Journal of Pathology Clinical Research最新文献_第9页

Cyto-Architectural Complexity of Dyshormonogenic Goitre can Closely Mimic a Thyroid Follicular Malignancy: A Case Report and Review of the Literature to Avoid Diagnostic Pitfall 激素生成障碍甲状腺的细胞结构复杂性与甲状腺滤泡性恶性肿瘤非常相似:一个病例报告和文献回顾以避免诊断缺陷

2区医学

Journal of Pathology Clinical Research Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000160

Nishat Afroz

{"title":"Cyto-Architectural Complexity of Dyshormonogenic Goitre can Closely Mimic a Thyroid Follicular Malignancy: A Case Report and Review of the Literature to Avoid Diagnostic Pitfall","authors":"Nishat Afroz","doi":"10.23880/cprj-16000160","DOIUrl":"https://doi.org/10.23880/cprj-16000160","url":null,"abstract":"A 13-year-old male child presented in the OPD with a midline 5x4cm thyroid swelling of 2 years duration with the chief complaint of difficulty in breathing. He also had growth and mental retardation since 3 years of age. His thyroid profile records revealed a severe degree of hypothyroidism and he was on thyroxine supplement since then. He underwent a right hemithyroidectomy for the right-sided nodular goitre causing on-and-off dyspnea. The gross specimen measured 5x4x3cm, which on cut section showed partially encapsulated multi-nodular solid areas. Microscopy yielded marked architectural complexity and prominent cellular and nuclear pleomorphism that mimicked a thyroid malignancy; for eg., a poorly differentiated papillary or follicular carcinoma. However, a thorough assessment of a range of histo-morphological features in the context of clinical history clinched the diagnosis of dyshormonogenetic goitre. One year postoperatively the patient is doing well on Thyroxine supplement. This case report reviews the literature about this rare benign entity of dyshormonogenetic goitre which closely mimics thyroid malignancy, notably a follicular malignancy on microscopy owing to its cytoarchitectural complexity and nuclear atypia. Hence, knowledge of its clinical presentation, gross and diverse microscopic features is extremely important to avoid misdiagnosis and thereby clinical management.","PeriodicalId":48612,"journal":{"name":"Journal of Pathology Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135551007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Analysis between Absolute Neutrophil Count and Absolute Monocyte Count as a Predictor of Haematopoietic Recovery in Patients with Acute Lymphoblastic Leukaemia 中性粒细胞绝对计数和单核细胞绝对计数作为急性淋巴细胞白血病患者造血恢复预测因子的比较分析

2区医学

Journal of Pathology Clinical Research Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000159

Yesmin MS

引用次数: 0

The Performance of the Thyroid Gland is Affected by the Intellectual and Psychological Pressures that College Students Endure During Exam Time 大学生在考试期间承受的智力和心理压力对甲状腺功能的影响

2区医学

Journal of Pathology Clinical Research Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000162

Majid M Mahmood

引用次数: 0

A Rare Torsion Case of Polycystic Ovarian Syndrome: A Natural Course with Laparoscopic, Cytological and Pathological Findings 一例罕见的多囊卵巢综合征扭转:腹腔镜、细胞学和病理结果的自然过程

2区医学

Journal of Pathology Clinical Research Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000157

Kenji Niwa

引用次数: 0

Ectopic Pregnancy in the Cervix-A Case Report with Review of Literature 宫颈异位妊娠1例报告并文献复习

2区医学

Journal of Pathology Clinical Research Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000161

Pranjal Shah

引用次数: 0

Serpentine Aneurysm of the Placenta with Good Fetal Outcome 胎儿结局良好的胎盘蛇形动脉瘤

2区医学

Journal of Pathology Clinical Research Pub Date : 2023-01-01 DOI: 10.23880/cprj-16000152

Leila Haghi

{"title":"Serpentine Aneurysm of the Placenta with Good Fetal Outcome","authors":"Leila Haghi","doi":"10.23880/cprj-16000152","DOIUrl":"https://doi.org/10.23880/cprj-16000152","url":null,"abstract":"We report an exceedingly rare case of placental serpentine aneurysm. A 21-year-old gravida 3 para 1-0-1-1 with the history of a prior C-section presented at 35 weeks of gestation with the complaint of decreasing or absent fetal movements, previously there were no complications during her pregnancy. She underwent an emergent C-section due to non-reassuring fetal heart tones and delivered a female infant weighing 2145 grams without malformation and Apgar scores of 6 and 8 at 1 and 5 minutes. The premature neonate was admitted to the neonatal intensive care unit (NICU) and was discharged a few days later in good health and has done well since. The placenta weighed 768 grams with a three-vessel umbilical cord. The fetal surface was blue-gray and had multiple markedly dilated tortuous vessels (ranging in diameter from 0.5-1.4 cm) which were attached to a single area on the fetal surface. A Verhoeff-Van Gieson stain was negative for elastic fibers. The placental disc had a 7.1 cm peripheral infarct involving approximately 10% of the disc. There have been 3 cases reported previously in which two were associated with intrauterine growth restriction and one with molar transformation. In conclusion, placental serpentine aneurysm is a rare finding and unlike prior cases was associated with prematurity, decreased fetal movements, and nonreassuring fetal heart tones; a good outcome occurred because of prompt medical intervention.","PeriodicalId":48612,"journal":{"name":"Journal of Pathology Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135551011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel NGS-based diagnostic algorithm for classifying multifocal lung adenocarcinomas in pN0M0 patients 一种新的基于ngs的pN0M0患者多灶性肺腺癌诊断算法

