Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health最新文献

{"title":"Rule-in and rule-out of pre-eclampsia using a novel point-of-care placental growth factor test","authors":"James Rogers ,&nbsp;Alice Hurrell ,&nbsp;Gaayen Ravii Sahgal,&nbsp;Louisa Samuels,&nbsp;Chileshe Mabula-Bwalya,&nbsp;Katy Kuhrt,&nbsp;Carolyn Gill,&nbsp;Anna Brockbank,&nbsp;Katie Dalrymple,&nbsp;Antonio De Marvao,&nbsp;Paul T. Seed,&nbsp;Lucy C. Chappell,&nbsp;Andrew H. Shennan ,&nbsp;Kate Bramham","doi":"10.1016/j.preghy.2025.101215","DOIUrl":"10.1016/j.preghy.2025.101215","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate test performance of the point-of-care Lepzi® Quanti placental growth factor (PlGF) test to rule-in and rule-out pre-eclampsia at various time points, in women presenting with suspected preeclampsia.</div></div><div><h3>Study design</h3><div>242 frozen plasma samples from women with suspected pre-eclampsia were analysed from a prospective cohort study. Participants were recruited from two obstetric tertiary referral centres in London.</div></div><div><h3>Main outcome measures</h3><div>PlGF concentration was quantified using the Lepzi® Quanti PlGF test, which is a point-of-care PlGF test. Test performance for diagnosis of pre-eclampsia was evaluated at various thresholds, and at different gestations. The area under the receiver operator curve (AUROC) was determined for the Lepzi® Quanti PlGF test and compared to that of the nationally recommended Delfia® Xpress PlGF1-2–3 test, in the same cohort of participants.</div></div><div><h3>Results</h3><div>The LEPZI® Quanti PlGF test showed high test performance for rule-out of pre-eclampsia within seven and 28 days. A threshold of ≥ 129 pg/ml (in plasma) had high negative predictive value (NPV) for rule out of preeclampsia within seven days of sampling: NPV 96.9 % at &lt; 34 weeks’ gestation (95 % confidence interval (CI) 91.2–99.4), NPV 97.0 %; at 34 – 37 weeks’ gestation (95 % CI 84.2–99.9), NPV 80.0 % at ≥ 37 weeks gestation (95 % CI 44.4–97.5).</div></div><div><h3>Conclusion</h3><div>The LEPZI® Quanti PlGF test demonstrates high test performance for diagnosis of pre-eclampsia, comparable to test performance for validated, nationally recommended PlGF tests. The LEPZI® Quanti PlGF test is a whole blood, point-of-care option to optimise risk stratification, enhanced surveillance, and appropriate management strategies; this would be suitable for low- and middle-income settings, as well as high-income settings.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"40 ","pages":"Article 101215"},"PeriodicalIF":2.5,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor: Glycosylated fibronectin as a biomarker for preeclampsia and preeclampsia-related complications","authors":"Farman Ullah Khan,&nbsp;Muhammad Salman,&nbsp;Muhsinullah Siddiqi,&nbsp;Muhammad Talha Hassan Khan","doi":"10.1016/j.preghy.2025.101217","DOIUrl":"10.1016/j.preghy.2025.101217","url":null,"abstract":"","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"40 ","pages":"Article 101217"},"PeriodicalIF":2.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of patients presenting with hypertensive disorders of pregnancy antenatally versus de-novo postpartum hypertension","authors":"Nadia Olivier ,&nbsp;Helen McDougall ,&nbsp;Grace Yuan ,&nbsp;David Langsford","doi":"10.1016/j.preghy.2025.101213","DOIUrl":"10.1016/j.preghy.2025.101213","url":null,"abstract":"<div><h3>Introduction</h3><div>To describe the characteristics of patient’s presenting with postpartum hypertension, comparing those with known hypertensive disorders of pregnancy (HDP) antenatally to patients presenting with de novo postpartum hypertension.</div></div><div><h3>Methods</h3><div>A retrospective audit of deliveries at Northern Health from January 2016 to December 2020. International Classification of Diseases (ICD) codes combined with a manual medical records search identified 72 records that resulted in representation to hospital with hypertension. Data was collected to observe and compare maternal, pregnancy and fetal characteristics.</div></div><div><h3>Results</h3><div>Of the 72 patients, 35 (48.6 %) readmissions had known HDP and 37 (51.4 %) had de novo postpartum HDP. Similarities were observed between both the patients with known HDP and de novo postpartum hypertension group, including maternal age at delivery (32.4 ± 4.9, 31.9 ± 5.6 years), BMI (32 (25–38), 31 (24–41) kg/m²) and nulliparity (48.6 %, 40.5 %). Aspirin prescription was similar in both groups (28.6 %, 27.0 %). The mean birthweight of the known HDP group was significantly less (2893.7 ± 231.4 g) compared to the de novo group (3362.4 ± 584.4 g). Differences were observed in the urine protein to creatinine ratio (uPCr) antenatally. Antenatally and postpartum the blood pressure readings for the known HDP were significantly higher than the de novo group.