Molecular & Cellular Biomechanics最新文献_第5页

New Concept in Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) 复苏性血管内球囊阻塞主动脉(REBOA)的新概念

Molecular & Cellular Biomechanics Pub Date : 2020-01-01 DOI: 10.32604/mcb.2019.07310

A. E. Dabiri, Matthew D. Martin, G. Kassab

{"title":"New Concept in Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)","authors":"A. E. Dabiri, Matthew D. Martin, G. Kassab","doi":"10.32604/mcb.2019.07310","DOIUrl":"https://doi.org/10.32604/mcb.2019.07310","url":null,"abstract":": The world-wide impact of traumatic injury and associated hemorrhage on human health and well-being is significant. Methods to manage bleeding from sites within the torso, referred to as non-compressible torso hemorrhage (NCTH), remain largely limited to the use of conventional operative techniques. The overall mortality rate of patients with NCTH is approximately 50%. Studies from the wars in Afghanistan and Iraq have suggested that up to 80% of potentially survivable patients die as a result of uncontrolled exsanguinating hemorrhage. The commercially available resuscitative endovascular balloon occlusion of the aorta (REBOA) is a percutaneous device for the rapid control of torso hemorrhage in trauma. A compliant balloon is inserted via the femoral artery and inflated in the thoracic or abdominal aorta, providing inflow control of the abdomen, pelvis, or groin/lower extremities. Recent studies indicate that REBOA carries an inherent risk of aortic injury due to over-inflation and possible risk of aortic or iliac artery rupture. A new approach is to resolve the issue of balloon sizing and over-inflation. We propose a novel concept to be used in trauma facility for arterial occlusion to eliminate arterial injury and the risk of vascular rupture through real time balloon diameter profile measurements to ensure proper inflation. The proposed concept, called Smart Resuscitative Endovascular Balloon Occlusion (SREBO) will be novel in the following aspects: 1) It will have electrical conductance-based navigation technology to target the desired site of balloon deployment in the aorta, 2) The balloon can determine the time of proper inflation using electrical conductance catheter technology. This technology would eliminate the risk of arterial rupture and simplify the procedure in the trauma facility or medical clinics without significant training. The results can be displayed on a handheld device. This novel device has the potential to save civilians in trauma or soldiers injured on the battlefield.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"8 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86652076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Kinematics and Surface Electromyography Characteristics of Round Kick of Martial Arts Athletes 武术运动员回旋踢的运动学和体表肌电特征

Molecular & Cellular Biomechanics Pub Date : 2020-01-01 DOI: 10.32604/mcb.2020.011236

Xin Wang

{"title":"The Kinematics and Surface Electromyography Characteristics of Round Kick of Martial Arts Athletes","authors":"Xin Wang","doi":"10.32604/mcb.2020.011236","DOIUrl":"https://doi.org/10.32604/mcb.2020.011236","url":null,"abstract":"In order to improve the level of athletes, modern scientific and technological means can be used to understand the characteristics and rules of movement. This study mainly analyzed the whip leg technique of Sanda athletes. Taking ten athletes as an example, the kinematics and surface electromyography (sEMG) data of them were measured, calculated and sorted out when they were doing the action of round kick. The results showed that the movement completion time of the first-level athletes was shorter, 0.34 ± 0.33 s. In the stage of turning hip and hitting, the angle of hip joint increased significantly. In the stage of turning hip, there was a significant difference in the angle of hip joint between different levels of athletes (p < 0.05), and there was no significant difference in other kinematics characteristics. In the aspect of sEMG, the duration of muscle discharge of the first-level athletes was shorter, but there was no significant difference in integrated electromyogram (IEMG) and root mean square (RMS). The experimental results reveal the importance of hip joint in the course of round kick and provide some theoretical bases for improving the level of athletes and carrying out targeted training.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73670971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Morphologies of Fibronectin Fibrils Formed under Shear Conditions and TheirCellular Adhesiveness Properties 剪切条件下形成的纤维连接蛋白原纤维形态及其细胞粘附特性

Molecular & Cellular Biomechanics Pub Date : 2020-01-01 DOI: 10.32604/mcb.2020.09643

