Zoological Research最新文献

{"title":"Evolutionary history of Old World cellar spiders in the context of Neo-Tethyan sea-land transformations.","authors":"Zhi-Yuan Yao, Shu-Qiang Li","doi":"10.24272/j.issn.2095-8137.2025.325","DOIUrl":"10.24272/j.issn.2095-8137.2025.325","url":null,"abstract":"<p><p>The ancient Neo-Tethyan region underwent profound tectonic transformations, including the orogenesis of the Xizang Plateau and the westward retreat and ultimate closure of the Neo-Tethyan Ocean. These events significantly influenced the diversification and biogeography of aquatic animals. However, the impact of these large-scale sea-land shifts on the long-range evolutionary history of terrestrial fauna remains unclear. This study investigated how geological changes in the Neo-Tethyan region shaped the evolutionary trajectories and dispersal patterns of <i>Pholcus</i> <i>sensu lato</i> cellar spiders across the Old World. Molecular dating, ancestral area reconstructions, and diversity analyses were conducted using sequences from seven genes across 234 samples representing 209 species. Results indicated that these spiders originated in the eastern Neo-Tethyan region during the Early Eocene, with their subsequent diversification driven by a series of concomitant geological events. The Eurasian (ER) Group dispersed into Europe following the westward retreat of the Neo-Tethyan Ocean in the Early Miocene, while the African (AF) Group migrated into Africa via the Arabian Plate land bridge following the closure of the Neo-Tethyan Ocean in the Oligocene. The East Asian (EA) Group, which expanded along the southeastern margin of the Himalayas, experienced explosive diversification in response to sustained orogenesis at the Eocene-Oligocene boundary. These findings illustrate how large-scale geological processes and sea-land changes shaped the evolutionary history of terrestrial fauna in the Neo-Tethyan region.</p>","PeriodicalId":48636,"journal":{"name":"Zoological Research","volume":"46 4","pages":"912-920"},"PeriodicalIF":4.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: DNA methylation-mediated expression of zinc finger protein 615 affects embryonic development in <i>Bombyx</i> <i>mori</i>.","authors":"Guan-Feng Xu, Cheng-Cheng Gong, Yu-Lin Tian, Tong-Yu Fu, Yi-Guang Lin, Hao Lyu, Yu-Ling Peng, Chun-Mei Tong, Qi-Li Feng, Qi-Sheng Song, Si-Chun Zheng","doi":"10.24272/j.issn.2095-8137.2025.215","DOIUrl":"10.24272/j.issn.2095-8137.2025.215","url":null,"abstract":"","PeriodicalId":48636,"journal":{"name":"Zoological Research","volume":"46 4","pages":"788"},"PeriodicalIF":4.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Genetically modified pigs with CD163 point mutation are resistant to HP-PRRSV infection.","authors":"Ying Liu, Lin Yang, Hong-Yong Xiang, Ming Niu, Jia-Cheng Deng, Xue-Yuan Li, Wen-Jie Hao, Hong-Sheng Ou-Yang, Tong-Yu Liu, Xiao-Chun Tang, Da-Xin Pang, Hong-Ming Yuan","doi":"10.24272/j.issn.2095-8137.2025.304","DOIUrl":"10.24272/j.issn.2095-8137.2025.304","url":null,"abstract":"","PeriodicalId":48636,"journal":{"name":"Zoological Research","volume":"46 4","pages":"811"},"PeriodicalIF":4.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcutaneous delivery of icariin via a gelatin methacryloyl (GelMA) hydrogel sustained-release system improves ovarian function in reproductively aged mice.","authors":"Jia-Lian Mao, Xiang-Yi Wu, Ling-Xi Li, Ning Li, Ya-Xuan Wang, Zhi-Wei Jiang, Chuan-Ming Liu, Hui-Dan Zhang, Ji-Dong Zhou, Yang Zhang, Li Chen, Gui-Jun Yan, Hai-Xiang Sun, Yi-Fan Li, Li-Jun Ding","doi":"10.24272/j.issn.2095-8137.2024.447","DOIUrl":"10.24272/j.issn.2095-8137.2024.447","url":null,"abstract":"<p><p>Ovarian aging is characterized by a progressive