Lancet Hiv最新文献

{"title":"Correction to Lancet HIV 2025; 12: e701-11.","authors":"","doi":"10.1016/S2352-3018(26)00080-9","DOIUrl":"https://doi.org/10.1016/S2352-3018(26)00080-9","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"13 5","pages":"e296"},"PeriodicalIF":13.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, risk factors, and cardiovascular impact of hypertension in people with HIV: a secondary analysis of the REPRIEVE trial.","authors":"Esteban Martínez, Maya Watanabe, Risa Hoffman, Markella V Zanni, Anton Pozniak, Saate S Shakil, Sara McCallum, Sarah M Chu, Suman Srinivasa, Carlos D Malvestutto, Carl J Fichtenbaum, Gerald S Bloomfield, Craig A Sponseller, Alex B Lu, Michael T Lu, Judith A Aberg, Judith S Currier, Pamela S Douglas, Heather J Ribaudo, Steven K Grinspoon","doi":"10.1016/S2352-3018(26)00036-6","DOIUrl":"https://doi.org/10.1016/S2352-3018(26)00036-6","url":null,"abstract":"<p><strong>Background: </strong>People living with HIV have an increased risk of cardiovascular disease, but data on the development and consequences of hypertension remain limited. Using data from REPRIEVE, a global randomised trial of pitavastatin for primary cardiovascular prevention among people with HIV, we evaluated whether pitavastatin reduces the incidence of hypertension among participants without hypertension at baseline and whether incident hypertension is associated with subsequent major adverse cardiovascular events (MACE).</p><p><strong>Methods: </strong>We conducted a prespecified secondary analysis of participants without evidence of hypertension at REPRIEVE entry (baseline). REPRIEVE (NCT02344290) was a global, randomised, double-blind, placebo-controlled trial that enrolled adults with HIV aged 40-75 years at low-to-moderate atherosclerotic cardiovascular risk, receiving stable antiretroviral therapy. The primary outcome in this secondary analysis was incident hypertension based on clinical diagnosis according to standard criteria. Included participants were those without hypertension at baseline; excluded were those with documented hypertension, antihypertensive treatment use, systolic blood pressure of 140 mm Hg or higher, or diastolic blood pressure of 90 mm Hg or higher. The association between incident hypertension and a secondary outcome of MACE was evaluated in a time-updated analysis. Analyses used both Cox and Fine-Gray proportional hazards models and Poisson regression.</p><p><strong>Findings: </strong>Of 7769 participants enrolled in REPRIEVE, 4989 (64%) without hypertension at baseline were included (2496 assigned to pitavastatin and 2493 to placebo) in this secondary analysis. The median age was 49 years (IQR 45-54); 1464 (29%) were women and 3525 (71%) men; and the median systolic and diastolic blood pressures at baseline were 102 mm Hg and 76 mm Hg, respectively. Over a median follow-up of 5·0 years (IQR 4·4-5·8), 668 (13%) participants developed hypertension. Participants randomly assigned to pitavastatin showed a modestly lower incidence of hypertension (24·7 per 1000 person-years vs 29·6 per 1000 person-years), corresponding to a 17% relative risk reduction (cause-specific hazard ratio [HR] 0·83, 95% CI 0·71-0·97; p=0·017). Risk factors of incident hypertension included old age, high BMI, metabolic syndrome, reduced estimated glomerular filtration rate (eGFR), and Black race in high-income regions. Among participants with incident hypertension, 581 (87%) initiated antihypertensive therapy. Of 213 who initiated antihypertensive therapy after diagnosis of hypertension, 159 (74·6%) were controlled 4 years after diagnosis. Incident hypertension was associated with a higher risk of MACE during follow-up (subdistribution HR 2·16, 95% CI 1·32-3·52) in modelling adjusted for baseline cardiovascular risk score.