Olivia Jones , Laura Ormesher , Kate E. Duhig , Linda Peacock , Jenny E. Myers
{"title":"Pre-eclampsia and future cardiovascular disease risk: Assessing British clinicians’ knowledge and practice","authors":"Olivia Jones , Laura Ormesher , Kate E. Duhig , Linda Peacock , Jenny E. Myers","doi":"10.1016/j.preghy.2024.101145","DOIUrl":"10.1016/j.preghy.2024.101145","url":null,"abstract":"<div><h3>Objective</h3><p>To explore UK-based clinicians’ knowledge of long-term cardiovascular disease (CVD) risks after pre-eclampsia and capture current risk management practice.</p></div><div><h3>Study design</h3><p>A voluntary online survey was designed to explore clinicians’ perception and management of CVD risks after pre-eclampsia. Distribution occurred May-July 2022 via social media and email. The survey assessed awareness of pre-eclampsia’s association with future CVD, knowledge of published guidelines on CVD risk management after pre-eclampsia, and current practice of risk-reduction counselling. Results were analysed descriptively.</p></div><div><h3>Main outcome measure</h3><p>Clinician knowledge of postpartum cardiovascular risk and management following pre-eclampsia.</p></div><div><h3>Results</h3><p>Of 240 respondents, 72 were midwives, 46 obstetricians, 8 cardiologists, and 114 general practitioners (GPs). Most clinicians knew that pre-eclampsia increases the risk of chronic hypertension (89 %) and stroke (75 %). Awareness was worse for heart failure (47 %) and peripheral vascular disease (55 %). Obstetricians provide CVD risk-reduction counselling to women with pre-eclampsia most frequently: 43 % always counsel and 27 % often counsel. Most other clinicians never counsel patients (midwives: 76 %, cardiologists: 75 %, GPs: 62 %). Most clinicians (84 %) were not aware of CVD risk management guidance after pre-eclampsia and 75 % of cardiologists and GPs never consider pre-eclampsia when assessing cardiovascular risk. Almost all clinicians (91 %) wished for greater education on the topic.</p></div><div><h3>Conclusions</h3><p>This study presents the first assessment of cardiovascular risk awareness after pre-eclampsia amongst UK-based clinicians. Although most knew pre-eclampsia increases CVD risk, patient counselling was limited. Targeted educational initiatives are needed to improve the knowledge-to-practice gap and reduce CVD prevalence after pre-eclampsia.</p></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2210778924001727/pdfft?md5=bc64d295cbbe3fb1d75c75e75f5003e6&pid=1-s2.0-S2210778924001727-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ehsan Joz Jalalian , Ali Taravati , Bagher Seyedalipour
{"title":"GSTP1-A313G genetic polymorphism and the risk of preeclampsia in pregnant women: A study in the northern population of Iran","authors":"Ehsan Joz Jalalian , Ali Taravati , Bagher Seyedalipour","doi":"10.1016/j.preghy.2024.101144","DOIUrl":"10.1016/j.preghy.2024.101144","url":null,"abstract":"<div><p>Preeclampsia or high blood pressure in pregnancy is one of the special disorders during pregnancy. It seems that oxidative stress plays an important role in the occurrence of this disease. The purpose of this study is to investigate the relationship between the A313G polymorphism in exon five of the glutathione S-transferase gene (GSTP1) and the risk of preeclampsia in a case-control study. In this study, blood samples were collected from 70 healthy pregnant women and 70 women with preeclampsia. After genomic DNA extraction, the PCR-RFLP method was performed to check the genotype in GSTP1-A313G and the genotypic frequencies of AA, AG, and GG were determined in all samples. Also, using bioinformatics software, the effect of the above polymorphism on the protein structure was investigated. Statistical analysis for A313G polymorphism showed that AG (OR: 1.1684, 95 % CI: 0.5877–2.3228, <em>p</em> = 0.657) and GG (OR: 1.3793, 95 % CI: 0.3376–5.6359, <em>p</em> = 0.654) genotypes were not associated with risk of preeclampsia in the population of northern Iran. However, bioinformatic analyzes have shown that this polymorphism does have a destructive effect on the protein structure. However, more studies with larger sample sizes are needed to draw firm conclusions.</p></div>","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nalini Sarah Newbigging, Audrin Lenin, Sudha Jasmine, Suceena Alexander, Nihal Thomas, Jennifer Livingstone
