Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health最新文献

{"title":"Sexually dimorphic associations between Vitamin D metabolites, blood pressure, and placental inflammatory markers in Normoevolutive, preeclamptic and obese pregnancies","authors":"Nicolás Salva-Pastor ,&nbsp;Rafael Vargas-Castro ,&nbsp;Andrea Olmos-Ortiz ,&nbsp;Janice García-Quiroz ,&nbsp;Euclides Avila ,&nbsp;Guadalupe Estrada-Gutierrez ,&nbsp;Otilia Perichart-Perera ,&nbsp;Juan M. Solis-Paredes ,&nbsp;Fernando Larrea ,&nbsp;Lorenza Díaz","doi":"10.1016/j.preghy.2025.101253","DOIUrl":"10.1016/j.preghy.2025.101253","url":null,"abstract":"<div><h3>Objectives</h3><div>Calcitriol, the active vitamin D (VD) metabolite, abates inflammation and reduces blood pressure (BP). In the human placenta, calcidiol bioconversion into calcitriol is sexually dimorphic, resulting in differential VD-dependent effects. During pregnancy, obesity (OB) and preeclampsia (PE) have been linked to inflammation, hypertension, and impaired VD metabolism. Thus, this study aimed to analyze the relationships between these conditions, accounting for fetal sex.</div></div><div><h3>Methods</h3><div>A total of 142 mother–child pairs from normoevolutive (NE), OB and PE pregnancies were included. Calcidiol was quantified each trimester in maternal serum, while calcitriol was determined in umbilical cord serum after birth. Placental expression of relevant inflammatory and BP-modulatory genes was analyzed by RT-qPCR.</div></div><div><h3>Results</h3><div>In PE and OB, cord serum calcitriol was significantly reduced in male subgroups. Throughout pregnancy, maternal serum calcidiol negatively correlated with BP, but only in NE. PE placentas, especially those from males, had increased gene expression of pro-inflammatory and BP modulatory factors, compared to NE and OB. VD metabolites showed inverse correlations with inflammatory and hypertension-associated genes, as well as with pre-pregnancy body mass index (pBMI).</div></div><div><h3>Conclusions</h3><div>Maternal calcidiol levels negatively correlated with BP only in normoevolutive pregnancies. Both OB and PE groups presented elevated pBMI, alongside reduced umbilical cord calcitriol in male-bearing pregnancies, partially explaining the pro-inflammatory/hypertensive signature in their placentas. The results highlight a sexually dimorphic detrimental effect of obesity in placental VD-metabolism, while support the beneficial effects of maintaining an adequate VD nutritional status in pregnancy, particularly when carrying a male fetus.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"41 ","pages":"Article 101253"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence: Aspirin for preeclampsia prevention in women with migraine","authors":"Anna C.M. Kluivers ,&nbsp;Linda Al-Hassany ,&nbsp;Ingrid A. Brussé ,&nbsp;Jerome M.J. Cornette ,&nbsp;Johannes J. Duvekot ,&nbsp;Christian Lampl ,&nbsp;Antoinette MaassenVanDenBrink ,&nbsp;Langeza Saleh","doi":"10.1016/j.preghy.2025.101252","DOIUrl":"10.1016/j.preghy.2025.101252","url":null,"abstract":"","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"41 ","pages":"Article 101252"},"PeriodicalIF":2.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144893379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a remote blood pressure monitoring program during pregnancy: utilization and implementation outcomes","authors":"Elizabeth J. Howard ,&nbsp;Emily W. Harville ,&nbsp;Sherri Longo ,&nbsp;Kirsten S. Dorans ,&nbsp;Joseph R. Biggio","doi":"10.1016/j.preghy.2025.101251","DOIUrl":"10.1016/j.preghy.2025.101251","url":null,"abstract":"<div><h3>Objectives</h3><div>To identify factors associated with enrollment, retention, and patient engagement in the antenatal remote blood pressure (BP) monitoring program, Connected MOM, and to evaluate program implementation by race and residence.</div></div><div><h3>Study design</h3><div>Retrospective cohort.