Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health最新文献

{"title":"Assessing the risk of preeclampsia/eclampsia in Mississippi black women with chronic kidney disease using electronic health records","authors":"John S. Clemmer ,&nbsp;Kaua A. Campos ,&nbsp;Seth T. Lirette ,&nbsp;Caroline C. Haley ,&nbsp;Tawhida Islam ,&nbsp;Eric M. George","doi":"10.1016/j.preghy.2025.101224","DOIUrl":"10.1016/j.preghy.2025.101224","url":null,"abstract":"<div><h3>Objectives</h3><div>Preeclampsia (PE) is risk factor for renal dysfunction, and chronic kidney disease (CKD) is associated with higher prevalence of PE. However, the role of preexisting CKD in PE development in minority mothers has been understudied. Additionally, previous studies rarely examine CKD on PE risk independent from common comorbidities seen in patients with CKD such as hypertension (HTN) and diabetes. Our objective was to determine whether there were disparities in PE risk and overall outcomes in mothers with and without preexisting CKD in white and black mothers from a single-center in Mississippi.</div></div><div><h3>Study design</h3><div>We retrospectively analyzed electronic health records (EHR) from de-identified mothers with known gestation dates (n = 29,451) from the University of Mississippi Medical Center from 2013 to 2022.</div></div><div><h3>Results</h3><div>Black mothers had a significantly increased prevalence of CKD (0.9%) as compared to white mothers (0.6%), which was associated with a higher prevalence of PE (38%) as compared to white CKD mothers (23%). Baseline CKD was also associated with a significantly increased risk of all-cause mortality in blacks but not whites. After controlling for age, medication, baseline HTN, and diabetes, black race (HR 1.7) and CKD (HR 3.2) were major independent risk factors for PE.</div></div><div><h3>Conclusion</h3><div>Although the underlying mechanisms remain unclear, these findings are crucial for improving pre- and post-parturition care for Black CKD pregnant patients to benefit both the fetus and mother. In a rural Mississippi population, our data demonstrates a significant association of pre-existing CKD and incident PE in black patients, suggesting a<!--> <!-->potential role for renal dysfunction in driving the increased prevalence of PE in this population. Future research aims to investigate genetic factors causing renal and endothelial changes to better understand and address the causes of higher rates of preeclampsia in black women with CKD.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"41 ","pages":"Article 101224"},"PeriodicalIF":2.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic health 8–12 years after pre-eclampsia: Role of obesity and gestational diabetes (FINNCARE study)","authors":"Anni Kivelä ,&nbsp;Michelle Renlund-Vikström ,&nbsp;Seppo Heinonen ,&nbsp;Taisto Sarkola ,&nbsp;Hannele Laivuori ,&nbsp;Tiina Jääskeläinen","doi":"10.1016/j.preghy.2025.101226","DOIUrl":"10.1016/j.preghy.2025.101226","url":null,"abstract":"<div><h3>Objective</h3><div>This study examined the long-term cardiometabolic health in subgroups of pre-eclampsia (PE) to identify individuals who would benefit from targeted cardiovascular screening.</div><div><strong>Design and main outcome:</strong> A cross-sectional cohort. We compared cardiometabolic profile (anthropometrics, body composition, blood biomarkers, and blood pressure) among normotensive control pregnancies (n = 92), <em>de novo</em> PE (n = 156), de novo PE with gestational diabetes mellitus (GDM) (PE + GDM, n = 16), and PE superimposed on chronic hypertension (n = 18). With sensitivity analysis, we compared early-onset PE (EOPE n = 27) and late-onset PE (LOPE n = 165) groups.</div></div><div><h3>Results</h3><div>Cardiometabolic profiles were similar between <em>de novo</em> PE and normotensive groups, except for higher blood pressure in the de novo PE group. Women with PE + GDM and superimposed PE had higher median BMI (30.8 kg/m², IQR 7.6 and 30.6 kg/m², IQR 9.6, respectively) and more adiposity than <em>de novo</em> PE and normotensive groups. In the multivariable models, BMI was associated with low-and high-density lipoprotein cholesterol (β = 0.19, 95 % CI: 0.008 to 0.05; β = -0.41, 95 % CI: −0.03 to −0.02, respectively), high-sensitivity C-reactive protein (β = 0.64, 95 % CI: 0.11–0.15), triglyceride (β = 0.52, 95 % CI: 0.03 to 0.05) as well as glucose and insulin concentrations in the whole study population. Women with EOPE had higher low-density lipoprotein and total cholesterol concentrations than women in LOPE and control groups.</div></div><div><h3>Conclusions</h3><div>Women with PE + GDM and with superimposed PE exhibited an adverse cardiometabolic profile characterized by high BMI. This highlights the need for targeted cardiovascular prevention. Women with de novo PE should undergo regular blood pressure monitoring.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"41 ","pages":"Article 101226"},"PeriodicalIF":2.