IF 4.1 2区医学

Journal of Pathology Clinical Research Pub Date : 2022-12-29 DOI: 10.1002/cjp2.306

Xin Zhang, Xiaoxi Fan, Changbo Sun, Liang Wang, Yuan Miao, Liming Wang, Peng Yang, Yang Xu, Xue Ren, Xue Wu, Shun Xu

{"title":"A novel NGS-based diagnostic algorithm for classifying multifocal lung adenocarcinomas in pN0M0 patients","authors":"Xin Zhang, Xiaoxi Fan, Changbo Sun, Liang Wang, Yuan Miao, Liming Wang, Peng Yang, Yang Xu, Xue Ren, Xue Wu, Shun Xu","doi":"10.1002/cjp2.306","DOIUrl":"10.1002/cjp2.306","url":null,"abstract":"The classification of multifocal lung adenocarcinomas (MLAs), including multiple primary lung adenocarcinomas (MPLAs) and intrapulmonary metastases (IPMs), has great clinical significance in staging and treatment determination. However, the application of molecular approaches in pN0M0 MLA diagnosis has not been well investigated. Here, we performed next-generation sequencing (NGS) analysis in 45 pN0M0 MLA patients (101 lesion pairs) who were initially diagnosed as having MPLA by comprehensive histologic assessment (CHA). Five additional patients with intrathoracic metastases were used as positive controls, while 197 patients with unifocal lung adenocarcinomas (425 random lesion pairs) were used as negative controls. By utilizing a predefined NGS criterion, all IPMs in the positive control group could be accurately classified, whereas 13 lesion pairs (3.1%) in the negative control cohort were misdiagnosed as IPMs. Additionally, 14 IPM lesion pairs were diagnosed in the study group, with at least 7 misdiagnoses. We thus developed a refined algorithm, incorporating both NGS and histologic results, that could correctly diagnose all the known MPLAs and IPMs. In particular, all IPMs identified by the refined algorithm were diagnosed to be IPMs or suspected IPMs by CHA reassessment. The refined algorithm-diagnosed MPLAs patients also had significantly better progression-free survival than the refined algorithm-diagnosed IPMs (p < 0.0001), which is superior to conventional NGS or CHA diagnoses. Overall, we developed an NGS-based algorithm that could accurately distinguish IPMs from MPLAs in MLA patients. Our results demonstrate a promising clinical utility of NGS to complement traditional CHA-based MLA diagnosis and help determine patient staging and treatment.","PeriodicalId":48612,"journal":{"name":"Journal of Pathology Clinical Research","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/81/CJP2-9-108.PMC9896159.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10730314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Tropomyosin receptor kinase B (TrkB) signalling: targeted therapy in neurogenic tumours 原肌球蛋白受体激酶B (TrkB)信号传导:神经源性肿瘤的靶向治疗

IF 4.1 2区医学

Journal of Pathology Clinical Research Pub Date : 2022-12-19 DOI: 10.1002/cjp2.307

Yuehua Li, Chengjiang Wei, Wei Wang, Qingfeng Li, Zhi-Chao Wang

引用次数: 2

Real-life data from standardized preanalytical coding (SPREC) in tissue biobanking and its dual use for sample characterization and process optimization 组织生物库中标准化分析前编码(SPREC)的真实数据及其用于样品表征和工艺优化的双重用途

IF 4.1 2区医学

Journal of Pathology Clinical Research Pub Date : 2022-12-08 DOI: 10.1002/cjp2.305

Magdalena Skoworonska, Annika Blank, Irene Centeno, Caroline Hammer, Aurel Perren, Inti Zlobec, Tilman T Rau