decline in oocyte quality and quantity with age. Icariin (ICA), a flavonoid compound derived from <i>Epimedium</i> species, has demonstrated potential as an agent for ovarian restoration. In this study, a subcutaneous implantation system using gelatin methacryloyl (GelMA) hydrogel embedded with ICA was developed to restore ovarian function in aged female mice. Mice were assigned to receive subcutaneous implantation of GelMA alone (GelMA group), GelMA containing ICA (GelMA/ICA group), or a sham operation. Ovarian morphology, serum hormone levels, follicle counts across developmental stages, and reproductive outcomes were evaluated. <i>In vitro</i> fertilization (IVF) and embryo culture assays were performed to assess oocyte developmental potential, while a 10 day natural mating trial was conducted to determine fertility restoration. RNA sequencing (RNA-seq) and RT-qPCR were performed to elucidate the underlying molecular mechanisms. Results showed that GelMA/ICA treatment significantly increased ovarian index (0.19±0.01 vs. 0.13±0.01, <i>P</i><0.0001) and follicle numbers at all developmental stages, including primordial (383.33±151.65 vs. 107.14±32.26, <i>P</i><0.0001), primary (203.33±83.22 vs. 91.43±27.04, <i>P</i>=0.003), and secondary follicles (154.17±52.00 vs. 59.28±20.50, <i>P</i>=0.029) compared to the sham controls. Hormonal analyses revealed a significant reduction in serum follicle-stimulating hormone (FSH, 11.97±3.53 vs. 53.10±17.89 ng/mL, <i>P</i>=0.0008), accompanied by elevated anti-Müllerian hormone (AMH, 22.97±2.26 vs. 5.54±1.56 ng/mL, <i>P</i><0.0001) and estradiol (E ₂, 315.30±37.62 vs. 168.5±14.78 pg/mL, <i>P</i><0.0001). Oocyte yield and developmental potential improved significantly, as reflected by the increased number of superovulated MII oocytes (17.83±5.15 vs. 4.83±4.79, <i>P</i>=0.0002), and higher proportions of two-cell (85.90%±6.16% vs. 50.00%±10.00%, <i>P</i>=0.0009), four-cell (81.67%±9.76% vs. 50.00%±10.00%, <i>P</i>=0.0061), and blastocyst stage embryos (64.25%±10.55% vs. 23.33%±15.28%, <i>P</i>=0.0067). Live birth numbers were significantly increased following GelMA/ICA treatment (6.90±3.21 vs. 1.72±2.05, <i>P</i>=0.0001). Transcriptomic analysis revealed up-regulation of genes associated with cytoskeletal organization ( <i>Vil1</i>, <i>Tubb3</i>), lipid storage ( <i>Soat2</i>, <i>Plin4</i>), oocyte maturation ( <i>Oosp2</i>), and cytokine secretion ( <i>Cxcl12</i>). Collectively, these findings suggest that GelMA/ICA hydrogels effectively reverse key hallmarks of ovarian aging and restore reproductive function in aged mice, offering a promising platform for fertility preservation and a novel therapeutic for future investigations into ovarian aging.</p>","PeriodicalId":48636,"journal":{"name":"Zoological Research","volume":"46 4","pages":"863-876"},"PeriodicalIF":4.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic architecture of ant social evolution.","authors":"Weiwei Liu, Guo Ding, Zijun Xiong, Guojie Zhang","doi":"10.24272/j.issn.2095-8137.2025.290","DOIUrl":"10.24272/j.issn.2095-8137.2025.290","url":null,"abstract":"","PeriodicalId":48636,"journal":{"name":"Zoological Research","volume":"46 4","pages":"789-791"},"PeriodicalIF":4.