Lancet HivPub Date : 2025-08-27DOI: 10.1016/S2352-3018(25)00184-5
Melanie A Gasper, Anna-Ursula Happel, Sonwabile Dzanibe, Jennifer Slyker, Heather B Jaspan
{"title":"Immunology of infants who are HIV-exposed uninfected in the parental combination antiretroviral therapy era.","authors":"Melanie A Gasper, Anna-Ursula Happel, Sonwabile Dzanibe, Jennifer Slyker, Heather B Jaspan","doi":"10.1016/S2352-3018(25)00184-5","DOIUrl":"https://doi.org/10.1016/S2352-3018(25)00184-5","url":null,"abstract":"<p><p>The introduction and programmatic scale-up of universal antiretroviral therapy in pregnancy (option B and option B+) and the subsequent universal test-and-treat approaches have dramatically reduced infant HIV-1 acquisitions globally, with a parallel increase in the number of infants who are HIV-exposed uninfected (HEU). Although infants who are HEU have historically had higher risk of morbidity and mortality than infants who are HIV unexposed, effective parental viral suppression has enabled people living with HIV to carry healthier pregnancies and realise the benefits of optimised feeding practices that support the transfer of key nutrients and immune factors through their parent's own milk. However, residual, heightened inflammation, altered gut microbiome, and differences in innate and adaptive immunology in infants who are HEU remain, and might contribute to persistent, heightened infectious morbidity. Parental HIV infection continues to influence child health in the option B and option B+ era; future research is needed to uncover underlying mechanisms and long-term implications of these strategies.</p>","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lancet HivPub Date : 2025-08-27DOI: 10.1016/s2352-3018(25)00130-4
Patrice Severe MD, Samuel Pierre MD, Fabienne Homeus MD, Jean Bernard Marc MD, Letizia Trevisi PhD, Maria Linda Aristhomene BS, Guirlaine R Bernadin BS, Kerlyne Lavoile BS, Vanessa Rivera BS, Carl Frederic Duchatellier MD, Marie Josee Joseph BS, John Wu MBA, Vanessa Rouzier MD, Fabiola Preval BS, Evens Jean BS, Jodany Bernadin BS, Abigail Zion BS, Guyrlaine Pierre Louis Forestal PharmD, Santiago Avila-Rios PhD, Claudia Garcia Morales PhD, Adina Zhang MS, Dennis Israelski MD, Alexandra Apollon BS, Emelyne Dumont BS, Elizabeth Fox PhD, Pierre-Yves Cremieux PhD, Prof Jean W Pape MD, Sean E Collins MD, Bernard Liautaud MD, Prof Paul E Sax MD, Serena P Koenig MD
{"title":"Bictegravir, emtricitabine, and tenofovir alafenamide versus ritonavir-boosted protease inhibitor-based antiretroviral therapy in people with HIV and viral suppression on second-line therapy in Haiti: an open-label, randomised, non-inferiority trial","authors":"Patrice Severe MD, Samuel Pierre MD, Fabienne Homeus MD, Jean Bernard Marc MD, Letizia Trevisi PhD, Maria Linda Aristhomene BS, Guirlaine R Bernadin BS, Kerlyne Lavoile BS, Vanessa Rivera BS, Carl Frederic Duchatellier MD, Marie Josee Joseph BS, John Wu MBA, Vanessa Rouzier MD, Fabiola Preval BS, Evens Jean BS, Jodany Bernadin BS, Abigail Zion BS, Guyrlaine Pierre Louis Forestal PharmD, Santiago Avila-Rios PhD, Claudia Garcia Morales PhD, Adina Zhang MS, Dennis Israelski MD, Alexandra Apollon BS, Emelyne Dumont BS, Elizabeth Fox PhD, Pierre-Yves Cremieux PhD, Prof Jean W Pape MD, Sean E Collins MD, Bernard Liautaud MD, Prof Paul E Sax MD, Serena P Koenig MD","doi":"10.1016/s2352-3018(25)00130-4","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00130-4","url":null,"abstract":"Patients on second-line protease inhibitor-based regimens in low-income and middle-income countries have high rates of nucleoside reverse transcriptase inhibitor (NRTI) resistance, but access to testing is scarce. We aimed to assess the efficacy of combination oral bictegravir, emtricitabine, and tenofovir alafenamide in this population.","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"33 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144924697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lancet HivPub Date : 2025-08-27DOI: 10.1016/s2352-3018(25)00186-9
Nicholas I Paton
