Zeitschrift Fur Kristallographie-Crystalline Materials最新文献

{"title":"Widespread Autonomic Physiological Coupling Across the Brain-Body Axis.","authors":"Taylor Bolt, Shiyu Wang, Jason S Nomi, Roni Setton, Benjamin P Gold, Blaise deB Frederick, B T Thomas Yeo, J Jean Chen, Dante Picchioni, R Nathan Spreng, Shella D Keilholz, Lucina Q Uddin, Catie Chang","doi":"10.1101/2023.01.19.524818","DOIUrl":"10.1101/2023.01.19.524818","url":null,"abstract":"<p><p>The brain is closely attuned to visceral signals from the body's internal environment, as evidenced by the numerous associations between neural, hemodynamic, and peripheral physiological signals. We show that these brain-body co-fluctuations can be captured by a single spatiotemporal pattern. Across several independent samples, as well as single-echo and multi-echo fMRI data acquisition sequences, we identify widespread co-fluctuations in the low-frequency range (0.01 - 0.1 Hz) between resting-state global fMRI signals, neural activity, and a host of autonomic signals spanning cardiovascular, pulmonary, exocrine and smooth muscle systems. The same brain-body co-fluctuations observed at rest are elicited by arousal induced by cued deep breathing and intermittent sensory stimuli, as well as spontaneous phasic EEG events during sleep. Further, we show that the spatial structure of global fMRI signals is maintained under experimental suppression of end-tidal carbon dioxide (PETCO2) variations, suggesting that respiratory-driven fluctuations in arterial CO2 accompanying arousal cannot explain the origin of these signals in the brain. These findings establish the global fMRI signal as a significant component of the arousal response governed by the autonomic nervous system.</p>","PeriodicalId":48676,"journal":{"name":"Zeitschrift Fur Kristallographie-Crystalline Materials","volume":"231 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11312447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88996149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular underpinnings of the selective vulnerability to tauopathic insults in Alzheimer's disease.","authors":"Justin Torok, Pedro D Maia, Chaitali Anand, Ashish Raj","doi":"10.1101/2023.07.06.548027","DOIUrl":"10.1101/2023.07.06.548027","url":null,"abstract":"<p><p>Neurodegenerative diseases such as Alzheimer's disease (AD) exhibit pathological changes in the brain that proceed in a stereotyped and regionally specific fashion, but the cellular and molecular underpinnings of regional vulnerability are currently poorly understood. Recent work has identified certain subpopulations of neurons in a few focal regions of interest, such as the entorhinal cortex, that are selectively vulnerable to tau pathology in AD. However, the cellular underpinnings of regional susceptibility to tau pathology are currently unknown, primarily because whole-brain maps of a comprehensive collection of cell types have been inaccessible. Here, we deployed a recent cell-type mapping pipeline, Matrix Inversion and Subset Selection (MISS), to determine the brain-wide distributions of pan-hippocampal and neocortical neuronal and non-neuronal cells in the mouse using recently available single-cell RNA sequencing (scRNAseq) data. We then performed a robust set of analyses to identify general principles of cell-type-based selective vulnerability using these cell-type distributions, utilizing 5 transgenic mouse studies that quantified regional tau in 12 distinct PS19 mouse models. Using our approach, which constitutes the broadest exploration of whole-brain selective vulnerability to date, we were able to discover cell types and cell-type classes that conferred vulnerability and resilience to tau pathology. Hippocampal glutamatergic neurons as a whole were strongly positively associated with regional tau deposition, suggesting vulnerability, while cortical glutamatergic and GABAergic neurons were negatively associated. Among glia, we identified oligodendrocytes as the single-most strongly negatively associated cell type, whereas microglia were consistently