</div></div><div><h3>Main outcome measures</h3><div>Implementation outcomes (adoption, reach, implementation, sustainability, acceptability) and rates of patient enrollment, retention and engagement.</div></div><div><h3>Results</h3><div>34,387 Connected MOM-eligible pregnancy episodes (29,897 unique patients) were identified between November 1, 2016 and October 1, 2023. Of those, 8,471 pregnancies (24.6 %) had no offer made by the provider; 1,371 pregnancies (4.0 %) declined participation; 7,509 pregnancies (21.8 %) had an order placed but did not sign the consent form; 6,471 pregnancies (18.8 %) consented and onboarded, but did not submit a remote BP reading required to become enrolled; and 10,565 pregnancies (30.7 %) enrolled. Of those who were offered participation, approximately 40 % of eligible patients enrolled in the program; however, White (44.3 %) and urban patients (40.0 %) were more likely to enroll than Black (35.3 %) and rural patients (24.5 %) (p &lt; 0.0001). Program attrition was very low (1.3 %) and patients averaged at least one BP reading per week about 50 % of the weeks enrolled. Lower patient engagement was associated with Black race (p &lt; 0.0001), rural residence (p = 0.030), and having a public insurance payer (p &lt; 0.0001). Highly engaged patients were more likely to have highly engaged providers (RR = 1.06, 95 % CI, 1.02–1.11).</div></div><div><h3>Conclusion</h3><div>Identifying and addressing barriers at each step along the enrollment pathway is required for equitable implementation and improvement in maternal outcomes. Provider engagement in the program should be encouraged to improve patient engagement once enrolled.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"41 ","pages":"Article 101251"},"PeriodicalIF":2.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular dilation function correlates to pregnant outcomes in women with gestational diabetes mellitus","authors":"Youxia Zhou ,&nbsp;Qianyu Lan ,&nbsp;Lin Qi","doi":"10.1016/j.preghy.2025.101248","DOIUrl":"10.1016/j.preghy.2025.101248","url":null,"abstract":"<div><h3>Background</h3><div>Gestational diabetes mellitus (GDM) poses significant risks to maternal and fetal health, necessitating a deeper understanding of its pathophysiology and interventions. Vascular endothelial dysfunction plays a crucial role in diabetic vascular complications, but its relationship with GDM outcomes remains unclear.</div></div><div><h3>Study design</h3><div>This study included 278 GDM patients categorized into high and low flow-mediated dilation (FMD) groups based on median FMD values. Clinical data, glycemic parameters, and serum biomarkers were assessed. Pregnancy outcomes were compared between groups, and logistic regression analysis was performed to evaluate associations.</div></div><div><h3>Results</h3><div>While demographic characteristics did not significantly differ between FMD groups, glycemic parameters were significantly better in the high FMD group. Negative correlations were observed between FMD and glycemic parameters. Patients with low FMD had higher rates of adverse pregnancy outcomes. A combined test model incorporating FMD, endothelin-1, and nitric oxide levels showed superior predictive accuracy for poor pregnancy outcomes. Vascular endothelial dysfunction, as indicated by impaired FMD, correlates with adverse pregnancy outcomes in GDM.</div></div><div><h3>Conclusion</h3><div>Multi-marker approaches may enhance risk stratification and personalized management strategies.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"41 ","pages":"Article 101248"},"PeriodicalIF":2.