P. Thi, Q. Le, V. Stoldt, N. Tran, Anh T. K. Le, Khon Huynh

{"title":"Morphologies of Fibronectin Fibrils Formed under Shear Conditions and Their\u0000Cellular Adhesiveness Properties","authors":"P. Thi, Q. Le, V. Stoldt, N. Tran, Anh T. K. Le, Khon Huynh","doi":"10.32604/mcb.2020.09643","DOIUrl":"https://doi.org/10.32604/mcb.2020.09643","url":null,"abstract":": Fibrillar ﬁ bronectin (FFN) is a biological active form of FN which form linear and branched meshwork around cells and support cellular activities. Previous studies have demonstrated that shear stress can induce cell-free FN ﬁ brillogenesis. In this study, we further examined the effect of shear stress conditions on morphology of formed FFN and preliminarily looked for relationship between FFN ’ s morphology and cell adhesion. Plasma FN at 50 µg/ml was perfused through channel slides at shear rates of 500 s -1 or 4000 s -1 . Our results showed that there were four FFN structures formed: (1) FN nodules, (2) ﬁ bril in different sizes (3) with or without nodule attachment, and (4) ﬁ brillar matrix. At 4000 s -1 , FFN ﬁ brils was formed within the ﬁ rst 10 min and reached the highest surface coverage only after 20 min. In contrast, FFN formation was signi ﬁ cant more slowly at 500 s -1 at which only FN nodules and small ﬁ brils were formed. Platelets bound on thin layer of FN and rarely found on large FN ﬁ brils. In contrast, ﬁ broblast stretched their shape on platform of FFN matrix and bound actively to all types of FFNs. Taken together, our data suggests a morphological dependent biological activity of FFN. adhesion assays were performed on FFN with diverse morphologies. Our microscopic analysis","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85129584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Study on the Finite Element Model for Head Injury in Facial Collision Accident 面部碰撞事故头部损伤有限元模型研究

Molecular & Cellular Biomechanics Pub Date : 2020-01-01 DOI: 10.32604/mcb.2019.07534

Bin Yang, Hao Sun, Aiyuan Wang, Qun Wang

{"title":"A Study on the Finite Element Model for Head Injury in Facial Collision Accident","authors":"Bin Yang, Hao Sun, Aiyuan Wang, Qun Wang","doi":"10.32604/mcb.2019.07534","DOIUrl":"https://doi.org/10.32604/mcb.2019.07534","url":null,"abstract":": In order to predict and evaluate injury mechanism and biomechanical response of the facial impact on head injury in a crash accident. With the combined modern medical imaging technologies, namely computed tomography (CT) and magnetic resonance imaging (MRI), both geometric and finite element (FE) models for human head-neck with detailed cranio-facial structure were developed. The cadaveric head impact tests were conducted to validate the head-neck finite element model. The intracranial pressure, skull dynamic response and skull-brain relative displacement of the whole head-neck model were compared with experimental data. Nine typical cases of facial traffic accidents were simulated, with the individual stress wave propagation paths to the intracranial contents through the facial and cranial skeleton being discussed thoroughly. Intracranial pressure, von Mises stress and shear stress distribution were achieved. It is proved that facial structure dissipates a large amount of impact energy to protect the brain in its most natural way. The propagation path and distribution of stress wave in the skull and brain determine the mechanism of brain impact injury, which provides a theoretic basis for the diagnosis, treatment and protection of craniocerebral injury caused by facial impact.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79926898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Retrospective Respiratory Gating System Based on Epipolar Consistency Conditions 基于极外一致性条件的回顾性呼吸门控系统

Molecular & Cellular Biomechanics Pub Date : 2020-01-01 DOI: 10.32604/mcb.2019.07383

Maosen Lian, Yi Li, Xiaohui Gu, Shouhua Luo

{"title":"A Retrospective Respiratory Gating System Based on Epipolar Consistency Conditions","authors":"Maosen Lian, Yi Li, Xiaohui Gu, Shouhua Luo","doi":"10.32604/mcb.2019.07383","DOIUrl":"https://doi.org/10.32604/mcb.2019.07383","url":null,"abstract":": Motion artifacts of in vivo imaging, due to rapid respiration rate and respiration displacements of the mice while free-breathing, is a major challenge in micro computed tomography(micro-CT). The respiratory gating is often served for either projective images acquisition or per projection qualification, so as to eliminate the artifacts brought by in vivo motion. In this paper, we propose a novel respiratory gating method, which firstly divides one rotation cycle into a number of segments, and extracts the respiratory signal from the projective image series of current segment by the value of the epipolar consistency conditions (ECC), then in terms of the measured average respiratory period, sets next segment’s start-up time and rotation speed of the gantry for respiratory phase synchronization, and so on so forth. The gating procedure is through the whole projections of three cycles, only one among three projections at each angle is qualified by their phase value and is retained for future use for tomographic image reconstruction. In practical experiment, the ECC based gating method and the conventional hardware gating method are employed on micro CT imaging of C57BL/6 mice respectively. The result shows that, compared with the hardware based one, the proposed method not only achieve much better consistency in the projection images, but also suppresses the streak artifacts more effectively on the different parts like the breast, abdomen and head of in vivo mice.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75432346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kinematic and Dynamic Characteristics of Pulsating Flow in 180�Tube 180°管内脉动流动的运动学与动力学特性

