ChemBioEng Reviews最新文献

{"title":"Rice Bran Stabilization: Methods and Nutritional Impacts on Rice Bran Oil and Protein","authors":"Penima R. Marak,&nbsp;P. M. Pradeep,&nbsp;Shashikumar Thimmaiah,&nbsp;K. S. M. S Raghavarao,&nbsp;Anil B. Vir","doi":"10.1002/cben.70073","DOIUrl":"https://doi.org/10.1002/cben.70073","url":null,"abstract":"<div>\u0000 \u0000 <p>Rice bran is a nutrient-dense by-product of rice milling, rich in proteins, lipids, fiber, and bioactive compounds including tocopherols, tocotrienols, and γ-oryzanol. However, lipase rapidly hydrolyzes rice bran lipids, resulting in rapid free fatty acid accumulation, leading to deterioration of quality during storage. Hence, immediate enzyme inactivation after milling is crucial to suppress lipid hydrolysis, preserve quality, and extend shelf life. This review provides a comprehensive analysis of conventional thermal, novel thermal and athermal methods for rice bran stabilization, focusing on their mechanisms, enzyme inactivation efficiency, processing requirements, scalability, and effects on rice bran oil and protein. Emerging methods including cold plasma, pulsed electric field and enzyme inhibitors show potential for reducing thermal damage and maintain the nutritional quality, however, their application to rice bran remains limited compared to the conventional methods. A comparasion between thermal and athermal methods and SWOT analysis is provided, emphasizing stabilization efficiency, nutritional quality, and scalable methods for balanced stabilization and maximal nutrient retention.</p>\u0000 </div>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 5","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149205674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfusion Cell Cultures: Is the Technology Worthwhile for Biopharmaceutical Production?","authors":"Francesco Iannacci,&nbsp;Mattia Sponchioni","doi":"10.1002/cben.70074","DOIUrl":"https://doi.org/10.1002/cben.70074","url":null,"abstract":"<p>An increasing demand for biopharmaceuticals, the growing pressure from the market, and the necessity to compress process development times represent current challenges in biopharma manufacturing. Traditional discontinuous bioreactors start to appear as obsolescent and unsuitable to address these challenges. On the other hand, perfusion cultures have been reported as promising alternatives, allowing to alleviate the batch-to-batch variability and to improve the volumetric yield. However, industrial inertia, requirement of higher investment costs, and increased complexity represent challenges limiting the scale up of the operation to manufacturing platforms. The aim of this review is to deconstruct the intricate perfusion problem and examine the potential advantages this technology could bring. Starting from basic operational fundamentals and an overview of the most recent applications, this review will span from an economic assessment of perfusion cultures to the analysis of their environmental sustainability and integration with advanced monitoring techniques. Finally, a discussion of existing hurdles and of the way to tackle the current inertia in industrial adoption is proposed.</p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 5","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cben.70074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149205795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State-of-the-Art Seed Separation Techniques for Horticultural Crops: A Review","authors":"Kohinoor Singh Bhullar,&nbsp;Gurveer Kaur,&nbsp;Preeti Birwal","doi":"10.1002/cben.70072","DOIUrl":"https://doi.org/10.1002/cben.70072","url":null,"abstract":"<div>\u0000 \u0000 <p>Fruit and vegetable processing generates large streams of seed-containing material during the manufacture of value-added products. Effective seed separation is essential to preserve product quality, prevent undesirable seed disruption, and enable recovery of seed-derived oils, proteins, and other valuable compounds. This review critically examines mechanical, chemical, enzymatic, fermentation-based, and emerging seed-separation technologies for horticultural crops. Technologies are assessed according to separation efficiency, seed recovery and purity, seed integrity, throughput, operational requirements, environmental implications, and industrial applicability. Mechanical methods currently provide the strongest basis for continuous, high-throughput processing, although their performance depends on crop properties and seed-pulp adhesion. Chemical treatments can rapidly remove pulp and mucilage but are constrained by chemical usage and safety concerns. Enzymatic methods offer selective, mild separation, but cost and scale-up remain limitations. Fermentation is simple but slow. Emerging mechanical–aerodynamic, thermal, ultrasound-assisted, and discrete-element-method-guided approaches require industrial validation. Future work should develop standardized metrics, crop-specific hybrid processes, automated control, and integrated techno-economic and environmental assessments to enable circular seed valorization.</p>\u0000 </div>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 5","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149145955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membrane Distillation for Water Treatment: Recent Advancements, Current Challenges, and Prospects","authors":"Nadeem Iqbal,&nbsp;Muhammad Nauman,&nbsp;Sami Ullah,&nbsp;Babar Hussain,&nbsp;Palanisamy Vasudhevan,&nbsp;Shengyan Pu","doi":"10.1002/cben.70071","DOIUrl":"https://doi.org/10.1002/cben.70071","url":null,"abstract":"<div>\u0000 \u0000 <p>Water demand from an exponentially growing population and rapid industrialization increases pressure on freshwater sources, drawing global attention to the development of promising water treatment technologies. Membrane distillation (MD) offers an effective solution for desalinating seawater and treating wastewater. MD systems with various configurations and membrane modules can achieve high rejection rates (&gt;99%) of salts and toxic contaminants. Recent advancements, including novel modules, configurations, membrane materials, and modifications, have revolutionized MD technology, steering it toward sustainable solutions for water scarcity. Although challenges such as membrane fouling can significantly affect MD performance, several potential solutions have been proposed to enhance membrane durability without harming the environment. An in-depth understanding of MD technology offers numerous avenues for future research that scientists and hydrologists can pursue to develop green solutions for water purification and wastewater treatment. Thus, MD technology has the potential to play a crucial role in water purification, enhancing global water security.