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The P4 Study: 6 months postpartum body composition in normotensive vs hypertensive pregnancies","authors":"Jennifer J. Yang ,&nbsp;Megan L. Gow ,&nbsp;Lynne M. Roberts ,&nbsp;Gregory K. Davis ,&nbsp;Anthony J. O’Sullivan ,&nbsp;Amanda Henry","doi":"10.1016/j.preghy.2025.101249","DOIUrl":"10.1016/j.preghy.2025.101249","url":null,"abstract":"<div><h3>Objectives</h3><div>Increased postpartum weight retention, a risk factor for long-term obesity and cardiometabolic diseases, is greater following hypertensive disorders of pregnancy (HDP), possibly mediated by body composition (BC) changes. However, normative postpartum BC data are lacking. This study aimed to: (1) construct a reference range for BC in normotensive women 6 months postpartum for Caucasian and Asian populations, (2) compare BC 6 months postpartum between women who had a normotensive pregnancy (NP), gestational hypertension (GH) and preeclampsia (PE) in pregnancy, and (3) explore predictors of postpartum BC.</div></div><div><h3>Study design</h3><div>Cross-sectional analysis 6 months postpartum from the Postpartum, Physiology, Psychology and Paediatrics (P4) prospective cohort study of women after NP, GH and PE.</div></div><div><h3>Main outcome measures</h3><div>The main BC measures were body fat percentage (BF%), fat mass, adipose tissue mass, lean tissue mass, and relative lean tissue mass determined using bio-impedance analysis at 6 months postpartum.</div></div><div><h3>Results</h3><div>388 women were included: 280 NP, 21 GH, 87 PE. 10^th–90th percentile range for BF% was 24–47 % amongst all NP women, 24–47 % for Caucasian, and 21–44 % for Asian (p = 0.016). Average postpartum BF% was highest after GH (44 ± 7 %), followed by PE (39 ± 9 %) and NP (36 ± 9 %) [p &lt; 0.001]. Significant predictors of higher postpartum BF% were HDP, Caucasian ethnicity, gestational diabetes mellitus, higher antenatal Edinburgh Depression Scale (EDS) score, and breastfeeding cessation by 6 months.</div></div><div><h3>Conclusion</h3><div>A postpartum BC reference range for NP, which differs between Caucasian and Asian women, was established. Experiencing HDP was independently associated with increased postpartum BF%, which may contribute to longer-term obesity and cardiometabolic risks.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"41 ","pages":"Article 101249"},"PeriodicalIF":2.9,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The timing of discontinuation of low-dose aspirin and postpartum hemorrhage risk","authors":"Muhammad Badarna ,&nbsp;Neta Hoffman ,&nbsp;Shai Stern ,&nbsp;Raneen Sawaid Kayal ,&nbsp;Ala Aiob ,&nbsp;Lior Lowenstein ,&nbsp;Inshirah Sgayer","doi":"10.1016/j.preghy.2025.101247","DOIUrl":"10.1016/j.preghy.2025.101247","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate associations of the timing of low-dose aspirin (LDA) discontinuation, with postpartum hemorrhage (PPH) and bleeding-related complications.</div></div><div><h3>Study design</h3><div>A retrospective cohort study was conducted at a tertiary medical center, of pregnant women who received LDA and delivered beyond 23 weeks of gestation. The women were categorized as having discontinued LDA ≤7 days or &gt;7 days before delivery. Exclusion criteria were: severe fetal malformations, intrauterine fetal death, multiple pregnancy, pre-conceptional use of LDA, and missing data on the timing of LDA discontinuation.</div></div><div><h3>Main outcome measures</h3><div>The primary outcome was a composite bleeding outcome that included at least one of the following: PPH, blood loss greater than 1000 ml, the need for blood product transfusions, and a drop in hemoglobin of ≥4 g/dL after delivery.</div></div><div><h3>Results</h3><div>Among 763 women, 192 (25.2 %) discontinued LDA ≤7 days of delivery, while 571 (74.8 %) discontinued &gt;7 days before delivery. Comparing these groups, PPH rates, severe blood loss, and transfusion requirements did not differ significantly, nor did the composite bleeding outcome (9.9 % vs. 8.6 %, p = 0.661). Placental abruption occurred more frequently among women who discontinued LDA ≤7 days compared to &gt;7 days before delivery (5.2 % vs. 1.1 %, p = 0.002). However, in multivariate analysis, the timing of LDA discontinuation was not independently associated with an increased risk of placental abruption.