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From injury to recovery: Spatiotemporal dynamics of the visual pathway during spontaneous structural and functional regeneration after optic nerve transection in zebrafish.","authors":"Bao-Guo Shen, Yuan Wen, Sheng-Jian Lu, Hong-Yuan Wei, Shu-Rui Huang, Guang-Ming Zhou, Wen-Tao Yan, Wen-Can Wu, Yi-Kui Zhang","doi":"10.24272/j.issn.2095-8137.2025.020","DOIUrl":"10.24272/j.issn.2095-8137.2025.020","url":null,"abstract":"<p><p>In adult mammals, optic nerve injury leads to irreversible vision loss due to its extremely limited regenerative capacity. In contrast, adult zebrafish possess a robust capacity for spontaneous visual system regeneration, although the spatiotemporal coordination of recovery across the retina, optic nerve, and brain remains poorly understood. In the present study, the regenerative dynamics following optic nerve transection were systematically characterized in adult zebrafish over a 5 week period using hematoxylin-eosin staining, immunohistochemistry, transmission electron microscopy, single-cell RNA sequencing, and optokinetic response (OKR) behavioral assessments. At 1 week post-injury (1 wpi), retinal ganglion cell depletion was evident but showed significant recovery by 2 wpi. Concurrently, the injured optic nerve displayed a marked increase in diameter and cell number at 2 wpi, including widespread expression of proliferating cell nuclear antigen, consistent with heightened proliferative activity. Single-cell transcriptomic profiling at 2 wpi revealed five principal cell populations: fibroblasts, mural cells, immune cells, mature oligodendrocytes, and myelin-forming oligodendrocytes. By 4-5 wpi, remyelination within the optic nerve and re-establishment of synaptic architecture in the optic tectum were strongly correlated with functional restoration of OKR behavior. These findings provide a comprehensive spatiotemporal framework of visual pathway regeneration in zebrafish, establishing a valuable model for elucidating conserved mechanisms of neural repair with translational potential for human vision restoration.</p>","PeriodicalId":48636,"journal":{"name":"Zoological Research","volume":"46 4","pages":"733-749"},"PeriodicalIF":4.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell RNA-seq provides insight into the underdeveloped immune system of germ-free mice.","authors":"Yi-Fei Sheng, Wei Cheng, Yin Zhang, Qi-Jun Liao, Juan Shen, Rui-Zhen Zhao, Tai-Liang Chai, Chao Wu, Wei-Ning Hu, Xiang Huang, Bo Wei, Shan-Shan Pan, Yang-Rui Zhang, Rou-Xi Chen, Jun-Pu Mei, Hong Wei, Li-Juan Han, Xiao-Dong Fang","doi":"10.24272/j.issn.2095-8137.2024.467","DOIUrl":"10.24272/j.issn.2095-8137.2024.467","url":null,"abstract":"<p><p>Germ-free mice exhibit profound immunological immaturity. Despite recent studies emphasizing the role of specific bacterium-derived metabolites in immune cell development and differentiation, the mechanisms linking microbiota absence to systemic immune deficits remain incompletely defined. Here, droplet-based single-cell RNA sequencing of bone marrow and peripheral blood from both germ-free and specific pathogen-free mice was performed, identifying 25 transcriptionally distinct cell types. Neutrophil apoptosis was elevated in germ-free mice, potentially due to the absence of niacin dehydrogenase, a metabolite primarily produced by <i>Pseudomonas</i>. In addition, germ-free mice exhibited increased excretion of 5'-methylthioadenosine, enhanced ERK activation driven by reactive oxygen species, and disruption of bone marrow stromal antigen 2 signaling. Monocytes and CD8 ⁺ T cells from germ-free mice showed diminished responses to interferon-β and interferon-γ, consistent with heightened viral susceptibility. These findings establish a microbiota-dependent regulatory pathway linking immunodeficiency to microbial absence in germ-free mice, confirmed through complementary validation techniques.</p>","PeriodicalId":48636,"journal":{"name":"Zoological Research","volume":"46 4","pages":"812-824"},"PeriodicalIF":4.