Sharifah Shahira Syed Putra, Yatimah Alias, Wan Jefrey Basirun, Mohd Izzudin Izzat Zainal Abidin, Adeeb Hayyan, Rikson Siburian
{"title":"Tunable Deep Eutectic Solvents for Biomass Fractionation: Physicochemical Insights and Toxicity","authors":"Sharifah Shahira Syed Putra, Yatimah Alias, Wan Jefrey Basirun, Mohd Izzudin Izzat Zainal Abidin, Adeeb Hayyan, Rikson Siburian","doi":"10.1002/cben.70064","DOIUrl":"https://doi.org/10.1002/cben.70064","url":null,"abstract":"<div>\u0000 \u0000 <p>Deep eutectic solvents (DESs) have emerged as promising green solvents for lignocellulosic biomass pretreatment due to their tunable properties, low cost, and sustainability. Their unique hydrogen-bonding networks, polarity, and ionic characteristics enable selective disruption of lignin–carbohydrate complexes. Despite these advantages, several challenges remain, including limited xylan recovery, an incomplete understanding of DES-biomass interactions, and insufficient toxicity assessments. Toxicity is strongly influenced by DES composition, particularly the hydrogen bond donor (HBD), highlighting the need for systematic evaluation of environmental and biological impacts. Furthermore, the behavior of aqueous DES systems and their interactions with biomass components require further investigation. This review summarizes recent advances in DES-based biomass pretreatment, emphasizing their physicochemical properties, mechanisms, and toxicity. By integrating current knowledge, it provides insights into DES behavior during biomass processing and offers guidance for the rational design of safer, more efficient solvents to support sustainable biorefinery development.</p>\u0000 </div>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 4","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148467195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Decarbonizing Composites: Policy-Oriented Review of Carbon Footprint, Circularity, and Carbon Trading","authors":"Chan Kok Lee, Hooi Ren Lim, Doris Ying Ying Tang, Pau Loke Show, Kit Wayne Chew","doi":"10.1002/cben.70063","DOIUrl":"https://doi.org/10.1002/cben.70063","url":null,"abstract":"<div>\u0000 \u0000 <p>Composite materials have been used since ancient times, notably in the form of “Cob,” where clay, earth, straw, and organic matter were combined to improve building performance. Many composite materials rely on carbon-intensive binders, fibers, fillers, or petroleum-derived polymer matrices, raising concerns about life cycle emissions, recyclability, and end-of-life management. Global climate commitments have triggered a shift toward carbon neutrality. The industry is transitioning from trend-driven “green” claims to measurable environmental compliance. Hence, this review examines how sustainable composite materials intersect with carbon governance mechanisms, including carbon taxes, emissions trading systems, and voluntary carbon markets, as well as the differentiation of carbon-accounting categories. The review also evaluates how life cycle assessment, circularity, and end-of-life pathways influence the credibility of sustainability claims. In summary, sustainable composites can support decarburization, but their eligibility for tradable carbon credit remains limited and depends on recognized methodologies, additionality, permanence, monitoring, reporting, and verification. From ancient Cob to modern concrete, composites have shaped construction. Now, the focus shifts to sustainability—where bio-based, circular, and carbon-neutral materials are redefining the future of building.</p>\u0000 </div>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 4","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148467311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Research Progress on Bacterial Imaging and Detection Based on Biomass Carbon Dots","authors":"Wenlu Li, Chunlong Sun, Wen Du","doi":"10.1002/cben.70061","DOIUrl":"https://doi.org/10.1002/cben.70061","url":null,"abstract":"<div>\u0000 \u0000 <p>Bacterial infections and antibiotic resistance pose global public health challenges, and traditional detection methods have many limitations. Biomass carbon dots (BCDs), as green fluorescent nanomaterials, have great potential in bacterial imaging and detection. This article systematically reviews the research progress of BCDs from 2014 to 2026, covering five major categories: plant sources, animal sources, microbial sources, waste biomass sources, and other biomass sources, mainstream preparation methods, and core biological and optical properties. It deeply elaborates on their mechanism of action in bacterial imaging and detection, as well as their application progress in point-of-care testing (POCT) and food safety monitoring. It also analyzes the current bottlenecks such as synthesis controllability, optical performance, specificity, and clinical translation. In the future, efforts should focus on controllable synthesis, optimization of near-infrared performance, and integrated diagnosis and treatment applications to accelerate the practical implementation of BCDs.</p>\u0000 </div>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 4","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rabia Nur Bozkurt, Ebru Kurtulbaş, İrem Toprakçı, Selin Şahin
