6","url":null,"abstract":"","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102179"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF DIFFERENT SURFACE MODIFICATIONS ON THE OSSEOINTEGRATION OF DENTAL IMPLANT UNDER DIABETIC CONDITIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF IN VITRO RESEARCH","authors":"LE HONG ,&nbsp;HAO LI","doi":"10.1016/j.jebdp.2025.102170","DOIUrl":"10.1016/j.jebdp.2025.102170","url":null,"abstract":"<div><h3>Background</h3><div>Osseointegration, the direct connection between bone and implant, is crucial for dental implant success, particularly in patients with diabetes mellitus (DM) where impaired bone healing poses a challenge. Surface modifications of dental implants have emerged as an effective strategy to enhance osseointegration in such compromised conditions. This systematic review aimed to evaluate the impact of various surface modifications on the osseointegration of dental implants under diabetic conditions, with a focus on alkaline phosphatase (ALP) activity, osteopontin (OPN) and osteocalcin (OCN) as markers of osteogenic potential.</div></div><div><h3>Methods</h3><div>This review was conducted following PRISMA guidelines and included studies assessing surface modifications on dental implants in diabetic models. A comprehensive literature search was performed across PubMed, Embase, and Web of Science up to July 2024. Inclusion criteria focused on studies that incorporated in vitro experiments with quantitative measurements of bone formation. Data extraction and quality assessment were performed on eight selected studies. Statistical analysis included the calculation of Response Ratios (RR) for ALP activity, and meta-analyses of OCN and OPN expression levels measured at certain time point. The pooled results were visualized using forest plots.</div></div><div><h3>Results</h3><div>The included studies demonstrated a consistent increase in ALP activity across surface-modified implants, particularly at 7 and 14 days postimplantation. The 7-day RR was 2.02 (95% CI: 1.76-2.29), and the 14-day RR was 1.36 (95% CI: 1.18-1.55), indicating enhanced osteogenic potential. Similarly, OCN expression at day 7 showed a significant pooled standardized mean difference (SMD) of 11.01 (95% CI: 3.02-19.00), and OPN expression at day 7 demonstrated a more consistent effect, with a pooled SMD of 3.76 (95% CI: 2.46-5.06), all suggesting a marked upregulation of osteogenic differentiation markers. However, significant heterogeneity was observed, attributed primarily to differences in cell lines and experimental conditions.</div></div><div><h3>Conclusion</h3><div>Surface modifications significantly enhance osseointegration of dental implants in diabetic conditions, as evidenced by increased ALP activity and elevated expression levels of key osteogenic markers such as OCN and OPN. Despite the promising results, future research should address the heterogeneity by standardizing methodologies and expanding the number of included studies to refine these techniques and their clinical applicability.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102170"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALGESIC EFFECTS OF PREEMPTIVE CELECOXIB OR TRAMADOL/ACETAMINOPHEN ADDED TO STANDARD POSTOPERATIVE PAIN MANAGEMENT IN IMPACTED MANDIBULAR THIRD MOLAR EXTRACTION: A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL","authors":"SOO-HO KIM ,&nbsp;SOMI KIM ,&nbsp;YOON-SEON KIM ,&nbsp;MI-KYOUNG SONG ,&nbsp;JI-YEON KANG","doi":"10.1016/j.jebdp.2025.102135","DOIUrl":"10.1016/j.jebdp.2025.102135","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to assess the efficacy and safety of adding single-dose preemptive celecoxib 200 mg (<em>Cc</em>) or tramadol 37.5 mg/acetaminophen 325.0 mg (<em>T/A</em>) to standard postoperative analgesia after impacted mandibular third molar extraction, a design not previously explored.</div></div><div><h3>Methods</h3><div>In this multicenter, prospective, randomized, double-blind, placebo-controlled, crossover within-subject study, participants were randomly assigned to 2 groups (<em>Cc</em> or placebo for group A; <em>T/A</em> or placebo for group B) and underwent impacted mandibular third molar extraction on both sides at 1-month intervals. Along with baseline characteristics, pain intensity in Visual Analogue Scale (VAS), first perceived pain occurrence, rescue medication use, and adverse events were evaluated.