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RNF122 targets STING for ubiquitination at residues K95, K117, and K155 to regulate antiviral responses in a teleost fish.","authors":"Xiao-Wei Qin, Chuan-Rui Li, Min-Cong Liang, Tian-Hao Li, Yan-Lin You, Shao-Ping Weng, Chang-Jun Guo, Jian-Guo He","doi":"10.24272/j.issn.2095-8137.2025.033","DOIUrl":"10.24272/j.issn.2095-8137.2025.033","url":null,"abstract":"<p><p>Ring finger protein 122 (RNF122), an E3 ubiquitin ligase, orchestrates antiviral immune responses in mammals by targeting retinoic acid-inducible gene 1 and melanoma differentiation-associated gene 5 for ubiquitination. However, its functional relevance in teleosts has yet to be clearly defined, particularly regarding the identification of substrate-specific regulatory sites. This study characterized RNF122 from mandarin fish ( <i>Siniperca chuatsi</i>), termed <i>sc</i>RNF122, and investigated its regulatory impact on stimulator of interferon genes (STING)-mediated antiviral signaling. Results showed that <i>sc</i>RNF122 expression was up-regulated in response to mandarin fish ranavirus (MRV) infection, and its overexpression suppressed <i>sc</i>STING-mediated interferon (IFN) production and enhanced MRV replication. Co-immunoprecipitation confirmed a direct interaction between <i>sc</i>RNF122 and <i>sc</i>STING. Functional assays demonstrated that <i>sc</i>RNF122 facilitated <i>sc</i>STING degradation through the ubiquitin-proteasome pathway, a process impeded by MG132 treatment. Ubiquitination analyses of various <i>sc</i>STING mutants revealed that <i>sc</i>RNF122 catalyzed <i>sc</i>STING ubiquitination at K95, K117, and K155 residues. Moreover, <i>sc</i>RNF122 significantly impaired <i>sc</i>STING-dependent antiviral responses by engaging negative regulatory elements within the signaling cascade. Overall, <i>sc</i>RNF122 was identified as a negative modulator of STING-mediated IFN signaling in mandarin fish, diminishing STING-dependent antiviral activity and promoting its degradation via the ubiquitin-proteasome pathway at lysine residues K95, K117, and K155. These findings provide mechanistic insight into the post-translational control of STING in teleosts and establish a foundation for future investigations into antiviral immune regulation.</p>","PeriodicalId":48636,"journal":{"name":"Zoological Research","volume":"46 4","pages":"750-760"},"PeriodicalIF":4.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phylogeography of a dominant desert lizard reveals the synergistic effects of topography and climate dynamics on diversification in arid eastern-Central Asia.","authors":"Abid Ali, Da-Li Chen, Tatjana N Dujsebayeva, Qi Song, Khayankhyarvaa Terbish, Jun Li, Yin Qi, Xian-Guang Guo","doi":"10.24272/j.issn.2095-8137.2024.327","DOIUrl":"10.24272/j.issn.2095-8137.2024.327","url":null,"abstract":"<p><p>Comprehensive phylogeographic insights require the integration of evidence across diverse taxa, ecosystems, and geographical regions. However, our understanding of the arid biota of the vast Asian drylands remains limited. Accordingly, this study combined phylogeographic analyses with ecological niche modeling to investigate patterns of diversification and demography of the Central Asian racerunner ( <i>Eremias vermiculata</i>), a widespread lizard inhabiting arid eastern-Central Asia (AECA). Mitochondrial DNA (mtDNA) sequences were obtained from 876 individuals across 113 localities, while three nuclear genes- <i>CGNL1</i>, <i>MAP1A</i>, and <i>β-fibint7</i>-were sequenced from 204, 170, and 138 individuals, respectively. Analyses identified four distinct mtDNA lineages corresponding to specific geographic subregions within the AECA, reflecting the topographic and ecological heterogeneity of the region. The detection of mito-nuclear discordance indicated the presence of complex evolutionary dynamics. Divergence dating placed