{"title":"Cover Image: ChemBioEng Reviews 4/2025","authors":"","doi":"10.1002/cben.70027","DOIUrl":"https://doi.org/10.1002/cben.70027","url":null,"abstract":"<p>Algae for biofuels as an alternative to fossil fuels. Copyright: toa555@AdobeStock\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"12 4","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cben.70027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Abbasi, Ahmad Rahbar-Kelishami, Matin Zareie, Luis Padrela
{"title":"Recent Developments in Nanoparticle Synthesis for Targeted Drug Delivery: A Comprehensive Review","authors":"Ali Abbasi, Ahmad Rahbar-Kelishami, Matin Zareie, Luis Padrela","doi":"10.1002/cben.70015","DOIUrl":"https://doi.org/10.1002/cben.70015","url":null,"abstract":"<p>In pharmaceutical and chemical engineering, addressing newly discovered drugs’ solubility and bioavailability challenges is imperative. Nanoparticle (NP)-based drug delivery systems have emerged as a promising strategy to enhance these compounds’ solubility and overall therapeutic efficacy while minimizing adverse effects. This review presents a comprehensive analysis of synthesis methods for drug-loaded NPs that effectively address solubility limitations. Various chemical synthesizing methods, such as nanoprecipitation, solvent evaporation, and supercritical fluid techniques, are discussed, along with physical methods, including milling, spray-drying, and freeze-drying. Each synthesis approach is evaluated in terms of its underlying principles, advantages, and limitations. Additionally, the importance of NP characterization techniques, such as evaluating drug loading, particle size, and surface properties, is emphasized. Understanding these synthesis methods is crucial for optimizing NP formulations to achieve desired drug delivery outcomes, including improved solubility, controlled release profiles, and targeted delivery to specific sites in the body.</p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"12 4","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Usman Bello, Haruna Adamu, Shafirah Samsuri, Mohammad Qamar, Wan Nur Aisyah Wan Osman
{"title":"Solvent-Aided Crystallization for Biodiesel Purification: A Review of the Technique's Proficiency","authors":"Usman Bello, Haruna Adamu, Shafirah Samsuri, Mohammad Qamar, Wan Nur Aisyah Wan Osman","doi":"10.1002/cben.70018","DOIUrl":"https://doi.org/10.1002/cben.70018","url":null,"abstract":"<p>Traces of impurities encountered after purification processes compromise biodiesel's stability, longevity, and quality performance. Techniques, such as wet washing, adsorbents, and membranes, have been extensively explored; however, they grapple with several challenges, including wastewater generation, time-demanding tasks, and environmentally unfriendly protocols. This study presents a comprehensive overview of solvent-aided crystallization (SAC) as a plausible biodiesel purification option that offers economic and environmental benefits through efficient solvent recovery and minimal waste generation. A total of 23,009 documents published between 2004 and 2024 in the Scopus database were analyzed using a bibliometric approach. This gives insight into research trends, identifies the most extensively explored techniques, highlights countries with a well-established research base in this domain, and offers a guide for evaluation and preference selection for a particular technique. Although conventional methods have been acknowledged for showing great promise in removing impurities such as glycerol and free fatty acids from biodiesel achieving about 98 %, SAC was reported to achieve 99.8 % purity. Moreover, the analysis presented herein underscores the fundamental principles of SAC, factors influencing its efficiency, and the role of selective solubility in enabling effective purification. Finally, it highlights the critical role of strengthened policy action and continued research as key elements, offering researchers valuable insights for advancing the broader adoption and commercialization of SAC.</p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"12 4","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhang Jin Ng, Rozi Nuraika Binti Ramli, Joo Shun Tan
{"title":"Purification Strategies for Bacteriocins and Bacteriocin-Like Inhibitory Substances (BLIS)","authors":"Zhang Jin Ng, Rozi Nuraika Binti Ramli, Joo Shun Tan","doi":"10.1002/cben.70017","DOIUrl":"https://doi.org/10.1002/cben.70017","url":null,"abstract":"<p>Bacteriocins and bacteriocin-like inhibitory substances (BLIS) are antimicrobial peptides produced by bacteria with diverse applications in food preservation, pharmaceuticals, and biotechnology. Their practical use depends on efficient purification from complex fermentation broths to ensure bioactivity, purity, and safety. A range of purification techniques have been explored, including ammonium sulfate precipitation, aqueous two-phase systems (ATPS), pH-mediated cell adsorption–desorption, chromatography, and polyethylene glycol (PEG)-impregnated resin systems. Each method offers specific advantages and limitations regarding selectivity, recovery yield, process scalability, and compatibility with downstream operations. Innovation such as ionic liquid-based ATPS has demonstrated improved separation efficiency and milder processing conditions, making them attractive for sensitive biomolecules. Understanding the underlying principles of these methods enables the development of tailored purification workflows that enhance product quality and support the commercialization of bacteriocin-based bioactive agents.