{"title":"Real-life data from standardized preanalytical coding (SPREC) in tissue biobanking and its dual use for sample characterization and process optimization","authors":"Magdalena Skoworonska, Annika Blank, Irene Centeno, Caroline Hammer, Aurel Perren, Inti Zlobec, Tilman T Rau","doi":"10.1002/cjp2.305","DOIUrl":"10.1002/cjp2.305","url":null,"abstract":"The standardized preanalytical code (SPREC) aggregates warm ischemia (WIT), cold ischemia (CIT), and fixation times (FIT) in a precise format. Despite its growing importance underpinned by the European in vitro diagnostics regulation or broad preanalytical programs by the National Institutes of Health, little is known about its empirical occurrence in biobanked surgical specimen. In several steps, the Tissue Bank Bern achieved a fully informative SPREC code with insights from 10,555 CIT, 4,740 WIT, and 3,121 FIT values. During process optimization according to LEAN six sigma principles, we identified a dual role of the SPREC code as a sample characteristic and a traceable process parameter. With this preanalytical study, we outlined real-life data in a variety of organs with specific differences in WIT, CIT, and FIT values. Furthermore, our FIT data indicate the potential to adapt the SPREC fixation toward concrete paraffin-embedding time points and to extend its categories beyond 72 h due to weekend delays. Additionally, we identified dependencies of preanalytical variables from workload, daytime, and clinics that were actionable with LEAN process management. Thus, streamlined biobanking workflows during the day were significantly resilient to workload peaks, diminishing the turnaround times of native tissue processing (i.e. CIT) from 74.6 to 46.1 min under heavily stressed conditions. In conclusion, there are surgery-specific preanalytics that are surgico-pathologically limited even under process optimization, which might affect biomarker transfer from one entity to another. Beyond sample characteristics, SPREC coding is highly beneficial for tissue banks and Institutes of Pathology to track WIT, CIT, and FIT for process optimization and monitoring measurements.","PeriodicalId":48612,"journal":{"name":"Journal of Pathology Clinical Research","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pathsocjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/cjp2.305","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9295781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significance of Siglec-15 expression in colorectal cancer: association with advanced disease stage and fewer tumor-infiltrating lymphocytes 结直肠癌中siglece -15表达的意义:与疾病晚期和肿瘤浸润淋巴细胞减少有关

IF 4.1 2区医学

Journal of Pathology Clinical Research Pub Date : 2022-11-24 DOI: 10.1002/cjp2.303

Zhao Lu, Pu Cheng, Fei Huang, Jiyun Li, Bingzhi Wang, Shuangmei Zou, Zhaoxu Zheng, Chunwei Peng

{"title":"Significance of Siglec-15 expression in colorectal cancer: association with advanced disease stage and fewer tumor-infiltrating lymphocytes","authors":"Zhao Lu, Pu Cheng, Fei Huang, Jiyun Li, Bingzhi Wang, Shuangmei Zou, Zhaoxu Zheng, Chunwei Peng","doi":"10.1002/cjp2.303","DOIUrl":"10.1002/cjp2.303","url":null,"abstract":"Siglec-15, a novel immune suppressor, is upregulated in many human cancers. The aim of this study was to explore the expression of Siglec-15 in colorectal cancer (CRC), and investigate whether Siglec-15 could be a potential target for cancer immunotherapy in patients with CRC. We performed immunohistochemical analyses of Siglec-15 on a cohort of 805 patients with CRC and made comparisons between clinicopathological characteristics, PD-L1 expression, CD3, CD8, CD45RO tumor-infiltrating lymphocytes (TILs), and prognosis. We found that Siglec-15 expression was commonly detected in tumor cells (48.3%) and tumor-associated stromal cells (33.4%), and was more frequently observed than PD-L1 expression in tumor cells. In contrast, Siglec-15 expression was weakly and scarcely found in normal mucosa (13%). Siglec-15 overexpression in tumor cells was associated with advanced TNM stage (p = 0.020). Co-expression of Siglec-15 and PD-L1 in tumor cells was found in 14.4% of patients, and Siglec-15 expression was detected in almost half of PD-L1 negative cases. Elevated Siglec-15 expression in tumor and stromal cells was associated with sparser CD45RO and CD8 TILs (p = 0.035 and p = 0.004, respectively). The expression of Siglec-15 did not have prognostic significance. In summary, compared to PD-L1, Siglec-15 protein expression is more prevalent in CRC and is associated with advanced disease stage and fewer TILs. These findings support Siglec-15 as a potential cancer immunotherapy target, in addition to PD-1/PD-L1 inhibitors, in patients with CRC.","PeriodicalId":48612,"journal":{"name":"Journal of Pathology Clinical Research","volume":null,"pages":null},"PeriodicalIF":4.1,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/96/84/CJP2-9-121.PMC9896156.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9280217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0