加拿大的民族文化状况和先兆子痫的风险

IF 2.5 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health Pub Date : 2025-02-07 DOI:10.1016/j.preghy.2025.101202

Nathalie Auger , Aimina Ayoub , Marianne Bilodeau-Bertrand , Nahantara Lafleur , Shu Qin Wei

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引用次数: 0

摘要

目的妊娠期高血压疾病的差异在美国很普遍，但在其他国家尚未得到充分研究。我们的目的是确定加拿大是否存在先兆子痫风险的种族文化差异。研究设计我们对加拿大魁北克省2008年至2020年间862,759例妊娠进行了回顾性队列研究。暴露的是女性的民族文化地位，由语言来源（英语国家或法语国家）定义。主要结局指标为先兆子痫，包括严重程度（重度、叠加性、轻度）、胎儿生长受限的存在和妊娠发病时间（早发型或晚发型高血压）。我们估计了风险比（RR）和95%可信区间（CI），以确定种族文化状况与经母体特征调整后的子痫前期风险之间的关联。结果在调整后的模型中，讲英语的孕妇发生子痫前期的风险略高于讲法语的孕妇(40.5 vs 37.2 / 1000；Rr 1.03, 95% ci 1.00-1.07)。某些子痫前期亚型的相关性更强，英语国家患轻度子痫前期（RR 1.09, 95% CI 1.04 - 1.13）、无胎儿生长受限的子痫前期（RR 1.04, 95% CI 1.00-1.08）和晚发型子痫前期（RR 1.04, 95% CI 1.01-1.08）的风险更高。与严重先兆子痫的关联不太明显，尽管说英语的人没有高中文凭（RR 1.46, 95% CI 1.12-1.90）或年龄小于25岁（RR 1.19, 95% CI 1.01-1.40）比说法语的人患严重先兆子痫的风险更大。结论以英语为母语者，尤其是易感亚群中以英语为母语者发生子痫前期的风险略高于法语者。缩写：CI，置信区间；help，溶血，肝酶升高，血小板降低；ICD-10-CA，国际疾病分类，第十次修订；mmHg，毫米汞柱；否。、数量;RR，风险比；美国，美国。

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Ethnocultural status and risk of preeclampsia in a Canadian setting

Objectives

Disparities in hypertensive disorders of pregnancy are prevalent in the U.S., but are understudied in other settings. Our objective was to determine if ethnocultural disparity in the risk of preeclampsia was present in Canada.

Study design

We carried out a retrospective cohort study of 862,759 pregnancies between 2008 and 2020 in Quebec, Canada. The exposure was the ethnocultural status of women, defined by linguistic origin (Anglophone or Francophone).

Main outcome measures

The outcome was preeclampsia, including severity (severe, superimposed, mild), presence of fetal growth restriction, and gestational onset time (early or late onset of hypertension). We estimated risk ratios (RR) and 95 % confidence intervals (CI) for the association between ethnocultural status and risk of preeclampsia adjusted for maternal characteristics.

Results

In adjusted models, Anglophones had a slightly elevated risk of preeclampsia compared with Francophones (40.5 vs. 37.2 per 1000 pregnancies; RR 1.03, 95 % CI 1.00–1.07). Associations were stronger for selected subtypes of preeclampsia, with Anglophones at greater risk of mild preeclampsia (RR 1.09, 95 % CI 1.04–1.13), preeclampsia without fetal growth restriction (RR 1.04, 95 % CI 1.00–1.08), and late onset preeclampsia (RR 1.04, 95 % CI 1.01–1.08). An association with severe preeclampsia was less apparent, although Anglophones lacking a high school diploma (RR 1.46, 95 % CI 1.12–1.90) or who were younger than 25 years (RR 1.19, 95 % CI 1.01–1.40) had a greater risk of severe preeclampsia compared with Francophones.

Conclusions

Anglophones, especially Anglophones in vulnerable subgroups, have a slightly elevated risk of preeclampsia compared with Francophones.

Abbreviations: CI, confidence interval; HELLP, hemolysis, elevated liver enzymes, and low platelets; ICD-10-CA, International Classification of Diseases, 10th revision; mmHg, millimeter of mercury; No., number; RR, risk ratio; U.S., United States.

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来源期刊

Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health OBSTETRICS & GYNECOLOGYPERIPHERAL VASCULAR-PERIPHERAL VASCULAR DISEASE

CiteScore

4.90

自引率

0.00%

发文量

127

期刊介绍： Pregnancy Hypertension: An International Journal of Women''s Cardiovascular Health aims to stimulate research in the field of hypertension in pregnancy, disseminate the useful results of such research, and advance education in the field. We publish articles pertaining to human and animal blood pressure during gestation, hypertension during gestation including physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy. The subtitle reflects the wider aspects of studying hypertension in pregnancy thus we also publish articles on in utero programming, nutrition, long term effects of hypertension in pregnancy on cardiovascular health and other research that helps our understanding of the etiology or consequences of hypertension in pregnancy. Case reports are not published unless of exceptional/outstanding importance to the field.