Ali Abbasi, Ahmad Rahbar-Kelishami, Matin Zareie, Luis Padrela
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Recent Developments in Nanoparticle Synthesis for Targeted Drug Delivery: A Comprehensive Review
In pharmaceutical and chemical engineering, addressing newly discovered drugs’ solubility and bioavailability challenges is imperative. Nanoparticle (NP)-based drug delivery systems have emerged as a promising strategy to enhance these compounds’ solubility and overall therapeutic efficacy while minimizing adverse effects. This review presents a comprehensive analysis of synthesis methods for drug-loaded NPs that effectively address solubility limitations. Various chemical synthesizing methods, such as nanoprecipitation, solvent evaporation, and supercritical fluid techniques, are discussed, along with physical methods, including milling, spray-drying, and freeze-drying. Each synthesis approach is evaluated in terms of its underlying principles, advantages, and limitations. Additionally, the importance of NP characterization techniques, such as evaluating drug loading, particle size, and surface properties, is emphasized. Understanding these synthesis methods is crucial for optimizing NP formulations to achieve desired drug delivery outcomes, including improved solubility, controlled release profiles, and targeted delivery to specific sites in the body.
ChemBioEng ReviewsBiochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
7.90
自引率
2.10%
发文量
45
期刊介绍:
Launched in 2014, ChemBioEng Reviews is aimed to become a top-ranking journal publishing review articles offering information on significant developments and provide fundamental knowledge of important topics in the fields of chemical engineering and biotechnology. The journal supports academics and researchers in need for concise, easy to access information on specific topics. The articles cover all fields of (bio-) chemical engineering and technology, e.g.,