</p><p><strong>Interpretation: </strong>These findings suggest additional cardiovascular benefits of pitavastat","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"13 5","pages":"e327-e337"},"PeriodicalIF":13.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The intersection of HIV and non-communicable diseases.","authors":"The Lancet Hiv","doi":"10.1016/S2352-3018(26)00081-0","DOIUrl":"https://doi.org/10.1016/S2352-3018(26)00081-0","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"13 5","pages":"e287"},"PeriodicalIF":13.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147821962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in incidence of HIV and other sexually transmissible infections among transgender people in Australia: a retrospective 10-year national clinical cohort study.","authors":"Denton Callander, Teddy Cook, Jason Asselin, David J Templeton, Arun Menon, Clara Tuck Meng Soo, Charlotte Bell, Christopher K Fairley, Mark Stoové, Margaret Hellard, Vincent Cornelisse, Rebecca Guy, Basil Dononvan","doi":"10.1016/S2352-3018(26)00010-X","DOIUrl":"https://doi.org/10.1016/S2352-3018(26)00010-X","url":null,"abstract":"<p><strong>Background: </strong>In Australia, transgender people have largely been excluded from public health surveillance for HIV and other sexually transmissible infections (STIs). We aimed to provide a comprehensive overview of HIV and STIs among transgender people in Australia, including to investigate trends over time and risk factors.</p><p><strong>Methods: </strong>A retrospective clinical cohort study was conducted using 10 years of health record data (between Jan 1, 2014, and Dec 31, 2023) from 87 health services across Australia. A primary transgender cohort and two comparative cisgender cohorts (gay and bisexual men, and heterosexual people) were established. Incidence was estimated using repeat testing, with the year fitted as an independent variable in Poisson regression while controlling for sociodemographic and behavioural characteristics.</p><p><strong>Findings: </strong>The primary cohort comprised 7284 transgender people (4672 transgender women, 2213 transgender men, and 399 non-binary people); the comparative cisgender cohorts comprised 152 144 gay and bisexual men and 394 332 heterosexual people. Among transgender people, HIV incidence decreased by 93·9%, from 1·19 per 100 person-years to 0·07 per 100 person-years (incidence rate ratio [IRR] per year 0·72 [95% CI 0·66-0·79]). For transgender people, HIV incidence was highest among women (0·37 per 100 person-years) and lowest among men (0·20 per 100 person-years; IRR 0·54 [95% CI 0·29-0·99]). Transgender people overall had an HIV incidence comparable with cisgender gay and bisexual men (0·33 per 100 person-years and 0·29 per 100 person-years, respectively; adjusted IRR 0·87 [95% CI 0·70-1·08]), whereas HIV incidence was lower among cisgender heterosexual people (0·003 per 100 person-years; 0·01 [0·01-0·01]). Incidences of other STIs were generally stable among transgender people over time (33·73 per 100 person-years for chlamydia, 30·18 per 100 person-years for gonorrhoea, and 2·67 per 100 person-years for syphilis), with some distinctions by anatomical site. Among transgender people, HIV pre-exposure prophylaxis was negatively associated with incident HIV (adjusted IRR 0·40 [95% CI 0·19-0·88]) but positively associated with other STIs (1·38 [1·31-1·46]).