</div></div><div><h3>Conclusions</h3><div>More than 50 % of patients representing are de novo HDP. It does not appear pre-eclampsia is unrecognised antenatally in the de novo group. Our study does not highlight key factors that aid the recognition of those at risk of developing postpartum hypertension separate to the risk factors that are associated with HDP generally.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"40 ","pages":"Article 101213"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevent-PE (pre-eclampsia prevention by timed birth at term): Protocol for a randomised trial","authors":"James Goadsby ,&nbsp;Siddesh Shetty ,&nbsp;Argyro Syngelaki ,&nbsp;Soley-Bori Marina ,&nbsp;Laura A. Magee ,&nbsp;Peter von Dadelszen ,&nbsp;Ranjit Akolekar ,&nbsp;Sergio A. Silverio ,&nbsp;Kayleigh Sheen ,&nbsp;Julia Fox-Rushby ,&nbsp;Alan Wright ,&nbsp;David Wright ,&nbsp;Kypros H. Nicolaides","doi":"10.1016/j.preghy.2025.101211","DOIUrl":"10.1016/j.preghy.2025.101211","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate whether term pre-eclampsia (PE) is reduced by screening for PE risk at 35 + 0–36 + 6 weeks’ gestation and offering risk-based, planned early term birth.</div><div>Study design: ‘PREVENT-PE’ is a multicentre, randomised trial (ISRCTN41632964).</div></div><div><h3>Inclusion</h3><div>Singleton pregnancy, presentation for routine fetal ultrasound at 35 + 0–36 + 6 weeks’, and can give informed consent.</div></div><div><h3>Exclusion</h3><div>PE, major fetal abnormality, or participation in a conflicting study. Randomisation (central, 1:1 ratio, minimised for study site, in random permuted blocks) to intervention (screening for term PE risk, and planned early term birth for PE risk ≥ 1 in 50) or control (usual care at term) arms.</div></div><div><h3>Outcomes</h3><div>Primary: Birth with PE (ISSHP 2021 criteria).</div></div><div><h3>Key secondaries</h3><div>Emergency caesarean and neonatal unit admission ≥ 48 h. Others include within-trial and intermediate-term economic evaluations, and mixed-methods surveys and interviews.</div></div><div><h3>Analysis</h3><div>3,201 participants/arm would be required to detect a relative risk (intervention/control) of 0.5, based on 2.0% PE incidence, 90% power, and two-tailed 2.5% significance level; an adaptive design will determine the final sample size (4000–8000) at interim analysis of the first 3,000 participants.</div></div><div><h3>Analyses</h3><div>Intention-to-treat. Economic evaluation will measure and value resources and health outcomes for mothers at risk of term PE and newborns (health service perspective). In within-trial cost-effectiveness analysis, the main outcome will be incremental cost per PE case averted, with costs and health outcomes calculated using patient-level data. A decision model will assess cost-utility of the intervention for one year postpartum.</div></div><div><h3>Conclusions</h3><div>PREVENT-PE will provide data to inform birth choices and maternity services planning.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"40 ","pages":"Article 101211"},"PeriodicalIF":2.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertensive disorders of pregnancy trends in the United States post aspirin recommendation guidelines","authors":"Mariam K. Ayyash ,&nbsp;Rodney A. Mclaren Jr. ,&nbsp;Huda B. Al-Kouatly ,&nbsp;Majid Shaman","doi":"10.1016/j.preghy.2025.101210","DOIUrl":"10.1016/j.preghy.2025.101210","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate changes in the rates of hypertensive disorders of pregnancy (HDP) in the US after the publication of aspirin (ASA) recommendation guidelines by the USPSTF and ACOG.</div></div><div><h3>Methods</h3><div>A population-based retrospective cohort study was performed using the US Natality database. The pre-ASA group included births between 2010–2014. The post-ASA group were births between 2016–2021. Births in 2015 were excluded. Outcomes were rates of HDP. Univariate and multivariate analyses were performed. Using the 2010–2014 HDP trend, a projected trend was calculated and compared to the actual trend across the entire cohort.</div></div><div><h3>Results</h3><div>There were 12,127,659 births in the pre-ASA group and 17,665,217 births in the post-ASA group. The post-ASA group had a significantly higher rate of overall HDP than the pre-ASA group (7.7 % vs 4.9 %; aOR 1.58, 95 % CI [1.57–1.59]). When stratified by gestational age at delivery, the post-ASA group had a significantly lower rate of preterm HDP prior to 37 weeks (21.6 % vs 23.7 %; aOR 0.90, 95 % CI [0.89–0.91]) and preterm HDP prior to 34 weeks (6.0 % vs 7.5 %; aOR 0.79, 95 % CI [0.78–0.81]). The actual HDP trend post-ASA recommendation was higher than projected for overall HDP and preterm HDP &lt; 37 weeks but was not different for preterm HPD &lt; 34 weeks.