不同双支架植入术冠状动脉分叉区血流动力学特性的数值研究

Q4 Biochemistry, Genetics and Molecular Biology
Guangyu Zhu, Wei Cai, Q. Yuan, Lianglong Chen
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引用次数: 1

摘要

据报道,经皮冠状动脉介入治疗(PCI)中冠状动脉分叉病变(CBL)的发生率约为15- 20% [Steigen(2006)]。复杂的手术技术和高发生率的再狭窄使得CBL的治疗仍然是PCI治疗中最具挑战性的领域之一。即使单支架技术在大多数CBL治疗中预后良好,但在某些情况下仍需要双支架技术。我们对双支架植入术的临床随访显示,优化后的临时t -支架(OPT)技术在CBL治疗中的再狭窄率较curot支架技术和t -支架小突出(TAP)技术低。虽然局部血流动力学特征已被认为是PCI后再狭窄的关键因素,但不同双支架植入构型的详细血流动力学特征尚待探讨。在本研究中,通过数值模拟研究了不同双支架术冠状动脉分叉的血流特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Numerical Investigation of the Hemodynamics Characteristics in Coronary Bifurcation Region with Different Dual Stent Implantation Techniques
The prevalence of coronary bifurcation lesions (CBL) in the percutaneous coronary intervention (PCI) was reported to be approximately 15-20 % [Steigen (2006)]. The complex surgical techniques and the high incidence of restenosis make the treatment of CBL is still one of the most challenging fields in PCI. Even the single stent technique showed prognosis in most CBL treatment, dual stenting technique is still required in some cases. Our clinical follow-ups of dual stent implantation showed that the optimized provisional T-stenting (OPT) technique in CBL treatment has a lower restenosis rate compare with the Culotte stenting technique and T-stenting and small protrusion (TAP) technique. Though the local hemodynamic characteristics have been suggested as a key factor of the restenosis post PCI, the detailed hemodynamics features of the different dual stent implantation configurations are yet to be explored. In this study, the numerical simulations were performed to investigate the flow characteristics in coronary bifurcations with different dual stenting techniques.
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来源期刊
Molecular & Cellular Biomechanics
Molecular & Cellular Biomechanics CELL BIOLOGYENGINEERING, BIOMEDICAL&-ENGINEERING, BIOMEDICAL
CiteScore
1.70
自引率
0.00%
发文量
21
期刊介绍: The field of biomechanics concerns with motion, deformation, and forces in biological systems. With the explosive progress in molecular biology, genomic engineering, bioimaging, and nanotechnology, there will be an ever-increasing generation of knowledge and information concerning the mechanobiology of genes, proteins, cells, tissues, and organs. Such information will bring new diagnostic tools, new therapeutic approaches, and new knowledge on ourselves and our interactions with our environment. It becomes apparent that biomechanics focusing on molecules, cells as well as tissues and organs is an important aspect of modern biomedical sciences. The aims of this journal are to facilitate the studies of the mechanics of biomolecules (including proteins, genes, cytoskeletons, etc.), cells (and their interactions with extracellular matrix), tissues and organs, the development of relevant advanced mathematical methods, and the discovery of biological secrets. As science concerns only with relative truth, we seek ideas that are state-of-the-art, which may be controversial, but stimulate and promote new ideas, new techniques, and new applications.
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