{"title":"不同双支架植入术冠状动脉分叉区血流动力学特性的数值研究","authors":"Guangyu Zhu, Wei Cai, Q. Yuan, Lianglong Chen","doi":"10.32604/MCB.2019.05733","DOIUrl":null,"url":null,"abstract":"The prevalence of coronary bifurcation lesions (CBL) in the percutaneous coronary intervention (PCI) was reported to be approximately 15-20 % [Steigen (2006)]. The complex surgical techniques and the high incidence of restenosis make the treatment of CBL is still one of the most challenging fields in PCI. Even the single stent technique showed prognosis in most CBL treatment, dual stenting technique is still required in some cases. Our clinical follow-ups of dual stent implantation showed that the optimized provisional T-stenting (OPT) technique in CBL treatment has a lower restenosis rate compare with the Culotte stenting technique and T-stenting and small protrusion (TAP) technique. Though the local hemodynamic characteristics have been suggested as a key factor of the restenosis post PCI, the detailed hemodynamics features of the different dual stent implantation configurations are yet to be explored. In this study, the numerical simulations were performed to investigate the flow characteristics in coronary bifurcations with different dual stenting techniques.","PeriodicalId":48719,"journal":{"name":"Molecular & Cellular Biomechanics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Numerical Investigation of the Hemodynamics Characteristics in Coronary Bifurcation Region with Different Dual Stent Implantation Techniques\",\"authors\":\"Guangyu Zhu, Wei Cai, Q. Yuan, Lianglong Chen\",\"doi\":\"10.32604/MCB.2019.05733\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The prevalence of coronary bifurcation lesions (CBL) in the percutaneous coronary intervention (PCI) was reported to be approximately 15-20 % [Steigen (2006)]. The complex surgical techniques and the high incidence of restenosis make the treatment of CBL is still one of the most challenging fields in PCI. Even the single stent technique showed prognosis in most CBL treatment, dual stenting technique is still required in some cases. Our clinical follow-ups of dual stent implantation showed that the optimized provisional T-stenting (OPT) technique in CBL treatment has a lower restenosis rate compare with the Culotte stenting technique and T-stenting and small protrusion (TAP) technique. Though the local hemodynamic characteristics have been suggested as a key factor of the restenosis post PCI, the detailed hemodynamics features of the different dual stent implantation configurations are yet to be explored. In this study, the numerical simulations were performed to investigate the flow characteristics in coronary bifurcations with different dual stenting techniques.\",\"PeriodicalId\":48719,\"journal\":{\"name\":\"Molecular & Cellular Biomechanics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-02-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular & Cellular Biomechanics\",\"FirstCategoryId\":\"1087\",\"ListUrlMain\":\"https://doi.org/10.32604/MCB.2019.05733\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular & Cellular Biomechanics","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.32604/MCB.2019.05733","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
Numerical Investigation of the Hemodynamics Characteristics in Coronary Bifurcation Region with Different Dual Stent Implantation Techniques
The prevalence of coronary bifurcation lesions (CBL) in the percutaneous coronary intervention (PCI) was reported to be approximately 15-20 % [Steigen (2006)]. The complex surgical techniques and the high incidence of restenosis make the treatment of CBL is still one of the most challenging fields in PCI. Even the single stent technique showed prognosis in most CBL treatment, dual stenting technique is still required in some cases. Our clinical follow-ups of dual stent implantation showed that the optimized provisional T-stenting (OPT) technique in CBL treatment has a lower restenosis rate compare with the Culotte stenting technique and T-stenting and small protrusion (TAP) technique. Though the local hemodynamic characteristics have been suggested as a key factor of the restenosis post PCI, the detailed hemodynamics features of the different dual stent implantation configurations are yet to be explored. In this study, the numerical simulations were performed to investigate the flow characteristics in coronary bifurcations with different dual stenting techniques.
期刊介绍:
The field of biomechanics concerns with motion, deformation, and forces in biological systems. With the explosive progress in molecular biology, genomic engineering, bioimaging, and nanotechnology, there will be an ever-increasing generation of knowledge and information concerning the mechanobiology of genes, proteins, cells, tissues, and organs. Such information will bring new diagnostic tools, new therapeutic approaches, and new knowledge on ourselves and our interactions with our environment. It becomes apparent that biomechanics focusing on molecules, cells as well as tissues and organs is an important aspect of modern biomedical sciences. The aims of this journal are to facilitate the studies of the mechanics of biomolecules (including proteins, genes, cytoskeletons, etc.), cells (and their interactions with extracellular matrix), tissues and organs, the development of relevant advanced mathematical methods, and the discovery of biological secrets. As science concerns only with relative truth, we seek ideas that are state-of-the-art, which may be controversial, but stimulate and promote new ideas, new techniques, and new applications.