</p>\u0000 </div>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 5","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149048419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofilm-Based Continuous Succinic Acid Production From Complex Feedstocks With In Situ Recovery","authors":"Zhong-Liang Sun,&nbsp;Yu Xie,&nbsp;Yu-Qi Li,&nbsp;Yong-Qiang Liu","doi":"10.1002/cben.70070","DOIUrl":"https://doi.org/10.1002/cben.70070","url":null,"abstract":"<div>\u0000 \u0000 <p>Succinic acid (SA) is an important C4 platform chemical for renewable polymers and value-added products, but bio-based production is still limited by costly substrates, cell washout, inhibitor stress, inefficient carbon dioxide transfer, and demanding downstream recovery. This review examines biofilm-based continuous fermentation as an integrated process-intensification route for SA biomanufacturing. Biofilm and immobilized-cell reactors are discussed as high-cell-density systems that retain biomass, stabilize metabolism, and support complex feedstocks such as lignocellulosic hydrolysates, food-processing residues, and crude glycerol. Advances in feedstock pretreatment, inhibitor mitigation, carbon dioxide utilization, bicarbonate delivery, and in situ product removal are evaluated for continuous operation. Strain engineering for biofilm formation, inhibitor tolerance, metabolic robustness, and microbial consortia is also considered. The review highlights that coupling feedstock conditioning, biofilm fermentation, product recovery, and microbial engineering is essential for carbon-efficient and circular SA biorefineries.</p>\u0000 </div>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 5","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149048174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-Assisted Waste Salt Detection: Intelligent Transformation of Reagents, Instruments, and Methods","authors":"Huaigang Cheng,&nbsp;Ruirui Hou,&nbsp;Fei Wang,&nbsp;Bo Wang","doi":"10.1002/cben.70069","DOIUrl":"https://doi.org/10.1002/cben.70069","url":null,"abstract":"<div>\u0000 \u0000 <p>Reliable characterization is essential for risk assessment, treatment selection, and resource recovery of industrial waste salts. Their variable composition, high salinity, heterogeneous impurities, and matrix effects complicate sampling, pretreatment, measurement, calibration, and interpretation. Artificial intelligence (AI) can support reagent and sensing-material optimization, instrumentation, signal interpretation, quantitative modeling, multimodal data fusion, validation, and deployment. This review evaluates AI-assisted waste salt analysis across these workflow stages. Current studies show potential in condition optimization, signal recognition, drift compensation, calibration management, uncertainty evaluation, and result routing. However, direct evidence from representative industrial waste salts remains limited, and validation across independent batches, instruments, and long-term operation is insufficient. Future work should prioritize matrix-relevant datasets, metrological traceability, quality assurance, transferability, and workflow-level evaluation of time, resource use, and reliability.</p>\u0000 </div>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 5","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148903899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of AI in Municipal Wastewater Treatment and Management: A Comprehensive Review","authors":"Abdulrazak Jinadu Otaru,&nbsp;Isaac Alhamdu Baba,&nbsp;Omoniyi Babajide Awe,&nbsp;Manase Auta,&nbsp;Zaid Abdulhamid Alhulaybi Albin Zaid,&nbsp;Mohammed Al-Yaari","doi":"10.1002/cben.70068","DOIUrl":"https://doi.org/10.1002/cben.70068","url":null,"abstract":"<div>\u0000 \u0000 <p>The fast pace of urbanization, tightening discharge requirements, and efficient wastewater treatment require that municipal wastewater treatment plants (WWTPs) move to adaptive and intelligent modes of operation. The present review provides an analysis of the application of artificial intelligence (AI) to different pre- and posttreatment steps in the context of municipal WWTPs. Specifically, this review considers how machine learning (ML), deep learning (DL), evolutionary optimization, reinforcement learning, and hybrid AI–mechanistic models can be utilized in municipal wastewater processes. AI-based approaches are reviewed in the area of activated sludge processes such as dissolved oxygen control, nutrient removal, effluent quality estimation, and energy management; membrane bioreactor (MBR) processes such as membrane fouling and transmembrane pressure prediction; anaerobic digestion (AD) processes for biogas generation, stability, energy recovery, and nutrients recovery; and sludge processes such as dewatering, polymer dosage optimization, digestion, and resource recovery. Moreover, AI methods are critically evaluated in the areas of nitrogen and phosphorus removal, N₂O emissions prediction, fault detection, predictive maintenance, and plant-wide optimization. Evidence is provided on the implementation of AI in full-scale municipal and WWTPs with a shift from prediction and soft sensing to