Lancet Hiv最新文献

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The promise and paradox of HIV self-testing in the era of twice-yearly PrEP. 在每年两次的PrEP时代,HIV自我检测的希望与矛盾。
IF 16.1 1区 医学
Lancet Hiv Pub Date : 2025-10-01 DOI: 10.1016/s2352-3018(25)00263-2
Victor Abiola Adepoju,Abdulrakib Abdulrahim,Shankar Biswas
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引用次数: 0
Russia spiralling into an HIV crisis. 俄罗斯陷入了艾滋病危机。
IF 16.1 1区 医学
Lancet Hiv Pub Date : 2025-10-01 DOI: 10.1016/s2352-3018(25)00272-3
The Lancet Hiv
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引用次数: 0
Bridging the gap in Ecuador's health system. 弥合厄瓜多尔卫生系统的差距。
IF 13 1区 医学
Lancet Hiv Pub Date : 2025-10-01 Epub Date: 2025-05-30 DOI: 10.1016/S2352-3018(25)00133-X
Joe Parkin Daniels
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引用次数: 0
Reimagining HIV prevention with artificial intelligence. 用人工智能重新构想艾滋病预防。
IF 13 1区 医学
Lancet Hiv Pub Date : 2025-10-01 Epub Date: 2025-06-11 DOI: 10.1016/S2352-3018(25)00158-4
Jirair Ratevosian, Michael Reid, Zhao Ni, Rouella Mendonca, Robyn Eakle, Cheryl Johnson, Izukanji Sikazwe, Meshack Ndirangu, Solange Baptiste, Linda-Gail Bekker
{"title":"Reimagining HIV prevention with artificial intelligence.","authors":"Jirair Ratevosian, Michael Reid, Zhao Ni, Rouella Mendonca, Robyn Eakle, Cheryl Johnson, Izukanji Sikazwe, Meshack Ndirangu, Solange Baptiste, Linda-Gail Bekker","doi":"10.1016/S2352-3018(25)00158-4","DOIUrl":"10.1016/S2352-3018(25)00158-4","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":" ","pages":"e670-e671"},"PeriodicalIF":13.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Community and care in MENA's HIV crisis. 中东和北非地区艾滋病毒危机中的社区和护理。
IF 13 1区 医学
Lancet Hiv Pub Date : 2025-10-01 Epub Date: 2025-06-24 DOI: 10.1016/S2352-3018(25)00187-0
Vijay Shankar Balakrishnan
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引用次数: 0
Love, resilience, and community in the Chilean desert. 智利沙漠中的爱、韧性和社区。
IF 16.1 1区 医学
Lancet Hiv Pub Date : 2025-09-26 DOI: 10.1016/s2352-3018(25)00238-3
Fio Trethewey
{"title":"Love, resilience, and community in the Chilean desert.","authors":"Fio Trethewey","doi":"10.1016/s2352-3018(25)00238-3","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00238-3","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"70 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nostalgic throwbacks in Sad Gay AIDS Play parody. 《悲伤的同性恋艾滋病戏》中的怀旧复古戏。
IF 16.1 1区 医学
Lancet Hiv Pub Date : 2025-09-26 DOI: 10.1016/s2352-3018(25)00237-1
Peter Ranscombe
{"title":"Nostalgic throwbacks in Sad Gay AIDS Play parody.","authors":"Peter Ranscombe","doi":"10.1016/s2352-3018(25)00237-1","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00237-1","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"327 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Creating a space where young people with HIV can be free. 为感染艾滋病毒的年轻人创造一个自由的空间。
IF 16.1 1区 医学
Lancet Hiv Pub Date : 2025-09-26 DOI: 10.1016/s2352-3018(25)00267-x
Roger Pebody
{"title":"Creating a space where young people with HIV can be free.","authors":"Roger Pebody","doi":"10.1016/s2352-3018(25)00267-x","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00267-x","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"65 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to Lancet HIV 2025; 12: e473-84. 《柳叶刀HIV 2025》修正;12: e473 - 84。
IF 13 1区 医学
Lancet Hiv Pub Date : 2025-09-25 DOI: 10.1016/S2352-3018(25)00297-8
{"title":"Correction to Lancet HIV 2025; 12: e473-84.","authors":"","doi":"10.1016/S2352-3018(25)00297-8","DOIUrl":"https://doi.org/10.1016/S2352-3018(25)00297-8","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":" ","pages":""},"PeriodicalIF":13.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ART-free HIV-1 remission in children with in-utero HIV-1 after very early ART (IMPAACT P1115): a multicentre, open-label, phase 1/2 proof-of-concept study. 早期ART治疗后子宫内HIV-1患儿无ART缓解(IMPAACT P1115):一项多中心、开放标签、1/2期概念验证研究
IF 16.1 1区 医学
Lancet Hiv Pub Date : 2025-09-24 DOI: 10.1016/s2352-3018(25)00189-4