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes following implementation of diagnostic testing for pre-eclampsia within a UK tertiary hospital setting using angiogenic biomarkers","authors":"M. Gibson ,&nbsp;E. Tomlinson ,&nbsp;N. Barry ,&nbsp;A. Kouvatsou ,&nbsp;J. Kingdom ,&nbsp;E.D. Johnstone ,&nbsp;J.E. Myers","doi":"10.1016/j.preghy.2025.101227","DOIUrl":"10.1016/j.preghy.2025.101227","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate real-world implementation of angiogenic biomarkers (sFLT1:PlGF, Roche Elecsys®) to enhance the diagnosis of pre-eclampsia within a UK tertiary maternity centre.</div></div><div><h3>Study design</h3><div>Retrospective cohort study.</div></div><div><h3>Main outcome measures</h3><div>Perinatal outcomes were collated from routine pregnancy data and compared before and after the introduction of sFLT1:PlGF ratio testing. For those women receiving a test (September 2019 to Feb 2021), the diagnosis of pre-eclampsia and adverse events were recorded.</div></div><div><h3>Results</h3><div>From routinely recorded data, there was a trend towards a rise in the proportion of births 34–37 weeks (4.8 % vs 5.4 %; p = 0.054) after test implementation, crude perinatal mortality rates were not different. Detailed outcomes were available for 660 pregnancies following sFLT1/PlGF testing of whom 30.7 % developed pre-eclampsia, 153 (23.2 %) required birth before 37 weeks. 99 % of the pregnancies complicated by a sFLT:PlGF ratio ≥ 85 had a clinical diagnosis of pre-eclampsia, 6/13 false negative tests (ratio &lt; 38) were in twin pregnancies. Higher sFLT:PlGF ratios or lower PlGF values correlated with preterm birth and lower birth weight percentiles, while higher sFLT levels were associated with a reduced test to birth interval.</div></div><div><h3>Conclusions</h3><div>Introduction of sFLT:PlGF ratio testing for suspected pre-eclampsia demonstrated very high diagnostic accuracy but was not associated with a measurable difference in perinatal outcomes within the maternity population. sFLT:PlGF testing identified a sub-group of women with ratio values ≥ 85 that were more likely to require high-dependency care, however absolute levels of either sFLT-1 or PlGF were not strongly associated with clinical features of maternal or perinatal disease severity.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"41 ","pages":"Article 101227"},"PeriodicalIF":2.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Detection of hypertension and blood pressure phenotypes using ambulatory blood pressure monitoring in women with past hypertensive disorders of pregnancies","authors":"Zara Aqil,&nbsp;Muskaan Zehra","doi":"10.1016/j.preghy.2025.101218","DOIUrl":"10.1016/j.preghy.2025.101218","url":null,"abstract":"","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"40 ","pages":"Article 101218"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title Page","authors":"","doi":"10.1016/S2210-7789(25)00045-5","DOIUrl":"10.1016/S2210-7789(25)00045-5","url":null,"abstract":"","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"40 ","pages":"Article 101229"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health disparities in pregnancies complicated by acute-onset severe hypertension","authors":"Julio Mateus Nino ,&nbsp;Kendall Parrott ,&nbsp;Leah Ledford ,&nbsp;Gretchen Hoelscher ,&nbsp;Roger B. Newman ,&nbsp;Meikim Wong ,&nbsp;Tasha L. Gill","doi":"10.1016/j.preghy.2025.101216","DOIUrl":"10.1016/j.preghy.2025.101216","url":null,"abstract":"<div><h3>Objective</h3><div>To examine health disparities in the management and clinical outcomes of singleton pregnancies diagnosed with acute-onset severe hypertension (AOSH) during hospitalization.</div></div><div><h3>Study design</h3><div>Retrospective cohort study (2016–2021) of pregnant patients with AOSH, defined as systolic blood pressure (SBP) ≥ 160 mmHg or diastolic blood pressure (DBP) ≥ 110 mmHg ≥ 15 min apart.</div></div><div><h3>Main outcome measures</h3><div>The primary outcome was timely therapy of AOSH, defined as correctly dosed first-line antihypertensive medication administered &lt;60 min. Secondary outcomes were adverse maternal and perinatal composite outcomes. Multivariate logistic regression models were built to assess the association between patient factors, type of OBGYN practice, institutional factors, and the primary and secondary outcomes.</div></div><div><h3>Results</h3><div>Of the 732 patients, 298 (40.7 %) were non-Hispanic white, 297 (40.6 %) were non-Hispanic black, and 137 (18.7 %) were Hispanic. The primary outcome was not associated with race/ethnicity or other patient factors. The odds of timely emergent therapy of AOSH were 50 % higher in the 15:00 h–22:59 h nursing shift versus other shifts (aOR = 1.48; 95 % CI: 1.02, 2.18; <em>P</em> = 0.04). Furthermore, patients managed by private OBGYN physicians had significantly lower odds of adverse perinatal composite outcomes than those managed by academic OBGYN physicians (aOR = 0.39, 95 % CI: 0.21, 0.73; <em>P</em> = 0.003). Maternal adverse outcomes were not associated with any of the study factors.