</p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"12 4","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Uptake of Inorganic Water Toxicants by Polyaniline Nanocomposite Adsorbents: A Review","authors":"Parmeshwar Lal Meena","doi":"10.1002/cben.70016","DOIUrl":"https://doi.org/10.1002/cben.70016","url":null,"abstract":"<p>Water contamination by organic and inorganic toxicants is a critical issue that needs to be successfully resolved using efficient remediation methodologies. Inorganic metal and nonmetal ions toxicants are contributed from industrial, urbanization, domestic, and natural activities to the water resources, and water-mediated consumption of these toxicants beyond the prescribed limit causes stern health problems for humans and other living beings and creates ecological imbalances. Polyaniline nanocomposites fabricated using various organic and inorganic nanomaterials attracted great attention in water purification owing to enhanced surface, physicochemical features, and better pollutant removal capacity. This review discusses recent advances in polyaniline nanocomposites as adsorbents for the removal of metallic and nonmetallic water pollutants, including key synthesis approaches, adsorption potential, and mechanisms followed in the exclusion of inorganic pollutants. It is deduced that polyaniline nanocomposites are efficient adsorbents for metallic and nonmetallic inorganic water pollutants. It concluded with major outcomes and challenges associated with the discussed adsorbents.</p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"12 4","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cover Picture: ChemBioEng Reviews 3/2025","authors":"","doi":"10.1002/cben.70014","DOIUrl":"https://doi.org/10.1002/cben.70014","url":null,"abstract":"<p>Algae for biofuels as an alternative to fossil fuels. Copyright: toa555@AdobeStock\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"12 3","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cben.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ghulam Mustafa, Muhammad Islam, Irfan Ahmad, Hafiz Abdullah Shakir, Muhammad Khan, Muhammad Irfan
{"title":"Harnessing the Anticancer Potential of Algae: A Comprehensive Review","authors":"Ghulam Mustafa, Muhammad Islam, Irfan Ahmad, Hafiz Abdullah Shakir, Muhammad Khan, Muhammad Irfan","doi":"10.1002/cben.70011","DOIUrl":"https://doi.org/10.1002/cben.70011","url":null,"abstract":"<p>Cancer is still a primary worldwide health concern because of poor prognosis, adverse therapeutic reactions, and drug resistance. Although developments in several disciplines offer promise, natural chemicals derived from algae offer a promising new direction. Algae provide a potential replacement for conventional chemotherapy due to their diverse chemical composition and possible advantages, including quicker effect and reduced toxicity. Though the use of chemicals generated from algae in drug development is still in its earliest stages, further research into this area could provide lots of information and open the door to new and safer cancer treatments. The potential of various algae in the fight against cancer is examined in this comprehensive review. The review explores the wide range of bioactive chemicals present in different forms of algae. It discusses their way of action, which includes immune response regulation, cell death induction, and angiogenesis inhibition. Particular substances, such as polysaccharides, and the methods used to isolate them are covered, as well as how well they work against different kinds of cancer.</p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"12 4","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ML@ChemE: Past, Present, and Future of Machine Learning in Chemical Engineering","authors":"Pınar Özdemir, Prof. Ramazan Yıldırım","doi":"10.1002/cben.70012","DOIUrl":"https://doi.org/10.1002/cben.70012","url":null,"abstract":"<p>This paper aims to review the machine learning (ML) applications in chemical engineering (ChemE) and provide perspectives for the future. First, the evolution of ML, data structures, and ML applications in ChemE were reviewed; then, the current state of the art in ML and its ChemE applications were summarized. Finally, a perspective for the future developments, including recently popularized tools like generative artificial intelligence (AI) and large language models (LLMs), as well as major challenges and limitations, was provided. Although the initial applications were mainly on fault detection, signal processing, and process modeling, the focus had been extended to other fields involving material development, property estimation, and performance analysis in later years with the use of more complex models and datasets. In future, new developments like LLMs will likely spread more; the other new applications like automated ML, physics-informed ML, and transfer learning, as well as field-specific databases, will also get more attention. ML applications in ChemE-related fields, like new energy technologies, environmental issues, and new material discovery, are expected to grow further.</p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"12 4","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cben.70012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}