</div></div><div><h3>Results</h3><div>A total of 33 participants per group completed the trial. <em>Cc</em> reduced pain at 3 (−0.91 ± 2.17; <em>P</em> = .011) and 6 hours (−0.85 ± 2.24; <em>P</em> = .018), while <em>T/A</em> reduced pain at 1 (−1.40 ± 2.37; <em>P</em> &lt; .001), 2 (−0.79 ± 2.32; <em>P</em> = .030), and 6 hours (−0.91 ± 1.94; <em>P</em> = .006) postextraction, with some insignificant reductions at other times. Both <em>Cc</em> and <em>T/A</em> were effective in reducing the first perceived pain. Notably, <em>Cc</em> significantly decreased pain intensity, <em>T/A</em> significantly delayed the pain perception. Both drugs had no significant effect on the need for rescue medication or adverse event rates.</div></div><div><h3>Conclusions</h3><div>Based on these results, both <em>Cc</em> and <em>T/A</em> appears to aid in reducing postoperative pain following impacted mandibular third molar extraction without significant adverse effects.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102135"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of myofunctional therapy for obstructive sleep apnea: A systematic review and network meta-analysis","authors":"Ying Xu Ph.D ,&nbsp;Ruicong Yang MSc ,&nbsp;Min Yu M.D. ,&nbsp;Xuemei Gao M.D., Ph.D.","doi":"10.1016/j.jebdp.2025.102137","DOIUrl":"10.1016/j.jebdp.2025.102137","url":null,"abstract":"<div><h3>Objectives</h3><div>Myofunctional therapy (MT) has emerged as an adjunct treatment for obstructive sleep apnea (OSA). This systematic review and network meta-analysis of randomized controlled trials (RCTs) aims to evaluate the efficacy of MT in treating adult and pediatric OSA.</div></div><div><h3>Methods</h3><div>Four electronic databases were searched until April 30, 2024. Meta-analysis, subgroup, and network meta-analysis using multivariate random effects were performed to estimate pooled differences, focusing on objective and subjective indicators.</div></div><div><h3>Results</h3><div>A total of 15 RCTs involving 473 adults and 139 children were eligible, with 10 adult studies (<em>n</em> = 380) included in the network meta-analysis. Compared to the controls, MT yielded an improved decrease in Epworth sleepiness scale (ESS) of −3.54 (95%CI −5.96 to −1.13, <em>P</em> = .004) and Pittsburgh sleep quality index (PSQI) of −2.24 (95%CI −3.46 to −1.01, <em>P</em> = .0003), though no statistically significant change in apnea-hypopnea index (AHI) (−8.73/h, 95%CI −21.19 to 3.74/h, <em>P</em> = 0.17). Improvements in arousal index and snoring intensity were also noted in adults. Combining MT with continuous positive airway pressure (CPAP) could lead to a pronounced reduction in AHI but did not significantly increase CPAP efficacy. Limited evidence suggests MT may benefit AHI and average SpO2 in pediatric OSA, with high compliance being essential.</div></div><div><h3>Conclusions</h3><div>The network meta-analysis supports MT as a promising adjunct for improving subjective indicators in adults and suggests that when daily training exceeds 30 minutes, MT can significantly improve AHI. Additionally, MTSP and MT combined with myofascial release may offer further benefits in subjective outcomes.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102137"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SAFETY AND EFFICACY OF DEXMEDETOMIDINE-KETAMINE COMBINATION VS DEXMEDETOMIDINE ALONE FOR PEDIATRIC DENTAL SEDATION: A SYSTEMATIC REVIEW AND META-ANALYSIS","authors":"AHMAD ABDUL KADER ABUOKAL ,&nbsp;MOUHAMMED RIHAN ,&nbsp;ABDULKARIM ALBACHA HJAZI ,&nbsp;ABDALLA IBRAHEM MOHAMMED IBRAHEM ELEMAM ,&nbsp;MAMDOUH MOHAMED RAGAEY AHMED EZZAT MOHAMED","doi":"10.1016/j.jebdp.2025.102158","DOIUrl":"10.1016/j.jebdp.2025.102158","url":null,"abstract":"<div><h3>Background</h3><div>Dexmedetomidine (D) and ketamine are widely used for pediatric dental sedation, each presenting unique benefits and potential adverse effects. Combining these agents, referred to as DK, was suggested to provide a balanced approach to pediatric sedation. This is the first systematic review and meta-analysis to evaluate the efficacy and safety of DK versus dexmedetomidine alone in pediatric dental procedures.