</div></div><div><h3>Conclusion</h3><div>Timely anti-hypertensive therapy for AOSH was not influenced by maternal race/ethnicity, language, or insurance status. However, timely therapy was more likely during the evening shift, and perinatal outcomes were better with private OBGYN practice.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"40 ","pages":"Article 101216"},"PeriodicalIF":2.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stage I hypertension and pregnancy: Scope of disease and pregnancy outcomes","authors":"Dana Marsh ,&nbsp;Melissa Mathes ,&nbsp;Amy Miller ,&nbsp;Kristian Menard ,&nbsp;Harlan Sayles ,&nbsp;Karen Carlson","doi":"10.1016/j.preghy.2025.101222","DOIUrl":"10.1016/j.preghy.2025.101222","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the rates of preeclampsia between obstetric patients with stage I hypertension and those who are normotensive. Secondary aims include identifying risk factors for preeclampsia within the stage I hypertension cohort and comparing the rates of other adverse pregnancy outcomes between cohorts.</div></div><div><h3>Study design</h3><div>We conducted a retrospective cohort study of individuals who delivered from January 1, 2019 to July 31, 2019, at a single academic center. Patients were assigned to cohorts comprised of normotensive pregnant patients and those with stage I hypertension prior to 20 weeks gestation. Stage I hypertension is defined as a systolic blood pressure of 130–139 mmHg, a diastolic blood pressure of 80–89 mmHg, or both. Differences in outcomes were evaluated using t- tests and logistic regression models.</div></div><div><h3>Results</h3><div>A total of 540 patients were included, 68 of whom were identified as having stage I hypertension. Among patients with stage I hypertension in pregnancy, 19 % developed preeclampsia compared to 10 % of normotensive patients (Odds Ratio (OR) = 2.14; p = 0.028). The odds of gestational diabetes (OR = 2.65, p = 0.01) and gestational hypertension (OR = 7.99, p &lt; 0.001) were also increased in the stage I hypertension cohort. Of the patients with stage I hypertension, a history of gestational diabetes was the only risk factor associated with subsequent development of preeclampsia (OR = 7.95, p = 0.034).</div></div><div><h3>Conclusion</h3><div>In our cohort, stage I hypertension prior to 20 weeks was associated with a significant increased rate of preeclampsia, gestational hypertension and gestational diabetes compared to normotensive patients.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"40 ","pages":"Article 101222"},"PeriodicalIF":2.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal association of hypertension in family members with preeclampsia-eclampsia in pregnant women: A two-sample Mendelian randomization study","authors":"Rui Hu,&nbsp;Yan Liang,&nbsp;Tongqiang He,&nbsp;Ying Zhou,&nbsp;Yanxiang Lv","doi":"10.1016/j.preghy.2025.101223","DOIUrl":"10.1016/j.preghy.2025.101223","url":null,"abstract":"<div><h3>Objectives</h3><div>The genetic risk factors for hypertension are also high-risk factors for preeclampsia-eclampsia. This study examined the association of hypertension in family members with preeclampsia-eclampsia in pregnant women through two-sample Mendelian randomization (MR).</div></div><div><h3>Study design</h3><div>Mendelian randomization.</div></div><div><h3>Main outcome measures</h3><div>The data for hypertension in siblings, mother, and father were from the UK Biobank, including 364,661, 426,391, and 402,899 individuals, respectively. The data for preeclampsia-eclampsia were FinnGEN R9 (7217 cases and 194,266 controls). Inverse-variance weighted was used as the main analysis method. Weighted median, MR-Egger, simple mode, and weighted mode were complementary MR methods. Heterogeneity was detected using Cochran’s Q-test, horizontal pleiotropy using MR-Egger regression, and driving single-nucleotide polymorphisms (SNPs) using the leave-one-out method.</div></div><div><h3>Results</h3><div>Mendelian randomization analysis showed that hypertension in family members was positively correlated with preeclampsia-eclampsia risk. The risk of preeclampsia-eclampsia in pregnant women who have siblings with hypertension was the highest (OR = 179.41, 95 % CI: 23.10–1393.65, P = 6.98E-07), followed by hypertension in the mothers (OR = 26.83, 95 % CI: 5.42–132.87, P = 5.56E-05) and the fathers (OR = 18.97, 95 % CI: 1.28–281.29, P = 0.032). The MR-Egger regression test indicated no horizontal pleiotropy (P &gt; 0.05). Cochran’s Q-test showed that the effects of the included SNPs exhibited heterogeneity (P &lt; 0.05). The leave-one-out analysis did not reveal SNPs driving the results by themselves.