</div></div><div><h3>Conclusion</h3><div>While overall HDP is increasing, the rate of preterm births complicated by HDP has been decreasing. The actual trend for the overall HDP category and the two preterm HDP categories, however, remains either higher or no different compared to the projected trend post aspirin recommendation guidelines.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"40 ","pages":"Article 101210"},"PeriodicalIF":2.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating follistatin-like 3 and its association with postpartum cardiovascular dysfunction and severe maternal morbidity","authors":"Junaid Nizamuddin ,&nbsp;Elizabeth Hall ,&nbsp;John Dreixler ,&nbsp;Ana Palei ,&nbsp;Joey Granger ,&nbsp;Avery Tung ,&nbsp;Ariel Mueller ,&nbsp;Sarosh Rana ,&nbsp;Sajid Shahul","doi":"10.1016/j.preghy.2025.101206","DOIUrl":"10.1016/j.preghy.2025.101206","url":null,"abstract":"<div><h3>Objectives</h3><div>Despite postpartum cardiovascular dysfunction being the leading cause of pregnancy-related mortality in the United States, it is difficult to identify at-risk patients. The objective of this study was to determine if antepartum follistatin-like 3 levels correlate with postpartum cardiovascular dysfunction and maternal morbidity.</div></div><div><h3>Study Design</h3><div>This observational cohort study included pregnant patients ≥ 18 years old and singleton gestation &lt; 41 weeks who delivered at the University of Chicago between May 2017 and November 2020.</div></div><div><h3>Main Outcome Measures</h3><div>The primary outcome was postpartum cardiovascular dysfunction, defined as postpartum hypertension, cardiomyopathy, and pulmonary edema. The secondary outcome was severe maternal morbidity.</div></div><div><h3>Results</h3><div>The final cohort included 408 women. Elevated FSTL3 levels were associated with postpartum cardiovascular dysfunction (OR per unit increase in FSTL3, 1.02 [95 % CI: 1.01, 1.04]; p &lt; 0.001). After adjustment for gestational age at delivery, maternal age, BMI, nulliparous status, hypertensive disorders of pregnancy, smoking, and diabetes, the association between FSTL3 levels and cardiovascular dysfunction persisted (p = 0.03), with good model discrimination between events (c-statistic 0.88). FSTL3 levels were also associated with severe maternal morbidity (OR per unit increase 1.02 [95 % CI: 1.01, 1.03]; p &lt; 0.0001). Additionally, Activin A levels were associated with cardiovascular dysfunction and severe maternal morbidity (c = 0.84, p = 0.01; c = 0.87, p = 0.02 respectively).</div></div><div><h3>Conclusions</h3><div>Higher follistatin-like 3 levels were associated with postpartum cardiovascular dysfunction and severe maternal morbidity. Follistatin-like 3 may be causal in cardiovascular dysfunction, and further work should define its potential as a biomarker.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"40 ","pages":"Article 101206"},"PeriodicalIF":2.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title Page","authors":"","doi":"10.1016/S2210-7789(25)00024-8","DOIUrl":"10.1016/S2210-7789(25)00024-8","url":null,"abstract":"","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"39 ","pages":"Article 101208"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood pressure patterns of gestational hypertension or non-severe pre-eclampsia beyond 36 weeks’ gestation and the adverse maternal outcomes: Secondary analysis of the HYPITAT study","authors":"Guiyou Yang ,&nbsp;Wessel Ganzevoort ,&nbsp;Sanne J. Gordijn ,&nbsp;Ben Mol ,&nbsp;Gerton Lunter ,&nbsp;Henk Groen","doi":"10.1016/j.preghy.2025.101207","DOIUrl":"10.1016/j.preghy.2025.101207","url":null,"abstract":"<div><h3>Objectives</h3><div>To identify patterns in changes of blood pressure for women with gestational hypertension (GH) or non-severe pre-eclampsia (PE) beyond 36 gestational weeks, and assess their association with a composite adverse maternal outcome.</div></div><div><h3>Study design</h3><div>Secondary analysis of a randomized controlled trial (HYPITAT).</div></div><div><h3>Main outcome measures</h3><div>We investigated patterns of one-week blood pressure changes post-admission, explored factors contributing to diverse patterns using ANOVA and Chi-square tests, and assessed the correlation between these patterns and a composite adverse maternal outcome defined as severe maternal morbidity, mortality, post-partum hemorrhage and cesarean section. Among 384 women, 187 developed the composite outcome.</div></div><div><h3>Results</h3><div>We identified three and four typical patterns in systolic and diastolic blood pressure changes, respectively. Diastolic blood pressure patterns statistically significantly varied across maternal ethnicity and diagnosis at admission. Compared to a pattern of steady diastolic blood pressure, the odds ratio (95 % confidence interval) for the composite adverse maternal outcome was 2.59 (1.31, 5.13) or 2.09 (1.02, 4.26), contingent on covariates, when a pattern of increasing diastolic blood pressure was present. The results of sensitivity analysis excluding severe hypertension from the composite outcome indicated that the main findings are robust.