optimization and supervision, including aeration control, carbon dosing, coagulant optimization, and sludge dewatering. Nevertheless, the findings heavily depend on plant layout, data quality, sensor accuracy, AI architecture, and validation scheme, and none of the AI architectures currently exist that can be deemed superior to other architectures across all applications. Digital twins, explainable AI, edge computing, and federated learning represent exciting directions for future integrated and robust WWTP management. In addition, autonomous plant-level control and AI-assisted AD-nutrient recovery have not been sufficiently developed yet. The main issues to solve are cross-plant validation, uncertainty analysis, cybersecurity, interpretability, seamless integration into existing supervisory control and data acquisition (SCADA)/programmable logic controller (PLC) networks, and long-term benefits demonstration.</p>\u0000 </div>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 5","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148903828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ceramic Membrane Bioreactors: Current Progress, Fouling Resistance, and Future Research Directions","authors":"Vahid Vatanpour,&nbsp;Meltem Agtas,&nbsp;Enise Pekgenc,&nbsp;Ismail Koyuncu","doi":"10.1002/cben.70067","DOIUrl":"https://doi.org/10.1002/cben.70067","url":null,"abstract":"<div>\u0000 \u0000 <p>The membrane bioreactor (MBR) process is a widely used method in wastewater (WW) treatment. It is frequently preferred in domestic and industrial WW treatment due to its easy integration with other treatment processes, low sludge production, operation with high biomass concentrations, and small footprint features. MBRs, which are generally used with polymeric membranes, can also be used with ceramic membranes, which have become increasingly popular in recent years. Ceramic membranes, which have higher mechanical and chemical strengths than polymeric membranes, are also more resistant to fouling. This review briefly discusses the fabrication techniques of ceramic membranes, which are reviewed, and next, MBRs integrated with different configurations of ceramic membranes were examined; their advantages and disadvantages were discussed and used in aerobic and anaerobic processes for domestic, municipal, and industrial WW. Moreover, the hybridization of ceramic-based MBRs with other treatment processes was investigated. The current studies in the literature were compiled, and a roadmap was developed for future studies with related challenges and perspectives.</p>\u0000 </div>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 4","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148616155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradation of Chlorinated Hydrocarbons: Mechanisms and Enhancement Strategies","authors":"Han Dong,&nbsp;Shengkai Zhao,&nbsp;Yingying Fan,&nbsp;Shuo Peng,&nbsp;Hui Li,&nbsp;Jiqian Wang","doi":"10.1002/cben.70065","DOIUrl":"https://doi.org/10.1002/cben.70065","url":null,"abstract":"<div>\u0000 \u0000 <p>Chlorinated hydrocarbons (CHCs) are pervasive industrial contaminants with high persistence, volatility, toxicity, and bioaccumulation potential, resulting in long-term risks to ecosystems and human health. Biodegradation offers a low-pollution alternative to physicochemical treatments by harnessing functional microorganisms to transform CHCs into less toxic products through aerobic oxidation, aerobic co-metabolism, and anaerobic reductive dechlorination. A diverse array of CHC-degrading bacteria has been identified, including <i>Dehalococcoides</i>, <i>Dehalobacter</i>, <i>Pseudomonas</i>, <i>Methylosinus</i>, and <i>Rhodococcus</i>. However, single-step biodegradation approaches remain constrained by slow reaction rates, accumulation of toxic intermediates, and limited microbial community stability. Various strategies for enhancing biodegradation, such as electrochemical–microbial coupling, material–microbial coupling, biostimulation, and bioaugmentation, have been developed and refined. This review systematically summarizes the degradation mechanisms and enhancement technologies for CHCs and discusses their laboratory research works and field applications.</p>\u0000 </div>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 4","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148467477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Scale Continuous-Flow Fluidic Strategies for Nanodrug Formulation, Engineering, and Delivery","authors":"Ali Abbasi,&nbsp;Ahmad Rahbar-Kelishami,&nbsp;Matin Zareie,&nbsp;Zahra Razmdideh,&nbsp;Luis Padrela","doi":"10.1002/cben.70066","DOIUrl":"https://doi.org/10.1002/cben.70066","url":null,"abstract":"<div>\u0000 \u0000 <p>Advances in milli-, micro-, and nanofluidic systems have transformed drug nanoparticle formation, each scale presenting distinct mixing and particle formation constraints. Millifluidics offer stability for formulation translation but limited operational tolerance. Microfluidics enable precise control over particle size and batch consistency via solvent exchange and micromixing. Nanofluidics, dominated by surface effects and molecular confinement, allow stimuli-triggered drug release (e.g., pH, heat) unattainable at larger scales. Emerging trends integrate all three scales into hybrid workflows, employ AI for process optimization, continuous manufacturing, and more biocompatible materials. Key challenges remain—channel clogging, material-dependent performance, narrow scale-up windows, and regulatory barriers to clinical translation. This review synthesizes progress across scales, identifies development needs, and explores future directions including multi-scale hybrid systems, smart process controls, and patient-tailored nanofluidic designs.</p>\u0000 </div>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 4","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148467143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}