</div></div><div><h3>Methods</h3><div>A systematic search was conducted in PubMed, Scopus, Web of Science, Embase, and CENTRAL, identifying randomized controlled trials (RCTs) comparing DK to D alone. Eligible studies were screened, and data were extracted following PRISMA guidelines. Meta-analyses were conducted using random effects models through RevMan software.</div></div><div><h3>Results</h3><div>Five studies involving 308 pediatric patients were included. Meta-analysis showed no significant difference in onset of sedation time (MD = −0.02 minutes; 95% CI = [−3.27, 3.23]; <em>P</em> = .99; I² = 29%), duration of sedation (MD = −7.39 minutes; 95% CI = [−21.69, 6.91]; <em>P</em> = .31; I² = 95%), or recovery time (MD = 4.71 minutes; 95% CI = [−12.80, 22.23]; <em>P</em> = .60; I² = 92%). Analysis of Anxiety and pain scores favored DK (SMD = −0.67; 95% CI = [−1.20, −0.14]; <em>P</em> = .01; I² = 35%), (MD = −1.11; 95% CI = [−2.04, −0.19]; <em>P</em> = .02; I² = 20%), respectively. Adverse events, including bradycardia, hypotension, and agitation, vomiting, nausea showed no significant differences between groups.</div></div><div><h3>Conclusion</h3><div>The combination of DK does not offer significant advantages over dexmedetomidine alone for pediatric dental sedation. However, DK showed a moderate reduction in anxiety and pain with a favorable safety profile, suggesting it is a viable option in clinical practice.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102158"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SILVER DIAMINE FLUORIDE MAY REDUCE DENTINE HYPERSENSITIVITY IN ADULTS","authors":"LINDA L. CHENG (Reviewer)","doi":"10.1016/j.jebdp.2025.102161","DOIUrl":"10.1016/j.jebdp.2025.102161","url":null,"abstract":"<div><h3>Article Title and Bibliographic Information</h3><div>Clinical evidence for silver diamine fluoride to reduce dentine hypersensitivity: A systematic review. Chan AKY, Tsang YC, Yu OY, Lo ECM, Leung KCM, Chu CH. J Dent. 2024 Mar; 142:104868. <span><span>doi: 10.1016/j.jdent.2024.104868</span><svg><path></path></svg></span>.</div></div><div><h3>Source of Funding</h3><div>None reported. The authors declare no conflicts of interest.</div></div><div><h3>Type of Study/Design</h3><div>Systematic review and meta-analysis.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 3","pages":"Article 102161"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECTS OF PREVENTIVE INTERVENTIONS FOR ORTHODONTICALLY INDUCED WHITE SPOT LESIONS: AN UMBRELLA REVIEW AND EVIDENCE MAPPING","authors":"JINGJING YU ,&nbsp;DANCHEN QIN ,&nbsp;FEIYANG GUO ,&nbsp;TINGTING ZHAO ,&nbsp;HONG HE ,&nbsp;FANG HUA","doi":"10.1016/j.jebdp.2025.102089","DOIUrl":"10.1016/j.jebdp.2025.102089","url":null,"abstract":"<div><h3>Objectives</h3><div>To summarize and evaluate systematic reviews (SRs) regarding preventive interventions for orthodontically induced white spot lesions (WSLs) and map currently available evidence in this field.</div></div><div><h3>Materials and methods</h3><div>An electronic search was conducted up to 20 June 2024 in the following 7 databases with no restrictions: PubMed, Embase, Web of Science, Cochrane Reviews, Scopus, WanFang, and CNKI. Screening, data extraction, and quality assessment (using AMSTAR 2 and ROBIS) were performed by 2 authors independently and in duplicate. Results were summarized and analyzed qualitatively. Evidence mapping was applied to display current evidence and research gaps.</div></div><div><h3>Results</h3><div>A total of 24 SRs were included. Only a few SRs were of ‘low’ risk of bias (<em>n</em> = 4) according to ROBIS, or of ‘high’ (<em>n</em> = 1) or ‘moderate’ overall confidence (<em>n</em> = 2) according to AMSTAR 2. The evidence mapping depicted the diversity of interventions, and 27 different comparisons in included SRs were identified. Remineralizing agents were the most frequently assessed types of interventions, while self-applied antibacterial agents and mechanical cleaning procedures were studied in few SRs. Topical fluoride applications, oral hygiene-related reminders and sealants were effective in preventing WSLs compared to control/placebo. No sufficient evidence supported the effectiveness of other interventions.