positively correlated. Strikingly, we found that there was no association between the gene expression relationships between cell types and their vulnerability or resilience to tau pathology. When we looked at the explanatory power of cell types versus GWAS-identified AD risk genes, cell type distributions were consistently more predictive of end-timepoint tau pathology than regional gene expression. To understand the functional enrichment patterns of the genes that were markers of the identified vulnerable or resilient cell types, we performed gene ontology analysis. We found that the genes that are directly correlated to tau pathology are functionally distinct from those that constitutively embody the vulnerable cells. In short, we have demonstrated that regional cell-type composition is a compelling explanation for the selective vulnerability observed in tauopathic diseases at a whole-brain level and is distinct from that conferred by risk genes. These findings may have implications in identifying cell-type-based therapeutic targets.</p>","PeriodicalId":48676,"journal":{"name":"Zeitschrift Fur Kristallographie-Crystalline Materials","volume":"200 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10705232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89308801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of awake prone positioning in hypoxaemic adult patients with COVID-19.","authors":"Nicola L Kelly, Alexandra Curtis, Sam Douthwaite, Anna Goodman, Luigi Camporota, Richard Leach, Nicholas Hart, Guy Glover","doi":"10.1177/1751143720961244","DOIUrl":"10.1177/1751143720961244","url":null,"abstract":"","PeriodicalId":48676,"journal":{"name":"Zeitschrift Fur Kristallographie-Crystalline Materials","volume":"10 1","pages":"32-34"},"PeriodicalIF":2.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1751143720961244","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89027208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Helical self-assembly of an unusual pseudopeptide: crystallographic evidence","authors":"Arpita Dutta, Suven Das, Purak Das","doi":"10.1515/zkri-2023-0034","DOIUrl":"https://doi.org/10.1515/zkri-2023-0034","url":null,"abstract":"Abstract Pseudopeptides are a versatile class of organic building blocks having potential applications in a wide range of domains. In the current study, N and C termini protected l -alanine based short pseudopeptide was synthesized, where 5-aminoisophthalic acid (5-AIA), a rigid non-proteogenic γ-amino butyric acid was incorporated as C-terminal residue. The single crystal X-ray analysis revealed that the l -Ala residue of the aforesaid peptide adopts ϕ and ψ values characteristic of polyproline II conformation. Self-assembly of the pseudopeptide seems to represent a supramolecular helical architecture via NH⋯O, CH⋯O hydrogen bonding and π–π interactions.","PeriodicalId":48676,"journal":{"name":"Zeitschrift Fur Kristallographie-Crystalline Materials","volume":"104 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136019566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cobalt-bearing adamite from Cap Garonne, Mine du Pradet, France – structural relationship to olivenite and magnetic behavior","authors":"Christian Paulsen, Maximilian Kai Reimann, Michael Holtkamp, Valérie Galéa-Clolus, Uwe Karst, Rainer Pöttgen","doi":"10.1515/zkri-2023-0037","DOIUrl":"https://doi.org/10.1515/zkri-2023-0037","url":null,"abstract":"Abstract The crystal structure of cobalt-bearing adamite (Zn, Co) 2 AsO 4 OH (so-called cobalton adamite) from Mine du Pradet, Cap Garonne, France has been refined from single crystal X-ray diffraction data: Pnnm , a = 831.39(4), b = 852.67(6), c = 605.84(6) pm, w R = 0.0568, 901 F 2 values, 48 variables. The composition of the single crystal and the bulk sample with EDX and ICP-OES was determined as Zn 1.94 Co 0.06 (AsO 4 )OH and (Co 0.085 Ni 0.037 Cu 0.270 Zn 1.608 )AsO 4 OH. The Co 2+ , Ni 2+ and Cu 2+ incorporation in the bulk sample leads to Curie paramagnetism with an experimental moment of 2.85 µ B / M 2+ cation and explains the pink