Anni Kivelä , Michelle Renlund-Vikström , Seppo Heinonen , Taisto Sarkola , Hannele Laivuori , Tiina Jääskeläinen
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引用次数: 0
Abstract
Objective
This study examined the long-term cardiometabolic health in subgroups of pre-eclampsia (PE) to identify individuals who would benefit from targeted cardiovascular screening.
Design and main outcome: A cross-sectional cohort. We compared cardiometabolic profile (anthropometrics, body composition, blood biomarkers, and blood pressure) among normotensive control pregnancies (n = 92), de novo PE (n = 156), de novo PE with gestational diabetes mellitus (GDM) (PE + GDM, n = 16), and PE superimposed on chronic hypertension (n = 18). With sensitivity analysis, we compared early-onset PE (EOPE n = 27) and late-onset PE (LOPE n = 165) groups.
Results
Cardiometabolic profiles were similar between de novo PE and normotensive groups, except for higher blood pressure in the de novo PE group. Women with PE + GDM and superimposed PE had higher median BMI (30.8 kg/m2, IQR 7.6 and 30.6 kg/m2, IQR 9.6, respectively) and more adiposity than de novo PE and normotensive groups. In the multivariable models, BMI was associated with low-and high-density lipoprotein cholesterol (β = 0.19, 95 % CI: 0.008 to 0.05; β = -0.41, 95 % CI: −0.03 to −0.02, respectively), high-sensitivity C-reactive protein (β = 0.64, 95 % CI: 0.11–0.15), triglyceride (β = 0.52, 95 % CI: 0.03 to 0.05) as well as glucose and insulin concentrations in the whole study population. Women with EOPE had higher low-density lipoprotein and total cholesterol concentrations than women in LOPE and control groups.
Conclusions
Women with PE + GDM and with superimposed PE exhibited an adverse cardiometabolic profile characterized by high BMI. This highlights the need for targeted cardiovascular prevention. Women with de novo PE should undergo regular blood pressure monitoring.
期刊介绍:
Pregnancy Hypertension: An International Journal of Women''s Cardiovascular Health aims to stimulate research in the field of hypertension in pregnancy, disseminate the useful results of such research, and advance education in the field.
We publish articles pertaining to human and animal blood pressure during gestation, hypertension during gestation including physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy. The subtitle reflects the wider aspects of studying hypertension in pregnancy thus we also publish articles on in utero programming, nutrition, long term effects of hypertension in pregnancy on cardiovascular health and other research that helps our understanding of the etiology or consequences of hypertension in pregnancy. Case reports are not published unless of exceptional/outstanding importance to the field.