Deborah Persaud,Anne Coletti,Bryan S Nelson,Jennifer Jao,Edmund V Capparelli,Diane Costello,Camlin Tierney,Adeodata R Kekitiinwa,Teacler Nematadzira,Boniface N Njau,John Moye,Patrick Jean-Philippe,Violet Korutaro,Annet Nalugo,Tapiwa Mbengeranwa,Tinashe Chidemo,Blandina T Mmbaga,Philoteus A Sakasaka,Mark Cotton,Cheryl Jennings,Carly Hoffmann,Laura Hovind,Yvonne Bryson,Ellen G Chadwick,
{"title":"ART-free HIV-1 remission in children with in-utero HIV-1 after very early ART (IMPAACT P1115): a multicentre, open-label, phase 1/2 proof-of-concept study.","authors":"Deborah Persaud,Anne Coletti,Bryan S Nelson,Jennifer Jao,Edmund V Capparelli,Diane Costello,Camlin Tierney,Adeodata R Kekitiinwa,Teacler Nematadzira,Boniface N Njau,John Moye,Patrick Jean-Philippe,Violet Korutaro,Annet Nalugo,Tapiwa Mbengeranwa,Tinashe Chidemo,Blandina T Mmbaga,Philoteus A Sakasaka,Mark Cotton,Cheryl Jennings,Carly Hoffmann,Laura Hovind,Yvonne Bryson,Ellen G Chadwick, ","doi":"10.1016/s2352-3018(25)00189-4","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00189-4","url":null,"abstract":"BACKGROUNDWe hypothesised that initiating antiretroviral therapy (ART) soon after birth could limit HIV-1 reservoirs and promote ART-free remission. This study aims to assess remission in children with in-utero HIV-1 infection who received very early ART as neonates by performing analytical treatment interruption (ATI).METHODSIMPAACT P1115 is an ongoing, open-label, proof-of-concept study at 30 research sites in 11 countries across Africa, Asia, and the Americas. Neonates (≥34 weeks gestational age) at high risk for in-utero HIV-1 were eligible. Neonates born to mothers with untreated HIV-1 (cohort 1) or mothers who might have been on ART (cohort 2) initiated three-drug oral nevirapine-based ART (6mg/kg per dose orally twice a day) within 48 h of birth (cohort 1), three-drug nevirapine-based prophylaxis (≥8 mg/kg per dose orally once a day), or nevirapine-based ART after HIV-1 diagnosis by age 10 days (cohort 2). Coformulated ritonavir 75 mg/m2 and lopinavir 300 mg/m2 orally twice a day was added when age appropriate for those with confirmed in-utero HIV-1. Nevirapine was discontinued 12 weeks after two consecutive plasma viral loads were below the assay limit. Children at least 2 years of age maintaining undetectable HIV-1 RNA since week 48 and who tested HIV-1 antibody negative, HIV-1 DNA not detected, and normal CD4 count and percentage qualified for ATI. The primary outcome was ART-free remission, defined as no HIV-1 RNA in plasma for 48 weeks or more off ART. A two-sided exact 95% CI was calculated to estimate the probability of remission. This study is registered with ClinicalTrials.gov (NCT02140255).FINDINGSAmong 54 children with in-utero HIV-1 enrolled between Jan 23, 2015, and Dec 14, 2017, six (11%) children (four girls, two boys; one in cohort 1, five in cohort 2) met criteria and underwent ATI at a median age of 5·5 years. Two children had early rebound at 3·4 weeks and 9·4 weeks. Four reached ART-free remission (67%; exact 95% CI 22-96), one of whom had late viral rebound at 79·3 weeks. All three children with viral rebound successfully resuppressed HIV-1 RNA below the assay limit on ART. Mild symptoms of acute retroviral syndrome occurred in two participants during rebound and resolved with ART resumption.INTERPRETATIONThis study shows that ART-free remission for 48 weeks or longer is achievable with very early ART in children with in-utero HIV-1, but close monitoring for viral rebound and acute retroviral syndrome during ATI is needed. These findings, observed in resource-constrained countries, exhibit the feasibility of testing at birth and initiating very early ART, show the potential to limit HIV-1 reservoirs for ART-free remission, and inform future remission strategies.FUNDINGThe US National Institute of Allergy and Infectious Diseases, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the US National Institute of Mental Health.","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"61 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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