the initial lineage splits at approximately 1.18 million years ago, coinciding with major tectonic activity and climatic aridification that likely promoted allopatric divergence. In particular, lineage diversification within the Tarim Basin suggests that recent environmental shifts may have contributed to genetic divergence. Demographic reconstructions revealed signatures of population expansion or range shifts across all lineages during the Last Glacial Maximum, signifying the combined influence of the unique topography and climate dynamics of the AECA on diversification and demographic change. These results highlight the need for fine-scale genomic investigations to clarify the mechanisms underlying mito-nuclear discordance and local adaptation. Such efforts are essential for advancing understanding of how genetic diversity in dryland taxa responds to environmental change, providing insights into the evolutionary adaptability of species in dynamic landscapes.</p>","PeriodicalId":48636,"journal":{"name":"Zoological Research","volume":"46 3","pages":"485-504"},"PeriodicalIF":4.7,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into the role of Fsh signaling in ovarian differentiation of <i>chorionic gonadotropin α</i> ( <i>cgα</i>)-deficient zebrafish.","authors":"Chuang Shi, Yuqing Zhang, Yao Lu, Qiyong Lou, Guohui Shang, Xuyan Peng, Xiangyan Dai, Xia Jin, Jiangyan He, Gang Zhai, Zhan Yin","doi":"10.24272/j.issn.2095-8137.2024.397","DOIUrl":"10.24272/j.issn.2095-8137.2024.397","url":null,"abstract":"<p><p>Chorionic gonadotropin α (Cgα) functions as the shared subunit for thyroid-stimulating hormone subunit β (Tshβ), luteinizing hormone subunit β (Lhβ), and follicle-stimulating hormone subunit β (Fshβ). While these β-subunits have been extensively studied using effective gene knockout models in zebrafish, the biological role of Cgα remains elusive. In this study, <i>cgα</i>-deficient zebrafish generated via transcription activator-like effector nucleases (TALENs) exhibited viability but displayed pronounced developmental abnormalities, including growth retardation, hyperpigmentation, reduced thyroxine (T4) levels, and defective anterior swim bladder inflation during juvenile stages. In adults, cgα deficiency led to disrupted gonadal development, impaired secondary sex characteristics (SSCs), and severely impacted reproductive behavior in both female and male fish. Notably, both testicular and ovarian differentiation were observed in <i>cgα</i>-deficient fish and <i>lhβ</i> ^<i>-</i>/- ; <i>fshβ</i> ^-/- mutants. Gonadal sex differentiation in <i>cgα</i>-deficient zebrafish exhibited a pronounced shift toward testicular fate upon additional disruption of <i>fshβ</i> ( <i>cgα</i> ^-/-; <i>fshβ</i> ^-/-), marked by elevated anti-Müllerian hormone ( <i>amh</i>) expression, or following loss of follicle-stimulating hormone receptor ( <i>fshr</i>) ( <i>cgα</i> ^-/-; <i>fshr</i> ^-/-). <i>In vitro</i> assays in Chinese hamster ovary (CHO) cells revealed increased cAMP response element (CRE) promoter activity following transfection with constructs encoding Fshr, Fshβ/Fshr, or Cgα/Fshβ/Fshr. Collectively, the phenotypes observed in <i>cgα</i>-deficient fish recapitulate those of thyrotropin- and gonadotropin-disrupted models, highlighting the essential role of Cgα in thyroid and gonadal function. Importantly, these findings uncover the role of Fsh signaling in maintaining proper ovarian differentiation in zebrafish, including Cgα-independent Fshβ activity and the constitutive functionality of Fshr.</p>","PeriodicalId":48636,"journal":{"name":"Zoological Research","volume":"46 3","pages":"695-708"},"PeriodicalIF":4.7,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}