{"title":"Sustainable Extraction of Bioactive Compounds: Engineering Principles and Technologies","authors":"Rabia Nur Bozkurt, Ebru Kurtulbaş, İrem Toprakçı, Selin Şahin","doi":"10.1002/cben.70062","DOIUrl":"https://doi.org/10.1002/cben.70062","url":null,"abstract":"<div>\u0000 \u0000 <p>There is an increasing demand for sustainable extraction technologies capable of efficiently isolating bioactive compounds from complex food matrices due to the rising interest in nutraceutical products. Traditional extraction procedures that use conventional solvents have big problems (environmental impact, solvent toxicity, and high energy consumption). Green extraction technologies are safer and more environmentally friendly options following the rules of green chemistry. This review provides a comprehensive overview of green extraction strategies applied to food matrices. Their methods, benefits, and process efficiency are examined through the impact of food matrix structure on extraction performance. Special focus is placed on the use of food-grade and alternative solvents, which enhance extraction efficiency while providing safety and environmental sustainability. In conclusion, green extraction technologies contribute to waste valorization, whereas they facilitate the efficient manufacture of high-quality functional components. So, this approach makes them a feasible strategy for the sustainable recovery of nutraceutical compounds.</p>\u0000 </div>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 4","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amirhossein Nazhand, Yuemin Li, Lidan Ye, Hongwei Yu
{"title":"Precision Engineering of Imine Reductases: From Structural Insights to Data-Driven Design","authors":"Amirhossein Nazhand, Yuemin Li, Lidan Ye, Hongwei Yu","doi":"10.1002/cben.70059","DOIUrl":"https://doi.org/10.1002/cben.70059","url":null,"abstract":"<div>\u0000 \u0000 <p>Imine reductases (IREDs) have emerged as powerful biocatalysts for the enantioselective synthesis of chiral amines via reductive amination, filling a critical gap in accessing optically pure amines essential to pharmaceutical and fine chemical synthesis. However, native IREDs face limitations, including narrow substrate scope, insufficient stability, and strict nicotinamide adenine dinucleotide phosphate (reduced form) (NADPH) dependency. Protein engineering has repositioned IREDs as programmable biocatalysts capable of overcoming these barriers. This review consolidates recent advances into an integrated framework linking structural insights to predictive engineering strategies: (1) structural “hardware”—understanding the multiscale IRED architecture governing substrate recognition and stereoselectivity; (2) structure-driven engineering—translating these structural insights into rational, semi-rational, and cofactor engineering to enhance activity and expand substrate compatibility; and (3) computational “software”—leveraging mechanism-based modeling and machine learning to guide variant prediction and accelerate enzyme discovery. This framework aims to enable precision engineering of IREDs for challenging synthetic transformations.</p>\u0000 </div>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 4","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148358170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Azzumawardhani Almi, R. A. Ilyas, Muhammad Asyraf Muhammad Rizal, S. M. Sapuan, Melbi Mahardika
{"title":"Smart and Active Packaging Using Bio-Based Polymers","authors":"Azzumawardhani Almi, R. A. Ilyas, Muhammad Asyraf Muhammad Rizal, S. M. Sapuan, Melbi Mahardika","doi":"10.1002/cben.70060","DOIUrl":"https://doi.org/10.1002/cben.70060","url":null,"abstract":"<div>\u0000 \u0000 <p>The development of smart and active packaging derived from bio-based polymers has gained considerable attention in recent years, although existing studies remain dispersed across different materials and functional applications. This review examines recent advances in key bio-based polymers, including polylactic acid (PLA), starch, chitosan, cellulose, gelatin, and polyhydroxyalkanoates (PHAs), for the fabrication of active packaging systems with antimicrobial, antioxidant, and gas- or ethylene-scavenging capabilities. In addition, intelligent packaging technologies such as pH-responsive indicators, freshness sensors, time–temperature indicators, radio-frequency identification (RFID), and biosensing platforms are discussed. Particular emphasis is placed on their applications in highly perishable foods and cold-chain distribution systems, supported by quantitative performance evaluations. The review also assesses environmental sustainability by comparing biodegradation behavior under industrial composting, soil, and marine environments, while highlighting the technical and regulatory challenges that hinder commercial implementation. Current evidence indicates that optimized formulations and the incorporation of nanomaterials can significantly improve barrier performance against oxygen and moisture while enabling effective visual or electronic monitoring functions. Nevertheless, the overall environmental benefits remain dependent on specific life-cycle conditions and end-of-life management scenarios.</p>\u0000 </div>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 4","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148358169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chao Liu, Jun Zhang, Jing Yin, Han Li, Runqiu Zhu, Jingshuai Zhu, Xiaobao Gong, Jianming Chen, Xungai Wang
{"title":"Toward Practical Silicon Anodes: Interfacial Stability, Structural Design, and Scalable Engineering","authors":"Chao Liu, Jun Zhang, Jing Yin, Han Li, Runqiu Zhu, Jingshuai Zhu, Xiaobao Gong, Jianming Chen, Xungai Wang","doi":"10.1002/cben.70058","DOIUrl":"https://doi.org/10.1002/cben.70058","url":null,"abstract":"<p>Lithium-ion batteries (LIBs) are essential energy-storage systems for electric vehicles and portable electronics, yet the conventional graphite anode is approaching its theoretical capacity limit. Silicon-based anodes have emerged as promising candidates for next-generation high-energy LIBs owing to their exceptionally high theoretical capacity, natural abundance, and low working potential. However, their practical application remains limited by severe volume expansion during lithiation/delithiation, poor intrinsic electrical conductivity, unstable solid electrolyte interphase, and low initial coulombic efficiency. In this review, we summarize recent progress in Si-based anode materials and engineering strategies, including nanostructuring, surface/bulk modification, composite design, binder engineering, electrolyte optimization, and pre-lithiation. In addition, this review emphasizes the relationships among intrinsic failure mechanisms, interfacial stability, electrode structural design, and practical scalability. Ultimately, current industrialization progress, remaining bottlenecks, and future directions toward practical Si-based anodes are discussed.