{"title":"Optimised second-line regimens in the public health approach","authors":"Nicholas I Paton","doi":"10.1016/s2352-3018(25)00186-9","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00186-9","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"25 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144924694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lancet HivPub Date : 2025-08-27DOI: 10.1016/s2352-3018(25)00243-7
Peter Hayward
{"title":"Highlights of the 13th IAS Conference on HIV Science","authors":"Peter Hayward","doi":"10.1016/s2352-3018(25)00243-7","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00243-7","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"31 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144924693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lancet HivPub Date : 2025-08-27DOI: 10.1016/s2352-3018(25)00244-9
The Lancet HIV
{"title":"A moment of reckoning","authors":"The Lancet HIV","doi":"10.1016/s2352-3018(25)00244-9","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00244-9","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"60 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144924700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lancet HivPub Date : 2025-08-27DOI: 10.1016/s2352-3018(25)00184-5
Melanie A Gasper,Anna-Ursula Happel,Sonwabile Dzanibe,Jennifer Slyker,Heather B Jaspan
{"title":"Immunology of infants who are HIV-exposed uninfected in the parental combination antiretroviral therapy era.","authors":"Melanie A Gasper,Anna-Ursula Happel,Sonwabile Dzanibe,Jennifer Slyker,Heather B Jaspan","doi":"10.1016/s2352-3018(25)00184-5","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00184-5","url":null,"abstract":"The introduction and programmatic scale-up of universal antiretroviral therapy in pregnancy (option B and option B+) and the subsequent universal test-and-treat approaches have dramatically reduced infant HIV-1 acquisitions globally, with a parallel increase in the number of infants who are HIV-exposed uninfected (HEU). Although infants who are HEU have historically had higher risk of morbidity and mortality than infants who are HIV unexposed, effective parental viral suppression has enabled people living with HIV to carry healthier pregnancies and realise the benefits of optimised feeding practices that support the transfer of key nutrients and immune factors through their parent's own milk. However, residual, heightened inflammation, altered gut microbiome, and differences in innate and adaptive immunology in infants who are HEU remain, and might contribute to persistent, heightened infectious morbidity. Parental HIV infection continues to influence child health in the option B and option B+ era; future research is needed to uncover underlying mechanisms and long-term implications of these strategies.","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"11 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lancet HivPub Date : 2025-08-27DOI: 10.1016/S2352-3018(25)00240-1
{"title":"Correction to Lancet HIV 2025; 12: e638-48.","authors":"","doi":"10.1016/S2352-3018(25)00240-1","DOIUrl":"https://doi.org/10.1016/S2352-3018(25)00240-1","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144974996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lancet HivPub Date : 2025-08-21DOI: 10.1016/s2352-3018(25)00234-6
Amanda Evangelista, Anderson Kirk Nigel G Tan, Adrian E Go
{"title":"The HIV care crisis in the Philippines","authors":"Amanda Evangelista, Anderson Kirk Nigel G Tan, Adrian E Go","doi":"10.1016/s2352-3018(25)00234-6","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00234-6","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"24 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144901739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lancet HivPub Date : 2025-08-21DOI: 10.1016/s2352-3018(25)00235-8
David Jackson-Perry, Alain Amstutz
{"title":"Should we be paying more attention to HIV and adult ADHD?","authors":"David Jackson-Perry, Alain Amstutz","doi":"10.1016/s2352-3018(25)00235-8","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00235-8","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"24 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144901785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}