Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health最新文献

{"title":"Season of delivery and risk of hypertensive disorders of pregnancy in Los Angeles, California.","authors":"Helen W Chung, Kevin S Gill, Brendan Grubbs, Melissa L Wilson","doi":"10.1016/j.preghy.2025.101261","DOIUrl":"https://doi.org/10.1016/j.preghy.2025.101261","url":null,"abstract":"<p><strong>Background: </strong>Studies in temperate regions have observed an increased risk of preeclampsia in the winter, while studies conducted in tropical regions have found an increased risk during the rainy season. The effectof season of conception and delivery have been inconsistent and poorly studied in moderate climates such as Los Angeles.</p><p><strong>Objectives: </strong>We aimed to study the effects of the season of delivery on the risk of hypertensive disorders of pregnancy.</p><p><strong>Study design: </strong>We conducted a retrospective cohort study among 24,843 predominantly Hispanic womenwho delivered at a large, urban safety nethospital from1995 and 2008. Logistic regression and multivariable multinomial logistic regression were used to estimateodds ratios and 95% CIs.</p><p><strong>Results: </strong>Mothers who delivered in the wet season had a significantly increased risk of developing hypertensive disorders of pregnancy compared to those who delivered in the dry season (OR = 1.11, 95 % CI: 1.02, 1.21). When stratifying based on disease severity, only mild preeclampsia indicated an association with season of delivery (OR = 1.12, 95 % CI: 1.01, 1.25). The effect for severe preeclampsia (OR = 1.12, 95 % Cl: 0.96, 1.31) and eclampsia/HELLP syndrome (OR = 0.80, 95 % CI: 0.49, 1.31) did not reach statistical significance, though power was limited in the more severe categories. Results evaluating season of conception as the outcome were similar to those for the season of delivery.</p><p><strong>Conclusions: </strong>Among the predominantly Hispanic women who delivered at Los Angeles County + University of Southern California between 1995 and 2008, deliveries in the wet, winter season were associated with an increased risk of hypertensive disorders of pregnancy.</p>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"42 ","pages":"101261"},"PeriodicalIF":2.9,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying cardiovascular health profiles in early pregnancy: A \"Life's Essential 8\"-based approach to assessing risk of hypertensive disorders of pregnancy.","authors":"Chelsea A DeBolt, Rebecca M Cohen, Zhan Zhao, Katharine McCarthy, Kimberly B Glazer","doi":"10.1016/j.preghy.2025.101260","DOIUrl":"https://doi.org/10.1016/j.preghy.2025.101260","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to characterize cardiovascular risk profiles in an obstetric population using American Heart Association's Life's Essential 8 components and investigate which combinations are associated with hypertensive disorders of pregnancy (HDP).</p><p><strong>Study design: </strong>Secondary analysis of a prospective observational cohort, Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b).</p><p><strong>Main outcome measures: </strong>We used latent class analysis to identify cardiovascular risk classes using Life's Essential 8 indicators at 6-14 weeks' gestation: blood pressure (BP), body mass index (BMI), and self-reported diet, sleep, smoke exposure, and physical activity. We assessed predictors of class membership and odds of HDP with logistic regression.</p><p><strong>Results: </strong>We identified a four-class solution with the following interpretative labels: (1) Healthy Behaviors/Normal BMI & BP (42%), (2) No Physical Activity/Normal BMI & BP (31%), (3) High Snoring/Elevated BMI (18%), and (4) Poor Behaviors/Normal BMI & BP (8%). Compared with the Healthy Behaviors/Normal BMI & BP class, individuals in the other risk profiles were more likely to be unmarried vs. married, Non-Hispanic Black vs. Non-Hispanic White, have government vs. commercial insurance, and report high vs. low periconceptual stress. Two risk profiles were associated with HDP: High Snoring/Elevated BMI had 2.4 times (95% CI 2.1-2.8) the odds and Poor Behaviors/Normal BMI & BP had 1.5 times (95% CI 1.2-1.8) the odds of HDP compared with Healthy Behaviors/Normal BMI & BP.</p><p><strong>Conclusions: </strong>Two cardiovascular risk profiles-High Snoring/Elevated BMI and Poor Behaviors/Normal BMI & BP-were linked to HDP, emphasizing the potential for personalized, multifactorial interventions targeting modifiable behaviors to reduce risk.