color along with the greenish edges. The Raman spectrum shows the characteristic vibrations of the AsO 4 tetrahedra and the M O 5 pyramids as well as the O–H stretching mode. The adamite structure is closely related with the olivenite type (space group P 2 1 / n 11). This structural relationship is discussed on the basis of a group–subgroup scheme (Bärnighausen formalism).","PeriodicalId":48676,"journal":{"name":"Zeitschrift Fur Kristallographie-Crystalline Materials","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135044399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Series of new cobalt (II) and nickel (II) trinuclear fluorotrifluoroacetates with tetrahydrofuran – contribution to the inverse coordination chemistry and unique cations","authors":"Mikhail E. Buzoverov, Tatyana Yu. Glazunova, Victoria E. Gontcharenko, Igor V. Morozov","doi":"10.1515/zkri-2023-0030","DOIUrl":"https://doi.org/10.1515/zkri-2023-0030","url":null,"abstract":"Abstract The six new trinuclear fluorocarboxylates with tetrahydrofuran (THF) molecules as terminal ligands are presented. The structures of compounds have been determined by single-crystal X-ray diffraction. According to the structure data, complexes of nickel (II) and cobalt (II) form isomorphous series, namely [K(CF 3 COOH) 6 ][M 3 (μ 3 -F)(CF 3 COO) 6 (THF) 3 ] (M = Co ( I ) and Ni ( II )), Na[M 3 (μ 3 -F)(CF 3 COO) 6 (THF)(CF 3 COOH) 2 ] (M = Co ( III ) and Ni ( IV )) and [Li(CF 3 COOH) 4 ][M 3 (μ 3 -F)(CF 3 COO) 6 (THF) 3 ] (M = Co ( V ) and Ni ( VI )). In crystal structures of I , II , V and VI , previously unknown cations [K(CF 3 COOH) 6 ] + and [Li(CF 3 COOH) 4 ] + have been detected. All substances were studied by IR spectroscopy, and bands sensitive to the nature of metal atoms included in the compounds have been found. The inverse coordination of tridentate fluoride-ion in cobalt (II) and nickel (II) fluorocarboxylates is discussed in the article.","PeriodicalId":48676,"journal":{"name":"Zeitschrift Fur Kristallographie-Crystalline Materials","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135790732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new layered potassium-based molybdenum–tungsten monophosphate: synthesis, crystal structure, XPS and magnetic studies","authors":"Meriem Goudjil, Giovanni Orazio Lepore, Paola Bonazzi, Djillali Mezaoui, Alessio Mezzi, Eleonora Bolli, Francesco Di Benedetto, Luca Bindi","doi":"10.1515/zkri-2023-0027","DOIUrl":"https://doi.org/10.1515/zkri-2023-0027","url":null,"abstract":"Abstract A new compound, K5[(Mo3.2W1.8)O11](PO4)3[(P0.5Mo0.5)O4], was synthesized via solid-state reaction and its crystal structure was determined by single-crystal X-ray diffraction. This compound crystallizes in the space group Pnma, with a = 9.0360(4) Å, b = 10.1603(4) Å, c = 26.1538(12) Å and V = 2401.14(18) Å3. The structure consists of a corner-sharing MO6–TO4 (M = Mo, W; T = P, Mo) polyhedral connection arranged to form an ordered packing of ∼14.9 Å-thick layers parallel to (001). The stacking of the layers forms trigonal, tetragonal and hexagonal channels. XPS study reveals the presence of W at the hexavalent state only, whereas Mo appears as a mixed-valent species (Mo6+, Mo5+ and Mo4+). Magnetic susceptibility reveals the occurrence of a relevant antiferromagnetic coupling and is consistent with the presence of reduced metal species as indicated by the XPS results.","PeriodicalId":48676,"journal":{"name":"Zeitschrift Fur Kristallographie-Crystalline Materials","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135248449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontmatter","authors":"","doi":"10.1515/zkri-2023-frontmatter9-10","DOIUrl":"https://doi.org/10.1515/zkri-2023-frontmatter9-10","url":null,"abstract":"","PeriodicalId":48676,"journal":{"name":"Zeitschrift Fur Kristallographie-Crystalline Materials","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135640077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of functional nutrients on chicken intestinal epithelial cells induced with oxidative stress.","authors":"Hyun