Molecular & Cellular Biomechanics Pub Date : 2020-01-01 DOI: 10.32604/mcb.2019.07854

T. Hung, Ruei-Hung Kuo, C. Chiang

引用次数: 0

Hierarchical Rigid Registration of Femur Surface Model Based on AnatomicalFeatures 基于解剖特征的股骨表面模型分层刚性配准

Molecular & Cellular Biomechanics Pub Date : 2020-01-01 DOI: 10.32604/mcb.2020.08933

Xiaozhong Chen

{"title":"Hierarchical Rigid Registration of Femur Surface Model Based on Anatomical\u0000Features","authors":"Xiaozhong Chen","doi":"10.32604/mcb.2020.08933","DOIUrl":"https://doi.org/10.32604/mcb.2020.08933","url":null,"abstract":"Existing model registration of individual bones does not have a high certainly of success due to the lack of anatomic semantic. In light of the surface anatomy and functional structure of bones, we hypothesized individual femur models would be aligned through feature points both in geometrical level and in anatomic level, and proposed a hierarchical approach for the rigid registration (HRR) of point cloud models of femur with high resolution. Firstly, a coarse registration between two simplified point cloud models was implemented based on the extraction of geometric feature points (GFPs); and then, according to the anatomic feature points (AFPs) in two level namely shape features and structure features, the fine weight-based registration was performed to achieve anatomical alignment; finally, the origin source model was automatically transformed by applying the obtained coarse matrix and fine one in sequence. Experimental results show that the hierarchical registration method can rapidly and accurately register point clouds of individual femurs, and achieves the medical semantic alignment, and provides a basic tool for the understanding and comparison of femur anatomy and structure.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78465455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Application of Dual Modality Contrast Agent Combined with Multi-Scale Representation in Ultrasound-Magnetic Resonance Imaging Registration Scheme 双模态造影剂结合多尺度表示在超声磁共振成像配准方案中的应用

Molecular & Cellular Biomechanics Pub Date : 2020-01-01 DOI: 10.32604/mcb.2020.010805

M. Hou, Wei-yu Kevin Chiang, Weiqiang Hong, Mao-Yun Yang, W. Yu

{"title":"Application of Dual Modality Contrast Agent Combined with Multi-Scale Representation in Ultrasound-Magnetic Resonance Imaging Registration Scheme","authors":"M. Hou, Wei-yu Kevin Chiang, Weiqiang Hong, Mao-Yun Yang, W. Yu","doi":"10.32604/mcb.2020.010805","DOIUrl":"https://doi.org/10.32604/mcb.2020.010805","url":null,"abstract":"To achieve the image registration/fusion and perfect the quality of the integration, with dual modality contrast agent (DMCA), a novel multi-scale representation registration method between ultrasound imaging (US) and magnetic resonance imaging (MRI) is presented in the paper, and how DMCA influence on registration accuracy is chiefly discussed. Owing to US’s intense speckle noise, it is a tremendous challenge to register US with any other modality images. How to improve the algorithms for US processing has become the bottleneck, and in the short term it is difficult to have a breakthrough. In that case, DMCA is employed in both US and MRI to enhance the region of interest. Then, because multi-scale representation is a strategy that attempts to diminish or eliminate several possible local minima and lead to convex optimization problems to be solved quickly and more efficiently, a multi-scale representation Gaussian pyramid based affine registration (MRGP-AR) scheme is constructed to complete the US-MRI registration process. In view of the above-mentioned method, the comparison tests indicate that US-MRI registration/fusion may be a remarkable method for gaining high-quality registration image. The experiments also show that it is feasible that novel nano-materials combined with excellent algorithm are used to solve some hard tasks in medical image processing field.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84402214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetically Encoded FRET Biosensor Detects the Enzymatic Activity ofProstate-Specific Antigen 基因编码FRET生物传感器检测前列腺特异性抗原的酶活性