</p>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"42 ","pages":"101260"},"PeriodicalIF":2.9,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of SIRT1 rs12415800 and SIRT6 rs350844 polymorphisms with preeclampsia: A case-control study","authors":"Chao Zhu ,&nbsp;Longqiang Xu ,&nbsp;Fumin Zheng ,&nbsp;Jingli Wang ,&nbsp;Yuanxuan Ma ,&nbsp;Jialiang Guan ,&nbsp;Ru Zhang ,&nbsp;Shiguo Liu","doi":"10.1016/j.preghy.2025.101259","DOIUrl":"10.1016/j.preghy.2025.101259","url":null,"abstract":"<div><h3>Background</h3><div>SIRT1 and SIRT6, key members of the Sirtuins (SIRTs) family, play crucial roles in regulating cell metabolism and survival, providing beneficial effects against aging and metabolic diseases, which may be involved in the pathogenesis of preeclampsia (PE) by modulating cell senescence phenotypes in the placenta through antioxidant and inflammatory responses. This study aimed to investigate the association of SIRT1 and SIRT6 polymorphisms with PE in Chinese Han women.</div></div><div><h3>Method</h3><div>A total of 619 healthy pregnant women were enrolled as controls, and 699 pregnant women with PE as cases. DNA was extracted from peripheral blood samples and was used for genotyping rs12415800 in <em>SIRT1</em> and rs350844 in <em>SIRT6</em> via real-time quantitative polymerase chain reaction (PCR). The relationship between SIRT1 and SIRT6 polymorphisms and PE was assessed by comparing genotypic and allelic frequencies between the two groups.</div></div><div><h3>Results</h3><div>The results indicated that the SIRT1 rs12415800 polymorphism may be associated with PE risk and the AA genotypes was associated with a lower risk of developing PE compared to the AG and GG (genotype χ2 = 6.612, P = 0.037; allele χ2 = 1.279, P = 0.258; OR = 0.720, 95 % CI = 0.548 ∼ 0.951, P = 0.002). Subgroup analyses (early-onset vs. late-onset PE, mild vs. severe PE) further supported these findings, showing consistent or even more pronounced associations.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that the genetic variant rs12415800 in SIRT1 may be linked to PE risk in Chinese Han women, with the AA genotype conferring a reduced risk. Further research is warranted to validate these findings in other populations and larger prospective studies.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"42 ","pages":"Article 101259"},"PeriodicalIF":2.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical insights on “Hypertensive disorders in a gestational diabetes cohort from Cape Town, South Africa”","authors":"Shanzay Jan ,&nbsp;Mariam Fatima ,&nbsp;Noor un nisa Irshad","doi":"10.1016/j.preghy.2025.101258","DOIUrl":"10.1016/j.preghy.2025.101258","url":null,"abstract":"","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"42 ","pages":"Article 101258"},"PeriodicalIF":2.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food security and barriers to healthy diet in pregnancies with or at risk for hypertensive disorders","authors":"Katherine Anais Sadaniantz ,&nbsp;Diana Sibai ,&nbsp;Mawulorm Denu ,&nbsp;Jenna Barnes ,&nbsp;Gianna Wilkie ,&nbsp;Lara C. Kovell","doi":"10.1016/j.preghy.2025.101254","DOIUrl":"10.1016/j.preghy.2025.101254","url":null,"abstract":"<div><div>Food insecurity is a major public health issue in the United States. The aim of this study was to examine maternal food insecurity and barriers to healthy diet in pregnant individuals with or at risk for hypertensive disorders of pregnancy (HDP). Among 53 pregnant individuals, 32.1% reported experiencing food insecurity. Food insecure individuals were significantly more likely to report barriers involving skills to plan/cook healthy foods, transportation, and home appliances/space. As healthy eating is one of the safest treatments for hypertension in pregnancy, it is essential to identify and address food insecurity in this population.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"42 ","pages":"Article 101254"},"PeriodicalIF":2.9,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The management of Lambert Eaton syndrome in the setting of hypertensive disorders of pregnancy: A literature review","authors":"Nicole Friedlich ,&nbsp;Elizabeth Slear ,&nbsp;Alicia Faszholz ,&nbsp;April Bleich","doi":"10.1016/j.preghy.2025.101255","DOIUrl":"10.1016/j.preghy.2025.101255","url":null,"abstract":"<div><h3>Objective</h3><div>To review the literature regarding the management of Lambert Eaton Myasthenic Syndrome (LEMS) in pregnancy, with a focus on the clinical challenges posed by coexisting hypertensive disorders, including preeclampsia and the routine use of magnesium sulfate for seizure prophylaxis.