</div></div><div><h3>Conclusion</h3><div>The timing of LDA discontinuation was not associated with increased PPH or major bleeding complications.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"41 ","pages":"Article 101247"},"PeriodicalIF":2.9,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144831313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pregnancy on hypertension and cardiovascular risks among reproductive aged Congolese women: Insights from the 2019 to 2024 May measurement month surveys","authors":"Jean Missel Selemani ,&nbsp;Tresor Mvunzi Swambulu ,&nbsp;Jacques Mbaz Musung ,&nbsp;Bertin Isaga ,&nbsp;Fortunat Chubaka Chimana ,&nbsp;Dieudonné Bihehe Masemo ,&nbsp;Nathan Buila Bimbi ,&nbsp;Olivier Ngeleza Nyakio ,&nbsp;Jean-René Mbuyamba-Kabangu ,&nbsp;Philippe Bianga Katchunga","doi":"10.1016/j.preghy.2025.101246","DOIUrl":"10.1016/j.preghy.2025.101246","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to analyze the influence of pregnancy on the prevalence and risk of arterial hypertension and its complications among women of reproductive age in the general Congolese population.</div></div><div><h3>Study design</h3><div>Cross-sectional design based on the DRC’s May Measurement Month (MMM) surveys.</div></div><div><h3>Main outcome measures</h3><div>Between 2019 and 2024, a total of 35,630 women aged 18 to 54 were interviewed. During the MMM campaigns, their blood pressure, weight and height were measured. Arterial hypertension was defined as having a blood pressure of ≥ 140/90 mmHg and/or the use of an antihypertensive medication.</div></div><div><h3>Results</h3><div>Pregnant women [n = 3,301 (9.3 %)] exhibited significantly higher prevalence of arterial hypertension compared to non-pregnant women (23.3 % vs. 21.7 %; p = 0.03). They also had higher rates of overweight/obesity (44.7 % vs. 36.3 %; p &lt; 0.0001), a history of hypertensive disorders of pregnancy (21.1 % vs. 2.6 %; p &lt; 0.0001), and diabetes mellitus (3.4 % vs. 1.9 %; p &lt; 0.0001). Independent predictors of arterial hypertension include age (adjusted OR = 1.07; p &lt; 0.0001), BMI (adjusted OR = 1.05; p &lt; 0.0001), diabetes mellitus [ORa = 2.48; p &lt; 0.0001], moderate physical activity (adjusted OR = 0.63; p &lt; 0.0001), and previous hypertensive disorders in pregnancy [adjusted OR = 2.96; p &lt; 0.0001]. Additionally, a previous history of Stroke was significantly more prevalent among hypertensive pregnant women (1.7 % vs. 0.6 %; p = 0.005) and those with previous hypertensive disorders of pregnancy (3.0 % vs. 0.7 %; p &lt; 0.0001).</div></div><div><h3>Conclusions</h3><div>This study highlights the impact of pregnancy on pre-existing arterial hypertension as well as cardiovascular morbidity among reproductive aged congolese women. It underscores the necessity to enhance prenatal consultations and family planning services to mitigate these effects.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"41 ","pages":"Article 101246"},"PeriodicalIF":2.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood pressure patterns during pregnancy and early postpartum in preeclampsia with severe features: predictors of chronic hypertension","authors":"L.W. Voskamp ,&nbsp;K. Verdonk ,&nbsp;J.E. Roeters van Lennep ,&nbsp;J.J. Duvekot ,&nbsp;S.P. Willemsen ,&nbsp;A.H.J. Danser ,&nbsp;R.P.M. Steegers-Theunissen ,&nbsp;M. Rousian","doi":"10.1016/j.preghy.2025.101240","DOIUrl":"10.1016/j.preghy.2025.101240","url":null,"abstract":"<div><h3>Rationale</h3><div>Women with a history of preeclampsia are at increased risk of chronic hypertension and subsequently cardiovascular disease. Early identification of high-risk patients facilitates personalized interventions to mitigate these risks. Reliable predictors for chronic hypertension after preeclampsia are lacking. This study analyzed blood pressure patterns during pregnancies with preeclampsia in relation to development of chronic hypertension.