</div></div><div><h3>Conclusion</h3><div>The risk of preeclampsia-eclampsia in pregnant women who have siblings with hypertension was the highest, followed by pregnant women with a mother or father with hypertension. Having siblings with hypertension should be considered as a high-risk factor for the early prediction of preeclampsia-eclampsia.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"40 ","pages":"Article 101223"},"PeriodicalIF":2.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is outpatient surveillance of preeclampsia without severe features still safe in contemporary obese Populations?","authors":"Olha Krichevskiy ,&nbsp;Luke Schuster ,&nbsp;Christina Nguyen ,&nbsp;Megan Howell ,&nbsp;Gene T Lee","doi":"10.1016/j.preghy.2025.101225","DOIUrl":"10.1016/j.preghy.2025.101225","url":null,"abstract":"<div><h3>Objective</h3><div>Outpatient surveillance of preeclamptic pregnancies was studied several decades ago when rates of obesity were lower. The rate of preeclampsia and overall morbidity are higher in contemporary obese cohorts. We sought to review the safety of outpatient management of preeclampsia without severe features in a contemporary obese population.</div></div><div><h3>Study design</h3><div>Institutional retrospective cohort study analyzing the outcomes of 183 patients diagnosed with preeclampsia without severe features from 1/1/2010 to 12/31/2020.</div></div><div><h3>Main outcome measures</h3><div>Latency in days between diagnosis and time of delivery.</div></div><div><h3>Results</h3><div>The average BMI was 35.4 (SD 8.2), and the inpatient and outpatient groups did not have differences in BMI (34.5 vs 36.5, p = 0.12). The outpatient group was found to have significantly longer latency (20.4 vs 11.8 days, p &lt; 0.01). After adjustment, differences in latency for the inpatient and outpatient group remained statistically significant (Mean Difference −7.0, 95 % CI −11.3 to −2.7). Additionally, the outpatient group had a higher gestational age at delivery (35.7 vs 34.2, p &lt; 0.01), fewer total hospital days (8.3 vs 12.1 days, p &lt; 0.01), and fewer occurrences of preterm delivery before 34 weeks gestational age (18 % vs 39 %, p &lt; 0.01). Analysis of neonatal outcomes found the outpatient group had greater birth weights (2544.8 vs 2187.6 g, p &lt; 0.01) and fewer total days in the NICU (24.9 vs 41.8 days, p &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>Outpatient management has become the expected practice when managing preeclampsia without severe features. Our study’s findings support this management strategy in the modern obese population.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"40 ","pages":"Article 101225"},"PeriodicalIF":2.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prior preterm preeclampsia and hemostatic balance in the non-pregnant state","authors":"Christine E. Horn ,&nbsp;Maria Cristina Bravo ,&nbsp;Thomas Orfeo ,&nbsp;Kelley McLean ,&nbsp;Ira Bernstein","doi":"10.1016/j.preghy.2025.101221","DOIUrl":"10.1016/j.preghy.2025.101221","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate whether a history of preterm preeclampsia (PreP) is associated with abnormal hemostatic features during the non-pregnant state, relative to people without a history of preeclampsia.</div></div><div><h3>Study design</h3><div>We conducted a retrospective sub-analysis of three prospective IRB approved studies in which individuals were evaluated outside of pregnancy during the follicular phase of their menstrual cycles. We compared parameters between subjects with prior PreP (n = 21) with a combined cohort (NL, n = 74) of healthy nulliparous subjects (n = 57) and subjects with a prior normotensive pregnancy (n = 17). T-tests were employed with P &lt; 0.05 accepted for significance.</div></div><div><h3>Main outcome measures</h3><div>Levels of eight coagulation factors, protein C (PC), and thrombin generation (TG) were assessed in the presence or absence of thrombomodulin (TM) to evaluate the activation of the anticoagulant PC pathway. Results: There were no differences in TG or factor composition between healthy nulliparous and healthy primiparous people. In contrast, the PreP cohort had increased levels of factors II, V, VII, IX, X, XI, and PC compared to the NL cohort without this history. In dynamic assays examining TG in the presence of TM, the PreP group had reduced rates (nM/min) of formation and diminished peak levels when compared to the NL group.</div></div><div><h3>Conclusions</h3><div>Increased procoagulant factor levels are typically associated with increased TG, suggesting here that individuals with prior PreP would have a procoagulant shift in the non-pregnant state. However, the observed concurrent increase in anticoagulant PC linked with a decrease in dynamic TG suggests a possible compensatory mechanism to maintain hemostatic balance.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"40 ","pages":"Article 101221"},"PeriodicalIF":2.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}