</p><p><strong>Interpretation: </strong>HIV incidence declined among transgender people in Australia, whereas other STIs were stable. To build on this success, HIV and STI policies, guidelines, interventions, and funding in Australia should more actively support transgender populations.</p><p><strong>Funding: </strong>Australian Department of Health & Aged Care and UNSW Health Systems Research.</p>","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lenacapavir PrEP roll-out begins in Africa.","authors":"Paul Adepoju","doi":"10.1016/s2352-3018(26)00103-7","DOIUrl":"https://doi.org/10.1016/s2352-3018(26)00103-7","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"13 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Russia's internet blackout affects HIV services.","authors":"Ed Holt","doi":"10.1016/s2352-3018(26)00099-8","DOIUrl":"https://doi.org/10.1016/s2352-3018(26)00099-8","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"66 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147751281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ending HIV requires research in and with South Africa","authors":"Danielle Giovenco, Millicent Atujuna, Don Operario, Linda-Gail Bekker","doi":"10.1016/s2352-3018(26)00077-9","DOIUrl":"https://doi.org/10.1016/s2352-3018(26)00077-9","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"9 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147681107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted universalism for long-acting PrEP: an urgent need to avoid risk targeting and build population-level impact.","authors":"Laura K Beres,Sheree R Schwartz,Ronald Olum,Lillian M Shipp,Natalie Vlahakis,Michael E Herce,Daniel K Were,Stefan Baral,Chama Mulubwa,Chanda Mwamba,Maurice Musheke,Chris Beyrer,Elvin H Geng","doi":"10.1016/s2352-3018(26)00034-2","DOIUrl":"https://doi.org/10.1016/s2352-3018(26)00034-2","url":null,"abstract":"New long-acting HIV prevention product choices, including lenacapavir, cabotegravir, and investigational monthly oral MK‑8527, usher in promise for ending HIV as a public health threat. Decisions taken at a product's launch determine who will access it and shape its population-level impact. We argue that targeted universalism should be used to organise the roll‑out of pre-exposure prophylaxis (PrEP) choices. Targeted universalism means setting the goal of universal access for anyone who wants effective prevention and then tailoring functional supports, such as convenient delivery points and improved provider capacity for supportive interactions, to: 1) guide distribution of limited supply, and 2) help groups facing the steepest barriers to engage with prevention on an equal footing. As a policy framework, targeted universalism thus seeks to avoid mistakes that have restricted the population-level impact of oral PrEP by eliminating epidemiologically driven risk targeting, reckoning with the social resistance associated with stigmatised interventions and populations, and facilitating equitable coverage through systems strengthening.","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"11 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147655756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The caveats of short-cycle antiretroviral therapy in adolescents living with HIV","authors":"Romain Palich, Jean-Jacques