</div></div><div><h3>Methods</h3><div>This prospective cohort study included only women with preeclampsia with severe features, treated at the Erasmus Medical Center between 2010 and 2022, who attended a follow-up visit 1 to 3 years postpartum. Maternal characteristics, pregnancy outcomes and blood pressure measurements were collected from hospital records. Blood pressure patterns were analyzed using linear mixed regression models and antihypertensive medication usage was evaluated with standardized defined daily doses.</div></div><div><h3>Results</h3><div>Among 72 participants, 29 (40 %) developed chronic hypertension, defined as blood pressure &gt;140/&gt;90 mmHg or antihypertensive medication use at follow-up (mean 1.78 years postpartum). Significant blood pressure differences were observed between weeks 8 and 24 of pregnancy peaking at week 18, where systolic blood pressure averaged 131 mmHg [95 % CI 127–134] in women with chronic hypertension at follow-up, versus 117 mmHg [114–120] in those without. Furthermore, women who developed chronic hypertension used higher antihypertensive dosages during pregnancy (3.8 [95 % CI 2.9–5.6] vs. 2.6 [1.5–3.7]).</div></div><div><h3>Conclusion</h3><div>A higher blood pressure before 24 weeks of pregnancy is significantly associated with chronic hypertension after preeclampsia. These findings suggest a role for blood pressure patterns in postpartum risk assessment, enabling personalized follow-up for women at increased risk for chronic hypertension.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"41 ","pages":"Article 101240"},"PeriodicalIF":2.9,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis evaluating the risks and outcomes of pulmonary hypertension in pregnant women","authors":"Yangting Li ,&nbsp;Xiaolei Yang ,&nbsp;Maoni Zeng ,&nbsp;Tao Luo ,&nbsp;Xiaoyuan Lian ,&nbsp;Jiali Liu ,&nbsp;Qiaolin Liu ,&nbsp;Fei Xiao","doi":"10.1016/j.preghy.2025.101241","DOIUrl":"10.1016/j.preghy.2025.101241","url":null,"abstract":"<div><h3>Objectives</h3><div>Pulmonary hypertension (PH) in pregnancy has traditionally been linked to a higher likelihood of negative outcomes for both the mother and the fetus. A systematic analysis of published papers in recent decades regarding outcomes of pregnancy in patients with PH.</div></div><div><h3>Methods</h3><div>To comprehensively investigate the dangers and final results associated with PH in pregnant women, this study conducted an extensive search across multiple databases. It mainly includes authoritative databases both domestically and internationally, such as PubMed, Web of Science, EMBASE, Cochrane Library, etc. Two authors screened the retrieved articles independently using predefined screening criteria, and assessed the quality of the included studies using the “RevMan5.3 Risk of Bias Assessment Tool”.</div></div><div><h3>Results</h3><div>By searching EMBASE, a total of 10 studies were deemed appropriate and brought into the subsequent <em>meta</em>-analysis. Among all the included studies, 10 trials reported the incidence of adverse pregnancy outcomes. The homogeneity test (<em>P</em> &lt; 0.01, <em>I² =</em> 64 %) showed the existence of heterogeneity, and a random effects model was employed for the analysis. The results of the <em>meta</em>-analysis indicate a significant difference in the incidence of adverse pregnancy outcomes between pregnant women with mild to moderate PH and those with severe PH (<em>RR</em> = 0.67, 95 % CI 0.60 ∼ 0.75, <em>P</em> &lt; 0.01). Among the included studies, 5 trials reported the incidence of adverse pregnancy outcomes. The homogeneity test (<em>P</em> = 0.05, <em>I² =</em> 58 %) showed the existence of heterogeneity, and a random effects model was employed for statistical analysis. The <em>meta</em>-analysis results revealed a significant difference in the proportion of patients with mild to moderate pulmonary arterial hypertension compared to pregnant women with severe disease in cardiac function grades III to IV (<em>RR</em> = 0.48, 95 % CI 0.39 ∼ 0.58, <em>P</em> &lt; 0.01). Using region and sample size as subgroup classifications, large samples (n &gt; 100, n &gt; 70) and small sample (n ≤ 100, n ≤ 70), the heterogeneity of non-China patients was lower (I² = 0 %); meanwhile, the heterogeneity of n &gt; 100, n &gt; 70 was higher than that of studies with n 100 and n 70, indicating that the heterogeneity decreased with the decrease in sample size.</div></div><div><h3>Conclusions</h3><div>After conducting a <em>meta</em>-analysis, it was found that the severity of pH is closely associated with maternal and fetal outcomes. In the subsequent analysis, we will further explore the impact of different treatments and nursing methods on maternal and infant results in patients who have PH.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"41 ","pages":"Article 101241"},"PeriodicalIF":2.9,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives of Ghanaian pregnant women on family involvement in home blood pressure Monitoring: A qualitative analysis","authors":"Noah Newman ,&nbsp;Titus K. Beyuo ,&nbsp;Betty A. Nartey ,&nbsp;Makafui Aku Klutse ,&nbsp;Cheryl A. Moyer ,&nbsp;Jody R. Lori ,&nbsp;Samuel A. Oppong ,&nbsp;Emma R. Lawrence","doi":"10.1016/j.preghy.2025.101245","DOIUrl":"10.1016/j.preghy.2025.101245","url":null,"abstract":"<div><h3>Objectives</h3><div>(1) To explore pregnant Ghanaian women’s perspectives on family involvement in their home blood pressure monitoring (HBPM); (2) to define forms of family involvement in pregnant women’s HBPM; and (3) to understand how family involvement influences HBPM for pregnant women in this setting.</div><div>Study Design.</div><div>This phenomenological qualitative study was conducted at a tertiary hospital in urban Ghana. Participants were adult pregnant women participating in HBPM. Enrolled participants received audiovisual and hands-on HBPM training and completed daily BP monitoring for 2–4 weeks.</div><div>Main Outcome measures.</div><div>Semi-structured interviews assessed participant perspectives on family involvement with their HBPM. Interviews were audio-recorded, translated, transcribed, coded, and thematically analyzed.</div></div><div><h3>Results</h3><div>Thirty-three participants completed in-depth interviews. Participants had a mean age of 31.2 ± 5.2 years, 30.3 % had not previously given birth, and 39.4 % had less than a senior high school education. Overall, participants felt their family’s involvement made HBPM easier and a more positive experience. There were three forms of family involvement: 1) approval, 2) assistance, and 3) participation. All family members approved of HBPM. Assistance and participation were associated with the most positive perceptions. Participants referenced family togetherness, enjoyment of HBPM, and decreased stress as outcomes. Negative aspects of family involvement were disruptions from children and participants’ preference to monitor alone, were experienced rarely, and were able to be overcome.</div></div><div><h3>Conclusions</h3><div>Among pregnant women in urban Ghana, family involvement in HBPM was perceived as helpful and enjoyable, resulted in psychosocial benefits, and may help overcome barriers to HBPM in low- and middle-income countries.</div><div>Abbreviations: BP, blood pressure; HBPM, home blood pressure monitoring; HDP, hypertensive disorders of pregnancy; LMID, low- and middle-income countries; KBTH, Korle Bu Teaching Hospital; OBGYN, Obstetrics and Gynaecology; ANC, antenatal care.</div></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":"41 ","pages":"Article 101245"},"PeriodicalIF":2.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}