{"title":"Secondary hyperaldosteronism due to renal agenesis: Rare cause of secondary hypertension in pregnancy","authors":"Nalini Sarah Newbigging, Audrin Lenin, Sudha Jasmine, Suceena Alexander, Nihal Thomas, Jennifer Livingstone","doi":"10.1016/j.preghy.2024.01.066","DOIUrl":"10.1016/j.preghy.2024.01.066","url":null,"abstract":"","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141950268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of serum uric acid levels in the evaluation and prediction of adverse outcomes in hypertensive disorders of pregnancy","authors":"Santosh Benjamin, Richa Sasmita Tirkey, Brijesh Yadav, Hilda Yenuberi, Swati Rathore, Jiji Elizabeth Mathews","doi":"10.1016/j.preghy.2024.01.067","DOIUrl":"10.1016/j.preghy.2024.01.067","url":null,"abstract":"","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141950271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Ann Magee , Marietta Charakida , Alan Wright , Argyro Syngelaki , Peter von Dadelszen , Ranjit Akolekar , David Wright , Kypros H. Nicolaides
{"title":"Prediction of future chronic hypertension from maternal characteristics in early pregnancy","authors":"Laura Ann Magee , Marietta Charakida , Alan Wright , Argyro Syngelaki , Peter von Dadelszen , Ranjit Akolekar , David Wright , Kypros H. Nicolaides","doi":"10.1016/j.preghy.2024.01.023","DOIUrl":"10.1016/j.preghy.2024.01.023","url":null,"abstract":"","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Padma Kaul , Olesya Barret , Ana Savu , Rose Yeung , Kara Nerenberg , Winnie Sia , Heather Boyd , Frederikke Lihme
{"title":"Postpartum clinic attendance, health services utilization and cardiometabolic screening in women with preeclampsia","authors":"Padma Kaul , Olesya Barret , Ana Savu , Rose Yeung , Kara Nerenberg , Winnie Sia , Heather Boyd , Frederikke Lihme","doi":"10.1016/j.preghy.2024.01.016","DOIUrl":"10.1016/j.preghy.2024.01.016","url":null,"abstract":"","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tunde Montgomery Csoban , Kimberley Kavanagh , Paul Murray , Chris Robertson , Laura A. Magee , Peter von Dadelszen
{"title":"panPIERS: A tool for risk prediction of adverse maternal outcomes for patients with pre-eclampsia using incomplete data","authors":"Tunde Montgomery Csoban , Kimberley Kavanagh , Paul Murray , Chris Robertson , Laura A. Magee , Peter von Dadelszen","doi":"10.1016/j.preghy.2024.01.027","DOIUrl":"10.1016/j.preghy.2024.01.027","url":null,"abstract":"","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serial placental profile of women with preeclampsia and normal outcome: Placental biometry/ uterine artery PI a promising marker","authors":"Manisha Kumar , Mrs Kirti Balyan , Ekta Debnath","doi":"10.1016/j.preghy.2024.01.032","DOIUrl":"10.1016/j.preghy.2024.01.032","url":null,"abstract":"","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Low-dose aspirin potentially mitigates placental inflammation by increasing LXA4 and decreasing NLRP3 in an in vitro model of preeclampsia","authors":"Padma Murthy , Anita Pratt , Jessica Davies , Shanika Panagodage , Hannah Yong , Shaun P. Brennecke","doi":"10.1016/j.preghy.2024.01.009","DOIUrl":"10.1016/j.preghy.2024.01.009","url":null,"abstract":"","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141952247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical study of fundoscopic findings in pregnancy induced hypertension","authors":"Bindushree V, Rajiniuday","doi":"10.1016/j.preghy.2024.01.073","DOIUrl":"10.1016/j.preghy.2024.01.073","url":null,"abstract":"","PeriodicalId":48697,"journal":{"name":"Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141953227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}