Parienti","doi":"10.1016/s2352-3018(25)00333-9","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00333-9","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"23 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147642186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of short-cycle, dolutegravir-based antiretroviral therapy in adolescents living with HIV (BREATHER Plus): a multicentre, open-label, randomised, parallel, two-arm, non-inferiority trial","authors":"Adeodata R Kekitiinwa MMed, Angus Jennings MSc, Mutsa Bwakura-Dangarembizi PhD, Cissy Kityo PhD, Prof Abraham Siika MMed, Prof Moherndran Archary PhD, Alexandra Green MSc, Lungile Jafta BComH, George Patrick Akabwai MMED, Prof Hilda Angela Mujuru MMed, Henry Mugerwa MSc, Cecilia Kiilu MMed, Rosie Mngqibisa MPH, Prof Janet Seeley PhD, Rashidah Nazzinda MBchB, Naomi Apoto MPH, Prof Simon Walker MSc, Prof David Burger PhD, Carlo Giaquinto MD, Resty Babirye Okello MSc, Godfrey Musoro MSc, Charity Wambui DrPH, Tiyara Arumugam MBChB, Magda Conway BAHons, Nadine Van Looy MSc, Annabelle South PhD, Alasdair Bamford PhD, Margaret J Thomason PhD, Deborah Ford PhD, Prof Sarah L Pett PhD, BREATHER Plus trial team, Sarah Pett, Deborah Ford, Margaret Thomason, Alasdair Bamford, Ellen White, Jessica Kirk, Angus Jennings, Helen Ainscough, Rebecca Dodds, Molly Bush, Simona Salomone, Hanh Nguyen, Anas Omar, Ben Spittle, Paul Crawley, Alexandra Green, George Pettitt, Jemima Shickle, Stephen Townsend, Hannah Sweeney, Margaret Hook, Sara Peres, Nadine Van Looy, Andy Sum, Diana Gibb, Annabelle South, Berta Terre-Torras, Elizabeth Chappell, Aoife Nolan, Adeodata Kekitiinwa, George Patrick Akabwai, Fredrick Katongole, Naomi Apoto, Resty Babirye Okello, Ronald Nabimba, Muzamil Nsibuka Kisekka, Collins Mujyanama, Gerald Agaba Muzorah, Gideon Ahimbisibwe, Florence Namuli, Rose Namaganda, Lameck Kiyimba, Angella Baita, Rachael Namuddu Kikabi, Henry Balwa, Susan Tukamuhebwa, Maria Benita Aino, Judith Tikabibamu, Anthony Kirabira, Lekku Lawrence, Barbra Nantume, Muhammad Lutalo, Diana Louis Anena, Rose Jacqueline Kadhuba, Patricia Nahirya Ntege, Teddy Kembabazi, Cissy Kityo, Victor Musiime, Shamim Nakabuye, Miriam Namasinga, Peace Hellen Masiga, Roselyn Kabasingo, Claire Nasaazi, Centurio Wandera, Josephine Kobusingye, Disan Mulima, Alex V Musiime, Faith Mbasani, Ezra Lutalo, Brenda Namukwaya Efrance, Odoch Denis, Baliruno David, Ampaire Phionah, Edgar Ayesiga Wandigali, Patrick Ssebunya, Barbara Mukanza, Rashidah Nazzinda, Ritah Mbabazi, Abigail Atwine, Juliet Ankunda, Priscilla Kyobutungi, Elizabeth Kaudha, Sharif Musumba, Jesca Nantale, Mariam Naabalamba, Mangadalen Nansaigi, Diana Antonia Rutebarika, Mary Nannungi, Benson Ouma, Edward Bagirigomwa, Eddie Rubanga, Josephine Namusanje, Henry Mugerwa, Crispus Katemba, Deborah Kahinju, Eram David Williams, Juliet Ategeka, Ocitti Sunday Paul Labeja, Joan Nantege, Shirat Nakabiri, Jeremy Kirunda, Charles Draleku, Jamilah Namwanga, Joan Nangiya, Baker Rubinga, Rodney Kazooba, Cate Naluyima, Christopher Lwanga, Faith Balmoi Labote, Dridah Nakiboneka, Bibian Nakigozi Nakato, Christine Nambi, Milly Ndigendawani, Jovia Kavuma, Timothy Lubwama, Frank Mbamanya, Nabuuma Haawa Muweesi, Carol Otike, Mwanje John Bosco, Anna Ritah Namuganga, Mutsawashe Bwakura-Dangarembizi, Kusum Nathoo, Hilda Mujuru, Misheck Phiri, Stuart Chitongo, Wendy Mapfumo, Sandra Musarurwa, Taona Mudzviti, Columbus Moyo, Shepherd Mudzingwa, Shirley Mutsai, Vivian Mumbiro, Joy Chimanzi, Makhosonke Ndlovu, Maureen Tshuma, Ruth Nhema, Ennie Chidziva, Cleopatra Langa, Godfrey Musoro, Dorinda Mukura, Edson Marimo, Tinashe