</p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 3","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cben.70058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148173854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Group IV Nanodots/Composites: Synthesis for Optical Sensing and Photocatalysis of Water Pollutants","authors":"Yi-Fan Wang, Xiaoyu Huang, Xinyuan Cheng","doi":"10.1002/cben.70057","DOIUrl":"https://doi.org/10.1002/cben.70057","url":null,"abstract":"<div>\u0000 \u0000 <p>Water pollution increasingly threatens public health and ecosystems, driving urgent demand for effective pollutant detection and removal methods. Although a series of methods have been reported, they are often applied solely for either detection or removal and face challenges such as high cost and secondary pollution. Group IV nanodots constructed with fourth main group elements, such as carbon and silicon, are not only low-toxic but also exhibit highly tunable optical properties and photocatalytic activity. Their functionalities can be precisely optimized through size control, heteroatom doping, and surface modification. Furthermore, engineering them into composite materials by integration with other components can leverage synergistic effects to further enhance specific optical sensing capabilities, photocatalytic removal efficiency, and reusability. Such materials, which integrate both detection and catalytic functions, offer the potential for simultaneous photocatalytic degradation and in situ monitoring. They are also economical and environmentally benign, aligning with the critical demands of green chemistry and sustainable development.</p>\u0000 </div>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 3","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148173721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simon Brinkmann, Thomas Grützner, Bernhard C. Seyfang
{"title":"Tar Removal From Biomass-Derived Syngas via Scrubbing: A Review on Process and Modeling","authors":"Simon Brinkmann, Thomas Grützner, Bernhard C. Seyfang","doi":"10.1002/cben.70056","DOIUrl":"https://doi.org/10.1002/cben.70056","url":null,"abstract":"<p>Tars in biomass-derived syngas cause fouling, clogging, and equipment degradation in downstream systems, making their removal essential across all utilization pathways, from combined heat and power to chemical synthesis. Among the available removal strategies, wet gas scrubbing has gained widespread adoption owing to its operational simplicity, scalability, and proven effectiveness. This review assesses the current state of tar scrubbing technology, drawing on plant experience from Güssing, Petten, and Gothenburg to illustrate how scrubber design, solvent selection, and process integration collectively determine removal performance. Oil-based systems are shown to be robust and broadly effective across a wide range of tar compounds. However, synthesis-grade gas quality typically requires multistage configurations with solvent recycling and regeneration. Thermodynamic modeling approaches are further evaluated, identifying persistent gaps in physicochemical property data, particularly binary interaction parameters for tar–solvent systems. Future development should focus on application-specific cleaning concepts, reliable regeneration, and improved system integration.</p>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 3","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cben.70056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148097099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gholamhossein Sodeifian, Seyed Ali Sajadian, Viplav Hari Pise
{"title":"Experimental Design, Scale-Up, and Techno-Economic Test for Advancing Sustainable SC-CO2 Technology","authors":"Gholamhossein Sodeifian, Seyed Ali Sajadian, Viplav Hari Pise","doi":"10.1002/cben.70053","DOIUrl":"https://doi.org/10.1002/cben.70053","url":null,"abstract":"<div>\u0000 \u0000 <p>Supercritical fluid (SF) technologies have wide applications in different industries. These are further gaining popularities owing to their high potential toward meeting sustainable goals (green technology). However, the properties of the fluids show a strong interplay of thermodynamic and kinetic properties owing to the large number of influential parameters like pressure, temperature, flow rate of SF, particle size, presence of cosolvents, time for extraction, influence of assisting mechanisms like ultrasound or microwave, and pretreatment or mix ratio of biomass subjected to extraction with their independent and interrelated influences. This review article aims to elaborate on the parameters influencing the SF properties, significance of experimental design (screening and optimization), need for mathematical modeling for data generation, and methods for data analysis. The article further studies the use of such generated and analyzed data toward scale-up for appropriate response prediction and techno-economic feasibility study for commercial implementation. Having enough knowledge about these issues helps us apply the SF as a sustainable and green technology in different fields.</p>\u0000 </div>","PeriodicalId":48623,"journal":{"name":"ChemBioEng Reviews","volume":"13 3","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148097098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}