靶向给药纳米颗粒合成研究进展综述

IF 6.2 3区 工程技术 Q1 ENGINEERING, CHEMICAL
Ali Abbasi, Ahmad Rahbar-Kelishami, Matin Zareie, Luis Padrela
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引用次数: 0

摘要

在制药和化学工程中,解决新发现药物的溶解度和生物利用度挑战是势在必行的。基于纳米颗粒(NP)的药物递送系统已经成为一种有前途的策略,可以提高这些化合物的溶解度和整体治疗效果,同时最大限度地减少不良反应。本文综述了有效解决溶解度限制的载药NPs合成方法的综合分析。讨论了各种化学合成方法,如纳米沉淀、溶剂蒸发和超临界流体技术,以及物理方法,包括研磨、喷雾干燥和冷冻干燥。每种综合方法根据其基本原理、优点和局限性进行评估。此外,强调了NP表征技术的重要性,例如评估药物负载,粒径和表面性质。了解这些合成方法对于优化NP配方以实现所需的药物传递结果至关重要,包括改善溶解度、控制释放谱和靶向递送到体内特定部位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Recent Developments in Nanoparticle Synthesis for Targeted Drug Delivery: A Comprehensive Review

Recent Developments in Nanoparticle Synthesis for Targeted Drug Delivery: A Comprehensive Review

In pharmaceutical and chemical engineering, addressing newly discovered drugs’ solubility and bioavailability challenges is imperative. Nanoparticle (NP)-based drug delivery systems have emerged as a promising strategy to enhance these compounds’ solubility and overall therapeutic efficacy while minimizing adverse effects. This review presents a comprehensive analysis of synthesis methods for drug-loaded NPs that effectively address solubility limitations. Various chemical synthesizing methods, such as nanoprecipitation, solvent evaporation, and supercritical fluid techniques, are discussed, along with physical methods, including milling, spray-drying, and freeze-drying. Each synthesis approach is evaluated in terms of its underlying principles, advantages, and limitations. Additionally, the importance of NP characterization techniques, such as evaluating drug loading, particle size, and surface properties, is emphasized. Understanding these synthesis methods is crucial for optimizing NP formulations to achieve desired drug delivery outcomes, including improved solubility, controlled release profiles, and targeted delivery to specific sites in the body.

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来源期刊
ChemBioEng Reviews
ChemBioEng Reviews Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
7.90
自引率
2.10%
发文量
45
期刊介绍: Launched in 2014, ChemBioEng Reviews is aimed to become a top-ranking journal publishing review articles offering information on significant developments and provide fundamental knowledge of important topics in the fields of chemical engineering and biotechnology. The journal supports academics and researchers in need for concise, easy to access information on specific topics. The articles cover all fields of (bio-) chemical engineering and technology, e.g.,
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