Chidemo, Bernadette Malunda, Musunga Tomu, Lynnet Nyakudya, Nicholas Dhibi, Alfed Kateta, Sidney Sithole, Lynette Chibanda, Deka Vincent, Elaine Mwandiwata, Secrecy Gondo, Moses Chitsamatanga, Farai Selina Matimba, Tsitsi Gwenzi, Nathalie Mudzimirema, Allen Matubu, Prosper Sibonile Dube, Pia Ngwaru, Joyline Bhiri, Trust Mukanganiki, Vinie Kouamou, Rufaro Chivaura, Xeshelihle Mhlanga, Hazel Patricia Munyama, Sibusisiwe Weza, Vongai Margaret Chanaiwa, Shamiso Barbara Gwande, Constantine Mutata, Dorothy Murungu, Abraham Siika, Winstone Nyandiko, Cecilia Kiilu, Charity Wambui, Ronald Tonui, Viola Kirui, Caroline Watiri Maina, Florence Kiwunja Njulu, Cornelius Chege, Natalie Sang, Beatrice K. Jakait, Damaris Lagat, Salinah Cherutich, Benedister Kangogo Cheruiyot, Brian Odul, Hilda Kaziga, Teri Tarus, Getruth Jerop Kiptoo, Vincent Kipchirchir, Clinton Otieno Achida, Tom Oyoo Osoro, Jairus Kipyego, Violah Samoei, Martha Mokeira Mokaya, Wilson Lokitala Ekiru, Ruth Bosire, Rispher Chepkoech, Festus Kirwa Rugut, Matthew Justus Mutuku, Hellen Jerotich Kiplagat, Millicent Orido, Eslyne Jepkemboi, Vincent Otieno Onyango, Alice Mudogo, Mary Chebet, Joan Chepkurui Kotut, Philemon Kipchirchir Mutai, Eunice Jepkemboi, Julie Chepchumba Choge, Evans Ochieng Ouno, Cecilia Chebet Mengich, Amina Msuo Shali, Solomon Kimurgor Ngetich, Dorcas Akinyi Opot, Shauri Kahindi Gona, Richard Kipsang Kirui, Damaris Jepchumba Kiprutto, Mowlem Pierre, Dorcus Adhiambo, Nicholas Kigen, Sophia Simatwa, Michael Njenga, Cornelius Magut, Kennedy Oyamo, Edna Jepngetich, Gideon Obila, Lydiah Maru, Victor Kibet Langat, Iris Jaluha Sande, Scholastica Njeri Wanjiru, Martha Kaimuri Mwongela, Moherndran Archary, Sundrapragasen Pillay, Rosie Mngqibisa, Raziya Bobat, Nozibusiso Rejoice Mosia, Precious Sphiwe Cebekhulu, Nombuso Nkosi, Rashina Nundlal, Saajida Rizvi, Jabu Mkhulise, Innocentia Thandokuhle Mncube, Nathaniel Malatjie, Shingirai Chimene, Zethu Mnyandu, Sheleika Singh, Clement Pillay, Tiyara Arumugam, Shauna Francis, Michelle Moodley, Sylvia Nylobo, Fathima Mather, Ida Mundhree, Popi Shabalala, Ntombizonta Ignatia Phewa, Khombisile Muthwa, Simangele Abigail Bengu, Tshamand Fulufhelo Netshitangani, Rayania Premoutt, Kelly Shermon Clark, Mthokozisi Khuzwayo, Janet Seeley, Sarah Bernays, Nothando Ngwenya, Tawanda Makusha, Zinhle Ngubo, Phindile Guga, Londiwe Shandu, Tamlyn Seunanden, Stella Namukwaya, Allen Asiimwe, Alice Nassanga, Paul Revill, Simon Walker, Yingying Zhang, David Burger, Angela Colbers, Tom Jacobs, Lisanne Bevers, Magda Conway, Lungile Jafta, Mercy Shibemba, Carlo Giaquinto, Karina Butler, Sam Phiri, Avy Violari, Nathan Ford, Imelda Mahaka, Addy Kekitiinwa, Hebron Kalikwani, Priscilla Nakiwala, Anton Pozniak, Rodolphe Thiebaut, Jane Crawley, Justus Ashaba","doi":"10.1016/s2352-3018(25)00326-1","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00326-1","url":null,"abstract":"Short-cycle antiretroviral therapy (ART), comprising 5 days on and 2 days off treatment, offers the potential for ART-free weekends, reduced toxicity, and improved quality of life for adolescents living with HIV, who typically have worse treatment outcomes than other age groups. We aimed to compare the efficacy and safety of short-cycle ART containing tenofovir disoproxil fumarate–lamivudine–dolutegravir with continuous ART in adolescents living with HIV in Africa.","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"51 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147642187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}