</div></div><div><h3>Conclusions</h3><div>Maternal ethnicity and diagnosis may affect diastolic blood pressure patterns, and a pattern of increasing diastolic blood pressure was likely associated with elevated risk of the composite adverse maternal outcome. This underscores the potential significance of recognizing these patterns for sequential risk assessment and individualized management in late GH and non-severe PE.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"40 ","pages":"Article 101207"},"PeriodicalIF":2.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The unintended consequences of modernity: Pollution and its effect on reproductive, maternal and fetal health","authors":"Gregory Ward ,&nbsp;Maria Pinto Correia Watts ,&nbsp;Stefan R. Hansson","doi":"10.1016/j.preghy.2025.101204","DOIUrl":"10.1016/j.preghy.2025.101204","url":null,"abstract":"<div><div>Over the past 50 years there has been an unprecedented increase in pollution globally.</div><div>Population growth and higher standards of living have resulted in increases in global consumption facilitated by industrialisation and globalisation of goods and services thus resulting in the release of environmental pollutants on a mass scale.</div><div>This article analyses the effects and consequences of pollution on important aspects of reproductive health including fertility, pregnancy and infant health. It is a narrative review based on a search of PubMed using the terms ‘pollution and fertility,’ ‘pollution and pregnancy,’ ‘pollution and infant health,’ and ‘history of pollution.’ Additional references were identified through articles provided by the authors of related studies. Studies were included based on their relevance to the topic and were prioritized for their methodological rigour and recency. While no formal quality assessment tools were employed, the potential limitations of individual studies are discussed where applicable.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"40 ","pages":"Article 101204"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of antenatal SARS-CoV-2 infection on development of hypertensive disorders of pregnancy in a large, diverse, cohort","authors":"Alexandra N. Mills ,&nbsp;Bethany Dubois ,&nbsp;Corina Lesseur ,&nbsp;Anna-Sophie Rommel ,&nbsp;Rushna Tubassum ,&nbsp;Elianna Kaplowitz ,&nbsp;Natalie Boychuk ,&nbsp;Toni Stern ,&nbsp;Jia Chen ,&nbsp;Whitney Lieb ,&nbsp;Teresa Janevic ,&nbsp;Rebecca H. Jessel","doi":"10.1016/j.preghy.2025.101205","DOIUrl":"10.1016/j.preghy.2025.101205","url":null,"abstract":"<div><h3>Objectives</h3><div>Various studies have noted an association between antenatal SARS-CoV-2 infection and increased risk for development of hypertensive disorders of pregnancy (HDP). Both disease processes have been shown to involve endothelial dysfunction systemically and in the placenta, suggesting common pathogenesis. We aim to further investigate this association in a diverse urban population.</div></div><div><h3>Study Design</h3><div>Generation C is a prospective pregnancy cohort study at a large academic institution in NYC established between April 2020 and February 2022. SARS-CoV-2 infection during pregnancy was ascertained using a combination of spike and nucleocapsid IgG antibodies, RT-PCR testing, and electronic medical record (EMR) diagnoses. Maternal demographic and medical data were ascertained from the EMR and/or self-report survey.</div></div><div><h3>Main Outcome Measures</h3><div>The primary outcome was HDP defined using the American College of Obstetrics and Gynecology diagnostic criteria. Covariates included maternal age ≥ 35 years, BMI ≥ 30, high social vulnerability index based on patient zip code, maternal chronic hypertension, pregestational diabetes, and nulliparity. Univariable and multivariable logistic regression was used to examine the association between antenatal SARS-CoV-2 infection and HDP.</div></div><div><h3>Results</h3><div>Among the 2402 participants, 15.4 % (369) were infected with SARS-CoV-2 during pregnancy and 18.2 % (67/369) of those exposed developed an HDP. In participants without evidence of antenatal SARS-COV-2 infection, 18.0 % (365/2033) developed an HDP. In an adjusted multivariable model, antenatal SARS-CoV-2 infection was not associated with HDP (aOR 0.89; 95 % CI, 0.65–1.22).</div></div><div><h3>Conclusions</h3><div>This study did not find an increased risk of HDP associated with antenatal SARS-CoV-2 infection in a diverse prospective cohort.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"39 ","pages":"Article 101205"},"PeriodicalIF":2.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}