</div></div><div><h3>Data sources</h3><div>A systematic search of PubMed, Embase, Web of Science, and Scopus was conducted through May 2024 using combinations of keywords and MeSH terms including “Lambert Eaton Myasthenic Syndrome,” “LEMS,” “pregnancy,” “preeclampsia,” “magnesium sulfate,” and “hypertensive disorders of pregnancy.”</div></div><div><h3>Study eligibility criteria</h3><div>Studies were included if they reported pregnancy outcomes, maternal complications, or management considerations in patients with LEMS or related myasthenic syndromes. Exclusion criteria included non-English language publications, animal studies, and review articles without case-level data.</div><div>Study appraisal and synthesis methods</div><div>Studies were appraised based on relevance to Lambert-Eaton Myasthenic Syndrome in pregnancy, with particular attention to hypertensive complications and seizure prophylaxis strategies. Due to the rarity of this condition, included articles were primarily case reports and case series. Data were synthesized using a qualitative narrative approach, focusing on clinical presentation, interventions, and maternal-neonatal outcomes. Studies involving myasthenia gravis were also reviewed for comparison, given overlapping neuromuscular risks. No formal risk-of-bias assessment or statistical pooling was conducted due to heterogeneity and limited sample size.</div></div><div><h3>Results</h3><div>Twenty-four citations were included, encompassing case reports, case series, and retrospective analyses. Of these, 5 (21%) specifically involved LEMS during pregnancy, and 2 (8%) reported transient neonatal LEMS. Magnesium sulfate was discussed in 3 (13%) studies, with at least one case documenting exacerbation of neuromuscular symptoms. Two cases involved the co-occurrence of preeclampsia and LEMS, highlighting the dilemma of balancing seizure prophylaxis with neuromuscular safety. No standardized treatment protocols were identified. Multidisciplinary care and individualized decision-making were emphasized across reports.</div></div><div><h3>Conclusions</h3><div>The intersection of LEMS and hypertensive disorders of pregnancy is clinically complex and underreported. The use of magnesium sulfate—a cornerstone of preeclampsia management—poses a potential risk for patients with LEMS, underscoring the need for heightened awareness, individualized treatment plans, and multidisciplinary collaboration. Further research is needed to establish safe, evidence-based guidelines for managing this rare but high-risk patient population.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"42 ","pages":"Article 101255"},"PeriodicalIF":2.9,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to aspirin in the prevention of pregnancy complications: a systematic review.","authors":"Jeske M Bij de Weg, Christianne J M de Groot, Johanna I P de Vries, Marjon A de Boer","doi":"10.1016/j.preghy.2025.101244","DOIUrl":"10.1016/j.preghy.2025.101244","url":null,"abstract":"<p><p>The risk-reducing effect of aspirin on pregnancy complications is suggested to depend on therapy adherence. To gain more insight, we reviewed the available literature on aspirin adherence in pregnancy. Three parameters were investigated: methods of assessment of aspirin adherence, definitions of aspirin adherence, and association between aspirin adherence and pregnancy complications. RCTs investigating the preventive effect of aspirin on pregnancy complications including aspirin adherence were included. An update search of the Cochrane review of Duley 2019 was performed, two trial registries were searched and forward citation chasing was performed on May 31, 2025. Risk of bias was assessed according to the criteria of Higgins, checking for selection, performance, detection, attrition, reporting and other bias. Data were summarized and tabulated, resulting in descriptive analyses. Due to the heterogeneity of the data, no meta-analysis could be performed. Adherence of aspirin use during pregnancy was tested with clearly described method(s) and results in 16/63 RCTs on the use of aspirin in pregnancy. From the applied methods, pill count was most frequently performed (n = 14), followed by interview (n = 9) and thromboxane B₂ (TxB₂) measurements (n = 2). Most studies used a multi-measure approach. Definitions of good adherence were provided in 11 studies: percentage tablet intake (n = 10) with thresholds between ≥50 % to ≥90 %, and/or drop of ≥50 % in serum TxB₂ (n = 2). Most common pill count threshold ≥80 % (n = 6) showed mean adherence of 79.5 %. An association between good adherence and lower incidence of PE was found in 2 studies. Limitations of the systematic review were the lack of a general definition of aspirin adherence and the large heterogeneity in methods, therefore being unable to perform a meta-analysis or draw hard conclusions. In conclusion, 25 % of the RCTs on aspirin in pregnancy investigated aspirin adherence including clearly described method(s) and results and in only 11 a definition on aspirin adherence was set. Multi-measure approach is recommended as test method. Future studies should focus on threshold of good aspirin adherence in pregnancy and dose-response effect.</p>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"41 ","pages":"101244"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review and meta-analysis of the importance of pre-pregnancy maternal health on the risk of hypertensive disorders of pregnancy.","authors":"Helena Rodriguez-Caro, Annabelle Frost, Eric O Ohuma, Chris Redman, Nia W Roberts, Grieven P Otieno, Paul Leeson, Ingrid Granne, Christina Aye","doi":"10.1016/j.preghy.2025.101243","DOIUrl":"10.1016/j.preghy.2025.101243","url":null,"abstract":"<p><p>Stratifying women using their medical history pre-pregnancy may allow early identification of women at high-risk of Hypertensive disorders of pregnancy (HDP), a common and high-burden obstetrical complication. This would allow the establishment of early preventative approaches, however, most research into pregestational conditions comes from data taken during pregnancy. To address this gap, we conducted a systematic review with meta-analysis, adhering to PRISMA and MOOSE guidelines. Our review comprehensively examined the impact of a broad range of medical disorders exclusively diagnosed pre-pregnancy on the development of HDP, including preeclampsia, gestational hypertension, superimposed preeclampsia, eclampsia and HELLP. We searched Medline (OvidSP) and Embase (OvidSP) databases from inception to 8th May 2021 and calculated relative risks ratios, adjusted for study quality, or percentage incidences. 406/8724 studies were included for qualitative research, 177 of which classified for quantitative assessment. HDP risk increased with pregestational renal conditions (7.76, CI: 5.62-10.71), hypertension (3.68, CI: 1.51-8.97), diabetes (3.57, CI: 2.71-4.70), and high body mass index (2.65, CI: 2.33-3.03); as well as with pregestational polycystic ovarian syndrome (1.90, CI: 1.46-2.48), rheumatoid arthritis (1.54, CI: 1.42-1.67), migraines (1.53, CI: 1.32-1.78), and anxiety/depression (1.52, CI: 1.16-2.00). Pregestational antiphospholipid syndrome, systemic lupus erythematosus, and Takayasu arteritis also increased the incidence of gestational hypertension (8 %, 7 %, 17 %) and preeclampsia (37 %, 17 %, 23 %). Overall, this review shows pre-pregnancy maternal health can help stratify HDP risk, and highlights the importance of often-overlooked risk factors in current national guidelines and assessment tools. Crucially, we provide an evidence-based graphical abstract/list of the identified pregestational risk factors as reference for medical practitioners providing pre-pregnancy counselling.</p>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"41 ","pages":"101243"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title Page","authors":"","doi":"10.1016/S2210-7789(25)00072-8","DOIUrl":"10.1016/S2210-7789(25)00072-8","url":null,"abstract":"","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"41 ","pages":"Article 101256"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Is there a relationship between visit-to-visit blood pressure variability and adverse perinatal outcomes?","authors":"Leenah Adil","doi":"10.1016/j.preghy.2025.101250","DOIUrl":"10.1016/j.preghy.2025.101250","url":null,"abstract":"<div><div>I am submitting a manuscript for consideration of publication in Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health. It has not been submitted simultaneously for publication elsewhere.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"41 ","pages":"Article 101250"},"PeriodicalIF":2.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}