Molecular & Cellular Biomechanics Pub Date : 2020-01-01 DOI: 10.32604/mcb.2020.09595

Hui Yao, Liqun Wang, Jia Guo, Weimin Liu, Jingjing Li, Yingxiao Wang, Linhong Deng, Mingxing Ouyang

{"title":"Genetically Encoded FRET Biosensor Detects the Enzymatic Activity of\u0000Prostate-Specific Antigen","authors":"Hui Yao, Liqun Wang, Jia Guo, Weimin Liu, Jingjing Li, Yingxiao Wang, Linhong Deng, Mingxing Ouyang","doi":"10.32604/mcb.2020.09595","DOIUrl":"https://doi.org/10.32604/mcb.2020.09595","url":null,"abstract":": Prostate cancer is the most common cancer among men beyond 50 years old, and ranked the second in mortality. The level of Prostate-speci ﬁ c antigen (PSA) in serum has been a routine biomarker for clinical assessment of the cancer development, which is detected mostly by antibody-based immunoassays. The proteolytic activity of PSA also has important functions. Here a genetically encoded biosensor based on ﬂ uorescence resonance energy transfer (FRET) tech-nology was developed to measure PSA activity. In vitro assay showed that the biosensor containing a substrate peptide ‘ RLSSYYSGAG ’ had 400% FRET change in response to 1 µg/ml PSA within 90 min, and could detect PSA activity at 25 ng/ml. PSA didn ’ t show enzymatic activity toward the biosensor in serum solution, likely re ﬂ ecting the existence of other inhibitory factors besides Zn 2+ . By expressing the biosensor on cell plasma membrane, the FRET responses were signi ﬁ cant, but couldn ’ t distinguish well the cultured prostate cancer cells from non-prostate cancer cells under microscopy imaging, indicating insuf ﬁ cient speci- ﬁ city to PSA. The biosensor with the previously known ‘ HSSKLQ ’ substrate showed little response to PSA in solution. In summary, we developed a genetically encoded FRET biosensor to detect PSA activity, which may serve as a useful tool for relevant applications, such as screening PSA activation substrates or inhi-bitors; the puri ﬁ ed biosensor protein can also be an alternative choice for measur-ing PSA activity besides currently commercialized Mu-HSSKLQ-AMC substrate from chemical synthesis.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79822379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Multifrequency Microwave Imaging for Brain Stroke Detection 多频微波成像用于脑卒中检测

Molecular & Cellular Biomechanics Pub Date : 2020-01-01 DOI: 10.32604/mcb.2019.07101

Lulu Wang

{"title":"Multifrequency Microwave Imaging for Brain Stroke Detection","authors":"Lulu Wang","doi":"10.32604/mcb.2019.07101","DOIUrl":"https://doi.org/10.32604/mcb.2019.07101","url":null,"abstract":": Early diagnosis of stroke with timely treatment could reduce adult permanent disability significantly [1]. Conventional medical imaging tools such as X-ray, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) have been widely used for diagnosis of brain disease. However, each of these methods has some limitations. X-ray imaging produces harmful radiation to the human body and challenging to identify early-stage abnormal tissue due to the relatively small dielectric proprieties contrast between the healthy tissue and abnormal tissue at X-ray frequencies [2]. PET provides useful information about soft tissues, but it is expensive and produces poor resolution. CT and MRI are unsuitable for continuously monitoring strokes due to produce harmful radiations (CT), expensive (MRI), time-consuming and not easy to develop a portable system [3,4]. Therefore, develop a new screening method is urgently needed to improve the effectiveness of disease detection. Microwave imaging is a relatively new non-invasive and cost-effective method for imaging of breast and brain tissues, which has continuously attracted many researchers’ interests the past two The authors previously developed a holographic microwave imaging (HMI) method for dielectric object detection with a particular focus on brain stroke This paper investigates the feasibility of multifrequency HMI for brain stroke detection. A numerical system was developed to demonstrate the proposed theory. Various experiments were carried out to evaluate the performance of the proposed method. Results of experiments carried out using multifrequency HMI have been compared with the results obtained by using single frequency HMI. Results showed that multifrequency HMI could detect strokes and provide more accurate results of size and location than the single frequency HMI algorithm.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77991862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1