</div></div><div><h3>Conclusion</h3><div>The number of high-quality SRs regarding the preventive intervention of WSLs is limited. Various preventive interventions for WSLs exist, but most current SRs focus on remineralizing agents. More high-quality randomized controlled trials are required to increase the certainty of evidence and to guide clinical practice.</div></div><div><h3>Registration</h3><div>PROSPERO (CRD42023428516).</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102089"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143550596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LOW-QUALITY EVIDENCE SUGGESTS SKELETAL ANCHORAGE MAY PROVIDE SHORT-TERM CORRECTION OF ANTERIOR OPEN BITE","authors":"ZORAN JEZDIC (Reviewers),&nbsp;MARKO LAZIC,&nbsp;ALEKSANDAR JAKOVLJEVIC","doi":"10.1016/j.jebdp.2025.102129","DOIUrl":"10.1016/j.jebdp.2025.102129","url":null,"abstract":"<div><h3>Article Title and Bibliographic Information</h3><div>Orthodontic correction of anterior open bite using skeletal anchorage: systematic review and meta-analysis. Kwon TG, Elnagar MH, Shirazi S, Goben AH, Miloro M, Han MD. Int J Oral Maxillofac Surg. 2024 May;53(5):393-404.</div></div><div><h3>Source of Funding</h3><div>The authors did not report funding for this investigation.</div></div><div><h3>Type of Study/Design</h3><div>Systematic Review with Meta-Analysis.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102129"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levels of Evidence—Grading System","authors":"","doi":"10.1016/S1532-3382(25)00067-3","DOIUrl":"10.1016/S1532-3382(25)00067-3","url":null,"abstract":"","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102152"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE MANAGEMENT OF TEETH IN ODONTOGENIC KERATOCYST AND AMELOBLASTOMA AND ITS PROGNOSTIC ROLE IN RECURRENCE: A SYSTEMATIC REVIEW AND META-ANALYSIS WITH TRIAL SEQUENTIAL ANALYSIS","authors":"PIERLUIGI MARIANI DDS ,&nbsp;DIANA RUSSO DDS, PhD ,&nbsp;MARCO CICCIÙ DDS, PhD ,&nbsp;LUIGI LAINO DDS, PhD","doi":"10.1016/j.jebdp.2025.102121","DOIUrl":"10.1016/j.jebdp.2025.102121","url":null,"abstract":"<div><h3>Introduction</h3><div>Odontogenic Keratocystic (OKC) and Ameloblastoma (AB) are pathological entities characterized by aggressive behavior, slow growth, local invasiveness, and high recurrence rates. The aim of this systematic review with meta-analysis and trial sequential analysis (TSA) is to assess the prognostic role of extracting involved teeth during the surgical enucleation of OKCs and ABs in terms of recurrence risk.</div></div><div><h3>Materials and Methods</h3><div>A search was conducted in PubMed/Medline, Scopus, and Web of Science databases for studies reporting data on teeth extraction and recurrence rates. This systematic review was performed according to guidelines in the Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. Meta-analysis was performed using the Mantel-Haenszel method with a random-effects model due to heterogeneity. The TSA was conducted to control and reduce for type I and II errors of statistical analysis.</div></div><div><h3>Results</h3><div>Six studies were identified and analyzed qualitatively and quantitatively. A total of 737 lesions (674 OKCs and 64 ABs) were included, of which 508 had involved teeth. The meta-analysis included 451 OKCs; 367 lesions were treated with teeth extraction, and in 141 cases, the teeth were preserved. The overall Risk Ratio was 0.17 (95% CI: [0.04, 0.74]; <em>P</em> &lt; .0001) for OKCs. Quantitative analysis could not be performed for ABs.</div></div><div><h3>Conclusion</h3><div>The analysis revealed that tooth extraction contextually to the enucleation of the lesion reduces the risk of recurrence by approximately 83% in the OKCs; this appears to have the same trend for ABs, but more evidence is needed.</div></div>","PeriodicalId":48736,"journal":{"name":"Journal of Evidence-Based Dental Practice","volume":"25 2","pages":"Article 102121"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}