Woo Kim, Seung Yun Lee, Sun Jin Hur, Dong Yong Kil, Jong Hyuk Kim","doi":"10.5187/jast.2023.e22","DOIUrl":"10.5187/jast.2023.e22","url":null,"abstract":"<p><p>The objective of this study was to investigate the protective effects of functional nutrients including various functional amino acids, vitamins, and minerals on chicken intestinal epithelial cells (cIECs) treated with oxidative stress. The cIECs were isolated from specific pathogen free eggs. Cells were exposed to 0 mM supplement (control), 20 mM threonine (Thr), 0.4 mM tryptophan (Trp), 1 mM glycine (Gly), 10 μM vitamin C (VC), 40 μM vitamin E (VE), 5 μM vitamin A (VA), 34 μM chromium (Cr), 0.42 μM selenium (Se), and 50 μM zinc (Zn) for 24 h with 6 replicates for each treatment. After 24 h, cells were further incubated with fresh culture medium (positive control, PC) or 1 mM H₂O₂ with different supplements (negative control, NC and each treatment). Oxidative stress was measured by cell proliferation, whereas tight junction barrier function was analyzed by fluorescein isothiocyanate (FITC)-dextran permeability and transepithelial electrical resistance (TEER). Results indicated that cell viability and TEER values were less (<i>p</i> < 0.05) in NC treatments with oxidative stress than in PC treatments. In addition, FITC-dextran values were greater (<i>p</i> < 0.05) in NC treatments with oxidative stress than in PC treatments. The supplementations of Thr, Trp, Gly, VC, and VE in cells treated with H₂O₂ showed greater (<i>p</i> < 0.05) cell viability than the supplementation of VA, Cr, Se, and Zn. The supplementations of Trp, Gly, VC, and Se in cells treated with H₂O₂ showed the least (<i>p</i> < 0.05) cellular permeability. In addition, the supplementation of Thr, VE, VA, Cr, and Zn in cells treated with H₂O₂ decreased (<i>p</i> < 0.05) cellular permeability. At 48 h, the supplementations of Thr, Trp, and Gly in cells treated with H₂O₂ showed the greatest (<i>p</i> < 0.05) TEER values among all treatments, and the supplementations of VC and VE in cells treated with H₂O₂ showed greater (<i>p</i> < 0.05) TEER values than the supplementations of VA, Cr, Se, and Zn in cells treated with H₂O₂. In conclusion, Thr, Trp, Gly, and VC supplements were effective in improving cell viability and intestinal barrier function of cIECs exposed to oxidative stress.</p>","PeriodicalId":48676,"journal":{"name":"Zeitschrift Fur Kristallographie-Crystalline Materials","volume":"62 1","pages":"1040-1052"},"PeriodicalIF":2.3,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10640939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89096061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uranyl silicate nanotubules in Rb2[(UO2)2O(Si3O8)]: synthesis and crystal structure","authors":"E. Nazarchuk, O. Siidra, D. Charkin, Yana G. Tagirova","doi":"10.1515/zkri-2023-0019","DOIUrl":"https://doi.org/10.1515/zkri-2023-0019","url":null,"abstract":"Abstract A new rubidium uranyl silicate, Rb2(UO2)2O(Si3O8) (1), was obtained using high-temperature approach from the melt in silica tubes. Its crystal structure was solved by direct methods: hexagonal, P6/m, a = 27.7992(7), c = 7.2346(2) Å, V = 4841.8(3) Å3, R1 = 0.033. The structure of 1 represents a new structure type with unprecedented topology not observed before among U(VI) oxides and oxysalts. It is comprised of layers with large voids derived from the U3O8 structure formed exclusively by pentagonal UrO5 bipyramids. The low-occupied Rb sites are located in the interlayer space. The SiO4 silicate tetrahedra in the structure of 1 share vertices to form rolled [Si6O16]8− chains. The nanotubules [(UO2)(Si6O16)]6− penetrate through both U3O8-derived layers and Rb interlayer. These tubules are attached to the U3O8 derived sheets via uranyl-uranyl interactions and edge-sharing between silicate tetrahedra and UrO5 bipyramids.","PeriodicalId":48676,"journal":{"name":"Zeitschrift Fur Kristallographie-Crystalline Materials","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46909600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}